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Article: Sociotechnoeconomic Consequences of Improved Sugarcane Cultivation among Sugarcane Growers

Thakur, Nidhi B. / Chaudhary, Mukesh V.

2022 Volume 38, Issue 2, Page(s) 289

Document type	Article
ZDB-ID	15373-4
ISSN	0970-0153
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Comparative Evaluation of Microleakage in Hall's with SDF, Hall's, and Conventional Technique Using Different Luting Cements.

Thakur, Nidhi S / Tyagi, Parimala / Tiwari, Shilpi / Mali, Shikha / Chhattani, Barkha / Bhargava, Sanjana

International journal of clinical pediatric dentistry

2023 Volume 16, Issue 1, Page(s) 16–21

Abstract: The most common pathological condition, dental caries when remain untreated which shows pulpal involvement and may lead to invasive treatment, such as crown placement followed by pulp therapy. Larger carious lesions on primary molars stainless steel ... ...

Abstract	The most common pathological condition, dental caries when remain untreated which shows pulpal involvement and may lead to invasive treatment, such as crown placement followed by pulp therapy. Larger carious lesions on primary molars stainless steel crowns (SSCs) placement by means of conventional tooth preparation. The modern approach to managing carious lesions concentrates on using less invasive treatment techniques, with the focus being on biofilm change. One among such alternative method of managing the primary molars is the Hall's technique. Another most important factor for the survival of a crown is its sealing ability, in which luting cements, such as adhesive cements, have a crucial role as they help in providing a suitable marginal seal and thereby cause a reduction in the microleakage. Silver diamine fluoride (SDF) has proven anticariogenic activity in arresting carious lesions. Hence the aim was to evaluate and compare the microleakage of SSCs placed by Hall's technique, Hall's technique with SDF, and the conventional crown technique using different luting cements. A total of 60 primary first and second molars with occlusoproximal caries, which were initial and moderate in nature. The blocks were randomly divided into three groups, in which precontoured SSCs were applied by using either the Hall's technique or the conventional technique. After subjecting tothermocycling, the samples were examined under stereomicroscopic for microleakage evaluation. A few samples were randomly selected from each subgroup, and a scanning electron microscopic (SEM) examination was done. Highest values of microleakage were noted with Hall's technique resin-modified glass ionomer cements (RMGIC) luting cement group. It can be concluded from the present study that the conventional technique was found to be superior over the Hall's technique with SDF and then by the Hall's group alone. SDF application beneath the Hall's crown appears to be promising approach for the reduction of microleakage. How to cite this article: Thakur NS, Tyagi P, Tiwari S,
Language	English
Publishing date	2023-02-16
Publishing country	India
Document type	Journal Article
ISSN	0974-7052
ISSN	0974-7052
DOI	10.5005/jp-journals-10005-2510
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Repurposing of artesunate, an antimalarial drug, as a potential inhibitor of hepatitis E virus.

Bhise, Neha / Agarwal, Megha / Thakur, Nidhi / Akshay, P S / Cherian, Sarah / Lole, Kavita

Archives of virology

2023 Volume 168, Issue 5, Page(s) 147

Abstract: Hepatitis E virus (HEV) is endemic in several developing countries of Africa and Asia. It mainly causes self-limiting waterborne infections, in either sporadic or outbreak form. Recently, HEV was shown to cause chronic infections in immunosuppressed ... ...

Abstract	Hepatitis E virus (HEV) is endemic in several developing countries of Africa and Asia. It mainly causes self-limiting waterborne infections, in either sporadic or outbreak form. Recently, HEV was shown to cause chronic infections in immunosuppressed individuals. Ribavirin and interferon, the current off-label treatment options for hepatitis E, have several side effects. Hence, there is a need for new drugs. We evaluated the antimalarial drug artesunate (ART) against genotype 1 HEV (HEV-1) and HEV-3 using a virus-replicon-based cell culture system. ART exhibited 59% and 43% inhibition of HEV-1 and HEV-3, respectively, at the highest nontoxic concentration. Computational molecular docking analysis showed that ART can bind to the helicase active site (affinity score, -7.4 kcal/mol), indicating its potential to affect ATP hydrolysis activity. An in vitro ATPase activity assay of the helicase indeed showed 24% and 55% inhibition at 19.5 µM (EC
MeSH term(s)	Female ; Pregnancy ; Animals ; Humans ; Hepatitis E virus/genetics ; Artesunate/pharmacology ; Artesunate/therapeutic use ; Antimalarials/pharmacology ; Drug Repositioning ; Molecular Docking Simulation ; Virus Replication ; Hepatitis E/drug therapy ; RNA-Dependent RNA Polymerase/genetics ; Adenosine Triphosphate
Chemical Substances	Artesunate (60W3249T9M) ; Antimalarials ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-04-28
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05770-1
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Article ; Online: Correction to: Repurposing of artesunate, an antimalarial drug, as a potential inhibitor of hepatitis E virus.

Bhise, Neha / Agarwal, Megha / Thakur, Nidhi / Akshay, P S / Cherian, Sarah / Lole, Kavita

Archives of virology

2023 Volume 168, Issue 7, Page(s) 193

Language	English
Publishing date	2023-06-28
Publishing country	Austria
Document type	Published Erratum
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05799-2
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Article: A double blind randomized controlled trial to evaluate the efficacy of green tea in gingivitis.

Thakur, Nidhi / Kumar, Vishal / Agarwal, Ankita / Kumari, Soni

Bioinformation

2021 Volume 17, Issue 9, Page(s) 805–808

Abstract: Gingivitis is the most common form of oral disease especially among patients undergoing fixed orthodontic treatment. Green tea, which is extensively used in Asian countries, can help to improve the overall gingival health, which can be assessed by using ... ...

Abstract	Gingivitis is the most common form of oral disease especially among patients undergoing fixed orthodontic treatment. Green tea, which is extensively used in Asian countries, can help to improve the overall gingival health, which can be assessed by using the gingival indices. Evaluation of the effectiveness of green tea on the gingival health of patients undergoing Orthodontic treatment is of interest. 40 otherwise healthy patients undergoing fixed orthodontic treatment were randomly divided in two groups namely (1) study group and (2) control group. Gingival indices were scored for all the patients. Study group was given mouth rinse with green tea extract and control group was given placebo with no green tea extract. Gingival indices were measured for all the patients after 21 days. Mann Whitney U test and Wilcoxon test was used for statistical analysis. The gingival indices scoring in which the values before and after the use of mouthwash were compared. The p value was found to be statistically significant (p<0.05) in study group. But in control group statistical significant could not be reached.
Language	English
Publishing date	2021-09-30
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630017805
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Online vs Offline Pedagogy amidst COVID-19 Pandemic from the Perspective of First Year Medical Students, their Educators and Parents

Sonam Bhatia / Seema Patel / Gini Garima / Mitasha Singh / Thakur Nidhi / Varsha Chauhan / Suman Bala Sharma

National Journal of Laboratory Medicine, Vol 12, Iss 2, Pp BO01-BO

A Cross-sectional Study

2023 Volume 08

Abstract: Introduction: Coronavirus Disease 2019 (COVID-19) pandemic has compelled medical education institutes to impart knowledge to the undergraduate MBBS students through online medium. In order to adopt the new online pedagogy it is important to understand ... ...

Abstract	Introduction: Coronavirus Disease 2019 (COVID-19) pandemic has compelled medical education institutes to impart knowledge to the undergraduate MBBS students through online medium. In order to adopt the new online pedagogy it is important to understand perceptions of students and their educators. Further, it is imperative for us to know the shortcomings of online teaching methodologies to develop and inculcate newer teaching methods to maintain quality education. Aim: To understand the perception and challenges faced by the first year MBBS students, faculty and their parents during the compelling online classes as teaching methodology compared to Offline. Materials and Methods: The present study was questionnaire- based, cross-sectional conducted in the Department of Biochemistry, Employees’ State Insurance Corporation (ESIC) Medical College and Hospital, Faridabad, Haryana, India, between August 2021 and October 2021. The present study included students of MBBS first year (n=123), faculty (n=27) from ESIC Medical College and Hospital, Faridabad, India, and parents/ guardians of students (n=94). A five-point Likert scale was used to determine the perception of students/faculty/parents. Mean value calculated greater than 3 was considered disagreement and less than 3 as agreement. Online mode (Edumarshal software, Google forms) was used. Statistical analysis was done calculating mean, Standard Deviation (SD) and Paired t-test was used to study significance of study parameters on continuous scale. Results: Student’s perception was that offline teaching was significantly better than online classes in term of enthusiasm, interaction, clarity, periodic assessments (p-value<0.001). Faculty perceived that interference of the external environment was significantly more during online class (Mean±SD=1.07±0.99), periodical assessments were better conducted offline (Mean±SD=1.04±1.05) compared to online. From parent’s view, offline teaching was preferred than online teaching for their ward (Mean±SD=1.75±1.04). Conclusion: ...
Keywords	coronavirus disease 2019 ; medical students ; teaching learning activity ; Microbiology ; QR1-502 ; Chemistry ; QD1-999
Subject code	370
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	JCDR Research and Publications Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative evaluation of antimicrobial efficacy of silver diamine fluoride, chlorhexidine varnish with conventional fluoride varnish as a caries arresting agent. An

Chhattani, Barkha / Kulkarni, Parimala / Agrawal, Nikita / Mali, Shikha / Kumar, Anup / Thakur, Nidhi Singh

Journal of the Indian Society of Pedodontics and Preventive Dentistry

2022 Volume 39, Issue 4, Page(s) 398–402

Abstract: Introduction: Silver diamine fluoride (SDF) is employed as an adjunct cariostatic agent in the management of dental caries in high-risk population. Other than fluorides, chlorhexidine (CHX) is the most potent antimicrobial and efficacious agent against ... ...

Abstract	Introduction: Silver diamine fluoride (SDF) is employed as an adjunct cariostatic agent in the management of dental caries in high-risk population. Other than fluorides, chlorhexidine (CHX) is the most potent antimicrobial and efficacious agent against Streptococcus mutans. Aim: The aim of this study is to evaluate and differentiate the efficacy of 38% silver diamine fluoride, CHX varnish, and fluoride varnish on carious primary teeth. Materials and methods: Ninety children having a count of ≥1 carious lesion were recruited. Thirty-eighty percent silver diamine fluoride or fluoride varnish and CHX varnish were topically applied on the lesion. The primary outcome measured was the arrest of carious lesion (lesion rendered inactive as per the Nyvad criteria) after a follow-up of 14-21 days. Dental biofilm sample was obtained from each child and subsequently assessed for microbial composition by colony-forming unit method before and after treatment followed by protein analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis method. Results: Average proportion of arrested caries lesions in the SDF group was higher followed by CHX and fluoride varnish groups. Decreased total protein amount was found in SDF group. This proves that there is decrease in microbial load posttreatment in SDF group. Conclusion: Thirty-eight percent SDF is more effective than CHX varnish and fluoride varnish in arresting dentin carious lesions in young children.
MeSH term(s)	Anti-Bacterial Agents ; Child ; Child, Preschool ; Chlorhexidine/therapeutic use ; Dental Caries/drug therapy ; Dental Caries/prevention & control ; Dental Caries Susceptibility ; Electrophoresis, Polyacrylamide Gel ; Fluorides ; Fluorides, Topical ; Humans ; Quaternary Ammonium Compounds ; Silver Compounds ; Sodium Dodecyl Sulfate ; Sodium Fluoride
Chemical Substances	Anti-Bacterial Agents ; Fluorides, Topical ; Quaternary Ammonium Compounds ; Silver Compounds ; Sodium Dodecyl Sulfate (368GB5141J) ; Sodium Fluoride (8ZYQ1474W7) ; silver diamine fluoride (DDU19UEV1Y) ; Fluorides (Q80VPU408O) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2022-01-28
Publishing country	India
Document type	Journal Article
ZDB-ID	1425154-1
ISSN	1998-3905 ; 0970-4388
ISSN (online)	1998-3905
ISSN	0970-4388
DOI	10.4103/jisppd.jisppd_246_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Computational analysis of protein-protein interaction network of differentially expressed genes in benign prostatic hyperplasia.

Sachdeva, Ruchi / Kaur, Navneet / Kapoor, Paras / Singla, Pooja / Thakur, Nidhi / Singhmar, Sakshi

Molecular biology research communications

2022 Volume 11, Issue 2, Page(s) 85–96

Abstract: Benign prostatic hyperplasia (BPH) is a commonly occurring disease in aging men. It involves cellular proliferation of stromal and glandular tissues leading to prostate enlargement. Current drug therapies show several adverse effects such as sexual ... ...

Abstract	Benign prostatic hyperplasia (BPH) is a commonly occurring disease in aging men. It involves cellular proliferation of stromal and glandular tissues leading to prostate enlargement. Current drug therapies show several adverse effects such as sexual dysfunctions and cardiovascular side effects. Therefore, there is a need to develop more effective medical treatment for BPH. In this regard, we aimed to identify genes which play a critical role in BPH. We have obtained the dataset of differentially expressed genes (DEGs) of BPH from NCBI GEO. DEGs were investigated in the context of their protein-protein interactions (PPI). Hub genes i.e. genes associated with BPH were scrutinized based on the topological parameters of the PPI network. These were analyzed for functional annotations, pathway enrichment analysis and transcriptional regulation. In total, 38 hub genes were identified. Hub genes such as transcription factor activator protein-1 and adiponectin were found to play key roles in cellular proliferation and inflammation. Another gene peroxisome proliferator activated receptor gamma was suggested to cause obesity, a common comorbidity of BPH. Moreover, our results indicated an important role of transforming growth factor-beta (TGF-β) signaling and smooth muscle cell proliferation which may be responsible for prostate overgrowth and associated lower urinary tract symptoms frequently encountered in BPH patients. Zinc finger protein Snai1 was the most prominent transcription factor regulating the expression of hub genes that participate in TGF-β signaling. Overall, our study has revealed significant hub genes that can be employed as drug targets to develop potential therapeutic interventions to treat BPH.
Language	English
Publishing date	2022-08-24
Publishing country	Iran
Document type	Journal Article
ISSN	2345-2005
ISSN (online)	2345-2005
DOI	10.22099/mbrc.2022.43721.1746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effectiveness of a Structured Instructional Module Regarding the Prevention of Oral Cancer among Adolescents in Urban Colleges.

Vibhakar, Vimal / Jethlia, Ankur / Thakur, Nidhi / Wasnik, Milind / Sah, Ram Prasad / Bandgar, Subhash

Journal of pharmacy & bioallied sciences

2021 Volume 13, Issue Suppl 1, Page(s) S167–S170

Abstract: Background: Oral cancer is a preventable disease that can be controlled by tobacco cessation and health education. For development of a healthy nation, a healthy society is desirable that is dependent on physically and mentally strong adolescents and ... ...

Abstract	Background: Oral cancer is a preventable disease that can be controlled by tobacco cessation and health education. For development of a healthy nation, a healthy society is desirable that is dependent on physically and mentally strong adolescents and adults. Objectives: The present study was conducted to assess the effectiveness and utilization of a structured instructional module on knowledge, attitude, and practice regarding the prevention of oral cancer among adolescents. Materials and methods: The study was conducted on 500 preuniversity urban college students, divided into two groups: experimental and control groups ( Results: The data were collected and compared for sociodemographic variables and knowledge, attitude, and practice of students for prevention of oral cancers. A statistically significant correlation was observed between all the parameters for both the groups. In the experimental group, a significant correlation ( Conclusion: It has been observed that there are several implications of the structured instructional module in the field of education, practice, administration, and research.
Language	English
Publishing date	2021-06-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.JPBS_633_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment of Anatomical Variations of Mandibular Canal Depicted in Panoramic Radiography.

Thakur, Nidhi / Kumar, Amish / Singh, Pinky / Gopalakrishnan, Dipti / Mishra, Bibhu Prasad / Jha, Mrigank Shekhar

Journal of pharmacy & bioallied sciences

2021 Volume 13, Issue Suppl 2, Page(s) S1394–S1397

Abstract: Background: Anatomical variations of the mandibular canal play a vital role while performing surgical procedures affecting an area with mandibular canal course in the mandible. The neurovascular bundle may be severed during surgical procedures carried ... ...

Abstract	Background: Anatomical variations of the mandibular canal play a vital role while performing surgical procedures affecting an area with mandibular canal course in the mandible. The neurovascular bundle may be severed during surgical procedures carried out mandible. Aims and objectives: The present retrospective study was aimed to assess and evaluate the mandibular canal and its variations on the panoramic radiography. Materials and methods: The study included 88 randomly selected panoramic radiographs with complete mandible and associated bone. On a panoramic radiograph, the following parameters were assessed including bifid mandibular canal and location of bifurcation, the diameter of the mandibular canal as recorded in the first molar region, trabeculation in submandibular gland fossa, anterior loop measurement, direction and diameter of the bifid mandibular canal were all evaluated. Statistical analysis was done. Results: In 51 hemimandibles, the mandibular canal was found to be corticalized, whereas in 21.59% ( Conclusion: The present study suggests that panoramic radiographs are a reliable tool for assessment of the mandibular canal and associated anatomical variations associated with it.
Language	English
Publishing date	2021-11-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_224_21
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