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  1. Book ; Online ; E-Book: Traumatic brain injury

    Whitfield, Peter C. / Welbourne, Jessie / Thomas, Elfyn / Summers, Fiona / Whyte, Maggie / Hutchinson, Peter J.

    a multidisciplinary approach

    2020  

    Author's details edited by Peter C. Whitfield, Jessie Welbourne, Elfyn Thomas, Fiona Summers, Maggie Whyte, Peter J. Hutchinson
    Keywords Brain / Wounds and injuries
    Language English
    Size 1 Online-Ressource (xii, 400 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020451461
    ISBN 978-1-108-35524-7 ; 9781108430869 ; 1-108-35524-2 ; 1108430864
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Warfarin and intracranial haemorrhage.

    Appelboam, Rebecca / Thomas, Elfyn O

    Blood reviews

    2009  Volume 23, Issue 1, Page(s) 1–9

    Abstract: Summary: Spontaneous intracerebral haemorrhage is one of the most feared complications of long-term anticoagulation. Warfarin therapy not only increases the likelihood of suffering an intracranial haemorrhage, but also increases the mortality associated ...

    Abstract Summary: Spontaneous intracerebral haemorrhage is one of the most feared complications of long-term anticoagulation. Warfarin therapy not only increases the likelihood of suffering an intracranial haemorrhage, but also increases the mortality associated with it. This review aims to examine the incidence, pathogenesis, and outcome following a warfarin associated intracranial haemorrhage. It also evaluates the available evidence regarding optimal management of these patients, including timing and strategies for reversal of the coagulopathy, the role of neurocritical care and surgery, and indications for re-anticoagulation once the acute phase has past. The specific management of patients with prosthetic heart valves is also discussed. A summary of current societal guidelines is also included, as are some key practice points.
    MeSH term(s) Anticoagulants/adverse effects ; Blood Coagulation Factors/therapeutic use ; Factor VIIa/therapeutic use ; Humans ; Incidence ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/mortality ; Intracranial Hemorrhages/physiopathology ; Intracranial Hemorrhages/therapy ; Recombinant Proteins/therapeutic use ; Vitamin K/therapeutic use ; Warfarin/adverse effects
    Chemical Substances Anticoagulants ; Blood Coagulation Factors ; Recombinant Proteins ; Vitamin K (12001-79-5) ; prothrombin complex concentrates (37224-63-8) ; Warfarin (5Q7ZVV76EI) ; recombinant FVIIa (AC71R787OV) ; Factor VIIa (EC 3.4.21.21)
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2008.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: The headache over warfarin in British neurosurgical intensive care units: a national survey of current practice.

    Appelboam, Rebecca / Thomas, Elfyn Owen

    Intensive care medicine

    2007  Volume 33, Issue 11, Page(s) 1946–1953

    Abstract: Objective: To ascertain current British practice regarding the emergency medical management of patients who sustain a spontaneous intracerebral haemorrhage (ICH) whilst receiving warfarin therapy and to compare this with established national and ... ...

    Abstract Objective: To ascertain current British practice regarding the emergency medical management of patients who sustain a spontaneous intracerebral haemorrhage (ICH) whilst receiving warfarin therapy and to compare this with established national and international guidelines.
    Design: Standardised, telephone based, questionnaire survey.
    Setting: All 32 adult British neuroscience intensive care units (ICUs)
    Participants: Duty consultant of each neuroscience ICU.
    Results: Response rate was 100%. The international normalised ratio (INR) would be reversed by over 90% of ICU consultants treating patients on warfarin with an ICH, except patients with mechanical heart valves (MHV), when only 59.4% would reverse. Prothrombin complex concentrate (PCC) was used by 15 ICUs (46.9%); however, only six units (18.8%) apply reversal strategies with PCC and intravenous vitamin K in accordance with national guidelines. Fresh frozen plasma (FFP) continues to be used by 71.9% of the ICUs. A protocol for warfarin reversal in ICH was present in five ICUs, of which four followed national guidelines. None of the units that use FFP had a protocol. Following ICH, two-thirds of the ICUs (65.6%) would commence bridging heparinisation in the first 4 days for MHV patients and 25% would recommence warfarin before, and 64.5% after, 7 days.
    Conclusion: There is considerable variation in practice amongst clinicians who regularly manage these patients and, in most cases (81.2%), practice is not in keeping with national or international guidelines. This study has demonstrated the need amongst senior ICU clinicians for a heightened awareness of current treatment recommendations and the availability of effective haemostatic therapies.
    MeSH term(s) Cerebral Hemorrhage/chemically induced ; Cerebral Hemorrhage/mortality ; Critical Care ; Humans ; Neurosurgery ; Practice Patterns, Physicians' ; Surveys and Questionnaires ; United Kingdom ; Warfarin/administration & dosage ; Warfarin/adverse effects
    Chemical Substances Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2007-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0342-4642 ; 0340-0964 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0342-4642 ; 0340-0964 ; 0935-1701
    DOI 10.1007/s00134-007-0765-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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