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Artikel ; Online: Mycobacterium tuberculosis infections in solid organ transplantation: Guidelines from the infectious diseases community of practice of the American Society of Transplantation.

Subramanian, Aruna K / Theodoropoulos, Nicole M

2019 Band 33, Heft 9, Seite(n) e13513

Abstract: These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tuberculosis in the pre- and post-transplant period. The challenges of screening ... ...

Abstract	These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tuberculosis in the pre- and post-transplant period. The challenges of screening for both latent and active TB in the setting of transplantation are reviewed. The use of interferon gamma release assays for detection of latent tuberculosis is discussed and compared to tuberculin skin testing. Given the limitations of both testing modality, it is important to consider exposure history and chest imaging. The clinical manifestations of active tuberculosis in transplantation are covered. New recommendations for treatment of latent tuberculosis and active tuberculosis are included.
Mesh-Begriff(e)	Anti-Bacterial Agents/therapeutic use ; Humans ; Mycobacterium tuberculosis/isolation & purification ; Organ Transplantation/adverse effects ; Practice Guidelines as Topic/standards ; Societies, Medical ; Transplant Recipients ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/etiology
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2019-03-22
Erscheinungsland	Denmark
Dokumenttyp	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13513
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Testing deceased organ donors for infections: An organ procurement organization survey.

Theodoropoulos, Nicole M / Greenwald, Melissa A / Chin-Hong, Peter / Ison, Michael G

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2021 Band 21, Heft 5, Seite(n) 1924–1930

Abstract: Organ procurement organizations (OPO) test potential deceased organ donors for infectious diseases required by policy, but many also perform testing for additional infections. The current state of donor testing in the United States is unknown. We sent an ...

Abstract	Organ procurement organizations (OPO) test potential deceased organ donors for infectious diseases required by policy, but many also perform testing for additional infections. The current state of donor testing in the United States is unknown. We sent an IRB approved survey to all 57 U.S. OPOs using REDCap. Descriptive statistics were performed. From the 57 OPOs, we received 46 (80.7%) unique responses with all 11 United Network of Organ Sharing regions represented. Forty of 46 (87%) OPO respondents consulted an Infectious Diseases physician when needed. Eighteen of 46 (39%) tested for West Nile virus (WNV) and 17 of 18 (94%) tested year-round. Eleven of 46 (23.9%) tested for Strongyloides infection while 17 of 46 (37%) tested for Chagas disease. All OPOs performed prospective nucleic acid testing (NAT) for HIV, hepatitis B and hepatitis C on all donors. OPO testing of additional infections has increased since prior surveys but remains variable. Standardization of organ donor infectious diseases evaluation should be considered.
Mesh-Begriff(e)	Hepatitis C ; Humans ; Prospective Studies ; Surveys and Questionnaires ; Tissue Donors ; Tissue and Organ Procurement ; United States
Sprache	Englisch
Erscheinungsdatum	2021-03-11
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16552
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Antibodies, boosters, and optimizing SARS-CoV-2 vaccines for transplantation: A call for more research.

Ison, Michael G / Blumberg, Emily / Halasa, Natasha / Kaul, Dan / Theodoropoulos, Nicole M / Wolfe, Cameron R

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2021 Band 22, Heft 1, Seite(n) 24–27

Abstract: Despite emerging data suggesting reduced antibody responses among solid organ transplant recipients following SARS-CoV-2 vaccine, critical unanswered questions remain. The clinical implications of the reduced humoral response need to be assessed through ... ...

Abstract	Despite emerging data suggesting reduced antibody responses among solid organ transplant recipients following SARS-CoV-2 vaccine, critical unanswered questions remain. The clinical implications of the reduced humoral response need to be assessed through prospective studies. Studies are likewise needed to inform which vaccine dosing strategies result in improved immunity and if such approaches maximize protection against severe infection in the vulnerable transplant population.
Mesh-Begriff(e)	Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Humans ; Prospective Studies ; SARS-CoV-2
Chemische Substanzen	Antibodies, Viral ; COVID-19 Vaccines
Sprache	Englisch
Erscheinungsdatum	2021-07-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16758
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Immunization of Solid Organ Transplant Candidates and Recipients: A 2018 Update.

Donato-Santana, Christian / Theodoropoulos, Nicole M

Infectious disease clinics of North America

2018 Band 32, Heft 3, Seite(n) 517–533

Abstract: This article discusses the recommended vaccines used before and after solid organ transplant period, including data regarding vaccine safety and efficacy and travel-related vaccines. Vaccination is an important part of the preparation for solid organ ... ...

Abstract	This article discusses the recommended vaccines used before and after solid organ transplant period, including data regarding vaccine safety and efficacy and travel-related vaccines. Vaccination is an important part of the preparation for solid organ transplantation, because vaccine-preventable diseases contribute to the morbidity and mortality of these patients. A pretransplantation protocol should be encouraged in every transplant center. The main goal of vaccination is to provide seroprotection before transplantation, because iatrogenically immunosuppressed patients posttransplant have a lower seroresponse to vaccines.
Mesh-Begriff(e)	Communicable Disease Control ; Humans ; Immunization ; Organ Transplantation/adverse effects ; Tissue Donors ; Transplant Recipients ; Vaccines/administration & dosage
Chemische Substanzen	Vaccines
Sprache	Englisch
Erscheinungsdatum	2018-08-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1077676-x
ISSN	1557-9824 ; 0891-5520
ISSN (online)	1557-9824
ISSN	0891-5520
DOI	10.1016/j.idc.2018.04.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Inadequate Cerebrospinal Fluid Concentrations of Available Salvage Agents Further Impedes the Optimal Treatment of Multidrug-Resistant

Wenzler, Eric / Adeel, Alina / Wu, Tiffany / Jurkovic, Michele / Walder, Jeremy / Ramasra, Emily / Campion, Maureen / Cerny, Jan / Theodoropoulos, Nicole M

Infectious disease reports

2021 Band 13, Heft 3, Seite(n) 843–854

Abstract: Background: Vancomycin-resistant Enterococcus faecium: Methods: We present a complex case of a patient with relapsed acute myeloid leukemia who underwent allogenic hematopoietic stem cell transplantation complicated by persistent VRE bacteremia and ... ...

Abstract	Background: Vancomycin-resistant Enterococcus faecium Methods: We present a complex case of a patient with relapsed acute myeloid leukemia who underwent allogenic hematopoietic stem cell transplantation complicated by persistent VRE bacteremia and meningitis. To optimize therapy, various blood and cerebrospinal fluid (CSF) samples were sent to a research laboratory for extensive susceptibility testing, pharmacokinetic analyses, and time-kill experiments. Results: In vitro testing revealed resistance to all first-line treatment options and CSF sampling demonstrated sub-optimal central nervous system concentrations achieved by each antimicrobial agent administered in relation to their respective MIC value. Time-kill analyses at observed CSF concentrations confirmed the lack of bactericidal activity despite use of a four-drug combination regimen. Conclusions: This work is the first to report CSF concentrations of oritavancin and tedizolid in humans and adds to the limited data regarding in vitro susceptibility of new antimicrobial agents such as eravacycline, omadacycline, and lefamulin against VRE. Our study provides new insights into various aspects of treatment of extensively drug-resistant
Sprache	Englisch
Erscheinungsdatum	2021-09-08
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ISSN	2036-7430
ISSN	2036-7430
DOI	10.3390/idr13030076
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Randomized Phase 3 Trial of Ruxolitinib for COVID-19-Associated Acute Respiratory Distress Syndrome.

Rein, Lindsay / Calero, Karel / Shah, Ronak / Ojielo, Charles / Hudock, Kristin M / Lodhi, Saba / Sadaka, Farid / Bellam, Shashi / Palma, Christopher / Hager, David N / Daniel, Jeannie / Schaub, Richard / O'Hayer, Kevin / Theodoropoulos, Nicole M

Critical care medicine

2022 Band 50, Heft 12, Seite(n) 1701–1713

Abstract: Objectives: Evaluate the safety and efficacy of the Janus kinase (JAK)1/JAK2 inhibitor ruxolitinib in COVID-19-associated acute respiratory distress syndrome requiring mechanical ventilation.: Design: Phase 3 randomized, double-blind, placebo- ... ...

Abstract	Objectives: Evaluate the safety and efficacy of the Janus kinase (JAK)1/JAK2 inhibitor ruxolitinib in COVID-19-associated acute respiratory distress syndrome requiring mechanical ventilation. Design: Phase 3 randomized, double-blind, placebo-controlled trial Ruxolitinib in Participants With COVID-19-Associated Acute Respiratory Distress Syndrome Who Require Mechanical Ventilation (RUXCOVID-DEVENT; NCT04377620). Setting: Hospitals and community-based private or group practices in the United States (29 sites) and Russia (4 sites). Patients: Eligible patients were greater than or equal to 12 years old, hospitalized with severe acute respiratory syndrome coronavirus 2 infection, and mechanically ventilated with a Pa o2 /F io2 of less than or equal to 300 mm Hg within 6 hours of randomization. Interventions: Patients were randomized 2:2:1 to receive twice-daily ruxolitinib 15 mg, ruxolitinib 5 mg, or placebo, each plus standard therapy. Measurements and main results: The primary endpoint, 28-day mortality, was tested for each ruxolitinib group versus placebo using a mixed-effects logistic regression model and one-tailed significance test (significance threshold: p < 0.025); no type 1 error was allocated to secondary endpoints. Between May 24, 2020 and December 15, 2020, 211 patients (age range, 24-87 yr) were randomized (ruxolitinib 15/5 mg, n = 77/87; placebo, n = 47). Acute respiratory distress syndrome was categorized as severe in 27% of patients (58/211) at randomization; 90% (190/211) received concomitant steroids. Day-28 mortality was 51% (39/77; 95% CI, 39-62%) for ruxolitinib 15 mg, 53% (45/85; 95% CI, 42-64%) for ruxolitinib 5 mg, and 70% (33/47; 95% CI, 55-83%) for placebo. Neither ruxolitinib 15 mg (odds ratio, 0.46 [95% CI, 0.201-1.028]; one-sided p = 0.029) nor 5 mg (odds ratio, 0.42 [95% CI, 0.171-1.023]; one-sided p = 0.028) significantly reduced 28-day mortality versus placebo. Numerical improvements with ruxolitinib 15 mg versus placebo were observed in secondary outcomes including ventilator-, ICU-, and vasopressor-free days. Rates of overall and serious treatment-emergent adverse events were similar across treatments. Conclusions: The observed reduction in 28-day mortality rate between ruxolitinib and placebo in mechanically ventilated patients with COVID-19-associated acute respiratory distress syndrome was not statistically significant; however, the trial was underpowered owing to early termination.
Mesh-Begriff(e)	Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; COVID-19/complications ; SARS-CoV-2 ; Respiratory Distress Syndrome/drug therapy ; Respiration, Artificial ; Treatment Outcome ; COVID-19 Drug Treatment
Chemische Substanzen	ruxolitinib (82S8X8XX8H)
Sprache	Englisch
Erscheinungsdatum	2022-10-13
Erscheinungsland	United States
Dokumenttyp	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000005682
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy.

Ison, Michael G / Avery, Robin / Blumberg, Emily / Chin-Hong, Peter / Halasa, Natasha / Kaul, Dan / Pergam, Steve / Theodoropoulos, Nicole M / Wolfe, Cameron R

Transplantation

2021 Band 105, Heft 10, Seite(n) e131–e132

Mesh-Begriff(e)	COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Humans ; Organ Transplantation ; SARS-CoV-2/immunology ; Vaccination
Chemische Substanzen	COVID-19 Vaccines
Sprache	Englisch
Erscheinungsdatum	2021-03-15
Erscheinungsland	United States
Dokumenttyp	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003747
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Treatment of Acute Graft-versus-Host Disease in Liver Transplant Recipients.

Kim, Edward / Adeel, Alina / Bozorgzadeh, Adel / Amano, Shinya / Barry, Curtis T / Daly, Jennifer S / Devuni, Deepika / Elaba, Zendee / Houk, Laura / Martins, Paulo N / Movahedi, Babak / Ramanathan, Muthalagu / Theodoropoulos, Nicole M

Case reports in transplantation

2021 Band 2021, Seite(n) 8981429

Abstract: Acute graft-versus-host disease (aGvHD) is a rare complication of liver transplantation associated with high morbidity and mortality. Death typically occurs due to complications related to severe infection, shock, and multiorgan failure. The clinical ... ...

Abstract	Acute graft-versus-host disease (aGvHD) is a rare complication of liver transplantation associated with high morbidity and mortality. Death typically occurs due to complications related to severe infection, shock, and multiorgan failure. The clinical presentation involves dysfunction of multiple organ systems with overlapping symptoms that often results in a diagnostic delay. As there are a limited number of cases reported in the literature, there are no clear guidelines for treatment. Many different therapeutic measures have been utilized that target various immune system pathways, but steroids remain the first line of therapy. We report on two patients who developed aGvHD after liver transplantation who were treated with ruxolitinib, a novel Janus kinase 1/2 (JAK) inhibitor that has been shown to improve outcomes in steroid refractory cases of aGvHD after allogenic hematopoietic stem cell transplantation. We reviewed the literature to discuss various therapeutic options currently available for aGvHD after liver transplantation.
Sprache	Englisch
Erscheinungsdatum	2021-11-30
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	2627657-4
ISSN	2090-6951 ; 2090-6943
ISSN (online)	2090-6951
ISSN	2090-6943
DOI	10.1155/2021/8981429
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Liver transplant evaluation for fulminant liver failure due to acute hepatitis A infection: Case series and literature review.

Navarro, Maria Eugenia D / Yao, Christine C / Whiteley, Adam / Movahedi, Babak / Devuni, Deepika / Barry, Curtis / Zacharias, Isabel / Theodoropoulos, Nicole M / Bozorgzadeh, Adel / Martins, Paulo N

Transplant infectious disease : an official journal of the Transplantation Society

2020 Band 23, Heft 2, Seite(n) e13476

Abstract: Hepatitis A virus can cause liver damage ranging from mild illness to fulminant hepatic failure, constituting 0.35% of all cases of fulminant liver failure. While rates of spontaneous remission are higher for hepatitis A, recent outbreaks attributable to ...

Abstract	Hepatitis A virus can cause liver damage ranging from mild illness to fulminant hepatic failure, constituting 0.35% of all cases of fulminant liver failure. While rates of spontaneous remission are higher for hepatitis A, recent outbreaks attributable to vaccine shortages in highly populated urban cities plagued by insufficient affordable housing and inaccessible sanitation, and changes in the epidemiology of viral strains have resulted in increased hospitalizations and deaths. While the prognosis for patients with FHF has improved since the introduction of transplantation, the decision to transplant is often difficult to reach. We present five patients with HAV and subsequent FHF, one of whom successfully received a liver transplant. We have reviewed all published cases of HAV FHF in the literature and report ten patients, seven of whom received liver transplantation. There are few predictive models that attempt to distinguish between fulminant hepatitis A and spontaneous recovery. Patients found to have positive hepatitis A IgM, encephalopathy, worsening LFT's and coagulation should be monitored closely and referred to transplant centers urgently for management.
Mesh-Begriff(e)	Acute Disease ; Hepatitis A/complications ; Humans ; Liver Failure, Acute/etiology ; Liver Transplantation ; Prognosis
Sprache	Englisch
Erscheinungsdatum	2020-12-04
Erscheinungsland	Denmark
Dokumenttyp	Journal Article ; Review
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13476
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Expecting the unexpected: COVID-19 in Kidney Transplant Recipients within United Network for Organ Sharing Region 1.

Zimmerman, Asha / Rogers, Ralph / Tan, Chen Sabrina / Pavlakis, Martha / Bodziak, Kenneth / Cardarelli, Francesca / Francis, Jean / Gabardi, Steven / Germain, Michael / Ghai, Sandeep / Gilligan, Hannah / Goyal, Nitender / Malinis, Maricar / Patel, Het / Rodig, Nancy / Theodoropoulos, Nicole M / Walshe, Edward / Wood, Emily / Chobanian, Michael

Transplant international : official journal of the European Society for Organ Transplantation

2020 Band 33, Heft 12, Seite(n) 1843–1844

Mesh-Begriff(e)	COVID-19/epidemiology ; COVID-19/etiology ; Health Surveys ; Humans ; Incidence ; Kidney Transplantation ; New England/epidemiology ; Postoperative Complications/epidemiology
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-10-21
Erscheinungsland	Switzerland
Dokumenttyp	Letter
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/tri.13757
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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