Article ; Online: The role of liquid biopsy in management of the neck with indeterminate response on post-treatment imaging following non-surgical management of oropharyngeal cancer.
2022 Volume 49, Issue 1, Page(s) 55–59
Abstract: Introduction: This study aimed to determine if post-treatment HPV cell-free DNA (cfDNA) can assist in the decision-making process for salvage neck dissection in patients following non-surgical treatment of oropharyngeal squamous cell carcinoma (OPSCC) ... ...
| Abstract | Introduction: This study aimed to determine if post-treatment HPV cell-free DNA (cfDNA) can assist in the decision-making process for salvage neck dissection in patients following non-surgical treatment of oropharyngeal squamous cell carcinoma (OPSCC) with a partial response in the neck on imaging at 12 weeks post-treatment. Methods: 86 patients who completed treatment were prospectively recruited through the regional multidisciplinary team (MDT). Treatment response was categorised as complete response (CR), partial response (PR) or progressive disease on 12-week post-treatment imaging. Pre- and post-treatment blood samples were assessed for HPV cfDNA through droplet digital PCR (ddPCR). Results: Eight patients had an isolated partial response in the neck. One (12.5%) had detectable HPV cfDNA (22.96 copies/ml) at ∼12 weeks post-treatment with positive disease on subsequent neck dissection (positive predictive value; PPV = 100%). Of the seven patients with undetectable HPV cfDNA, two patients had evidence of regional disease recurrence at 23.9 and 27.4 months respectively (negative predictive value; NPV = 71%). Conclusion: The detection of HPV cfDNA may help target salvage therapy in patients with a partial response in the neck. Follow-up studies in larger cohorts would be required to further validate the use of post-treatment HPV cfDNA in the management of OPSCC. |
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| MeSH term(s) | Humans ; Papillomavirus Infections/complications ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/therapy ; Carcinoma, Squamous Cell/pathology ; Neoplasm Recurrence, Local/pathology ; Oropharyngeal Neoplasms/diagnostic imaging ; Oropharyngeal Neoplasms/therapy ; Oropharyngeal Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Squamous Cell Carcinoma of Head and Neck/therapy ; Liquid Biopsy ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/therapy ; Cell-Free Nucleic Acids |
| Chemical Substances | Cell-Free Nucleic Acids |
| Language | English |
| Publishing date | 2022-09-29 |
| Publishing country | England |
| Document type | Journal Article ; Comment |
| ZDB-ID | 632519-1 |
| ISSN | 1532-2157 ; 0748-7983 |
| ISSN (online) | 1532-2157 |
| ISSN | 0748-7983 |
| DOI | 10.1016/j.ejso.2022.09.016 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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