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  1. Article ; Online: von Willebrand factor: from figurant to main character in the scene of inflammation.

    Lenting, Peter J / Texier, Alexis / Casari, Caterina

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 4, Page(s) 710–713

    MeSH term(s) Humans ; von Willebrand Factor ; Inflammation ; von Willebrand Diseases ; Factor VIII
    Chemical Substances von Willebrand Factor ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2023-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  2. Article ; Online: Angiopoietin-2 binds to multiple interactive sites within von Willebrand factor.

    Texier, Alexis / Lenting, Peter J / Denis, Cécile V / Roullet, Stéphanie / Christophe, Olivier D

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 7, Page(s) 102204

    Abstract: Background: Biosynthesis of von Willebrand factor (VWF) in endothelial cells drives the formation of storage-organelles known as Weibel-Palade bodies (WPBs). WPBs also contain several other proteins, including angiopoietin-2 (Ang-2).: Objectives: At ... ...

    Abstract Background: Biosynthesis of von Willebrand factor (VWF) in endothelial cells drives the formation of storage-organelles known as Weibel-Palade bodies (WPBs). WPBs also contain several other proteins, including angiopoietin-2 (Ang-2).
    Objectives: At present, the molecular basis of the VWF-Ang-2 interaction is poorly understood. Here, we used immunosorbent-binding assays and specific recombinant VWF fragments to analyze VWF-Ang-2 interactions.
    Results: We found that VWF bound to immobilized Ang-2 most efficiently (half-maximal binding at 0.5 ± 0.1 μg/mL) under conditions of high CaCl
    Conclusion: Our data show that both Ang-1 and Ang-2 bind to VWF, seemingly using different interactive sites. Ang-2 modulates the binding of VWF to Ang-1, the (patho)-physiological consequences of which remain to be investigated.
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.102204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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