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  1. Article ; Online: Hop-derived Humulinones Reveal Protective Effects in in vitro Models of Hepatic Steatosis, Inflammation and Fibrosis.

    Mahli, Abdo / Thasler, Wolfgang E / Biendl, Martin / Hellerbrand, Claus

    Planta medica

    2023  Volume 89, Issue 12, Page(s) 1138–1146

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha acids, hop-derived bitter compounds in beer, have been shown to ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha acids, hop-derived bitter compounds in beer, have been shown to beneficially affect NAFLD pathology. Humulinones are further hop derived bitter acids particularly found in modern styles of beer. So far, biological effects of humulinones have been unknown. Here, we investigated the effect of humulinones in
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Inflammation/drug therapy ; Inflammation/pathology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Fatty Acids/metabolism ; Fatty Acids/pharmacology ; Liver
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-2103-3230
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  2. Article ; Online: Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro.

    Kersten, Vanessa / Seitz, Tatjana / Sommer, Judith / Thasler, Wolfgang E / Bosserhoff, Anja / Hellerbrand, Claus

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrosis and, thus, build the "soil" for hepatocarcinogenesis. Furthermore, HSCs are known to promote the progression of hepatocellular carcinoma (HCC), but the molecular mechanisms are ... ...

    Abstract Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrosis and, thus, build the "soil" for hepatocarcinogenesis. Furthermore, HSCs are known to promote the progression of hepatocellular carcinoma (HCC), but the molecular mechanisms are only incompletely understood. Recently, we newly described the expression of bone morphogenetic protein 13 (BMP13) by HSCs in fibrotic liver tissue. In addition, BMP13 has mostly been studied in the context of cartilage and bone repair, but not in liver disease or cancer. Thus, we aimed to analyze the expression and function of BMP13 in HCC. Expression analyses revealed high BMP13-expression in activated human HSCs, but not in human HCC-cell-lines. Furthermore, analysis of human HCC tissues showed a significant correlation between BMP13 and α-smooth muscle actin (α-SMA), and immunofluorescence staining confirmed the co-localization of BMP13 and α-SMA, indicating activated HSCs as the cellular source of BMP13 in HCC. Stimulation of HCC cells with recombinant BMP13 increased the expression of the
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/metabolism ; Cell Line, Tumor ; Hepatic Stellate Cells/metabolism ; Bone Morphogenetic Proteins/metabolism ; Cell Proliferation
    Chemical Substances Bone Morphogenetic Proteins
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241311059
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  3. Article ; Online: Das ACO-Kurrikulum „Chirurgische Onkologie“ – Voraussetzungen zur Teilnahme, Anmeldung und Ablauf.

    Vilz, Tim O / Piso, Pompiliu / Wahba, Roger / Thasler, Wolfgang E / Kleeff, Jörg

    Chirurgie (Heidelberg, Germany)

    2023  Volume 95, Issue 4, Page(s) 294–298

    Abstract: For solid malignancies of the gastrointestinal tract, surgical removal is a central pillar of treatment and often the only possibility to achieve a long-term cure. While there are additional qualifications for an oncological subspecialization in other ... ...

    Title translation The Association of Surgical Oncology (ACO) curriculum "Surgical oncology"-Prerequisites for participation, registration and course.
    Abstract For solid malignancies of the gastrointestinal tract, surgical removal is a central pillar of treatment and often the only possibility to achieve a long-term cure. While there are additional qualifications for an oncological subspecialization in other surgical disciplines, such as gynecology or urology nothing comparable exists for visceral surgery in Germany, despite the fact that interdisciplinary cancer treatment strategies are becoming increasingly more complex. The Association of Surgical Oncology (ACO) in cooperation with the European Union of Medical Specialists (UEMS) has created the curriculum for surgical oncology, a structured further education concept, which concludes with the European Board of Surgical Qualification (EBSQ) examination. This results in a standardization and improvement in surgical and oncological treatment in Germany. Furthermore, successful graduates receive an ACO as well as a UEMS certificate and are Fellows of the European Board of Surgery (FEBS).
    MeSH term(s) Surgical Oncology/education ; Germany ; European Union ; Gynecology/education ; Curriculum
    Language German
    Publishing date 2023-12-28
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-023-02016-3
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  4. Article: Hop-derived Humulinones Reveal Protective Effects in in vitro Models of Hepatic Steatosis, Inflammation and Fibrosis

    Mahli, Abdo / Thasler, Wolfgang E. / Biendl, Martin / Hellerbrand, Claus

    Planta Medica

    2023  Volume 89, Issue 12, Page(s) 1138–1146

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha acids, hop-derived bitter compounds in beer, have been ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is emerging as leading cause of liver disease worldwide. Specific pharmacologic therapy for NAFLD is a major unmet medical need. Recently, iso-alpha acids, hop-derived bitter compounds in beer, have been shown to beneficially affect NAFLD pathology. Humulinones are further hop derived bitter acids particularly found in modern styles of beer. So far, biological effects of humulinones have been unknown. Here, we investigated the effect of humulinones in in vitro models for hepatic steatosis, inflammation and fibrosis. Humulinones dose-dependently inhibited fatty acid induced lipid accumulation in primary human hepatocytes. Humulinones reduced the expression of fatty acid uptake transporter CD36 and key enzymes of ( de novo ) lipid synthesis. Conversely, humulinones increased the expression of FABP1, CPT1 and ACOX1, indicative for increased lipid combustion. Furthermore, humulinones ameliorated steatosis induced pro-inflammatory gene expression. Furthermore, humulinones significantly reduced the expression of pro-inflammatory and pro-fibrogenic factors in control as well as lipopolysaccharide treated activated hepatic stellate cells, which play a key role in hepatic fibrosis. In conclusion, humulinones beneficially affect different pathophysiological steps of NAFLD. Our data suggest humulinones as promising therapeutic agents for the prevention and treatment of NAFLD.
    Keywords Cannabaceae ; humulinones ; nonalcoholic fatty liver disease ; steatosis ; inflammation ; fibrosis
    Language English
    Publishing date 2023-06-21
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-2103-3230
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  5. Article ; Online: Cold Preservation of Human Hepatocytes with High Viability.

    Lee, Serene M L / Kern, Armin / Jauch, Karl-Walter / Thasler, Reinhard / Niess, Hanno / Thasler, Wolfgang E

    Biopreservation and biobanking

    2022  Volume 21, Issue 4, Page(s) 367–377

    Abstract: Freshly isolated human hepatocytes are an important model for translational research, validation of experiments done in animals, and preclinical studies. Human hepatocyte isolation often cannot be carried out easily on demand in common research ... ...

    Abstract Freshly isolated human hepatocytes are an important model for translational research, validation of experiments done in animals, and preclinical studies. Human hepatocyte isolation often cannot be carried out easily on demand in common research laboratories, and researchers often collaborate to share hepatocytes or outsource hepatocyte isolations. As a prerequisite for such a strategy, hepatocytes have to maintain their phenotypes after transport. Therefore, this study aimed to determine if overnight storage or shipment of hepatocytes affects their quality when viability, adherence, and cytochrome P450 (CYP) activities are considered. Hepatocytes were stored overnight or shipped to a collaborator in a cold storage solution on wet ice. On the next day, viability of hepatocytes was assessed before plating the cells to determine adherence. Hepatocytes were also cultured in a sandwich culture to determine CYP activities and inducibility. The results showed that although viability (79% ± 0.7% on isolation) was significantly decreased by overnight storage or shipment by 11% (
    MeSH term(s) Animals ; Humans ; Female ; Male ; Hepatocytes ; Liver ; Cryopreservation ; Cytochrome P-450 Enzyme System ; Cells, Cultured ; Cell Survival
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2021.0173
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  6. Article: Vielfäiltige Möglichkeiten zur Versorgung von Leistenhernien. Ein Bruchband kommt nur noch selten zum Einsatz.

    Thasler, Wolfgang E

    MMW Fortschritte der Medizin

    2012  Volume 153, Issue 49-50, Page(s) 36–37

    Title translation Surgical options for inguinal hernia repair.
    MeSH term(s) Algorithms ; Germany ; Guideline Adherence ; Hernia, Inguinal/diagnosis ; Hernia, Inguinal/surgery ; Humans ; Minimally Invasive Surgical Procedures ; Surgical Mesh ; Trusses
    Language German
    Publishing date 2012-02-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478211-x
    ISSN 1438-3276
    ISSN 1438-3276
    DOI 10.1007/bf03369204
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    Zs.MG 72: Show issues

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  7. Article: Minimalinvasive Chirurgie: Nur ein Aspekt der „besseren Kosmetik“?

    Thasler, Wolfgang E

    Der Klinikarzt

    2014  Volume 43, Issue 04, Page(s) 179–179

    Language German
    Publishing date 2014-04-01
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 184285-7
    ISSN 1439-3859 ; 0341-2350
    ISSN (online) 1439-3859
    ISSN 0341-2350
    DOI 10.1055/s-0034-1376436
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  8. Article ; Online: Preparation and Culture of Human Liver Resident Immune Cells.

    Feng, Hao / Ou, Baochi / Dong, Wei / Thasler, Wolfgang E

    Current protocols in cell biology

    2018  Volume 80, Issue 1, Page(s) e50

    Abstract: Co-cultivation of tumor cells and liver resident immune cells or other non-parenchymal cells (NPCs) from the same donor is important for the study of cancer metastasis. So far, little is known about the mechanism of tumor cell or pathogen clearance, ... ...

    Abstract Co-cultivation of tumor cells and liver resident immune cells or other non-parenchymal cells (NPCs) from the same donor is important for the study of cancer metastasis. So far, little is known about the mechanism of tumor cell or pathogen clearance, leukocyte infiltration, and immune cell recruitment in the human liver. To investigate these processes in vitro, the use of primary human hepatocytes and non-parenchymal cell, especially immune cell, co-culture systems play essential roles in the establishment of cell-cell and cell-extracellular matrix communications similar to native liver tissues. Hepatic non-parenchymal cells mainly comprise liver sinusoid endothelial cells (LSECs), microvascular endothelial cells, hepatic stellate cells, Kupffer cells (KCs), natural killer T (iNKT) cells, and dendritic cells (DCs). Here we describe procedures for preparation, isolation, and culture of human liver resident immune cells and other non-parenchymal cells. © 2018 by John Wiley & Sons, Inc.
    MeSH term(s) Cell Culture Techniques/methods ; Cell Separation ; Cells, Cultured ; Centrifugation ; Coculture Techniques ; Dendritic Cells/cytology ; Endothelial Cells/cytology ; Humans ; Kupffer Cells/cytology ; Liver/cytology ; Liver/immunology ; Natural Killer T-Cells/cytology
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1934-2616
    ISSN (online) 1934-2616
    DOI 10.1002/cpcb.50
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  9. Book ; Online ; Thesis: Der hepatotrophe Wachstumsfaktor Augmenter of liver regeneration (ALR) wirkt leberspezifisch protektiv gegenüber metabolischen Noxen

    Ilowski, Maren / Thasler, Wolfgang E

    2013  

    Author's details Maren Ilowski. Betreuer: Wolfgang E. Thasler
    Language German
    Size Online-Ressource (Online-Ressource)
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis München, Ludwig-Maximilians-Universität, Diss., 2013
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article: Minimalinvasive Techniken beim kolorektalen Karzinom

    Rüth, Stefan / Heinrich, Tobias / Thasler, Wolfgang E.

    Allgemein- und Viszeralchirurgie up2date

    2018  Volume 12, Issue 06, Page(s) 571–582

    Keywords Proktologie ; minimalinvasive Chirurgie ; MIC ; Darmkrebs ; Tumorchirurgie ; da-Vinci-System
    Language German
    Publishing date 2018-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2317051-7
    ISSN 1611-6461 ; 1611-6437
    ISSN (online) 1611-6461
    ISSN 1611-6437
    DOI 10.1055/a-0642-3317
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