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  1. Article ; Online: Who Is Dying of Pulmonary Embolism?

    Monteleone, Peter / Thangam, Manoj

    The American journal of cardiology

    2023  Volume 207, Page(s) 490–492

    MeSH term(s) Humans ; Pulmonary Embolism ; Cause of Death
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.08.099
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  2. Article ; Online: Artificial neural network-based prediction of prolonged length of stay and need for post-acute care in acute coronary syndrome patients undergoing percutaneous coronary intervention.

    Kulkarni, Hemant / Thangam, Manoj / Amin, Amit P

    European journal of clinical investigation

    2020  Volume 51, Issue 3, Page(s) e13406

    Abstract: Background: Prolonged length of stay (LOS) and post-acute care after percutaneous coronary intervention (PCI) is common and costly. Risk models for predicting prolonged LOS and post-acute care have limited accuracy. Our goal was to develop and validate ... ...

    Abstract Background: Prolonged length of stay (LOS) and post-acute care after percutaneous coronary intervention (PCI) is common and costly. Risk models for predicting prolonged LOS and post-acute care have limited accuracy. Our goal was to develop and validate models using artificial neural networks (ANN) to predict prolonged LOS > 7days and need for post-acute care after PCI.
    Methods: We defined prolonged LOS as ≥7 days and post-acute care as patients discharged to: extended care, transitional care unit, rehabilitation, other acute care hospital, nursing home or hospice care. Data from 22 675 patients who presented with ACS and underwent PCI was shuffled and split into a derivation set (75% of dataset) and a validation dataset (25% of dataset). Calibration plots were used to examine the overall predictive performance of the MLP by plotting observed and expected risk deciles and fitting a lowess smoother to the data. Classification accuracy was assessed by a receiver-operating characteristic (ROC) and area under the ROC curve (AUC).
    Results: Our MLP-based model predicted prolonged LOS with an accuracy of 90.87% and 88.36% in training and test sets, respectively. The post-acute care model had an accuracy of 90.22% and 86.31% in training and test sets, respectively. This accuracy was achieved with quick convergence. Predicted probabilities from the MLP models showed good (prolonged LOS) to excellent calibration (post-acute care).
    Conclusions: Our ANN-based models accurately predicted LOS and need for post-acute care. Larger studies for replicability and longitudinal studies for evidence of impact are needed to establish these models in current PCI practice.
    MeSH term(s) Acute Coronary Syndrome/surgery ; Aged ; Angina, Unstable/surgery ; Female ; Hospices ; Hospitals, Rehabilitation ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Neural Networks, Computer ; Non-ST Elevated Myocardial Infarction/surgery ; Nursing Homes ; Patient Discharge ; Percutaneous Coronary Intervention ; Risk Assessment ; ST Elevation Myocardial Infarction/surgery ; Skilled Nursing Facilities ; Subacute Care/statistics & numerical data ; Transitional Care
    Language English
    Publishing date 2020-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13406
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    Zs.A 677: Show issues Location:
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  3. Article ; Online: Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle.

    Karlstaedt, Anja / Khanna, Radhika / Thangam, Manoj / Taegtmeyer, Heinrich

    Circulation research

    2019  Volume 126, Issue 1, Page(s) 60–74

    Abstract: Rationale: Metabolic and structural remodeling is a hallmark of heart failure. This remodeling involves activation of the mTOR (mammalian target of rapamycin) signaling pathway, but little is known on how intermediary metabolites are integrated as ... ...

    Abstract Rationale: Metabolic and structural remodeling is a hallmark of heart failure. This remodeling involves activation of the mTOR (mammalian target of rapamycin) signaling pathway, but little is known on how intermediary metabolites are integrated as metabolic signals.
    Objective: We investigated the metabolic control of cardiac glycolysis and explored the potential of glucose 6-phosphate (G6P) to regulate glycolytic flux and mTOR activation.
    Methods and results: We developed a kinetic model of cardiomyocyte carbohydrate metabolism,
    Conclusions: The reduction of PGI activity directly affects myocyte growth by regulating mTOR activation.
    MeSH term(s) Animals ; Cells, Cultured ; Click Chemistry ; Computer Simulation ; Glucose/pharmacology ; Glucose-6-Phosphate/metabolism ; Glucose-6-Phosphate Isomerase/antagonists & inhibitors ; Glycolysis ; Hexokinase/metabolism ; Mice ; Mitochondria, Heart/metabolism ; Models, Biological ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Oxidation-Reduction ; Oxygen Consumption ; Protein Biosynthesis/drug effects ; Rats ; Rats, Sprague-Dawley ; Sugar Phosphates/pharmacology ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Sugar Phosphates ; Glucose-6-Phosphate (56-73-5) ; erythrose 4-phosphate (585-18-2) ; Hexokinase (EC 2.7.1.1) ; mTOR protein, mouse (EC 2.7.1.1) ; mTOR protein, rat (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Glucose-6-Phosphate Isomerase (EC 5.3.1.9) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.119.315180
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  4. Article ; Online: "Eyeing" the Cause of Heart Failure: Visible Telltale Clues.

    Fred, Herbert L / Thangam, Manoj

    Texas Heart Institute journal

    2016  Volume 43, Issue 6, Page(s) 472–557

    MeSH term(s) Adult ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Arteriovenous Fistula/complications ; Arteriovenous Fistula/diagnosis ; Carcinoid Heart Disease/complications ; Carcinoid Heart Disease/diagnosis ; Endocarditis/complications ; Endocarditis/diagnosis ; Fabry Disease/complications ; Fabry Disease/diagnosis ; Female ; Heart Failure/diagnosis ; Heart Failure/etiology ; Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Humans ; Hyperthyroidism/complications ; Hyperthyroidism/diagnosis ; Male ; Melanoma/complications ; Melanoma/diagnosis ; Melanoma/secondary ; Myotonic Dystrophy/complications ; Myotonic Dystrophy/diagnosis ; Physical Examination ; Predictive Value of Tests ; Pseudoxanthoma Elasticum/complications ; Pseudoxanthoma Elasticum/diagnosis ; Risk Factors ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Skin Neoplasms/complications ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-16-6085
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    Zs.MO 484: Show issues

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  5. Article: Pathogens transmitted in red blood cell transfusions: An up-to-date table.

    Fred, Herbert L / Thangam, Manoj / Aisenberg, Gabriel M

    Proceedings (Baylor University. Medical Center)

    2018  Volume 31, Issue 3, Page(s) 307–309

    Language English
    Publishing date 2018-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2018.1459397
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  6. Article ; Online: Adequate Evidence, Inadequate Incentives for Disease Management Programs.

    Thangam, Manoj / Joynt Maddox, Karen E

    Journal of cardiac failure

    2018  Volume 24, Issue 10, Page(s) 638–639

    MeSH term(s) Cost-Benefit Analysis ; Heart Failure ; Humans ; Motivation
    Language English
    Publishing date 2018-10-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2018.09.017
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    Zs.A 4340: Show issues Location:
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  7. Article ; Online: Synthesis of systematic reviews of percutaneous device closure of patent foramen ovale (PFO) for prevention of recurrent cryptogenic stroke: Redundant publications and methodological deficiencies.

    Husaini, Mustafa / Esmaeeli, Amir / Thangam, Manoj / Doering, Michelle / Brown, David L

    American heart journal

    2020  Volume 232, Page(s) 57–60

    Abstract: Critical assessments of systemic reviews and meta-analyses have found them to often be redundant, lacking in novel perspectives, of poor methodological quality, and written by authors with potential conflicts of interest. We sought to investigate these ... ...

    Abstract Critical assessments of systemic reviews and meta-analyses have found them to often be redundant, lacking in novel perspectives, of poor methodological quality, and written by authors with potential conflicts of interest. We sought to investigate these issues as they relate to systemic reviews and meta-analyses of percutaneous patent foramen ovale closure for the prevention of recurrent cryptogenic stroke.
    MeSH term(s) Cardiac Catheterization ; Conflict of Interest ; Foramen Ovale, Patent/surgery ; Humans ; Ischemic Stroke/prevention & control ; Meta-Analysis as Topic ; Research Support as Topic ; Secondary Prevention ; Septal Occluder Device ; Systematic Reviews as Topic/standards
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Letter
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2020.10.051
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  8. Article: Costs associated with transradial access and same-day discharge after percutaneous coronary intervention: a systematic review and meta-analysis.

    Kulkarni, Hemant / Thangam, Manoj / Liu, Spencer / DeVries, James T / Rothstein, Eric / Young, Michael N / Amin, Amit P

    Reviews in cardiovascular medicine

    2021  Volume 22, Issue 2, Page(s) 429–438

    Abstract: Transradial access for PCI (TRI) along with same day discharge (SDD) is associated with varying estimates of cost savings depending on the population studied, the clinical scenario and application to low-risk vs high-risk patients. A summary estimate of ... ...

    Abstract Transradial access for PCI (TRI) along with same day discharge (SDD) is associated with varying estimates of cost savings depending on the population studied, the clinical scenario and application to low-risk vs high-risk patients. A summary estimate of the true cost savings of TRI and SDD are unknown. We searched the PubMed, EMBASE®, CINAHL® and Google Scholar® databases for published studies on hospitalization costs of TRI and SDD. Primary outcome of interest in all included studies was the cost saving with TRI (or SDD), inflation-corrected US$ 2018 values using the medical consumer price index. For meta-analytic synthesis, we used Hedges' summary estimate (g) in a random-effects framework of the DerSimonian and Laird model, with inverse variance weights. Heterogeneity was quantified using the I
    MeSH term(s) Cost Savings ; Humans ; Length of Stay ; Patient Discharge ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 2108910-3
    ISSN 1530-6550
    ISSN 1530-6550
    DOI 10.31083/j.rcm2202048
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  9. Article ; Online: Sociodemographic differences in utilization and outcomes for temporary cardiovascular mechanical support in the setting of cardiogenic shock.

    Thangam, Manoj / Luke, Alina A / Johnson, Daniel Y / Amin, Amit P / Lasala, John / Huang, Kristine / Joynt Maddox, Karen E

    American heart journal

    2021  Volume 236, Page(s) 87–96

    Abstract: Background: Temporary mechanical circulatory support (MCS) devices are increasingly used in cardiogenic shock, but whether sociodemographic differences by sex, race and/or ethnicity, insurance status, and neighborhood poverty exist in the utilization of ...

    Abstract Background: Temporary mechanical circulatory support (MCS) devices are increasingly used in cardiogenic shock, but whether sociodemographic differences by sex, race and/or ethnicity, insurance status, and neighborhood poverty exist in the utilization of these devices is unknown.
    Methods: Retrospective cross-sectional study using the National Inpatient Sample for 2012-2017. Logistic regression models were used to examine predictors of use of temporary MCS devices and for in-hospital mortality, clustering by hospital-year.
    Results: Our study population included 109,327 admissions for cardiogenic shock. Overall, 14.3% of admissions received an intra-aortic balloon pump, 4.2% a percutaneous ventricular assist device, and 1.8% extracorporeal membranous oxygenation (ECMO). After adjusting for age, comorbidities, and hospital characteristics, use of temporary MCS was lower in women compared to men (adjusted odds ratio [aOR] = 0.76, P < .001), Black patients compared to white ones (aOR = 0.73, P < .001), those insured by Medicare (aOR = 0.75, P < .001), Medicaid (aOR = 0.74, P < .001), or uninsured (aOR = 0.90, P = .015) compared to privately insured, and those in the lowest income neighborhoods (aOR = 0.94, P = .003) versus other neighborhoods. Women, admissions covered by Medicare, Medicaid, or uninsured, and those from low-income neighborhoods also had higher mortality rates even after adjustment for MCS implantation.
    Conclusions: There are differences in the use of temporary MCS in the setting of cardiogenic shock among specific populations within the United States. The growing use of MCS for treating cardiogenic shock highlights the need to better understand its impact on outcomes.
    MeSH term(s) Cross-Sectional Studies ; Demography ; Extracorporeal Membrane Oxygenation/methods ; Extracorporeal Membrane Oxygenation/statistics & numerical data ; Female ; Healthcare Disparities ; Heart-Assist Devices/statistics & numerical data ; Hospital Mortality ; Humans ; Intra-Aortic Balloon Pumping/methods ; Intra-Aortic Balloon Pumping/statistics & numerical data ; Male ; Medicare/statistics & numerical data ; Middle Aged ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/mortality ; Shock, Cardiogenic/therapy ; Socioeconomic Factors ; United States/epidemiology
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2020.12.014
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  10. Article ; Online: Timing of Stent Thrombosis After 1-Month Discontinuation of Dual Antiplatelet Therapy.

    Thangam, Manoj / Nazif, Tamim M / Parke, Maria / Kandzari, David E / Windecker, Stephan / Latib, Azeem / Kedhi, Elvin / Mehran, Roxana / Stone, Gregg W / Kirtane, Ajay J

    Journal of the American College of Cardiology

    2022  Volume 79, Issue 19, Page(s) 1963–1965

    MeSH term(s) Coronary Thrombosis/etiology ; Coronary Thrombosis/prevention & control ; Drug Therapy, Combination ; Drug-Eluting Stents/adverse effects ; Dual Anti-Platelet Therapy ; Humans ; Platelet Aggregation Inhibitors/adverse effects ; Thrombosis/drug therapy ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2022.03.342
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