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  1. Book ; Thesis: Beeinflussung der Expression der Tumormarker CA 125, CA 15-3 und CEA durch Applikation von Interferon a [Alpha] bei Patientinnen mit malignen und benignen Erkrankungen des Ovars

    Thiel, Gundula

    1999  

    Author's details vorgelegt von Gundula Thiel
    Language German
    Size 62 Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 1999
    HBZ-ID HT013156909
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 MB 2585 order for loan Magazin

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  2. Book ; Thesis: Genetische Grundlagen der Gliomentwicklung

    Thiel, Gundula

    zytogenetische Befunde und somatische Mutationen im Neurofibromatose-Typ-1-Gen

    1994  

    Author's details von Gundula Thiel
    Language German
    Size 106 Bl. : Ill.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Habil.-Schr., 1994
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT006655758
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 MB 1174 order for loan Magazin

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  3. Article ; Online: Potential life-threatening complication of tonsillectomy: cervicofacial surgical emphysema.

    Shoemaker, Kirsten / Thompson, Christopher Sg / Sawant, Rupali / Thiel, Gundula

    BMJ case reports

    2019  Volume 12, Issue 1

    Abstract: A 30-year-old woman presented to the accident and emergency department 3 days post-tonsillectomy with bleeding from the tonsillar fossa and left-sided facial swelling. The patient denied any dysphagia or breathing difficulties but experienced pain on ... ...

    Abstract A 30-year-old woman presented to the accident and emergency department 3 days post-tonsillectomy with bleeding from the tonsillar fossa and left-sided facial swelling. The patient denied any dysphagia or breathing difficulties but experienced pain on neck movement. On examination, although the bleeding had stopped on reaching the emergency department, a small clot was noted in her left tonsillar fossa. A left facial/submandibular swelling was seen, which had been present since her operation and was slowly enlarging. Flexible nasendoscopy showed a mild left sided oropharyngeal swelling but was otherwise normal. She was treated initially with antibiotics and hydrogen peroxide gargles. After 24 hours of observation and a slight worsening of the swelling she underwent a CT of the neck. This showed widespread indurated subcutaneous surgical emphysema, originating from the left tonsillar bed. Following a period of observation and improvement in her symptoms, she was discharged home with safety netting.
    MeSH term(s) Adult ; Conservative Treatment ; Female ; Humans ; Oropharynx/diagnostic imaging ; Subcutaneous Emphysema/diagnostic imaging ; Tomography, X-Ray Computed ; Tonsillectomy/adverse effects
    Language English
    Publishing date 2019-01-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-228377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: How to fashion earplugs using cotton wool and petroleum jelly.

    Thiel, Gundula

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2005  Volume 30, Issue 4, Page(s) 378

    MeSH term(s) Cotton Fiber ; Ear Protective Devices ; Humans ; Petrolatum
    Chemical Substances Petrolatum (8009-03-8)
    Language English
    Publishing date 2005-08
    Publishing country England
    Document type Letter
    ZDB-ID 2205891-6
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/j.1365-2273.2005.01028.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1309: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The behavior of mastoidectomy cavities following modified radical mastoidectomy.

    Thiel, Gundula / Rutka, John A / Pothier, David D

    The Laryngoscope

    2014  Volume 124, Issue 10, Page(s) 2380–2385

    Abstract: Objectives/hypothesis: An analysis of the frequency and intensity of postoperative aftercare required for modified radical mastoidectomy (MRM) and patterns of healing in the postoperative period.: Study design: A retrospective review of all primary ... ...

    Abstract Objectives/hypothesis: An analysis of the frequency and intensity of postoperative aftercare required for modified radical mastoidectomy (MRM) and patterns of healing in the postoperative period.
    Study design: A retrospective review of all primary modified radical mastoidectomies carried out for cholesteatoma under the care of the senior author between the years of 2004 and 2009 with minimum follow-up of 2 years.
    Methods: The time and number of interventions required to achieve a stable and dry mastoid cavity were collected. Cross-sectional and longitudinal analysis of the behavior of the cavities was carried out.
    Results: Overall, 73 cases (71 patients) were identified. Patients were followed up for a median of 45.7 months (interquartile range, 31.8-70.5). After initial debridement, most cavities settled rapidly, but this was not always predictable, with a large proportion requiring further clinical intervention after the cavity was stable, sometimes for prolonged periods of time. At the time of analysis, 73% had achieved a stable cavity, 17 (23%) still required attention (nine for wax removal and eight for debridement); two were lost to follow-up. No revision surgeries were required. At 6 months, 36% of cavities were settled, 42% at 1 year, 53% at 18 months, and 62% at 2 years. After two standard postoperative visits, a total of 632 visits were made by these patients.
    Conclusions: Following MRM, the majority of patients achieve a dry, self-cleaning mastoid cavity. This might require periods of intense care interspersed with periods of quiescence. These results allow the benefits of this procedure to be put in the context of the entire patient journey.
    MeSH term(s) Adult ; Cholesteatoma, Middle Ear/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Mastoid/surgery ; Middle Aged ; Otologic Surgical Procedures/methods ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.24610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul II Zs.82: Show issues Location:
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  6. Article ; Online: Results of myringoplasty operations in active and inactive ears in adults.

    Mills, Robert / Thiel, Gundula / Mills, Nadtaya

    The Laryngoscope

    2013  Volume 123, Issue 9, Page(s) 2245–2249

    Abstract: Objectives/hypothesis: To determine whether the presence of aural discharge at the time of surgery adversely affects the success rate of myringoplasty operations.: Study design: Case series comparing the success rate of surgery in active and inactive ...

    Abstract Objectives/hypothesis: To determine whether the presence of aural discharge at the time of surgery adversely affects the success rate of myringoplasty operations.
    Study design: Case series comparing the success rate of surgery in active and inactive ears.
    Methods: Data pertaining to 268 operations involving repair of the tympanic membrane without ossiculoplasty carried out in Edinburgh, United Kingdom, between 1999 and 2009 by one senior surgeon and trainees working under his supervision were collected prospectively. Other factors that might potentially influence the outcome of the surgery were investigated using logistical regression analysis. The main outcome measure was number of patients with an intact tympanic membrane 6 months after surgery in the two groups (active and inactive).
    Results: Of the 268 operations carried out, 203 were successful, with an intact tympanic membrane, 6 months postoperatively, 43 had persistent perforations, and 22 patients were lost to follow-up before 6 months. The success rates for closure of the perforation at 6 months after surgery were 83% for inactive and 82% for active ears (P = .9).
    Conclusions: There is no clinically significant difference in the success rate for myringoplasty in patients whose ears are active or inactive at the time of surgery.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Cohort Studies ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myringoplasty/adverse effects ; Myringoplasty/methods ; Otoscopy/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/physiopathology ; Recurrence ; Regression Analysis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Time Factors ; Tomography, X-Ray Computed/methods ; Treatment Outcome ; Tympanic Membrane Perforation/diagnosis ; Tympanic Membrane Perforation/surgery ; United Kingdom ; Young Adult
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.23772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul II Zs.82: Show issues Location:
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  7. Article ; Online: Further evidence for complex inheritance of holoprosencephaly: Lessons learned from pre- and postnatal diagnostic testing in Germany.

    Hinreiner, Sophie / Wieczorek, Dagmar / Mueller, Dietmar / Roedl, Tanja / Thiel, Gundula / Grasshoff, Ute / Chaoui, Rabih / Hehr, Ute

    American journal of medical genetics. Part C, Seminars in medical genetics

    2018  Volume 178, Issue 2, Page(s) 198–205

    Abstract: Holoprosencephaly (HPE) has been defined as a distinct clinical entity with characteristic facial gestalt, which may-or may not-be associated with the true brain malformation observed postmortem in autopsy or in pre- or postnatal imaging. Affected ... ...

    Abstract Holoprosencephaly (HPE) has been defined as a distinct clinical entity with characteristic facial gestalt, which may-or may not-be associated with the true brain malformation observed postmortem in autopsy or in pre- or postnatal imaging. Affected families mainly show autosomal dominant inheritance with markedly reduced penetrance and extremely broad clinical variability even between mutation carriers within the same families. We here present advances in prenatal imaging over the last years, increasing the proportion of individuals with HPE identified prenatally including milder HPE forms and more frequently allowing to detect more severe forms already in early gestation. We report the results of diagnostic genetic testing of 344 unrelated patients for HPE at our lab in Germany since the year 2000, which currently with the application of next generation sequencing (NGS) panel sequencing identifies causal mutations for about 31% (12/38) of unrelated individuals with normal chromosomes when compared to about 15% (46/306) using conventional Sanger sequencing and Multiplex Ligation-dependent Probe Amplification (MLPA). More comprehensive genetic testing by our in house NGS panel sequencing of 10 HPE associated genes (MiSeq™ and NextSeq™500, Illumina, Inc., San Diego, CA) not only allowed to include genes with smaller contribution to the phenotype, but may also unravel additional low frequency or more common genetic variants potentially contributing to the observed large intrafamiliar variability and may ultimately guide our understanding of the individual clinical manifestation of this complex developmental disorder.
    MeSH term(s) Brain/abnormalities ; Brain/diagnostic imaging ; Brain/embryology ; Branchial Region/abnormalities ; Branchial Region/diagnostic imaging ; Chromosome Deletion ; Chromosomes, Human, Pair 1/genetics ; Eye Proteins/genetics ; Facies ; Female ; Genetic Testing/methods ; Germany ; Hedgehog Proteins/genetics ; High-Throughput Nucleotide Sequencing/methods ; Holoprosencephaly/diagnosis ; Holoprosencephaly/diagnostic imaging ; Holoprosencephaly/genetics ; Homeodomain Proteins/genetics ; Humans ; Male ; Microphthalmos/diagnosis ; Microphthalmos/diagnostic imaging ; Microphthalmos/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Pedigree ; Pregnancy ; Prenatal Diagnosis ; Transcription Factors/genetics ; Homeobox Protein SIX3
    Chemical Substances Eye Proteins ; Hedgehog Proteins ; Homeodomain Proteins ; Nerve Tissue Proteins ; Nuclear Proteins ; SHH protein, human ; Transcription Factors ; ZIC2 protein, human
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108622-9
    ISSN 1552-4876 ; 0148-7299 ; 1552-4868
    ISSN (online) 1552-4876
    ISSN 0148-7299 ; 1552-4868
    DOI 10.1002/ajmg.c.31625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1376/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The management of laryngeal clefts.

    Thiel, Gundula / Clement, W Andrew / Kubba, Haytham

    International journal of pediatric otorhinolaryngology

    2011  Volume 75, Issue 12, Page(s) 1525–1528

    Abstract: Objective: To review the clinical presentation and management of all infants and children presenting with laryngeal clefts to a tertiary pediatric ENT centre and to identify changes in practice over time.: Patients and methods: A retrospective case ... ...

    Abstract Objective: To review the clinical presentation and management of all infants and children presenting with laryngeal clefts to a tertiary pediatric ENT centre and to identify changes in practice over time.
    Patients and methods: A retrospective case note review of the management of all infants and children with a diagnosis of a laryngeal cleft identified in our Department between 01/11/2003 and 31/12/2010.
    Results: Twelve children with laryngeal clefts were identified. Six clefts were grade 1, five grade 2 and one grade 3b. All grade 1 clefts were managed conservatively. Of the grade 2 clefts, four required surgery with one being managed conservatively. Two were repaired using an open technique and two using an endoscopic technique. The grade 3b cleft was repaired endoscopically. Two cleft repairs broke down post-operatively requiring further surgery.
    Conclusions: Conservative management remains the management of choice for lower grade clefts. Where a laryngeal cleft requires repair there has been a trend towards the endoscopic over open technique, even of more extensive clefts.
    MeSH term(s) Child ; Child, Preschool ; Congenital Abnormalities/surgery ; Congenital Abnormalities/therapy ; Female ; Humans ; Infant ; Infant, Newborn ; Laryngoscopy ; Larynx/abnormalities ; Larynx/surgery ; Male ; Reoperation ; Retrospective Studies
    Language English
    Publishing date 2011-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2011.08.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1507: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 134: Show issues

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  9. Book ; Thesis: Beeinflussung der Expression der Tumormarker CA 125, CA 15-3 und CEA durch Applikation von Interferon a [Alpha] bei Patientinnen mit malignen und benignen Erkrankungen des Ovars

    Thiel, Gundula

    1999  

    Author's details vorgelegt von Gundula Thiel
    Language German
    Size 1 Mikrofiche, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nürnberg, Univ., Diss--Erlangen, 1999
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  10. Book ; Thesis: Genetische Grundlagen der Gliomentwicklung, zytogenetische Befunde und somatische Mutationen im Neurofibromatose-Typ-1-Gen

    Thiel, Gundula

    1994  

    Author's details vorgelegt von Gundula Thiel
    Language German
    Size 106 Bl, Ill, 30 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Habil.-Schr.--Berlin, 1994
    Database Former special subject collection: coastal and deep sea fishing

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