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Article ; Online: Iron Deficiency Anemia in Colorectal Cancer Patients: Is Preoperative Intravenous Iron Infusion Indicated? A Narrative Review of the Literature.

Chardalias, Leonidas / Papaconstantinou, Ioannis / Gklavas, Antonios / Politou, Marianna / Theodosopoulos, Theodosios

Cancer diagnosis & prognosis

2023 Volume 3, Issue 2, Page(s) 163–168

Abstract: Iron deficiency anemia is the most common extraintestinal symptom in patients with colorectal cancer (CRC). Inflammation associated with malignancy leads to functional iron deficiency via the hepcidin pathway, whereas chronic blood loss causes absolute ... ...

Abstract	Iron deficiency anemia is the most common extraintestinal symptom in patients with colorectal cancer (CRC). Inflammation associated with malignancy leads to functional iron deficiency via the hepcidin pathway, whereas chronic blood loss causes absolute iron deficiency and depletion of iron stores. The assessment and treatment of preoperative anemia is of great importance in patients with CRC, since published data have consistently shown that preoperative anemia is associated with increased need for perioperative blood transfusions and more postoperative complications. Recent studies have documented mixed results regarding the preoperative intravenous iron administration in anemic CRC patients in terms of efficacy for anemia correction, cost-effectiveness, need for transfusions and risk for postoperative complications.
Language	English
Publishing date	2023-03-03
Publishing country	Greece
Document type	Journal Article ; Review
ISSN	2732-7787
ISSN (online)	2732-7787
DOI	10.21873/cdp.10196
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Article: Optimizing Adjuvant Therapy after Surgery for Colorectal Cancer Liver Metastases: A Systematic Review.

Georgilis, Emmanouil / Gavriatopoulou, Maria / Tsilimigras, Diamantis I / Malandrakis, Panagiotis / Theodosopoulos, Theodosios / Ntanasis-Stathopoulos, Ioannis

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: The liver is the most common site of colorectal cancer metastatic spread. Although metastasectomy is the gold standard for fit patients with resectable colorectal cancer liver metastases (CRLMs), their management after surgical treatment remains ... ...

Abstract	The liver is the most common site of colorectal cancer metastatic spread. Although metastasectomy is the gold standard for fit patients with resectable colorectal cancer liver metastases (CRLMs), their management after surgical treatment remains controversial. The objective of this systematic review was to collate the currently available data of the agents used in the adjuvant setting in order to define the most optimal therapeutic strategy. A systematic review of the literature was conducted by searching PubMed/Medline and Cochrane library databases. We included studies that evaluated the efficacy, the tolerability and the safety profile of various chemotherapeutic agents that are used as adjuvant treatment after surgical resection of CRLMs. The outcomes of interest were regression-free survival (RFS), disease-free survival (DFS), overall survival (OS) and severe toxicities. From 543 initial articles, 29 publications with 7028 patients were finally included. In general, the results of the eligible studies indicated that adjuvant therapy after resection of CRLMs led to improved RFS/DFS rates, but this benefit did not contribute to a statistically significant prolongation of OS. Moreover, the choice of the therapeutic strategy, namely systematic or regional chemotherapy or the combination of both, did not seem to have a differential impact on patient outcomes. However, these results should be interpreted with caution since the majority of the chosen studies are of low or moderate quality. In this context, further high-quality clinical trials conducted on patient sub-populations with modern therapies are required in order to reduce in-study and between-study heterogeneity and determine which patients are expected to derive the maximum benefit from adjuvant therapy after surgery for CRLMs.
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062401
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Article: Giant Ovarian Thecoma Associated with Meigs Syndrome: A Striking Case.

Dellaportas, Dionysios / Kollia, Dimitra / Myoteri, Despoina / Nastos, Constantinos / Gkiokas, George / Carvounis, Eleni / Theodosopoulos, Theodosios

Chirurgia (Bucharest, Romania : 1990)

2021 Volume 116, Issue eCollection, Page(s) 1–5

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Ascites/etiology ; CA-125 Antigen ; Female ; Humans ; Meigs Syndrome/complications ; Meigs Syndrome/diagnosis ; Meigs Syndrome/surgery ; Middle Aged ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/surgery ; Thecoma/complications ; Thecoma/diagnosis ; Thecoma/surgery ; Treatment Outcome
Chemical Substances	CA-125 Antigen
Language	English
Publishing date	2021-08-31
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
DOI	10.21614/chirurgia.116.eC.1912
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Article ; Online: Left Gastroepiploic Artery True Aneurysm: Case Report and Review of the Literature.

Kotsis, Thomas / Iliakopoulos, Konstantinos / Christoforou, Panagitsa / Theodosopoulos, Theodosios

Annals of vascular surgery

2018 Volume 53, Page(s) 268.e7–268.e11

Abstract: Although the aneurysm of the splenic artery represents the third most common abdominal arterial aneurysm next to the aortic and iliac aneurysms, the aneurysm of the gastroepiploic artery is extremely rare occurring at a frequency of 3-4% of all visceral ... ...

Abstract	Although the aneurysm of the splenic artery represents the third most common abdominal arterial aneurysm next to the aortic and iliac aneurysms, the aneurysm of the gastroepiploic artery is extremely rare occurring at a frequency of 3-4% of all visceral arteries' aneurysms; only 17 cases have been reported in the English literature. We present the case of a 65-year-old woman with an asymptomatic visceral artery aneurysm, which was an incidental ultrasonography finding. Magnetic resonance imaging showed an arterial aneurysm close to the peripheral splenic artery with intense tortuosity of the celiac and splenic artery. Abdominal computed tomography angiography confirmed the existence of an arterial aneurysm with a diameter of 2.3 cm near the splenic hilus without identifying the involved vessel. Endoluminal treatment was considered cumbersome due to anticipated anatomic obstacles; the patient underwent an elective open surgery in which the tortuosity of the celiac and splenic arteries and the aneurysm of the left gastroepiploic artery were revealed. The aneurysm was resected after proximal and distal ligation of the gastroepiploic artery; the flow of the splenic artery was intact. Histologically, it was a true aneurysm. The patient left the hospital on the fourth postoperative day without any complication. Historically, most aneurysms of the gastroepiploic arteries have been observed in men in the sixth decade of their life and after rupture; in modern times, their early incidental apocalypse is frequent due to the widespread use of imaging studies. Diagnostic approach and preoperative planning is of paramount importance to avoid complications. Current therapeutic modalities include catheter-based techniques or laparoscopic surgery.
MeSH term(s)	Aged ; Aneurysm/diagnostic imaging ; Aneurysm/physiopathology ; Aneurysm/surgery ; Computed Tomography Angiography ; Female ; Gastroepiploic Artery/diagnostic imaging ; Gastroepiploic Artery/physiopathology ; Gastroepiploic Artery/surgery ; Humans ; Incidental Findings ; Ligation ; Magnetic Resonance Angiography ; Treatment Outcome ; Vascular Surgical Procedures
Language	English
Publishing date	2018-08-06
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2018.04.040
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Article: Retroperitoneal Solitary Fibrous Tumor: A "Patternless" Tumor.

Myoteri, D / Dellaportas, D / Nastos, C / Gioti, I / Gkiokas, G / Carvounis, E / Theodosopoulos, T

Case reports in oncological medicine

2017 Volume 2017, Page(s) 4634235

Abstract: Introduction: Solitary fibrous tumor is a rare type of mesenchymal, spindle-cell tumor reported mostly in the pleura. Retroperitoneal occurrence is rare and histopathological diagnosis is challenging.: Case presentation: A 55-year-old woman with ... ...

Abstract	Introduction: Solitary fibrous tumor is a rare type of mesenchymal, spindle-cell tumor reported mostly in the pleura. Retroperitoneal occurrence is rare and histopathological diagnosis is challenging. Case presentation: A 55-year-old woman with nonspecific abdominal pain was found to have a retroperitoneal/pelvic mass adjacent to the upper rectum. The patient underwent surgical resection in clear margins of this pelvic tumor, entering the total mesenteric excision surgical plane. Final histopathology revealed a solitary fibrous tumor and the case is presented herein. Discussion: Solitary fibrous tumor in the retroperitoneum is rarely found in the literature and to the best of our knowledge less than a hundred cases are described so far. Histopathological diagnosis is mostly based on a "patternless pattern" on microscopic examination, which is a storiform arrangement of spindle cells combined with a "hemangiopericytoma-like appearance" and increased vascularity of the lesion. Surgery is the mainstay of treatment and recurrence rates are generally low.
Language	English
Publishing date	2017-09-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629911-2
ISSN	2090-6714 ; 2090-6706
ISSN (online)	2090-6714
ISSN	2090-6706
DOI	10.1155/2017/4634235
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Article ; Online: Multidisciplinary management of complicated small bowel adenocarcinoma on the ground of Crohn's disease.

Ntanasis-Stathopoulos, Ioannis / Gavriatopoulou, Maria / Tsilimigras, Diamantis / Theodosopoulos, Theodosios

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2019 Volume 24, Issue 1, Page(s) 408–409

MeSH term(s)	Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Crohn Disease/pathology ; Crohn Disease/therapy ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2019-04-02
Publishing country	Greece
Document type	Case Reports ; Letter
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article: Primary adrenal leiomyosarcoma: A case report.

Sakellariou, Maria / Dellaportas, Dionysios / Grapsa, Eirini / Tzikanoulas, Menelaos / Dellis, Athanasios / Theodosopoulos, Theodosios / Nastos, Constantinos

Molecular and clinical oncology

2020 Volume 12, Issue 4, Page(s) 317–320

Abstract: Adrenal leiomyosarcomas are rare mesenchymal tumors of the suprarenal region that are usually diagnosed after they have reached a large size. We report the case of a 62-year-old male with an incidentally found left adrenal mass. Magnetic resonance ... ...

Abstract	Adrenal leiomyosarcomas are rare mesenchymal tumors of the suprarenal region that are usually diagnosed after they have reached a large size. We report the case of a 62-year-old male with an incidentally found left adrenal mass. Magnetic resonance imaging of the retroperitoneal space showed a heterogeneously enhanced mass, measuring 10x8.2 cm, with characteristics suspicious of malignancy. The patient underwent left radical adrenalectomy after the hormonal evaluation of the tumor due to the high probability of adrenocortical carcinoma. However, microscopic examination of the tumor showed a spindle cell sarcoma. Immunohistochemically the neoplastic cells were found positive for desmin and smooth muscle actin and the diagnosis of a well differentiated adrenal leiomyosarcoma was established. During follow-up the patient presented an aggressive course as he developed bone, liver and pulmonary metastases early postoperatively, which were treated with radiation therapy and chemotherapy. The patient has progressive metastatic disease while on chemotherapy 31 months after surgery.
Language	English
Publishing date	2020-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2020.1987
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Article ; Online: Neoadjuvant chemoradiotherapy in rectal cancer and anorectal sphincter dysfunction: Review of the literature.

Massaras, Dimitrios / Pantiora, Eirini / Sotirova, Eirini / Dellaportas, Dionysios / Dafnios, Nikolaos / Zygogianni, Anna / Theodosopoulos, Theodosios

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2020 Volume 25, Issue 1, Page(s) 35–39

Abstract: Purpose: The purpose of this article was to review the current medical literature regarding deterioration of anorectal function in patients receiving neoadjuvant chemoradiotherapy before surgery for locally advanced rectal cancer.: Methods: We ... ...

Abstract	Purpose: The purpose of this article was to review the current medical literature regarding deterioration of anorectal function in patients receiving neoadjuvant chemoradiotherapy before surgery for locally advanced rectal cancer. Methods: We reviewed the current literature including research studies, electronic database PUBMED-MEDLINE, published research results and metanalysis papers from high-volume institutes, collecting and comparing the different results. Pathophysiology as well as emerging solutions for treating anorectal sphincter dysfunction were researched in order to provide an insight of this complex issue. Results: All available data suggest that neoadjuvant radiation therapy impairs internal anal sphincter function mostly through nerve damaging mechanisms, as nerves are more susceptible to damage than muscular fibers. Conclusion: Current radiotherapy recommendations are oriented in exclusion of anal canal from radiation field when oncologically safe or using new sphincter-sparing techniques for neoadjuvant radiotherapy aiming to improve the patient quality of life receiving radiation therapy prior to surgery. However, more well designed studies are required to assess the pathophysiology as well as treatment options for this complex matter, which strongly affects the quality of life of rectal cancer patients.
MeSH term(s)	Anus Neoplasms/drug therapy ; Anus Neoplasms/radiotherapy ; Chemoradiotherapy/methods ; Female ; Humans ; Male ; Neoadjuvant Therapy/methods ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy
Language	English
Publishing date	2020-04-25
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article ; Online: Comparison of the laparoscopic versus open surgery in patients aged over 75 years old with colorectal cancer. Short- and Mid-term outcomes.

Sotirova, Ira / Gklavas, Antonios / Nastos, Constantinos / Micha, Georgia / Dafnios, Nikolaos / Dellaportas, Dionysios / Theodosopoulos, Theodosios

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2020 Volume 25, Issue 5, Page(s) 2186–2191

Abstract: Purpose: The benefit of minimally invasive surgery in colorectal cancer patients has been established, however it is not clear whether these advantages apply to older patients as well. The aim of this study was to review short- and mid-term outcomes in ... ...

Abstract	Purpose: The benefit of minimally invasive surgery in colorectal cancer patients has been established, however it is not clear whether these advantages apply to older patients as well. The aim of this study was to review short- and mid-term outcomes in elderly patients, over the age of 75 years, with colorectal cancer. Methods: This was a retrospective study of selected patients over the age of 75 who underwent laparoscopic and open surgery for colorectal cancer between February 2013 and January 2018 in a tertiary referral center. All patients were categorized in two groups: Group 1 included patients who had open procedure (OP) and Group 2 those who underwent laparoscopic procedure (LP). Demographic, clinical, short- and midterm postoperative data were collected and analyzed between the two study groups. Results: A total of 78 patients were included in our cohort; 39 (50%) were operated with LP. The LP was equally safe in comparison with the OP, considering the similar postoperative complications [9 patients (34.6%) in LP and 5 patients (18.5%) in OP (p=0.224)], including anastomotic leakage in 2 patients (7.7%) in LP and 1 patient (3.7%) in OP group (p=0.61). The median postoperative hospital stay favored the laparoscopic approach (6 days in LP group and 8 days in OP group; p=0.001). The number of harvested lymph nodes were without statistically significant differences [LP group retrieved 20.0 nodes in comparison with 20.5 nodes in OP group (p= 0.816)]. The overall survival analysis showed no difference between the two approaches in 12 and 24 postoperative months (p=0.098 and 0.387, respectively).
MeSH term(s)	Aged ; Aged, 80 and over ; Colectomy/methods ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Laparoscopy/methods ; Male ; Postoperative Complications ; Treatment Outcome
Language	English
Publishing date	2020-12-10
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article: Large Paraesophageal Hiatus Hernia: Is Surgery Mandatory?

Dellaportas, Dionysios / Papaconstantinou, Ioannis / Nastos, Constantinos / Karamanolis, Georgios / Theodosopoulos, Theodosios

Chirurgia (Bucharest, Romania : 1990)

2018 Volume 113, Issue 6, Page(s) 765–771

Abstract: Purpose/Aim: Paraesophageal hiatus hernias are seldom found, however the incidence is increasing accounting for 5-10% of all hiatal hernias. The aim of this review is to emphasize controversies in clinical presentation, essential workup investigations ... ...

Abstract	Purpose/Aim: Paraesophageal hiatus hernias are seldom found, however the incidence is increasing accounting for 5-10% of all hiatal hernias. The aim of this review is to emphasize controversies in clinical presentation, essential workup investigations and highlight non-surgical and surgical management options.
MeSH term(s)	Aged ; Hernia, Hiatal/complications ; Hernia, Hiatal/diagnosis ; Hernia, Hiatal/surgery ; Humans ; Laparoscopy ; Necrosis/pathology ; Stomach/pathology ; Stomach/surgery ; Stomach Volvulus/etiology ; Stomach Volvulus/therapy ; Treatment Outcome
Language	English
Publishing date	2018-12-30
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	419244-8
ISSN	1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
ISSN (online)	1842-368X
ISSN	1221-9118 ; 0009-4730 ; 0377-5003
DOI	10.21614/chirurgia.113.6.765
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