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  1. Book: Follow-up strategies and management of recurrence in urologic oncology

    Theodorescu, Dan

    (The urologic clinics of North America ; 30,4)

    2003  

    Author's details Dan Theodorescu, guest ed
    Series title The urologic clinics of North America ; 30,4
    Collection
    Language English
    Size XV S., S. 669 - 915 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013877968
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 269 -30,4- verfügbar in Königswinter Königswinter

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  2. Article: CD44 in Bladder Cancer.

    Duex, Jason / Theodorescu, Dan

    Cancers

    2024  Volume 16, Issue 6

    Abstract: The glycoprotein CD44, with its many isoforms and variations in carbohydrate patterning, participates in a diverse set of cellular functions. This fact leads to the protein playing a role in many normal and pathologic cellular processes including a role ... ...

    Abstract The glycoprotein CD44, with its many isoforms and variations in carbohydrate patterning, participates in a diverse set of cellular functions. This fact leads to the protein playing a role in many normal and pathologic cellular processes including a role in cancer progression and metastasis. These same facts make CD44 a strong therapeutic target in many cancer types, including bladder cancer.
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Potential of Combination Therapies and Patient Stratification to Improve CCR2 Inhibition Therapeutics.

    Duex, Jason E / Theodorescu, Dan

    Journal of cellular immunology

    2022  Volume 3, Issue 3, Page(s) 198–200

    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ISSN 2689-2812
    ISSN (online) 2689-2812
    DOI 10.33696/immunology.3.099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Using Cell Lines To Guide Neoadjuvant Therapy in Bladder Cancer: COXEN and SWOG S1314.

    Dancik, Garrett M / Theodorescu, Dan

    European urology focus

    2022  Volume 8, Issue 3, Page(s) 648–650

    Abstract: There are no predictive biomarkers in clinical use for the neoadjuvant treatment of bladder cancer. Here we report on a recent randomized phase 2 trial validating the identification of predictive biomarkers using cell lines in the absence of patient ... ...

    Abstract There are no predictive biomarkers in clinical use for the neoadjuvant treatment of bladder cancer. Here we report on a recent randomized phase 2 trial validating the identification of predictive biomarkers using cell lines in the absence of patient response data.
    MeSH term(s) Biomarkers ; Cell Line ; Humans ; Neoadjuvant Therapy ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-03-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2022.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Immunotherapy of High Risk Non-Muscle Invasive Bladder Cancer.

    Ahdoot, Michael / Theodorescu, Dan

    Expert review of clinical pharmacology

    2021  Volume 14, Issue 11, Page(s) 1345–1352

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/pharmacology ; BCG Vaccine/administration & dosage ; Drug Approval ; Genetic Therapy/methods ; Humans ; Immunotherapy/methods ; Neoplasm Grading ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/therapy
    Chemical Substances Antineoplastic Agents, Immunological ; BCG Vaccine
    Language English
    Publishing date 2021-07-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2021.1950531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Identifying novel biomarkers associated with bladder cancer treatment outcomes.

    Castaneda, Peris R / Theodorescu, Dan / Rosser, Charles J / Ahdoot, Michael

    Frontiers in oncology

    2023  Volume 13, Page(s) 1114203

    Abstract: Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift ... ...

    Abstract Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift toward personalized treatment of bladder cancer is underway. To this end, several biomarkers have been developed and tested in their ability to predict response to treatment in patients with bladder cancer and potentially help direct therapy. We performed a search of recently published PubMed articles using terms "biomarker," "bladder cancer," and the respective treatment discussed (i.e., "neoadjuvant" or "BCG"). In this review, we summarize the latest studies on novel biomarkers in bladder cancer with a focus on those intended to improve risk stratification and treatment selection.
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1114203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sex differences in bladder cancer: emerging data and call to action.

    Theodorescu, Dan / Li, Zihai / Li, Xue

    Nature reviews. Urology

    2022  Volume 19, Issue 8, Page(s) 447–449

    MeSH term(s) Female ; Humans ; Male ; Rare Diseases ; Risk Factors ; Sex Characteristics ; Sex Factors ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/therapy
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-022-00591-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6030: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Determinants of Resistance to Checkpoint Inhibitors.

    Tran, Linda / Theodorescu, Dan

    International journal of molecular sciences

    2020  Volume 21, Issue 5

    Abstract: The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug ... ...

    Abstract The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug Administration (FDA)-approved for multiple cancers, and hundreds of clinical trials are currently ongoing. These antibodies disrupt T-cell inhibitory pathways established by tumor cells and thus re-activate the host's antitumor immune response. While successful in many cancers, several types remain relatively refractory to treatment or patients develop early recurrence. Hence, there is a great need to further elucidate mechanisms of resistant disease and determine novel, effective, and tolerable combination therapies to enhance efficacy of ICIs.
    MeSH term(s) Combined Modality Therapy/methods ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/physiology ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/pharmacology ; Immunotherapy/methods ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/immunology ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21051594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Author Correction: Y chromosome loss in cancer drives growth by evasion of adaptive immunity.

    Abdel-Hafiz, Hany A / Schafer, Johanna M / Chen, Xingyu / Xiao, Tong / Gauntner, Timothy D / Li, Zihai / Theodorescu, Dan

    Nature

    2024  Volume 626, Issue 7999, Page(s) E11

    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07104-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  10. Article ; Online: Re: Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy.

    Zuiverloon, Tahlita C M / Theodorescu, Dan

    European urology

    2019  Volume 75, Issue 4, Page(s) 694

    MeSH term(s) Chemotherapy, Adjuvant ; Cisplatin ; Cystectomy ; Genomics ; Humans ; Neoadjuvant Therapy ; Urinary Bladder Neoplasms
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-01-17
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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