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  1. Article ; Online: SRSF1, a splicing-factor oncoprotein: Prospective biomarker and therapeutic target for oral cancer.

    Thiruvengadam, Rekha / Thiruvengadam, Muthu

    Journal of stomatology, oral and maxillofacial surgery

    2024  Volume 125, Issue 6, Page(s) 101800

    Language English
    Publishing date 2024-02-16
    Publishing country France
    Document type Editorial
    ZDB-ID 2916276-2
    ISSN 2468-7855 ; 2468-8509
    ISSN (online) 2468-7855
    ISSN 2468-8509
    DOI 10.1016/j.jormas.2024.101800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic strategy for oncovirus-mediated oral cancer: A comprehensive review.

    Thiruvengadam, Rekha / Kim, Jin Hee

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 165, Page(s) 115035

    Abstract: Oral cancer is a neoplastic disorder of the oral cavities, including the lips, tongue, buccal mucosa, and lower and upper gums. Oral cancer assessment entails a multistep process that requires deep knowledge of the molecular networks involved in its ... ...

    Abstract Oral cancer is a neoplastic disorder of the oral cavities, including the lips, tongue, buccal mucosa, and lower and upper gums. Oral cancer assessment entails a multistep process that requires deep knowledge of the molecular networks involved in its progression and development. Preventive measures including public awareness of risk factors and improving public behaviors are necessary, and screening techniques should be encouraged to enable early detection of malignant lesions. Herpes simplex virus (HSV), human papillomavirus (HPV), Epstein-Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (KSHV) are associated with other premalignant and carcinogenic conditions leading to oral cancer. Oncogenic viruses induce chromosomal rearrangements; activate signal transduction pathways via growth factor receptors, cytoplasmic protein kinases, and DNA binding transcription factors; modulate cell cycle proteins, and inhibit apoptotic pathways. In this review, we present an up-to-date overview on the use of nanomaterials for regulating viral proteins and oral cancer as well as the role of phytocompounds on oral cancer. The targets linking oncoviral proteins and oral carcinogenesis were also discussed.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections/complications ; Herpesvirus 4, Human/physiology ; Retroviridae ; Mouth Neoplasms/therapy ; Risk Factors
    Language English
    Publishing date 2023-06-24
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Boosting plant resilience: The promise of rare earth nanomaterials in growth, physiology, and stress mitigation.

    Thiruvengadam, Rekha / Easwaran, Maheswaran / Rethinam, Senthil / Madasamy, Sivagnanavelmurugan / Siddiqui, Shahida Anusha / Kandhaswamy, Anandhi / Venkidasamy, Baskar

    Plant physiology and biochemistry : PPB

    2024  Volume 208, Page(s) 108519

    Abstract: Rare earth elements (REE) have been extensively used in a variety of applications such as cell phones, electric vehicles, and lasers. REEs are also used as nanomaterials (NMs), which have distinctive features that make them suitable candidates for ... ...

    Abstract Rare earth elements (REE) have been extensively used in a variety of applications such as cell phones, electric vehicles, and lasers. REEs are also used as nanomaterials (NMs), which have distinctive features that make them suitable candidates for biomedical applications. In this review, we have highlighted the role of rare earth element nanomaterials (REE-NMs) in the growth of plants and physiology, including seed sprouting rate, shoot biomass, root biomass, and photosynthetic parameters. In addition, we discuss the role of REE-NMs in the biochemical and molecular responses of plants. Crucially, REE-NMs influence the primary metabolites of plants, namely sugars, amino acids, lipids, vitamins, enzymes, polyols, sorbitol, and mannitol, and secondary metabolites, like terpenoids, alkaloids, phenolics, and sulfur-containing compounds. Despite their protective effects, elevated concentrations of NMs are reported to induce toxicity and affect plant growth when compared with lower concentrations, and they not only induce toxicity in plants but also affect soil microbes, aquatic organisms, and humans via the food chain. Overall, we are still at an early stage of understanding the role of REE in plant physiology and growth, and it is essential to examine the interaction of nanoparticles with plant metabolites and their impact on the expression of plant genes and signaling networks.
    MeSH term(s) Humans ; Resilience, Psychological ; Metals, Rare Earth/analysis ; Metals, Rare Earth/chemistry ; Metals, Rare Earth/metabolism ; Plants/metabolism ; Plant Development ; Soil/chemistry ; Nanostructures
    Chemical Substances Metals, Rare Earth ; Soil
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2024.108519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseases.

    Thiruvengadam, Rekha / Venkidasamy, Baskar / Samynathan, Ramkumar / Govindasamy, Rajakumar / Thiruvengadam, Muthu / Kim, Jin Hee

    Chemico-biological interactions

    2023  Volume 380, Page(s) 110535

    Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the cellular antioxidant defense system at the posttranscriptional level. During oxidative stress, Nrf2 is released from its negative regulator Kelch-like ECH- ... ...

    Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the cellular antioxidant defense system at the posttranscriptional level. During oxidative stress, Nrf2 is released from its negative regulator Kelch-like ECH-associated protein 1 (Keap1) and binds to antioxidant response element (ARE) to transcribe antioxidative metabolizing/detoxifying genes. Various transcription factors like aryl hydrocarbon receptor (AhR) and nuclear factor kappa light chain enhancer of activated B cells (NF-kB) and epigenetic modification including DNA methylation and histone methylation might also regulate the expression of Nrf2. Despite its protective role, Keap1/Nrf2/ARE signaling is considered as a pharmacological target due to its involvement in various pathophysiological conditions such as diabetes, cardiovascular diseases, cancers, neurodegenerative diseases, hepatotoxicity and kidney disorders. Recently, nanomaterials have received a lot of attention due to their unique physiochemical properties and are also used in various biological applications, for example, biosensors, drug delivery systems, cancer therapy, etc. In this review, we will be discussing the functions of nanoparticles and Nrf2 as a combined therapy or sensitizing agent and their significance in various diseases such as diabetes, cancers and oxidative stress-mediated diseases.
    MeSH term(s) Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Antioxidants/metabolism ; Neoplasms/drug therapy ; Nanoparticles
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Antioxidants
    Language English
    Publishing date 2023-05-13
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2023.110535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Optimization of photosynthetically active radiation, temperature, and urea deprivation for increasing neutral lipids and fatty acids in Scenedesmus obliquus and Chlorella vulgaris as biodiesels

    Govindarajan, Rasiravathanahalli Kaveriyappan / Thiruvengadam, Rekha / Alanazi, Amer M. / Pandiaraj, Saravanan / Mathivanan, Krishnamurthy / Thiruvengadam, Muthu / Kim, Jin Hee

    Biomass and Bioenergy. 2023 July, v. 174 p.106854-

    2023  

    Abstract: The present study investigated the impact of photosynthetically active radiation (PAR), culture temperature, and urea addition on the biomass, total lipid, lipidomic profile, and fatty acid productivity in Scenedesmus obliquus (S. obliquus) and Chlorella ...

    Abstract The present study investigated the impact of photosynthetically active radiation (PAR), culture temperature, and urea addition on the biomass, total lipid, lipidomic profile, and fatty acid productivity in Scenedesmus obliquus (S. obliquus) and Chlorella vulgaris (C. vulgaris) for sustainable biodiesels. In this study, S. obliquus and C. vulgaris, respectively, showed generally high cell densities with 1.23 g/L and 1.22 g/L of dried cell weights and 18.2% and 17.65% of lipids. Of the various PARs tested (10, 20, 40, and 60 μmol/m²/sec), 60 μmol/m²/sec showed maximal biomass yields for both species (1.78 g/L of dried cell weight and 25.7% of lipids for S. obliquus; and 1.74 g/L of dried cell weight and 24.6% of lipids for C. vulgaris). Of the various temperatures (27 °C, 37 °C, and 47 °C), 27 °C showed maximal dried cell weights (1.22 g/L for S. obliquus and 1.23 g/L for C. vulgaris), whereas 47 °C accumulated high levels of lipids (23.5% for S. obliquus and 21.6% for C. vulgaris). On the other hands, urea deprivation in the medium increased lipid levels in both species compared to no deprivation (10% increase for S. obliquus and 8% increase for C. vulgaris). The fatty acid profile showed that palmitic acid with 16 carbons and double bonds was dominant among major fatty acids, accounting for 30.55% for S. obliquus and 26.6% for C. vulgaris. Furthermore, urea deprivation and 60 μmol/m²/sec of PAR showed the highest proportions of unsaturated fatty acids in both species (27.55% for urea deprivation and 30.55% for PAR in S. obliquus; and 28.33% for urea deprivation and 26.6% for PAR in C. vulgaris).
    Keywords Chlorella vulgaris ; Scenedesmus obliquus ; biodiesel ; biomass ; fatty acid composition ; lipidomics ; palmitic acid ; photosynthetically active radiation ; temperature ; urea ; Microalgae ; Lipids ; Fatty acids
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 1090121-8
    ISSN 0961-9534
    ISSN 0961-9534
    DOI 10.1016/j.biombioe.2023.106854
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Green synthesis of silver and gold nanoparticles in Callistemon viminalis extracts and their antimicrobial activities.

    Khan, Shahid / Rauf, Abdur / Aljohani, Abdullah S M / Al-Awthan, Yahya S / Ahmad, Zubair / Bahattab, Omar S / Khan, Shehla / Saadiq, Muhammad / Khan, Shahid Ali / Thiruvengadam, Rekha / Thiruvengadam, Muthu

    Bioprocess and biosystems engineering

    2024  

    Abstract: In the current study, the bottlebrush [Callistemon viminalis (Sol. ex Gaertn.) G. Don] plant was selected for the green synthesis of silver (Ag) and gold (Au) nanoparticles and to evaluate its antibacterial and antifungal activities. Phytochemical ... ...

    Abstract In the current study, the bottlebrush [Callistemon viminalis (Sol. ex Gaertn.) G. Don] plant was selected for the green synthesis of silver (Ag) and gold (Au) nanoparticles and to evaluate its antibacterial and antifungal activities. Phytochemical screening of C. viminalis confirmed the presence of alkaloids, anthraquinones, saponins, tannins, betacyanins, phlobatanins, coumarins, terpenoids, steroids, glycosides, and proteins. To characterize the synthesized Ag and Au NPs, UV-Visible spectroscopy, FTIR spectroscopy for functional group identification, field emission scanning electron microscopy (FE-SEM) for particle size, and elemental analysis were performed using EDX. The UV-Visible absorption spectra of the green-synthesized Ag and Au nanoparticles were found to have a maximum absorption band at 420 nm for Ag NPs and 525 nm for Au NPs. FE-SEM analysis of the synthesized NPs revealed a circular shape with a size of 100 nm. Elemental analysis was performed for the synthesis of Ag and Au NPs, which confirmed the purity of the nanoparticles. The greenly synthesized Ag and Au NPs were also evaluated for their anti-bacterial and anti-fungal activities, which exhibited prominent inhibition activities against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans, C. krusei, Aspergillus sp., and Trichoderma species. The highest zone of inhibition 15.5 ± 0.75 and 15 ± 0.85 mm was observed for Ag NPs against E. coli and P. aeruginosa. Similarly, Trichoderma sp. and Aspergillus sp. were inhibited by Ag NPs up to 13.5 ± 0.95 and 13 ± 0.70 mm. This work will open doors for the development of new antimicrobial agents using green chemistry.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1476357-6
    ISSN 1615-7605 ; 1432-0797 ; 1615-7591
    ISSN (online) 1615-7605 ; 1432-0797
    ISSN 1615-7591
    DOI 10.1007/s00449-024-02994-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comprehensive review of the repositioning of non-oncologic drugs for cancer immunotherapy.

    Rauf, Abdur / Joshi, Payal B / Olatunde, Ahmed / Hafeez, Nabia / Ahmad, Zubair / Hemeg, Hassan A / Aljohani, Abdullah S M / Al Abdulmonem, Waleed / Thiruvengadam, Muthu / Viswanathan, Dhivya / Rajakumar, Govindasamy / Thiruvengadam, Rekha

    Medical oncology (Northwood, London, England)

    2024  Volume 41, Issue 5, Page(s) 122

    Abstract: Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases or disorders. Drug repurposing essentially refers to uncovering approved or failed compounds for ... ...

    Abstract Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases or disorders. Drug repurposing essentially refers to uncovering approved or failed compounds for use in various diseases. Cancer is a deadly disease and leading cause of mortality. The search for approved non-oncologic drugs for cancer treatment involved in silico modeling, databases, and literature searches. In this review, we provide a concise account of the existing non-oncologic drug molecules and their therapeutic potential in chemotherapy. The mechanisms and modes of action of the repurposed drugs using computational techniques are also highlighted. Furthermore, we discuss potential targets, critical pathways, and highlight in detail the different challenges pertaining to drug repositioning for cancer immunotherapy.
    MeSH term(s) Humans ; Drug Repositioning/methods ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/therapy ; Immunotherapy/methods ; Antineoplastic Agents/therapeutic use
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-024-02368-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways.

    Islam, Md Rezaul / Rauf, Abdur / Alash, Shopnil / Fakir, Md Naeem Hossain / Thufa, Gazi Kaifeara / Sowa, Mahbuba Sharmin / Mukherjee, Dattatreya / Kumar, Harendra / Hussain, Md Sadique / Aljohani, Abdullah S M / Imran, Muhammad / Al Abdulmonem, Waleed / Thiruvengadam, Rekha / Thiruvengadam, Muthu

    Medical oncology (Northwood, London, England)

    2024  Volume 41, Issue 6, Page(s) 134

    Abstract: Primary liver cancer is a type of cancer that develops in the liver. Hepatocellular carcinoma is a primary liver cancer that usually affects adults. Liver cancer is a fatal global condition that affects millions of people worldwide. Despite advances in ... ...

    Abstract Primary liver cancer is a type of cancer that develops in the liver. Hepatocellular carcinoma is a primary liver cancer that usually affects adults. Liver cancer is a fatal global condition that affects millions of people worldwide. Despite advances in technology, the mortality rate remains alarming. There is growing interest in researching alternative medicines to prevent or reduce the effects of liver cancer. Recent studies have shown growing interest in herbal products, nutraceuticals, and Chinese medicines as potential treatments for liver cancer. These substances contain unique bioactive compounds with anticancer properties. The causes of liver cancer and potential treatments are discussed in this review. This study reviews natural compounds, such as curcumin, resveratrol, green tea catechins, grape seed extracts, vitamin D, and selenium. Preclinical and clinical studies have shown that these medications reduce the risk of liver cancer through their antiviral, anti-inflammatory, antioxidant, anti-angiogenic, and antimetastatic properties. This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer.
    MeSH term(s) Humans ; Liver Neoplasms/prevention & control ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Signal Transduction/drug effects ; Carcinoma, Hepatocellular/prevention & control ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Animals ; Dietary Supplements ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
    Chemical Substances Antineoplastic Agents, Phytogenic ; Phytochemicals
    Language English
    Publishing date 2024-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-024-02333-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus.

    Lin, Ta-Wei / Lo, Chi-Wen / Lai, Su-Yuan / Fan, Ruey-Jane / Lo, Chao-Jung / Chou, Yu-Mei / Thiruvengadam, Rekha / Wang, Andrew H-J / Wang, Min-Ying

    Journal of virology

    2007  Volume 81, Issue 16, Page(s) 8730–8741

    Abstract: Infectious bursal disease virus (IBDV) causes a highly contagious disease in young chicks and leads to significant economic losses in the poultry industry. The capsid protein VP2 of IBDV plays an important role in virus binding and cell recognition. VP2 ... ...

    Abstract Infectious bursal disease virus (IBDV) causes a highly contagious disease in young chicks and leads to significant economic losses in the poultry industry. The capsid protein VP2 of IBDV plays an important role in virus binding and cell recognition. VP2 forms a subviral particle (SVP) with immunogenicity similar to that of the IBDV capsid. In the present study, we first showed that SVP could inhibit IBDV infection to an IBDV-susceptible cell line, DF-1 cells, in a dose-dependent manner. Second, the localizations of the SVP on the surface of DF-1 cells were confirmed by fluorescence microscopy, and the specific binding of the SVP to DF-1 cells occurred in a dose-dependent manner. Furthermore, the attachment of SVP to DF-1 cells was inhibited by an SVP-induced neutralizing monoclonal antibody against IBDV but not by denatured-VP2-induced polyclonal antibodies. Third, the cellular factors in DF-1 cells involved in the attachment of SVP were purified by affinity chromatography using SVP bound on the immobilized Ni(2+) ions. A dominant factor was identified as being chicken heat shock protein 90 (Hsp90) (cHsp90) by mass spectrometry. Results of biotinylation experiments and indirect fluorescence assays indicated that cHsp90 is located on the surface of DF-1 cells. Virus overlay protein binding assays and far-Western assays also concluded that cHsp90 interacts with IBDV and SVP, respectively. Finally, both Hsp90 and anti-Hsp90 can inhibit the infection of DF-1 cells by IBDV. Taken together, for the first time, our results suggest that cHsp90 is part of the putative cellular receptor complex essential for IBDV entry into DF-1 cells.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Viral/pharmacology ; Biotinylation ; Cell Line ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Chickens/virology ; Fluorescent Antibody Technique, Indirect ; HSP90 Heat-Shock Proteins/analysis ; HSP90 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/pharmacology ; Infectious bursal disease virus/drug effects ; Infectious bursal disease virus/physiology ; Mass Spectrometry ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; Viral Structural Proteins/analysis ; Viral Structural Proteins/metabolism ; Virion/drug effects ; Virion/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; HSP90 Heat-Shock Proteins ; Receptors, Virus ; VP2 protein, infectious bursal disease virus ; Viral Structural Proteins
    Language English
    Publishing date 2007-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00332-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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