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  1. Article ; Online: Histamine provides an original vista on cardiorenal syndrome.

    Tharaux, Pierre-Louis

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 11, Page(s) 5550–5552

    MeSH term(s) Anti-Inflammatory Agents ; Cardio-Renal Syndrome ; Heart Failure ; Histamine ; Humans ; Receptors, Histamine
    Chemical Substances Anti-Inflammatory Agents ; Receptors, Histamine ; Histamine (820484N8I3)
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2001336117
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    Zs.A 1148: Show issues Location:
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  2. Article ; Online: Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?

    Lenoir, Olivia / Tharaux, Pierre-Louis

    Kidney international

    2022  Volume 101, Issue 6, Page(s) 1110–1112

    Abstract: Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton ...

    Abstract Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation of albuminuria and proteinuria was observed in 4 children treated with cinacalcet. Here we discuss the potential mechanisms whereby CaSR displays a favorable effect in podocytes and the context in which calcimimetics may alleviate nephrotic syndrome.
    MeSH term(s) Animals ; Cinacalcet/pharmacology ; Cinacalcet/therapeutic use ; Mice ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/metabolism ; Podocytes/metabolism ; Proteinuria/drug therapy ; Proteinuria/metabolism ; Receptors, Calcium-Sensing/genetics ; Receptors, Calcium-Sensing/metabolism
    Chemical Substances Receptors, Calcium-Sensing ; Cinacalcet (UAZ6V7728S)
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  3. Article ; Online: Posttranslational modifications of sickle hemoglobin in microparticles may promote injury.

    Tharaux, Pierre-Louis

    Kidney international

    2019  Volume 95, Issue 6, Page(s) 1289–1291

    MeSH term(s) Anemia, Sickle Cell ; Cell-Derived Microparticles ; Hemoglobin, Sickle ; Hemoglobins ; Humans ; Oxidative Stress ; Protein Processing, Post-Translational
    Chemical Substances Hemoglobin, Sickle ; Hemoglobins
    Language English
    Publishing date 2019-05-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.02.023
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    Zs.A 797: Show issues Location:
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  4. Article ; Online: From bench to bedside: lessons learned from translational podocyte research.

    Lenoir, Olivia / Huber, Tobias B / Tharaux, Pierre-Louis

    Kidney international

    2023  Volume 103, Issue 6, Page(s) 1018–1020

    Abstract: Polat et al. report that mice with a podocyte-specific expression of a constitutively active Rac1 form displayed similar injury and albuminuria, regardless of transient receptor potential canonical 5 activity. This article confirms the pathogenic role of ...

    Abstract Polat et al. report that mice with a podocyte-specific expression of a constitutively active Rac1 form displayed similar injury and albuminuria, regardless of transient receptor potential canonical 5 activity. This article confirms the pathogenic role of deregulated Rac1 and challenges models involving the role of transient receptor potential canonical 5 in podocytes. We learned from this study and propose a roadmap for this controversial field to help new drug candidates succeed in clinical trials and safely reach patients.
    MeSH term(s) Mice ; Animals ; Podocytes/pathology ; Albuminuria/metabolism
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.03.008
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    Zs.A 797: Show issues Location:
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  5. Article ; Online: Podocyte healthy self-eating boosted by a spermidine meal?

    Lenoir, Olivia / Tharaux, Pierre-Louis

    Kidney international

    2020  Volume 98, Issue 6, Page(s) 1390–1392

    Abstract: The mechanisms sustaining a high level of autophagy in podocytes are not well delineated. Seminal studies had unraveled that the polyamine pathway is involved in the regulation of aging and autophagy. Polyamines (e.g., spermine, spermidine, and ... ...

    Abstract The mechanisms sustaining a high level of autophagy in podocytes are not well delineated. Seminal studies had unraveled that the polyamine pathway is involved in the regulation of aging and autophagy. Polyamines (e.g., spermine, spermidine, and putrescine) are ubiquitous molecules essential for the physiological processes, including cell growth, development, and differentiation. Liang et al. examined the role of ornithine decarboxylase, and spermidine synthase, and demonstrated that endogenous spermidine is required to maintain intact podocyte autophagy.
    MeSH term(s) Adenosylmethionine Decarboxylase ; Autophagy ; Cell Division ; Podocytes ; Spermidine
    Chemical Substances Adenosylmethionine Decarboxylase (EC 4.1.1.50) ; Spermidine (U87FK77H25)
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.07.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Cellular regeneration of podocytes from parietal cells: the debate is still open.

    Moeller, Marcus J / Tharaux, Pierre-Louis

    Kidney international

    2019  Volume 96, Issue 3, Page(s) 542–544

    Abstract: The study by Kaverina et al. in this issue addresses an important question: can podocytes be replenished by parietal epithelial cells (PECs)? The authors use a complex transgenic mouse model in which podocytes are labeled with GFP and PECs are ... ...

    Abstract The study by Kaverina et al. in this issue addresses an important question: can podocytes be replenished by parietal epithelial cells (PECs)? The authors use a complex transgenic mouse model in which podocytes are labeled with GFP and PECs are simultaneously labeled with tdTomato. When Kaverina and colleagues induce focal segmental glomerulosclerosis (FSGS), they find that individual PECs are doubly labeled, coexpress podocyte markers, and form structures similar to foot processes, suggesting that these PECs may have transdifferentiated into podocytes.
    MeSH term(s) Animals ; Epithelial Cells ; Glomerulosclerosis, Focal Segmental ; Kidney Glomerulus ; Mice ; Podocytes ; Regeneration
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.04.038
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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease.

    Mahtal, Nassim / Lenoir, Olivia / Tharaux, Pierre-Louis

    Frontiers in medicine

    2021  Volume 8, Page(s) 659013

    Abstract: Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating ... ...

    Abstract Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Among its components, glomerular endothelial cells are known to be central safeguards of plasma filtration. An array of evidence has recently pinpointed its intricate relations with podocytes, highly specialized pericytes surrounding glomerular capillaries. During diabetic nephropathy, endothelial cells and podocytes are stressed and damaged. Besides, each can communicate with the other, directly affecting the progression of glomerular injury. Here, we review recent studies showing how
    Language English
    Publishing date 2021-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.659013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nuclear receptors in podocyte biology and glomerular disease.

    Agrawal, Shipra / He, John C / Tharaux, Pierre-Louis

    Nature reviews. Nephrology

    2020  Volume 17, Issue 3, Page(s) 185–204

    Abstract: Nuclear receptors have a broad spectrum of biological functions in normal physiology and in the pathology of various diseases, including glomerular disease. The primary therapies for many glomerular diseases are glucocorticoids, which exert their ... ...

    Abstract Nuclear receptors have a broad spectrum of biological functions in normal physiology and in the pathology of various diseases, including glomerular disease. The primary therapies for many glomerular diseases are glucocorticoids, which exert their immunosuppressive and direct podocyte protective effects via the glucocorticoid receptor (GR). As glucocorticoids are associated with important adverse effects and a substantial proportion of patients show resistance to these therapies, the beneficial effects of selective GR modulators are now being explored. Peroxisome proliferator-activated receptor-γ (PPARγ) agonism using thiazolidinediones has potent podocyte cytoprotective and nephroprotective effects. Repurposing of thiazolidinediones or identification of novel PPARγ modulators are potential strategies to treat non-diabetic glomerular disease. Retinoic acid receptor-α is the key mediator of the renal protective effects of retinoic acid, and repair of the endogenous retinoic acid pathway offers another potential therapeutic strategy for glomerular disease. Vitamin D receptor, oestrogen receptor and mineralocorticoid receptor modulators regulate podocyte injury in experimental models. Further studies are needed to better understand the mechanisms of these nuclear receptors, evaluate their synergistic pathways and identify their novel modulators. Here, we focus on the role of nuclear receptors in podocyte biology and non-diabetic glomerular disease.
    MeSH term(s) Animals ; Humans ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/pathology ; Podocytes/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism
    Chemical Substances Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00339-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  9. Article ; Online: Parietal epithelial cells role in repair versus scarring after glomerular injury.

    Lazareth, Hélène / Lenoir, Olivia / Tharaux, Pierre-Louis

    Current opinion in nephrology and hypertension

    2020  Volume 29, Issue 3, Page(s) 293–301

    Abstract: Purpose of review: The recent years have been marked by the publication of several articles highlighting the pathophysiological role of glomerular parietal epithelial cells (PEC) and refining their phenotypic heterogeneity.: Recent findings: The ... ...

    Abstract Purpose of review: The recent years have been marked by the publication of several articles highlighting the pathophysiological role of glomerular parietal epithelial cells (PEC) and refining their phenotypic heterogeneity.
    Recent findings: The present review synthetizes recent findings on (i) the potential regenerative role of PEC in glomerular diseases, and (ii) the mechanisms and signaling of leading to PEC pathogenic involvement in crescentic glomerulonephritis (CGN) and focal segmental glomerulosclerosis (FSGS).
    Summary: The debate is still open regarding the podocyte regenerative properties of PEC in glomerular disease, whereas the pathogenic involvement of PEC activation in glomerular disease is increasingly admitted. Recent highlights on the podocyte regenerative role of PEC, on one hand, and on their pathological function, on the other hand, for sure will feed the debate in the kidney community for the next years. Nevertheless, from a therapeutic perspective, the two options, boosting cellular regeneration and blocking PECs pathogenicity, should not be seen as antagonistic but, rather, complementary.
    MeSH term(s) Animals ; Cicatrix/etiology ; Glomerulonephritis/physiopathology ; Glomerulosclerosis, Focal Segmental/physiopathology ; Humans ; Kidney Glomerulus/physiology ; Podocytes/physiology ; Regeneration ; Signal Transduction/physiology
    Language English
    Publishing date 2020-03-28
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  10. Article: Cardiomyopathie toxique induite par l’hydroxychloroquine compliquant le traitement d’un lupus systémique.

    Bories, Marie-Cécile / Gibault, Laure / Tharaux, Pierre-Louis / Bruneval, Patrick

    Annales de pathologie

    2021  Volume 41, Issue 1, Page(s) 101–104

    Abstract: Hydroxychloroquine (HCQ) is considered as efficient and safe to treat systemic lupus. We report a case of fatal toxic cardiomyopathy, an underrecognized adverse effect of HCQ. A 72-year-old woman with systemic lupus erythematosus treated for 24 years by ... ...

    Title translation Toxic hydroxychloroquine-induced cardiomyopathy complicating systemic lupus treatment.
    Abstract Hydroxychloroquine (HCQ) is considered as efficient and safe to treat systemic lupus. We report a case of fatal toxic cardiomyopathy, an underrecognized adverse effect of HCQ. A 72-year-old woman with systemic lupus erythematosus treated for 24 years by HCQ received a kidney allograft. One year later she developed a cardiomyopathy with conductive disorders. An endomyocardial biopsy showed severe non-specific myocardial fibrosis and hypertrophic vacuolated myocytes. Transmission electron microscopy showed curvilinear bodies and pseudomyelin figures consistent with HCQ-induced cardiomyopathy. At immunohistochemistry LC3b, p62 and beclin-1 accumulated in vacuolated cardiac myocytes suggesting impaired cell autophagy. When unexplained cardiac disease develops in patients receiving long-term HCQ treatment, toxic cardiomyopathy should be considered leading to a diagnostic endomyocardial biopsy.
    MeSH term(s) Aged ; Biopsy ; Cardiomyopathies/chemically induced ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language French
    Publishing date 2021-01-06
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 225720-8
    ISSN 0242-6498
    ISSN 0242-6498
    DOI 10.1016/j.annpat.2020.09.007
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