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  1. Book ; Thesis: Exfoliativzytologie von Schleimhautläsionen des Kopf-Hals-Bereiches

    Thiele, Alexander

    Evaluation ihrer Bedeutung in der mikroinvasiven Diagnostik

    2007  

    Author's details eingereicht von: Alexander Thiele
    Language German
    Size 88 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 2007
    HBZ-ID HT015331773
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 D 1294 order for loan Magazin

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  2. Article ; Online: Stimulus dependence of directed information exchange between cortical layers in macaque V1.

    Gieselmann, Marc Alwin / Thiele, Alexander

    eLife

    2022  Volume 11

    Abstract: Perception and cognition require the integration of feedforward sensory information with feedback signals. Using different sized stimuli, we isolate spectral signatures of feedforward and feedback signals, and their effect on communication between layers ...

    Abstract Perception and cognition require the integration of feedforward sensory information with feedback signals. Using different sized stimuli, we isolate spectral signatures of feedforward and feedback signals, and their effect on communication between layers in primary visual cortex of male macaque monkeys. Small stimuli elicited gamma frequency oscillations predominantly in the superficial layers. These Granger-causally originated in upper layer 4 and lower supragranular layers. Unexpectedly, large stimuli generated strong narrow band gamma oscillatory activity across cortical layers. They Granger-causally arose in layer 5, were conveyed through layer six to superficial layers, and violated existing models of feedback spectral signatures. Equally surprising, with large stimuli, alpha band oscillatory activity arose predominantly in granular and supragranular layers and communicated in a feedforward direction. Thus, oscillations in specific frequency bands are dynamically modulated to serve feedback and feedforward communication and are not restricted to specific cortical layers in V1.
    MeSH term(s) Animals ; Macaca ; Male ; Photic Stimulation ; Visual Cortex
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.62949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1.

    Herrero, Jose L / Thiele, Alexander

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 8384

    Abstract: Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons ...

    Abstract Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in conjunction with feedback from higher visual areas. The strength of lateral interactions is affected by cholinergic neuromodulation. Blockade of muscarinic receptors should increase the strength of lateral intracortical interactions, while nicotinic blockade should reduce thalamocortical feed-forward drive. Here we test this proposal through local iontophoretic application of the muscarinic receptor antagonist scopolamine and the nicotinic receptor antagonist mecamylamine, while recording single cells in parafoveal representations in awake fixating macaque V1. Collinear flankers generally reduced neuronal contrast sensitivity. Muscarinic and nicotinic receptor blockade equally reduced neuronal contrast sensitivity. Contrary to our hypothesis, flanker interactions were not systematically affected by either receptor blockade.
    MeSH term(s) Animals ; Contrast Sensitivity/drug effects ; Contrast Sensitivity/physiology ; Macaca mulatta ; Male ; Muscarinic Antagonists/pharmacology ; Neurons/drug effects ; Neurons/physiology ; Nicotinic Antagonists/pharmacology ; Photic Stimulation ; Receptors, Muscarinic/chemistry ; Receptors, Muscarinic/metabolism ; Receptors, Nicotinic/chemistry ; Receptors, Nicotinic/metabolism ; Visual Cortex/drug effects ; Visual Cortex/physiology
    Chemical Substances Muscarinic Antagonists ; Nicotinic Antagonists ; Receptors, Muscarinic ; Receptors, Nicotinic
    Language English
    Publishing date 2021-04-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-88044-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Distinct feedforward and feedback pathways for cell-type specific attention effects.

    Spyropoulos, Georgios / Schneider, Marius / van Kempen, Jochem / Gieselmann, Marc Alwin / Thiele, Alexander / Vinck, Martin

    Neuron

    2024  

    Abstract: Selective attention is thought to depend on enhanced firing activity in extrastriate areas. Theories suggest that this enhancement depends on selective inter-areal communication via gamma (30-80 Hz) phase-locking. To test this, we simultaneously recorded ...

    Abstract Selective attention is thought to depend on enhanced firing activity in extrastriate areas. Theories suggest that this enhancement depends on selective inter-areal communication via gamma (30-80 Hz) phase-locking. To test this, we simultaneously recorded from different cell types and cortical layers of macaque V1 and V4. We find that while V1-V4 gamma phase-locking between local field potentials increases with attention, the V1 gamma rhythm does not engage V4 excitatory-neurons, but only fast-spiking interneurons in L4 of V4. By contrast, attention enhances V4 spike-rates in both excitatory and inhibitory cells, most strongly in L2/3. The rate increase in L2/3 of V4 precedes V1 in time. These findings suggest enhanced signal transmission with attention does not depend on inter-areal gamma phase-locking and show that the endogenous gamma rhythm has cell-type- and layer-specific effects on downstream target areas. Similar findings were made in the mouse visual system, based on opto-tagging of identified interneurons.
    Language English
    Publishing date 2024-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  5. Article ; Online: Muscarinic signaling in the brain.

    Thiele, Alexander

    Annual review of neuroscience

    2013  Volume 36, Page(s) 271–294

    Abstract: Muscarinic signaling affects attention, action selection, learning, and memory through multiple signaling cascades, which act at different timescales and which alter ion channels in cell type-specific manners. The effects of muscarinic signaling differ ... ...

    Abstract Muscarinic signaling affects attention, action selection, learning, and memory through multiple signaling cascades, which act at different timescales and which alter ion channels in cell type-specific manners. The effects of muscarinic signaling differ between cortical layers and between brain areas. Muscarinic signaling adds flexibility to the processing mode of neuronal networks, thereby supporting processing according to task demands. This review outlines possible scenarios to describe how it contributes to cellular mechanisms of attention and how it affects channeling of information in different neuronal circuits.
    MeSH term(s) Animals ; Brain/physiology ; Cholinergic Agents/metabolism ; Humans ; Neurons/metabolism ; Signal Transduction/physiology
    Chemical Substances Cholinergic Agents
    Language English
    Publishing date 2013-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-062012-170433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ripples in macaque V1 and V4 are modulated by top-down visual attention.

    Doostmohammadi, Jafar / Gieselmann, Marc Alwin / van Kempen, Jochem / Lashgari, Reza / Yoonessi, Ali / Thiele, Alexander

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 5, Page(s) e2210698120

    Abstract: Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to ... ...

    Abstract Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to memory consolidation, spatial navigation, and spatial decision-making. Recently, SWRs have been reported during visual search, a form of remote spatial exploration, in macaque hippocampus. However, the association between SWRs and multiple forms of awake conscious and goal-directed behavior is unknown. We report that ripple activity occurs in macaque visual areas V1 and V4 during focused spatial attention. The occurrence of ripples is modulated by stimulus characteristics, increased by attention toward the receptive field, and by the size of the attentional focus. During attention cued to the receptive field, the monkey's reaction time in detecting behaviorally relevant events was reduced by ripples. These results show that ripple activity is not limited to hippocampal activity during offline states, rather they occur in the neocortex during active attentive states and vigilance behaviors.
    MeSH term(s) Animals ; Macaca ; Hippocampus/physiology ; Wakefulness/physiology ; Neocortex ; Sleep/physiology
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2210698120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex.

    Smart, Caitlin / Mitchell, Anna / McCutcheon, Fiona / Medcalf, Robert L / Thiele, Alexander

    iScience

    2023  Volume 26, Issue 2, Page(s) 105947

    Abstract: Tissue-type plasminogen activator (tPA) is a serine protease that is expressed in various compartments in the brain. It is involved in neuronal plasticity, learning and memory, and addiction. We evaluated whether tPA, exogenously applied, could influence ...

    Abstract Tissue-type plasminogen activator (tPA) is a serine protease that is expressed in various compartments in the brain. It is involved in neuronal plasticity, learning and memory, and addiction. We evaluated whether tPA, exogenously applied, could influence neuroplasticity within the mouse auditory cortex. We used a frequency-pairing paradigm to determine whether neuronal best frequencies shift following the pairing protocol. tPA administration significantly affected the best frequency after pairing, whereby this depended on the pairing frequency relative to the best frequency. When the pairing frequency was above the best frequency, tPA caused a best frequency shift away from the conditioned frequency. tPA significantly widened auditory tuning curves. Our data indicate that regional changes in proteolytic activity within the auditory cortex modulate the fine-tuning of auditory neurons, supporting the function of tPA as a modulator of neuronal plasticity.
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.105947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: NMDA receptors figure it out.

    Thiele, Alexander

    Proceedings of the National Academy of Sciences of the United States of America

    2012  Volume 109, Issue 27, Page(s) 10749–10750

    MeSH term(s) Animals ; Macaca mulatta/physiology ; Receptors, AMPA/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Thalamus/physiology ; Visual Cortex/physiology ; Visual Perception/physiology
    Chemical Substances Receptors, AMPA ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2012-06-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1207975109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Stay focussed - muffle that resonant bass!

    Thiele, Alexander

    Trends in cognitive sciences

    2012  Volume 16, Issue 4, Page(s) 194–195

    Abstract: Increased rhythmic brain activity in the high frequency range and decreased rhythmic activity in the low frequency range is a hallmark of cognitive function and ability. A novel study links these findings to the cholinergic theory of attention, ... ...

    Abstract Increased rhythmic brain activity in the high frequency range and decreased rhythmic activity in the low frequency range is a hallmark of cognitive function and ability. A novel study links these findings to the cholinergic theory of attention, demonstrating that attention-induced rebalancing of brain rhythms is augmented by acetylcholine.
    MeSH term(s) Acetylcholine/metabolism ; Animals ; Attention ; Brain/cytology ; Brain/physiology ; Brain Waves/physiology ; Humans ; Periodicity
    Chemical Substances Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2012.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Book: Europarecht

    Thiele, Alexander

    2015  

    Author's details Alexander Thiele
    Keywords Recht ; Europäische Union
    Language German
    Size 344 S., graph. Darst., 21 cm
    Edition 12. Aufl., völlige Neubearb., Rechtsstand: 15.02.2015
    Publisher Niederle Media
    Publishing place Altenberge
    Document type Book
    Note Literaturangaben
    ISBN 9783867240789 ; 3867240787
    Database Former special subject collection: coastal and deep sea fishing

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