Article ; Online: Phase-Resolved Functional Lung (PREFUL) MRI to Quantify Ventilation: Feasibility and Physiological Relevance in Severe Asthma.
2024
Abstract: Rationale and objectives: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been ... ...
Abstract | Rationale and objectives: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been demonstrated in patients with asthma. This study compares PREFUL-derived ventilation defect percent (VDP) in severe asthma patients to healthy controls and measures its responsiveness to bronchodilator therapy and relation to established measures of airways disease. Materials and methods: Forty-one adults with severe asthma and seven healthy controls performed same-day free-breathing Results: PREFUL VDP measured pre-bronchodilator (19.1% [7.4-43.3], p = 0.0002) and post-bronchodilator (16.9% [6.1-38.4], p = 0.0007) were significantly greater than that of healthy controls (7.5% [3.7-15.5]) and was significantly decreased post-bronchodilator (from 21.9% [10.1-36.9] to 16.9% [6.1-38.4], p = 0.0053). PREFUL VDP was correlated with spirometry (FEV Conclusion: PREFUL-derived VDP is responsive to bronchodilator therapy in asthma and is associated with measures of airflow obstruction and small airway dysfunction. These findings validate PREFUL VDP as a physiologically relevant and accessible ventilation imaging outcome measure in asthma. |
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Language | English |
Publishing date | 2024-02-19 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1355509-1 |
ISSN | 1878-4046 ; 1076-6332 |
ISSN (online) | 1878-4046 |
ISSN | 1076-6332 |
DOI | 10.1016/j.acra.2024.01.039 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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