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  1. Book ; Thesis: Supplementierung von Riboflavin bei schwangeren Frauen in Burkina Faso

    Thaler, Julian Matthias

    Einfluss auf die Inzidenz von Malaria als klinische Diagnose

    2006  

    Author's details vorgelegt von Julian Matthias Thaler
    Language German
    Size 111 Bl. : Ill., graph. Darst., Kt.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2007
    HBZ-ID HT015123232
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 E 979 order for loan Magazin

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  2. Article ; Online: Contrast-enhanced point of care ultrasound for the evaluation of stable blunt abdominal trauma by the emergency physician: A prospective diagnostic study.

    Donner, Viviane / Thaler, Julian / Hautz, Wolf E / Sauter, Thomas Christian / Ott, Daniel / Klingberg, Karsten / Exadaktylos, Aristomenis K / Lehmann, Beat

    Journal of the American College of Emergency Physicians open

    2024  Volume 5, Issue 2, Page(s) e13123

    Abstract: Objectives: Clinical examination alone cannot reliably rule out significant traumatic abdominal injury. Computed tomography (CT) has become the primary method for evaluating blunt abdominal trauma and clinicians rely heavily on it to rule out abdominal ... ...

    Abstract Objectives: Clinical examination alone cannot reliably rule out significant traumatic abdominal injury. Computed tomography (CT) has become the primary method for evaluating blunt abdominal trauma and clinicians rely heavily on it to rule out abdominal injury. Ultrasound examination may miss significant abdominal injury particularly in stable patients. The use of a contrast agent improves ultrasound sensitivity to visceral abdominal injuries. The objective of this diagnostic study is to compare bedside contrast enhanced ultrasound (CEUS) performed by emergency physicians to CT in hemodynamically stable adults for the assessment of blunt abdominal trauma and evaluate CEUS accuracy outcomes.
    Methods: Hemodynamically stable patients with blunt trauma were prospectively enrolled in the trauma bay. After initial evaluation, we included patients at risk of abdominal injury and for whom an abdominal CT was planned by the trauma leader. Ultrasonography was performed prospectively and at the bedside by the emergency physician followed by abdominal CT used as a reference standard.
    Results: Thirty-three patients were enrolled in the study; among them, 52% showed positive traumatic findings in abdominal CT scans, and 42% were diagnosed with solid organ lesions. Compared to CT, a focused abdominal sonography (FOCUS) examination, looking for free fluid or perirenal hematoma, showed limited performance for traumatic findings with a sensitivity of 65% (95% confidence interval [CI]: 38%-86%), a specificity of 75% (95% CI: 48%-93%), a negative likelihood ratio (NLR) of 0.47 (95% CI: 0.23-0.95), and a positive likelihood ratio (PLR) of 2.59 (95% CI: 1.03-6.48). When combining FOCUS with CEUS, the sensitivity of the sonography increased to 94% (95% CI: 71%-100%) with a specificity of 75% (95% CI: 48%-93%). The PLR was 3.76 (95% CI: 1.6-8.87) and the NLR was 0.08 (95% CI: 0.01-0.54). In our population, abdominal sonography with contrast failed to identify a single positive abdominal CT with a grade 1 kidney injury.
    Conclusions: A FOCUS examination shows limited sensitivity and specificity to detect positive abdominal CT in stable adults with abdominal trauma. With the addition of contrast and careful inspection of solid organs, abdominal sonography with contrast performed by the emergency physician improves the ability to rule out traumatic findings on abdominal CT. CEUS performed by emergency physicians may miss injuries, especially in the absence of free fluid, in cases of low-grade injuries, simultaneous injuries, or poor-quality examinations.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.13123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Decompression illness treated at the Geneva hyperbaric facility 2010-2016: A retrospective analysis of local cases.

    Thaler, Julian / Pignel, Rodrigue / Magnan, Marie-Anne / Pellegrini, Michel / Louge, Pierre

    Diving and hyperbaric medicine

    2020  Volume 50, Issue 4, Page(s) 370–376

    Abstract: Introduction: The Geneva hyperbaric chamber is the main treatment centre for decompression illness (DCI) in Switzerland. The characteristics, symptomatology, treatment and short-term outcome of divers treated at this chamber have not previously been ... ...

    Abstract Introduction: The Geneva hyperbaric chamber is the main treatment centre for decompression illness (DCI) in Switzerland. The characteristics, symptomatology, treatment and short-term outcome of divers treated at this chamber have not previously been investigated.
    Methods: This was a retrospective study of patients treated with hyperbaric oxygen (HBO) for DCI from 2010 to 2016. Data were analysed to provide a description of the cases and statistical analysis for possible factors associated with an unfavourable outcome.
    Results: One hundred and thirty-five patients were treated for DCI. Ninety-two were included in the study. Sixty-four presented with neurological and 28 with mild DCI. One hundred and thirty-five patients were treated for DCI. Ninety-two were included in the study. Sixty-four presented with neurological and 28 with mild DCI. Patients with mild DCI mainly had musculoskeletal symptoms (79%). Patients with neurological DCI mainly had spinal (55%), followed by vestibular (36%) symptoms. Arterial gas embolism was diagnosed in 30% of cases. Diving depths ranged between 15 and 142 metres, and dive times between two and 241 min. Median time to treatment was 6 h. Patients with neurological DCI had a high rate (25%) of persisting deficits after treatment. Older age was associated with an unfavourable outcome in univariate but not in multivariate analysis. No adverse effects of HBO were observed. For spinal DCI, a high Boussuges score was associated with persisting deficits after treatment.
    Conclusions: Our findings are consistent with other series. Severe DCI was associated with a high rate of persisting deficits. No single factor was associated with a negative outcome. A Boussuges score > 7 had sensitivity of 90% and positive predictive value 53% for predicting an unfavourable outcome in spinal DCI.
    MeSH term(s) Aged ; Decompression ; Decompression Sickness/epidemiology ; Decompression Sickness/therapy ; Diving/adverse effects ; Embolism, Air ; Humans ; Hyperbaric Oxygenation ; Retrospective Studies
    Language English
    Publishing date 2020-12-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2237920-4
    ISSN 1833-3516
    ISSN 1833-3516
    DOI 10.28920/dhm50.4.370-376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4375: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Supplementierung von Riboflavin bei schwangeren Frauen in Burkina Faso

    Thaler, Julian M. [Verfasser]

    Einfluss auf die Inzidenz von Malaria als klinische Diagnose

    2008  

    Author's details Julian M Thaler
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Shaker
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    ISBN 978-3-8322-6877-0 ; 3-8322-6877-4
    Database Digital theses on the web

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  5. Article ; Online: Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis.

    Longchamp, Alban / Longchamp, Justine / Manzocchi-Besson, Sara / Whiting, Livia / Haller, Claude / Jeanneret, Séverin / Godio, Manoelle / Garcia Martinez, Juan Jose / Bonjour, Thierry / Caillat, Mary / Maitre, Guillaume / Thaler, Julian Matthias / Pantet, Rémy / Donner, Viviane / Dumoulin, Alexis / Emonet, Stéphane / Greub, Gilbert / Friolet, Raymond / Robert-Ebadi, Helia /
    Righini, Marc / Sanchez, Bienvenido / Delaloye, Julie

    Research and practice in thrombosis and haemostasis

    2020  Volume 4, Issue 5, Page(s) 842–847

    Abstract: Background: The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronavirus disease 2019 (COVID-19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis ... ...

    Abstract Background: The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronavirus disease 2019 (COVID-19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with COVID-19.
    Objectives: To determine the prevalence of venous thromboembolism (VTE) in critically ill patients with COVID-19, using lower limbs venous ultrasonography screening.
    Methods: Beginning March 8, we enrolled 25 patients who were admitted to the intensive care unit (ICU) with confirmed SARS-CoV-2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography between day 5 and 10 after admission. The data reported here are those available up to May 9, 2020.
    Results: The mean (± standard deviation) age of the patients was 68 ± 11 years, and 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) had a VTE; 6 (24%) a proximal DVT, and 5 (20%) a pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen-detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9, 2020, 5 patients had died (20%), 2 remained in the ICU (8%), and 18 were discharged (72%).
    Conclusions: In critically ill patients with SARS-CoV-2 infections, DVT screening at days 5-10 of admission yielded a 32% prevalence of VTE. Seventy-five percent of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Venous Thromboembolism in Critically Ill Patients with Covid-19: Results of a Screening Study for Deep Vein Thrombosis

    Longchamp, Alban / Longchamp, Justine / Manzocchi-Besson, Sara / Whiting, Livia / Haller, Claude / Jeanneret, Séverin / Godio, Manoelle / Garcia Martinez, Juan Jose / Bonjour, Thierry / Caillat, Mary / Maitre, Guillaume / Thaler, Julian Matthias / Pantet, Rémy / Donner, Viviane / Dumoulin, Alexis / Emonet, Stéphane / Greub, Gilbert / Friolet, Raymond / Robert-Ebadi, Helia /
    Righini, Marc / Sanchez, Bienvenido / Delaloye, Julie

    Res. Pract. Thromb. Haemost.

    Abstract: Background: The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and coronavirus disease (Covid-19), has caused more than 3.9 millions of cases worldwide. Currently, there is great interest to assess venous thrombosis ... ...

    Abstract Background: The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and coronavirus disease (Covid-19), has caused more than 3.9 millions of cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with Covid-19. Objectives: To determine the prevalence of venous thromboembolic events (VTE) in critically ill patients with Covid-19, using lower limbs venous ultrasonography screening. Methods: Since March 8 th, we enrolled 25 patients, who were admitted to the intensive care unit (ICU) with confirmed SARS-CoV-2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography, between day 5 and 10 after admission. The data reported here are those available up until May 9 th2020. Results: The mean (±SD) age of the patients was 68±11 years, 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) suffered from VTE; 6 (24%) proximal DVT, 5 (20%) pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen-detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9 th, 2020; 5 patients died (20%), 2 remain in the ICU (8%), and 18 were discharged (72%). Conclusions: In critically ill patients with SARS-CoV-2 infections, DVT screening at day 5-10 of admission, yielded a 32% prevalence of VTE. 75% of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with Covid-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #260014
    Database COVID19

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  7. Article ; Online: Venous thromboembolism in critically Ill patients with COVID‐19

    Longchamp, Alban / Longchamp, Justine / Manzocchi‐Besson, Sara / Whiting, Livia / Haller, Claude / Jeanneret, Séverin / Godio, Manoelle / Garcia Martinez, Juan Jose / Bonjour, Thierry / Caillat, Mary / Maitre, Guillaume / Thaler, Julian Matthias / Pantet, Rémy / Donner, Viviane / Dumoulin, Alexis / Emonet, Stéphane / Greub, Gilbert / Friolet, Raymond / Robert‐Ebadi, Helia /
    Righini, Marc / Sanchez, Bienvenido / Delaloye, Julie

    Research and Practice in Thrombosis and Haemostasis

    Results of a screening study for deep vein thrombosis

    2020  Volume 4, Issue 5, Page(s) 842–847

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 2475-0379
    DOI 10.1002/rth2.12376
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Intraindividual comparison of 1.0 M gadobutrol and 0.5 M gadopentetate dimeglumine for time-resolved contrast-enhanced three-dimensional magnetic resonance angiography of the upper torso.

    Fink, Christian / Puderbach, Michael / Ley, Sebastian / Risse, Frank / Kuder, Tristan A / Bock, M / Thaler, Julian / Plathow, Christian / Kauczor, Hans-Ulrich

    Journal of magnetic resonance imaging : JMRI

    2005  Volume 22, Issue 2, Page(s) 286–290

    Abstract: Purpose: To compare the signal characteristics and bolus dynamics of 1.0 M gadobutrol and 0.5 M Gd-DTPA for time-resolved, three-dimensional, contrast-enhanced (CE) MRA of the upper torso.: Materials and methods: Ten healthy volunteers were examined ... ...

    Abstract Purpose: To compare the signal characteristics and bolus dynamics of 1.0 M gadobutrol and 0.5 M Gd-DTPA for time-resolved, three-dimensional, contrast-enhanced (CE) MRA of the upper torso.
    Materials and methods: Ten healthy volunteers were examined with time-resolved three-dimensional CE-MRA (scan time per three-dimensional data set: 0.86 second; voxel size: 3.6 x 2 x 6.3 mm(3)). Each volunteer underwent eight individual examinations after intravenous injection of 0.05 and 0.1 mmol/kg body weight (b.w.) of 1.0 M gadobutrol and 0.5 M Gd-DTPA using two injection rates (2.5 and 5 mL/second). The data analysis included quantitative measurements of the peak signal-to-noise ratio (SNR) and bolus dispersion (full width at half maximum (FWHM)) in the pulmonary artery, left atrium, and thoracic and abdominal aortas.
    Results: No significant differences in the peak SNR and bolus dispersion were observed between gadobutrol and Gd-DTPA for all dose levels and injection rates in any of the vascular segments. For both contrast agents a dose of 0.1 mmol/kg b.w. injected with 5 mL/second achieved the highest SNR in all vascular segments.
    Conclusion: For the imaging parameters used in this study, higher-concentrated gadolinium chelates offer no relevant advantages for time-resolved three-dimensional CE-MRA of the upper torso.
    MeSH term(s) Body Mass Index ; Cohort Studies ; Contrast Media ; Dose-Response Relationship, Drug ; Female ; Gadolinium DTPA/pharmacology ; Humans ; Imaging, Three-Dimensional ; Injections, Intravenous ; Magnetic Resonance Angiography/methods ; Male ; Organometallic Compounds/pharmacology ; Radiographic Image Enhancement ; Reference Values ; Sensitivity and Specificity ; Statistics, Nonparametric ; Thorax/blood supply ; Thorax/pathology
    Chemical Substances Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L) ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.20381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3648: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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