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Book ; Thesis: 3D-Evaluation des Transplantatvolumens und Rezidivverhaltens in der Therapie oraler Tumorerkrankungen

Thönissen, Philipp Nikolaus

2020

Author's details	vorgelegt 2019 von Dr. med. Philipp Nikolaus Thönißen
Language	German
Size	67 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Freiburg i. Br
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Albert-Ludwigs-Universität Freiburg i. Br., 2020
HBZ-ID	HT020615924
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2020 E 1327	order for loan	Magazin

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Book ; Thesis: Sensitivität und Spezifität der Knochendarstellung in der DVT

Thönissen, Philipp Nikolaus

eine klinische Studie

2016

Author's details	vorgelegt von Philipp Nikolaus Thönissen
Language	German
Size	60 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Freiburg im Breisgau
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2016
HBZ-ID	HT019130835
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2016 E 1573	order for loan	Magazin

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Article ; Online: Volume reduction of vascularized flaps in the field of cranio-maxillofacial surgery: A narrative-style review.

Thoenissen, Philipp / Najafi, Ramin / Sader, Robert / Ghanaati, Shahram

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2023 Volume 52, Issue 2, Page(s) 203–211

MeSH term(s)	Humans ; Surgical Flaps/surgery ; Plastic Surgery Procedures ; Surgery, Oral
Language	English
Publishing date	2023-12-12
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2023.12.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 882: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The role of magnetic resonance imaging and computed tomography in oral squamous cell carcinoma patients' preoperative staging.

Thoenissen, Philipp / Heselich, Anja / Burck, Iris / Sader, Robert / Vogl, Thomas / Ghanaati, Shahram

Frontiers in oncology

2023 Volume 13, Page(s) 972042

Abstract: Introduction: The aim of the study was to evaluate the accuracy of MRI and CT with regard to the detection of lymph node metastases based on the data of specific patients with OSCC who received bilateral neck dissection.: Materials and methods: In a ... ...

Abstract	Introduction: The aim of the study was to evaluate the accuracy of MRI and CT with regard to the detection of lymph node metastases based on the data of specific patients with OSCC who received bilateral neck dissection. Materials and methods: In a retrospective analysis from 01/2014 to 12/2020 patients who underwent primary tumor resection and bilateral neck dissection were evaluated. Results: 174 preoperative MRI (78.74%, N=137) and CT (21.26%, N=37) were correlated with the histopathological findings. CT had a sensitivity of 67% and specificity of 68% (p=0.76). MRI showed an overall sensitivity of 66% and a specificity of 68% (p=0.76). In 52.87% of all cases no differences between cN and pN were found. MRI is the method to overestimate lymph node involvement compared to CT (overestimation in 27% vs. 21.62%). Conclusion: The current data indicate that MR and CT show poor efficacy in the detection of cervical metastases. Accordingly, attention must be paid to alternatives to correct local staging modalities. The application of structured bilateral neck dissection needs to be questioned.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.972042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Image Fusion Improves Interdisciplinary Communication in the Treatment of Head and Neck Cancer.

Thoenissen, Philipp / Bucher, Andreas / Burck, Iris / Sader, Robert / Vogl, Thomas / Ghanaati, Shahram

The Journal of craniofacial surgery

2022 Volume 33, Issue 4, Page(s) e439–e443

Abstract: Introduction: The diagnosis and therapy of oral squamous cell carcinoma (Osee) in Germany is according to guidelines and relies on interdisciplinary board meetings. Standard examination techniques are computed tomography (CT) and magnet resonance ... ...

Abstract	Introduction: The diagnosis and therapy of oral squamous cell carcinoma (Osee) in Germany is according to guidelines and relies on interdisciplinary board meetings. Standard examination techniques are computed tomography (CT) and magnet resonance imaging (MRI). These technologies are used as objective tools for serial presentation in an oncologic board meeting. The presentation of multiple series at different time points can be time consuming and might not often depict a patients case clearly for all involved disciplinaries. A conclusive image fusion could improve the communication. Thus, this study aims to introduce a novel idea of image fusion into the field of craniomaxillofacial surgery in order to ease understanding and improve therapy in complex Osee patients' cases. Materials and methods: Three key data sets of a patient with OSCC at the right tongue have been merged by image fusion of 3 MRi of head and neck with 3 CT thorax and abdomen using Syngo via (Siemens). Fused images were used as at a glance picture for presenting and discussion a patients case. Focus was on presenting a case of a primary manifestation of OSCC with the potential of a local relapse and distant metastases in an interdisciplinary oncol-ogic board meeting. Results: Image fusion enabled to visualize the primary tumor, local relapse as well as distant pulmonary metastasis and within the suprarenal gland, which have been occurred in a linear time line of 13 months. Discussion: Image fusion of different modalities that is CT and MRi, which were gathered at different time points, presents a new approach within the field of craniomaxillofacial surgery and helped to understand cancer localization and relapse at 1 glance. This new approach will enable a compact data set of patients oncological history as a more decisive tool for all involved disciplinaries. Conclusions: Image fusion might have the potential to become a standard approach in order to ease multiple therapists to make therapy decisions in oncologic board meetings on basis of current three-dimensional ready CT imaging and MRI.
MeSH term(s)	Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Germany ; Governing Board ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/surgery ; Humans ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional ; Interdisciplinary Communication ; Magnetic Resonance Imaging ; Medical Oncology ; Mouth Neoplasms/diagnostic imaging ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000008447
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Hyperspectral Imaging Allows Evaluation of Free Flaps in Craniomaxillofacial Reconstruction.

Thoenissen, Philipp / Heselich, Anja / Al-Maawi, Sarah / Sader, Robert / Ghanaati, Shahram

The Journal of craniofacial surgery

2022 Volume 34, Issue 3, Page(s) e212–e216

Abstract: Introduction: Treatment of extended defects after tumor resection in oral, maxillofacial, and facial surgery (craniomaxillofacial) is usually performed by free microvascular flaps. Evaluation of flap survival is crucial, especially in the first hours ... ...

Abstract	Introduction: Treatment of extended defects after tumor resection in oral, maxillofacial, and facial surgery (craniomaxillofacial) is usually performed by free microvascular flaps. Evaluation of flap survival is crucial, especially in the first hours after insertion and connection. For flap evaluation various invasive and noninvasive methods have been developed. This retrospective clinical study examined the ability of a hyperspectral imaging (HSI) camera (Tivita, Diaspective Vision, Germany) to assess postoperative flap properties in comparison to established clinical parameters. Materials and methods: Thirteen patients with tumor resection and free flap reconstruction were included for camera analysis and another 10 patients as control group. For this purpose, at defined time intervals and under standardized conditions, recordings of transplants 3 to 100 hours postoperatively were performed. Images were used to examine oxygenation (StO 2 %), tissue hemoglobin index, tissue water index, near infrared range perfusion index of free flaps quantitatively and qualitatively. Results: HSI provides values differing between patients observed with no intraindividual significant difference. After 24 hours a mean reduction of 16.77% for StO 2 %, 9.16% for tissue hemoglobin index and 8.46% was observed, going in line with no loss of flap was noted in the observation period. Conclusion: HSI is suitable as a noninvasive measure for the evaluation of free flaps in craniomaxillofacial surgery in case of stable imaging conditions with respect to light, surrounding and position of the camera. However, clinical measurements are still the method of choice.
MeSH term(s)	Humans ; Free Tissue Flaps ; Hyperspectral Imaging ; Retrospective Studies ; Neoplasms ; Hemoglobins/analysis
Chemical Substances	Hemoglobins
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article: Evaluation of Flap Shrinkage Using Magnetic Resonance Imaging Follow-up in the Treatment of Oral Cancer

Thoenissen, Philipp / Bucher, Andreas M. / Heselich, Anja / Sader, Robert / Vogl, Thomas / Ghanaati, Shahram

Journal of Reconstructive Microsurgery Open

2023 Volume 08, Issue 01, Page(s) e12–e17

Abstract: Objective: Tumor resection and reconstruction in patients with oral squamous cell carcinoma often involves free flaps followed by radiation therapy. Volume loss of free flaps is common following transplantation and radiation therapy. Therefore, this ... ...

Abstract	Objective: Tumor resection and reconstruction in patients with oral squamous cell carcinoma often involves free flaps followed by radiation therapy. Volume loss of free flaps is common following transplantation and radiation therapy. Therefore, this study investigates the volume loss of free radial forearm flaps in the field of craniomaxillofacial surgery. Methods: In a retrospective single-center clinical study, postsurgery magnetic resonance imaging (MRI) was analyzed in patients with a free radial forearm flap. Additional functional outcomes were observed. The size of transplants and volume shrinkage were measured over time. Additional functional outcomes were observed with a questionnaire at any follow-up. Transplant size and volume shrinkage were evaluated in 12 patients and showed a mean transplant volume loss in radial forearm free flaps of 33% within 100 weeks postsurgery. Results: Depending on the site of transplantation, volume loss differed between the buccal region (38.33%), alveolar process (36.29%), and tongue (17.50%) and loss varied according to both radiation and chemotherapy (51.5%) or adjuvant radiotherapy (51.5%) compared with none of those (30%). Nine patients (75%) stated full functional satisfaction after this evaluation period. Conclusion: MRI follow-up imaging is an adequate tool for measuring the volume shrinkage of free flaps. This study proves that overcorrection of flaps is necessary by expecting a loss of volume that depends on the site of transplantation and adjuvant therapy to reach a satisfying quality of life.
Keywords	MRI ; free flap surgery ; microsurgery
Language	English
Publishing date	2023-01-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2863089-0
ISSN	2377-0821 ; 2377-0813
ISSN (online)	2377-0821
ISSN	2377-0813
DOI	10.1055/s-0043-1760756
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 7099: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Patterns of Craniomaxillofacial Trauma After E-Scooter Accidents in Germany.

Thoenissen, Philipp / Salewski, Deborah / Heselich, Anja / Sader, Robert / Marzi, Ingo / Muehlenfeld, Nils / Ghanaati, Shahram

The Journal of craniofacial surgery

2021 Volume 32, Issue 4, Page(s) 1587–1589

Abstract: Introduction: E-Scooters are trending as an individual transport vehicle with electric drive in Germany. But there is less data about the frequency, demographic details and possible injuries and therapy needs in context with E-scooter accidents. ... ...

Abstract	Introduction: E-Scooters are trending as an individual transport vehicle with electric drive in Germany. But there is less data about the frequency, demographic details and possible injuries and therapy needs in context with E-scooter accidents. Therefore, the primary aim of this study was to analyze the frequency and the characteristics of facial trauma as well as the consecutive hospitalization and management after injuries with E-scooters in a German clinic specialized in craniomaxillofacial surgery. Materials and methods: Retrospective data analysis of the hospital information system of patients admitted to central emergency unit driving e-scooters and injuries between June and December 2019. Results: A total of 28 consecutive patients were admitted to the emergency care unit of a level one trauma center from June to December 2019. 85% had a minimum of two or more facial injuries. Most common were soft tissue injuries with 64% (n = 18), fractures with 54% (n = 15) and teeth injuries with 39% (n = 11). 82% percent of injuries were related with consumption of alcohol. Discussion: The data show a variety of different injuries from teeth injury, wounds and facial fractures in varying degrees in a predominantly young and male cohort (mean age 33.57, 68% male) often associated with alcohol. As accidents happen especially at nighttime and on weekends personnel capacities should be provided. Still bicycle accidents and following injuries stay a major problem.
MeSH term(s)	Accidents ; Adult ; Emergency Service, Hospital ; Female ; Germany/epidemiology ; Humans ; Male ; Retrospective Studies ; Trauma Centers
Language	English
Publishing date	2021-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000007694
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article: Extent of Neck Dissection and Cervical Lymph Node Involvement in Oral Squamous Cell Carcinoma.

Thoenissen, Philipp / Heselich, Anja / Deeg, Stefanie / Al-Maawi, Sarah / Tanneberger, Anna / Sader, Robert / Ghanaati, Shahram

Frontiers in oncology

2022 Volume 12, Page(s) 812864

Abstract: Introduction: Tumor resection combined with neck dissection (ND) or radiotherapy are established methods for the treatment of patients with oral squamous cell carcinoma (OSCC). However, the extent of ND can lead to postoperative complications. Therefore, ...

Abstract	Introduction: Tumor resection combined with neck dissection (ND) or radiotherapy are established methods for the treatment of patients with oral squamous cell carcinoma (OSCC). However, the extent of ND can lead to postoperative complications. Therefore, for the first time, this study aims to identify lymph node involvement in OSCC performed in a bilateral systematic approach based on oncologic board meetings relying on presurgical magnetic resonance imaging (MRI) and computed tomography (CT). Materials and methods: In a retrospective single-center study, patients with primary OSCC resection and systematic ND performed in 4 different manners (MRND III bilateral, MRND III left and SND right, MRND III right, SND left, and SND bilateral) were examined. Lymph node involvement allocated to levels was evaluated depending on primary localization and T-stage. Results: A total of 177 consecutive patients (mean age 63.64; 92 female, male 85) were enrolled in this study. A total of 38.98% showed cervical lymph node involvement, and metastases were found in levels 1-4. The distribution of positive lymph node metastases (n=190 LNs) was 39.47% in level 1, 38.95% in level 2, 10.53% in level 3, and 11.05% in level 4. Discussion: In a cohort of OSCC patients with systematic bilateral ND, levels 1 and 2 had positive lymph node involvement, and no lymph node involvement was seen at level 5. Without any clinical or imaging suspicion, ND expanding 5-level MRND should be avoided regardless of the primary tumor localization, T-stage and intraoperative proof of cervical metastases.
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.812864
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Three-Dimensional Magnetic Resonance Imaging Volumetry of Radial Forearm Flap Reconstructions After Craniomaxillofacial Tumor Resection.

Thoenissen, Philipp / Heselich, Anja / Sader, Robert / Vogl, Thomas Joseph / Ghanaati, Shahram / Bucher, Andreas Michael

The Journal of craniofacial surgery

2020 Volume 31, Issue 5, Page(s) e465–e469

Abstract: Background: Oral cancer is a common and life threatening disease that requires interdisciplinary treatment and often necessitates complex facial reconstruction. Standard care includes tumor resection, while reconstruction is routinely performed with ... ...

Abstract	Background: Oral cancer is a common and life threatening disease that requires interdisciplinary treatment and often necessitates complex facial reconstruction. Standard care includes tumor resection, while reconstruction is routinely performed with free radial forearm flaps. As esthetic results are crucial for quality of life, flap size, flap volume, and flap composition have to be considered. To date no standardized measurement of flap volume and shrinkage has been established for routine use. The purpose of this study was therefore to evaluate the transplant volume of radial forearm flaps in craniomaxillofacial reconstruction using magnetic resonance imaging (MRI) volumetry. Material and methods: Ten postoperative MR sequences of 5 patients were included. All patients had received transplantation of radial forearm flaps after tumor resection and radiation therapy. Evaluated parameters were: sex, age, type of flap, flap volume. Two different observers (1 surgeon and 1 radiologist) segmented transplant volume at three different time points in a postoperative MRI independently and in consensus, using both axial and coronal slices. A nonfat saturated T1 spin echo sequence was used. Mean transplant volume was calculated. Results: A total of 90 volumetric measurements were included. Overall Tvolm was 24.83 cm from axial sections and 27.25 cm from coronal sections. Measurements for axial and coronal orientations differed significantly. Results showed excellent intra- and inter-rater correlation, coefficient for rater A and rater B were 0.91 (axial) and 0.96 (coronal). Conclusion: MRI volumetry is a noninvasive reproducible method to quantify volume of free radial forearm flaps in situ but should follow specific considerations for best results.
MeSH term(s)	Aged ; Female ; Forearm/diagnostic imaging ; Forearm/surgery ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mouth Neoplasms/diagnostic imaging ; Mouth Neoplasms/surgery ; Quality of Life ; Reconstructive Surgical Procedures ; Surgical Flaps/surgery
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000006445
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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