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  1. Article: Eliminating Hepatitis C Virus Infection in Indigent Patients.

    Thomas, Emmanuel

    Gastroenterology & hepatology

    2022  Volume 18, Issue 6, Page(s) 333–336

    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6543: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 517: Show issues

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  2. Book ; Thesis: Ergebnisse nach Kyphoplastie und Vertebral Body Stent unter besonderer Berücksichtigung von Strategien bei Komplikationen

    Lehmann, Christophe Thomas Emmanuel

    2012  

    Author's details von Christophe Thomas Emmanuel Lehmann
    Language German
    Size 52 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2012
    HBZ-ID HT017522411
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 E 68 order for loan Magazin

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  3. Article ; Online: Hepatitis B virus X protein: TRIMming antiviral defences in hepatocytes.

    Thomas, Emmanuel

    Gut

    2017  

    Language English
    Publishing date 2017-05-05
    Publishing country England
    Document type Editorial
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2017-314013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Genomics in the Early Detection of Cholangiocarcinoma.

    Thomas, Emmanuel

    Gastroenterology & hepatology

    2016  Volume 11, Issue 6, Page(s) 412–414

    Language English
    Publishing date 2016-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6543: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 517: Show issues

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  5. Article ; Online: RT-LAMP-Based Molecular Diagnostic Set-Up for Rapid Hepatitis C Virus Testing.

    Sharma, Sandhya / Thomas, Emmanuel / Caputi, Massimo / Asghar, Waseem

    Biosensors

    2022  Volume 12, Issue 5

    Abstract: Hepatitis C virus (HCV) infections occur in approximately 3% of the world population. The development of an enhanced and extensive-scale screening is required to accomplish the World Health Organization's (WHO) goal of eliminating HCV as a public health ... ...

    Abstract Hepatitis C virus (HCV) infections occur in approximately 3% of the world population. The development of an enhanced and extensive-scale screening is required to accomplish the World Health Organization's (WHO) goal of eliminating HCV as a public health problem by 2030. However, standard testing methods are time-consuming, expensive, and challenging to deploy in remote and underdeveloped areas. Therefore, a cost-effective, rapid, and accurate point-of-care (POC) diagnostic test is needed to properly manage the disease and reduce the economic burden caused by high case numbers. Herein, we present a fully automated reverse-transcription loop-mediated isothermal amplification (RT-LAMP)-based molecular diagnostic set-up for rapid HCV detection. The set-up consists of an automated disposable microfluidic chip, a small surface heater, and a reusable magnetic actuation platform. The microfluidic chip contains multiple chambers in which the plasma sample is processed. The system utilizes SYBR green dye to detect the amplification product with the naked eye. The efficiency of the microfluidic chip was tested with human plasma samples spiked with HCV virions, and the limit of detection observed was 500 virions/mL within 45 min. The entire virus detection process was executed inside a uniquely designed, inexpensive, disposable, and self-driven microfluidic chip with high sensitivity and specificity.
    MeSH term(s) Hepacivirus ; Hepatitis C/diagnosis ; Humans ; Molecular Diagnostic Techniques ; Nucleic Acid Amplification Techniques ; Pathology, Molecular ; Sensitivity and Specificity
    Language English
    Publishing date 2022-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12050298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of Dead Sea Climatotherapy on Psoriasis; A Prospective Cohort Study

    Thomas Emmanuel / Dorte Lybæk / Claus Johansen / Lars Iversen

    Frontiers in Medicine, Vol

    2020  Volume 7

    Abstract: Background: Dead Sea climatotherapy (DSC) is a treatment option for psoriasis in Denmark. However, the response to DSC has not been particularly well studied.Aim: We sought to determine effectiveness and response duration of DSC on psoriasis-related ... ...

    Abstract Background: Dead Sea climatotherapy (DSC) is a treatment option for psoriasis in Denmark. However, the response to DSC has not been particularly well studied.Aim: We sought to determine effectiveness and response duration of DSC on psoriasis-related outcome parameters.Methods: Eighteen patients participated in a 4-week treatment program in Ein Gedi in Israel. Treatment, consisting of sun exposure and bathing, was individualized.Results: DSC was associated with a mean 13.0-point reduction (88%) in Psoriasis Area and Severity Index and a mean reduction of 2.3 (76.7%) on the 5-point Investigator's Global Assessment Scale. Furthermore, patients' quality of life improved measured by the Dermatology Quality of Life Index and EuroQol 5D index values. The mean time from treatment end to reappearance of visible skin symptoms was 93.8 days (SD: 62.5, range: 31–219 days).Conclusions: Our results confirm that DSC has an immediate effect on skin manifestations and improves quality of life, but long-term disease control is not observed.
    Keywords psoriasis ; Dead Sea ; climatotherapy ; heliotherapy ; cohort ; Ein Gedi ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tissue-Resident Memory T Cells in Skin Diseases

    Thomas Emmanuel / Josephine Mistegård / Anne Bregnhøj / Claus Johansen / Lars Iversen

    International Journal of Molecular Sciences, Vol 22, Iss 9004, p

    A Systematic Review

    2021  Volume 9004

    Abstract: In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to ... ...

    Abstract In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to conduct a systematic literature review on the current understanding of the role of TRMs in skin diseases and identify gaps as well as future research paths. EMBASE, PubMed, SCOPUS, Web of Science, Clinicaltrials.gov and WHO Trials Registry were searched systematically for relevant studies from their inception to October 2020. Included studies were reviewed independently by two authors. This study was conducted in accordance with the PRISMA-S guidelines. This protocol was registered with the PROSPERO database (ref: CRD42020206416). We identified 96 studies meeting the inclusion criteria. TRMs have mostly been investigated in murine skin and in relation to infectious skin diseases. Pathogenic TRMs have been characterized in various skin diseases including psoriasis, vitiligo and cutaneous T-cell lymphoma. Studies are needed to discover biomarkers that may delineate TRMs poised for pathogenic activity in skin diseases and establish to which extent TRMs are contingent on the local skin microenvironment. Additionally, future studies may investigate the effects of current treatments on the persistence of pathogenic TRMs in human skin.
    Keywords tissue-resident memory T cells ; TRMs ; TRM ; T cells ; inflammation ; skin disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Physiologically relevant microsystems to study viral infection in the human liver.

    McDuffie, Dennis / Barr, David / Agarwal, Ashutosh / Thomas, Emmanuel

    Frontiers in microbiology

    2022  Volume 13, Page(s) 999366

    Abstract: Viral hepatitis is a leading cause of liver disease and mortality. Infection can occur acutely or chronically, but the mechanisms that govern the clearance of virus or lack thereof are poorly understood and merit further investigation. Though cures for ... ...

    Abstract Viral hepatitis is a leading cause of liver disease and mortality. Infection can occur acutely or chronically, but the mechanisms that govern the clearance of virus or lack thereof are poorly understood and merit further investigation. Though cures for viral hepatitis have been developed, they are expensive, not readily accessible in vulnerable populations and some patients may remain at an increased risk of developing hepatocellular carcinoma (HCC) even after viral clearance. To sustain infection
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.999366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Special Issue "IFN-Independent ISG Expression and its Role in Antiviral Cell-Intrinsic Innate Immunity".

    Thomas, Emmanuel / Saito, Takeshi

    Viruses

    2019  Volume 11, Issue 11

    Abstract: Over the last few decades, accumulating evidence has demonstrated that numerous Interferon(IFN) stimulate genes (ISGs) can be directly upregulated following virus infection independent ofIFN signaling [ ... ]. ...

    Abstract Over the last few decades, accumulating evidence has demonstrated that numerous Interferon(IFN) stimulate genes (ISGs) can be directly upregulated following virus infection independent ofIFN signaling [...].
    MeSH term(s) Humans ; Immunity, Innate ; Interferon-alpha/genetics ; Interferon-alpha/immunology ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/virology ; Viruses/genetics ; Viruses/immunology
    Chemical Substances Interferon-alpha
    Language English
    Publishing date 2019-10-24
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11110981
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  10. Article ; Online: An investigation of laboratory-based positive and negative emotional suppression in relation to posttraumatic stress disorder symptom clusters.

    Kiefer, Reina / Thomas, Emmanuel D / Lawrence, Elijah R / Goldstein, Silvi C / Dixon-Gordon, Katherine L / Weiss, Nicole H

    Psychological trauma : theory, research, practice and policy

    2024  

    Abstract: Background: Emotional suppression is a clinically significant aspect of emotion regulation with robust associations to psychopathology, including posttraumatic stress disorder (PTSD). Despite the fast-growing body of literature highlighting the role of ... ...

    Abstract Background: Emotional suppression is a clinically significant aspect of emotion regulation with robust associations to psychopathology, including posttraumatic stress disorder (PTSD). Despite the fast-growing body of literature highlighting the role of positive emotion regulation difficulties in the development and maintenance of PTSD, extant work on emotional suppression and PTSD has almost exclusively focused on the role of negative emotions.
    Objective: The present study aimed to advance this literature by examining the associations between PTSD symptom clusters and participants' use of state emotional suppression during a laboratory task designed to elicit negative or positive emotions.
    Method: Participants were 108 community women (
    Results: Results of the moderation analyses showed that, when controlling for state emotional intensity, women experiencing clinical levels of PTSD symptom Clusters B (intrusive recollections), D (negative alterations in cognitions and mood), and E (alterations in arousal and reactivity) were significantly more likely to utilize emotional suppression, but only in the context of positive-not negative-emotions.
    Conclusions: Findings provide evidence for a link between PTSD and positive emotional suppression among women currently experiencing IPV by a male partner and using substances, highlighting positive emotional suppression as a potential target in PTSD treatment for IPV populations with comorbid substance use concerns. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0001644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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