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  1. Article ; Online: Therapeutic-dose heparin in preventing COVID-19-associated acute kidney injury: What about bleeding risk?

    Kow, Chia Siang / Thiruchelvam, Kaeshaelya

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 8, Page(s) 102246

    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.102246
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  2. Article ; Online: Anticoagulant Therapy in COVID-19 Associated Venous Thromboembolism: A Pivotal Risk Factor.

    Kow, Chia Siang / Thiruchelvam, Kaeshaelya

    Angiology

    2023  , Page(s) 33197231224484

    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Letter
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231224484
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  3. Article ; Online: Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    The International journal of pharmacy practice

    2024  

    Abstract: Objectives: To determine risks associated with uricosurics in COVID-19 patients.: Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases.: Key findings: The pooled analysis of the included ... ...

    Abstract Objectives: To determine risks associated with uricosurics in COVID-19 patients.
    Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases.
    Key findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65-0.94).
    Conclusions: The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1087040-4
    ISSN 2042-7174 ; 0961-7671
    ISSN (online) 2042-7174
    ISSN 0961-7671
    DOI 10.1093/ijpp/riae003
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    Zs.A 3320: Show issues Location:
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  4. Article ; Online: Comment on: "Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: the GeroCovid Study".

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    Drugs & aging

    2024  Volume 41, Issue 3, Page(s) 283–285

    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; Antibody Formation ; Polypharmacy ; Long-Term Care ; COVID-19/prevention & control ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-02-28
    Publishing country New Zealand
    Document type Letter ; Comment
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-024-01106-z
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    Zs.A 3481: Show issues Location:
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  5. Article ; Online: Navigating the Shadows: COVID-19's Lingering Threat - Pulmonary Fibrosis.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    The American journal of medicine

    2024  Volume 137, Issue 4, Page(s) e81

    MeSH term(s) Humans ; Pulmonary Fibrosis ; COVID-19
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.10.034
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    Ua VI Zs.289: Show issues Location:
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  6. Article ; Online: Insights into COVID-19 pneumonia among older adults: Understanding aspiration and risk factors for mortality.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    Journal of the American Geriatrics Society

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18927
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    Ud II Zs.168: Show issues Location:
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  7. Article ; Online: Unveiling the nexus: Understanding post-COVID parkinsonism and its neurological ramifications.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    Parkinsonism & related disorders

    2024  , Page(s) 106974

    Abstract: This article explores the potential link between COVID-19 and parkinsonism, synthesizing existing evidence and recent research findings. It highlights limitations in current understanding, emphasizes the direct impact of the virus on dopamine neurons, ... ...

    Abstract This article explores the potential link between COVID-19 and parkinsonism, synthesizing existing evidence and recent research findings. It highlights limitations in current understanding, emphasizes the direct impact of the virus on dopamine neurons, and calls for continued research to elucidate long-term neurological implications and optimize patient care strategies.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106974
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    Zs.A 4553: Show issues Location:
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    Zs.MO 420: Show issues

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  8. Article ; Online: Systematic review and meta-analysis of anti-CD20 treatments in patients with COVID-19: an assessment of severe illness and mortality outcomes.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    Inflammopharmacology

    2023  Volume 31, Issue 6, Page(s) 3339–3355

    Abstract: Background: The use of anti-CD20 monoclonal antibodies, such as rituximab and ocrelizumab, has emerged as a matter of concern, in patients with coronavirus disease 2019 (COVID-19).: Objective: We aimed to summarize the overall evidence on the pre- ... ...

    Abstract Background: The use of anti-CD20 monoclonal antibodies, such as rituximab and ocrelizumab, has emerged as a matter of concern, in patients with coronavirus disease 2019 (COVID-19).
    Objective: We aimed to summarize the overall evidence on the pre-admission/pre-diagnosis use of anti-CD20 among patients with COVID-19 with regards to mortality and severe illness outcomes.
    Methods: A systematic literature search with no language restriction was performed in electronic databases, including PubMed, Google Scholar, Scopus, and preprint servers (medRxiv, Research Square, SSRN), to identify eligible studies published up to June 13, 2023. The outcomes of interest were the development of severe illness and all-cause mortality. A random-effects model was used to estimate the pooled odds ratio for outcomes of interest using anti-CD20 monoclonal antibodies relative to non-use of anti-CD20 monoclonal antibodies, at 95% confidence intervals.
    Results: Our systematic review and meta-analysis revealed significantly increased odds for development of severe illness (pooled odds ratio 2.95; 95% confidence interval 2.30, 3.78; n = 534,349) and significantly increased odds for mortality (pooled odds ratio 2.14; 95% confidence interval 1.37, 3.35; n = 333,462) with the use of anti-CD20 monoclonal antibodies, relative to non-use of anti-CD20 monoclonal antibodies, in patients with COVID-19.
    Conclusion: Healthcare practitioners should exercise caution when prescribing these anti-CD20 monoclonal antibodies during the COVID-19 pandemic to patients who are indicated for these agents, particularly those with underlying conditions like multiple sclerosis or rheumatoid arthritis.
    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Antibodies, Monoclonal/adverse effects ; Antineoplastic Agents ; Multiple Sclerosis
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents
    Language English
    Publishing date 2023-10-07
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01349-z
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    Zs.A 3274: Show issues Location:
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  9. Article ; Online: COVID-19 Vaccination: Safeguarding Against Post-COVID Cardiovascular Complications.

    Kow, Chia Siang / Ramachandram, Dinesh Sangarran / Hasan, Syed Shahzad / Thiruchelvam, Kaeshaelya

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  

    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad732
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  10. Article ; Online: Pharmacotherapeutic considerations for the management of cardiovascular diseases among hospitalized COVID-19 patients.

    Kow, Chia Siang / Thiruchelvam, Kaeshaelya / Hasan, Syed Shahzad

    Expert review of cardiovascular therapy

    2020  Volume 18, Issue 8, Page(s) 475–485

    Abstract: Introduction: Cardiovascular diseases (CVDs) are among the most frequently identified comorbidities in hospitalized patients with COVID-19. Patients with CV comorbidities are typically prescribed with long-term medications. We reviewed the management of ...

    Abstract Introduction: Cardiovascular diseases (CVDs) are among the most frequently identified comorbidities in hospitalized patients with COVID-19. Patients with CV comorbidities are typically prescribed with long-term medications. We reviewed the management of co-medications prescribed for CVDs among hospitalized COVID-19 patients.
    Areas covered: There is no specific contraindication or caution related to COVID-19 on the use of antihypertensives unless patients develop severe hypotension from septic shock where all antihypertensives should be discontinued or severe hyperkalemia in which continuation of renin-angiotensin system inhibitors is not desired. The continuation of antiplatelet or statin is not desired when severe thrombocytopenia or severe transminitis develop, respectively. Patients with atrial fibrillation receiving oral anticoagulants, particularly those who are critically ill, should be considered for substitution to parenteral anticoagulants.
    Expert opinion: An individualized approach to medication management among hospitalized COVID-19 patients with concurrent CVDs would seem prudent with attention paid to changes in clinical conditions and medications intended for COVID-19. The decision to modify prescribed long-term CV medications should be entailed by close follow-up to check if a revision on the decision is needed, with resumption of any long-term CV medication before discharge if it is discontinued during hospitalization for COVID-19, to ensure continuity of care.
    MeSH term(s) Anticoagulants/therapeutic use ; Antihypertensive Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/virology ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Hospitalization ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Chemical Substances Anticoagulants ; Antihypertensive Agents
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2020.1797492
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