LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: IgE-sensitization to food and inhalant allergens in IBD patients compared with normal blood donors at Oslo University Hospital, Norway.

    Johnson, Egil / Therkelsen, Stig Palm / Nentwich, Ivo / Nissen-Meyer, Lise Sofie Haug / Hetland, Geir

    Scandinavian journal of gastroenterology

    2019  Volume 54, Issue 9, Page(s) 1107–1110

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Adult ; Aged ; Allergens/immunology ; Blood Donors ; Case-Control Studies ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/immunology ; Crohn Disease/blood ; Crohn Disease/immunology ; Female ; Food Hypersensitivity/immunology ; Hospitals, University ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Male ; Middle Aged ; Norway ; Young Adult
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2019-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2019.1663445
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 567: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies

    Hetland, Geir / Tangen, Jon-Magnus / Mahmood, Faiza / Mirlashari, Mohammad Reza / Nissen-Meyer, Lise Sofie Haug / Nentwich, Ivo / Therkelsen, Stig Palm / Tjønnfjord, Geir Erland / Johnson, Egil

    Nutrients. 2020 May 08, v. 12, no. 5

    2020  

    Abstract: Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine. ... ...

    Abstract Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine. Special focus has been on their antitumor effects, but the mushrooms’ anti-inflammatory and antiallergic properties have also been investigated. The antitumor mechanisms were either direct tumor attack, e.g., apoptosis and metastatic suppression, or indirect defense, e.g., inhibited tumor neovascularization and T helper cell (Th) 1 immune response. The anti-inflammatory mechanisms were a reduction in proinflammatory cytokines, oxidative stress and changed gut microbiota, and the antiallergic mechanism was amelioration of a skewed Th1/Th2 balance. Since a predominant Th2 milieu is also found in cancer, which quite often is caused by a local chronic inflammation, the three conditions—tumor, inflammation and allergy—seem to be linked. Further mechanisms for HE were increased nerve and beneficial gut microbiota growth, and oxidative stress regulation. The medicinal mushrooms AbM, HE and GF appear to be safe, and can, in fact, increase longevity in animal models, possibly due to reduced tumorigenesis and oxidation. This article reviews preclinical and clinical findings with these mushrooms and the mechanisms behind them.
    Keywords Agaricus subrufescens ; CD4-positive T-lymphocytes ; Erinaceus ; Grifola frondosa ; Hericium ; angiogenesis ; animal models ; anti-allergic agents ; antineoplastic activity ; apoptosis ; carcinogenesis ; clinical trials ; cytokines ; immune response ; inflammation ; intestinal microorganisms ; longevity ; medicinal fungi ; metastasis ; mushrooms ; neoplasms ; nerve tissue ; nutrients ; oxidation ; oxidative stress ; traditional medicine
    Language English
    Dates of publication 2020-0508
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12051339
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study.

    Therkelsen, Stig Palm / Hetland, Geir / Lyberg, Torstein / Lygren, Idar / Johnson, Egil

    PloS one

    2016  Volume 11, Issue 3, Page(s) e0150191

    Abstract: Background: Ingestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because of reduction of pro-inflammatory cytokines in healthy individuals and patients with ulcerative ... ...

    Abstract Background: Ingestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because of reduction of pro-inflammatory cytokines in healthy individuals and patients with ulcerative colitis. In this randomized single-blinded placebo controlled study we examined whether intake of AndoSan™ also resulted in clinical effects.
    Methods and findings: 50 patients with symptomatic ulcerative colitis were block-randomized and blinded for oral daily intake of AndoSan™ or placebo for the 21 days' experimental period. The patients reported scores for symptoms, fatigue and health related quality of life (HRQoL) at days 0, 14 and 21. Fecal calprotectin and general blood parameters were also analyzed. In the AndoSan™ group (n = 24) symptoms improved from baseline (day 0) to days 14 and 21, with respective mean scores (95% CI) of 5.88 (4.92-6.83), 4.71 (3.90-5.52) (p = 0.002) and 4.50 (3.70-5.30) (p = 0.001). Corresponding improved mean scores (±SD) for total fatigue were 16.6 (5.59), 14.1 (4.50) (p = 0.001) and 15.1 (4.09) (p = 0.023). These scores in the placebo group (n = 26) were not improved. When comparing the two study groups using mixed model statistics, we found significant better scores for the AndoSan™-patients. HRQoL for dimensions bodily pain, vitality, social functioning and mental health improved in the AndoSan™ group. There were no alterations in general blood samples and fecal calprotectin.
    Conclusions: Beneficiary effects on symptoms, fatigue and HRQoL from AndoSan™ consumption were demonstrated in this per-protocol study, supporting its use as a supplement to conventional medication for patients with mild to moderate symptoms from ulcerative colitis. The patients did not report any harms or unintended effects of AndoSan™ in this study.
    Trial registration: ClinicalTrials.gov NCT01496053.
    MeSH term(s) Adult ; Agaricus/chemistry ; Aged ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Complex Mixtures/chemistry ; Complex Mixtures/therapeutic use ; Fatigue/blood ; Fatigue/complications ; Fatigue/drug therapy ; Feces/chemistry ; Female ; Humans ; Leukocyte L1 Antigen Complex/analysis ; Male ; Middle Aged ; Placebo Effect ; Quality of Life ; Single-Blind Method ; Young Adult
    Chemical Substances AndoSan ; Anti-Inflammatory Agents ; Complex Mixtures ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0150191
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study.

    Therkelsen, Stig Palm / Hetland, Geir / Lyberg, Torstein / Lygren, Idar / Johnson, Egil

    PloS one

    2016  Volume 11, Issue 7, Page(s) e0159288

    Abstract: Background: Ingestion of AndoSanTM, based on the mushroom Agaricus blazei Murill, has previously shown an anti-inflammatory effect through reduction of pro-inflammatory cytokines in healthy individuals and patients with Crohn's disease (CD). In this ... ...

    Abstract Background: Ingestion of AndoSanTM, based on the mushroom Agaricus blazei Murill, has previously shown an anti-inflammatory effect through reduction of pro-inflammatory cytokines in healthy individuals and patients with Crohn's disease (CD). In this randomized single-blinded placebo-controlled study we examined whether intake of AndoSanTM also resulted in clinical effects.
    Methods and findings: 50 patients with symptomatic CD were randomized for oral daily consumption of AndoSanTM or placebo for a 21-day experimental period, in this per-protocol study. Patients reported validated scores for symptoms, fatigue and health related quality of life (HRQoL) at days 0, 14 and 21. Fecal calprotectin and general blood parameters were also analyzed. In the AndoSanTM group (n = 25) symptoms improved from baseline (day 0) to days 14 and 21, with respective mean scores (95% CI) of 5.52 (4.64-6.40), 4.48 (3.69-5.27) and 4.08 (3.22-4.94) (p<0,001). We found significant improvements in symptom score for both genders in the AndoSanTM group, and no significant changes in the placebo (n = 25) group. There were however no significant differences between the groups (p = 0.106), although a marginal effect in symptom score for men (p = 0.054). There were comparable improvements in physical, mental and total fatigue for both groups. HRQoL versus baseline were at day 21 improved for bodily pain and vitality in the AndoSanTM group and for vitality and social functioning in the placebo group. No crucial changes in general blood samples and fecal calprotectin were detected.
    Conclusions: The results from this single-blinded randomized clinical trial shows significant improvement on symptoms, for both genders, in the AndoSanTM group, but no significant differences between the study groups. The results on fatigue, HRQoL, fecal calprotectin and blood samples were quite similar compared with placebo. The patients did not report any harms or unintended effects of AndoSanTM. CD patients with mild to moderate symptoms may have beneficiary effects of AndoSanTM as a safe supplement in addition to conventional medication.
    Trial registration: ClinicalTrials.gov NCT01496053.
    MeSH term(s) Adult ; Agaricus/chemistry ; Aged ; Complex Mixtures/therapeutic use ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Fatigue/drug therapy ; Fatigue/etiology ; Female ; Humans ; Male ; Middle Aged ; Quality of Life ; Single-Blind Method ; Treatment Outcome ; Young Adult
    Chemical Substances AndoSan ; Complex Mixtures
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0159288
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Antitumor, Anti-Inflammatory and Antiallergic Effects of

    Hetland, Geir / Tangen, Jon-Magnus / Mahmood, Faiza / Mirlashari, Mohammad Reza / Nissen-Meyer, Lise Sofie Haug / Nentwich, Ivo / Therkelsen, Stig Palm / Tjønnfjord, Geir Erland / Johnson, Egil

    Nutrients

    2020  Volume 12, Issue 5

    Abstract: Since the 1980s, medicinal effects have been documented in scientific studies with the ... ...

    Abstract Since the 1980s, medicinal effects have been documented in scientific studies with the related
    MeSH term(s) Agaricus/chemistry ; Animals ; Anti-Allergic Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Basidiomycota/chemistry ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cytokines/metabolism ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Grifola/chemistry ; Hericium/chemistry ; Humans ; Inflammation Mediators/metabolism ; Mice ; Neoplasms/blood supply ; Neoplasms/drug therapy ; Neovascularization, Pathologic ; Oxidative Stress/drug effects ; Rats ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Anti-Allergic Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Biological Products ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12051339
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Uventede og uoppklarte dødsfall blant yngre personer med diabetes mellitus.

    Ramsli, Håvard M / Therkelsen, Stig Palm / Søvik, Oddmund / Thordarson, Hrafnkell

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2004  Volume 124, Issue 23, Page(s) 3064–3065

    Abstract: Background: We studied the occurrence of unexpected and unexplained deaths in 0-39 year-old subjects with diabetes.: Material and methods: Statistics Norway provided information about persons who had died in the 1991-1995 period with a diagnosis of ... ...

    Title translation Unexpected and unexplained deaths among young patients with diabetes mellitus.
    Abstract Background: We studied the occurrence of unexpected and unexplained deaths in 0-39 year-old subjects with diabetes.
    Material and methods: Statistics Norway provided information about persons who had died in the 1991-1995 period with a diagnosis of diabetes on their death certificate. Relevant information was obtained from autopsy reports and patients' physicians.
    Results: 117 deaths from all causes were ascertained. Four patients (3.4%) fulfilled the criteria of "dead in bed" syndrome; three males and one female, age range 21-36 years, duration of diabetes 5-23 years. Severe episodes of hypoglycaemia were reported in three cases. Autopsy, performed in three cases, was negative.
    Interpretation: Dead in bed syndrome in young persons with diabetes is a rare, but dramatic condition. The relationship to nocturnal hypoglycaemia remains hypothetical.
    MeSH term(s) Adolescent ; Adult ; Cause of Death ; Child ; Death, Sudden/epidemiology ; Death, Sudden/etiology ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/mortality ; Female ; Humans ; Male ; Norway/epidemiology ; Registries
    Language Norwegian
    Publishing date 2004-12-02
    Publishing country Norway
    Document type English Abstract ; Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 546: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top