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  1. Article ; Online: Service utilization and HIV outcomes among transgender women receiving Ryan White Part A services in New York City.

    Thomas, Jacinthe A / Irvine, Mary K / Xia, Qiang / Harriman, Graham A

    PloS one

    2021  Volume 16, Issue 7, Page(s) e0253444

    Abstract: Background: Prior research has found evidence of gender disparities in U.S. HIV healthcare access and outcomes. In order to assess potential disparities in our client population, we compared demographics, service needs, service utilization, and HIV care ...

    Abstract Background: Prior research has found evidence of gender disparities in U.S. HIV healthcare access and outcomes. In order to assess potential disparities in our client population, we compared demographics, service needs, service utilization, and HIV care continuum outcomes between transgender women, cisgender women, and cisgender men receiving New York City (NYC) Ryan White Part A (RWPA) services.
    Methods: The analysis included HIV-positive clients with an intake assessment between January 2016 and December 2017 in an NYC RWPA services program. We examined four service need areas: food and nutrition, harm reduction, mental health, and housing. Among clients with the documented need, we ascertained whether they received RWPA services targeting that need. To compare HIV outcomes between groups, we applied five metrics: engagement in care, consistent engagement in care, antiretroviral therapy (ART) use, point-in-time viral suppression, and durable viral suppression.
    Results: All four service needs were more prevalent among transgender women (N = 455) than among cisgender clients. Except in the area of food and nutrition services, timely (12-month) receipt of RWPA services to meet a specific assessed need was not significantly more or less common in any one of the three client groups examined. Compared to cisgender women and cisgender men, a lower proportion of transgender women were durably virally suppressed (39% versus 52% or 50%, respectively, p-value < 0.001).
    Conclusions: Compared with cisgender women and cisgender men, transgender women more often presented with basic (food/housing) and behavioral-health service needs. In all three groups (with no consistent between-group differences), assessed needs were not typically met with the directly corresponding RWPA service category. Targeting those needs with RWPA outreach and services may support the National HIV/AIDS Strategy 2020 goal of reducing health disparities, and specifically the objective of increasing (to ≥90%) the percentage of transgender women in HIV medical care who are virally suppressed.
    MeSH term(s) Adult ; Anti-Retroviral Agents/therapeutic use ; Community Health Services/statistics & numerical data ; Continuity of Patient Care/statistics & numerical data ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Health Services Accessibility/statistics & numerical data ; Healthcare Disparities/statistics & numerical data ; Humans ; Male ; Middle Aged ; New York City/epidemiology ; Retrospective Studies ; Transgender Persons/statistics & numerical data
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0253444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Durable Viral Suppression Among Young Adults Living with HIV Receiving Ryan White Services in New York City.

    Feldman, Matthew B / Montero, Noelisa / Thomas, Jacinthe A / Hoffman, Susie / Nguyen, Nadia / Lentz, Cody L / Sukumaran, Stephen / Mellins, Claude A

    AIDS and behavior

    2023  Volume 27, Issue 10, Page(s) 3197–3205

    Abstract: Identifying factors associated with durable viral suppression (DVS) can inform interventions to support young adults living with HIV (YALWH) in sustaining optimal health. We examined associations between client characteristics and DVS among YALWH aged 18- ...

    Abstract Identifying factors associated with durable viral suppression (DVS) can inform interventions to support young adults living with HIV (YALWH) in sustaining optimal health. We examined associations between client characteristics and DVS among YALWH aged 18-29 who completed an intake assessment and received ≥ 1 Ryan White Part A service in New York City from 1/2017 to 12/2019. Individuals were classified as achieving DVS at least once if they had ≥ 2 suppressed viral load test results ≥ 90 days apart with: (a) no intervening unsuppressed viral load test results in a 12-month period; and (b) no unsuppressed viral load test results after achieving DVS in that 12-month period. Of 2208 YALWH, 92.1% (n = 2034) had sufficient data in the New York City HIV Surveillance Registry to ascertain DVS status. Of these, 68% achieved DVS at least once. Controlling for ART prescription status at intake, YALWH with higher incomes were significantly more likely to achieve DVS at least once. YALWH with lifetime and recent histories of incarceration and/or drug use were significantly less likely to achieve DVS. Our findings underscore the potential role of tailored harm reduction and post-incarceration programs in reducing health inequities among YALWH.
    MeSH term(s) Humans ; Young Adult ; Harm Reduction ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Income ; New York City/epidemiology
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-023-04040-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Associations between drug use patterns and viral load suppression among HIV-positive individuals who use support services in New York City.

    Feldman, Matthew B / Kepler, Kelsey L / Irvine, Mary K / Thomas, Jacinthe A

    Drug and alcohol dependence

    2019  Volume 197, Page(s) 15–21

    Abstract: Background: Drug use (DU) represents a significant barrier to maintaining physical health among people living with HIV (PLWH). Few studies, however, have examined the relationship between DU over time and HIV treatment outcomes. Such studies are needed ... ...

    Abstract Background: Drug use (DU) represents a significant barrier to maintaining physical health among people living with HIV (PLWH). Few studies, however, have examined the relationship between DU over time and HIV treatment outcomes. Such studies are needed because an individual's risk of poor health outcomes may vary with their DU behaviors. We examined associations between DU patterns over time and unsuppressed viral load (VL).
    Methods: The sample included 7896 PLWH in New York City who completed ≥3 substance use assessments over a 24-month period. DU was defined as crystal methamphetamine, crack/cocaine, heroin, and/or recreational prescription medication use in the last three months. Four behavior patterns were constructed: (1) persistent use (DU reported on each assessment); (2) intermittent use-active (DU reported on the third, but not all previous assessments); (3) intermittent use-inactive (DU reported previously with no DU reported on the third assessment); (4) persistent non-use (no DU reported on any assessment). Unsuppressed VL (>200 copies/mL) was assessed based on the last VL value in the New York City HIV Surveillance Registry in the 12 months following an individual's third DU assessment.
    Results: Compared with persistent non-users, individuals with intermittent use-inactive (aOR = 1.24, 95% CI = 1.03-1.49), intermittent use-active (aOR = 1.68, 95% CI = 1.36-2.06), and persistent use (aOR = 2.21, 95% CI = 1.69-2.89) were significantly more likely to have unsuppressed VL.
    Conclusions: While providers may be more likely to intervene with persistent or active drug users, our findings suggest the importance of addressing the risk of poor HIV treatment outcomes among those with any DU behavior.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Female ; HIV ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/psychology ; Humans ; Male ; Middle Aged ; New York City/epidemiology ; Registries ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/virology ; Treatment Outcome ; Viral Load
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2019-01-15
    Publishing country Ireland
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2018.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Crystal methamphetamine use and HIV medical outcomes among HIV-infected men who have sex with men accessing support services in New York.

    Feldman, Matthew B / Thomas, Jacinthe A / Alexy, Emily R / Irvine, Mary K

    Drug and alcohol dependence

    2015  Volume 147, Page(s) 266–271

    Abstract: Background: Drug use poses multiple challenges to maintaining physical health among HIV-infected individuals, particularly with regard to disease progression. Few studies, however, have examined the association between the use of crystal methamphetamine ...

    Abstract Background: Drug use poses multiple challenges to maintaining physical health among HIV-infected individuals, particularly with regard to disease progression. Few studies, however, have examined the association between the use of crystal methamphetamine ("crystal meth") and HIV disease progression specifically among HIV-infected men who have sex with men (MSM). Understanding this relationship among HIV-infected MSM is particularly critical because of the high rates of crystal meth use reported in the population.
    Methods: Associations between recent crystal meth use and poor HIV medical outcomes (viral load>200 copies/mL, CD4 count <350 cells/mm(3)) were analyzed for 2896 HIV-infected MSM enrolled in Ryan White Part A programs in the greater New York metropolitan area between November 2010 and June 2012.
    Results: Crystal meth use (reported by 4%) was independently associated with unsuppressed viral load (AOR=1.8, CI=1.1-2.9) in multivariate analyses controlling for sociodemographic characteristics. There was no significant relationship between crystal meth use and low CD4 counts.
    Conclusions: To date, little research has examined how crystal meth use influences HIV medical outcomes among HIV-infected MSM. This analysis showed a significant independent association between crystal meth use and unsuppressed viral load among MSM in an HIV service population. Future studies should examine biological and psychosocial mediators, moderators and confounders of this relationship to inform intervention development for MSM crystal meth users in HIV care settings.
    MeSH term(s) Amphetamine-Related Disorders/complications ; Amphetamine-Related Disorders/epidemiology ; CD4 Lymphocyte Count ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Homosexuality, Male/statistics & numerical data ; Humans ; Male ; New York City/epidemiology ; Viral Load
    Language English
    Publishing date 2015-02-01
    Publishing country Ireland
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2014.09.780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Association Between Food Insufficiency and HIV Treatment Outcomes in a Longitudinal Analysis of HIV-Infected Individuals in New York City.

    Feldman, Matthew B / Alexy, Emily R / Thomas, Jacinthe A / Gambone, Gina F / Irvine, Mary K

    Journal of acquired immune deficiency syndromes (1999)

    2014  Volume 69, Issue 3, Page(s) 329–337

    Abstract: Background: To date, there have been few longitudinal studies of food insecurity among people living with HIV (PLWH). Food insufficiency (FI) is one dimension of the food insecurity construct that refers to periods of time during which individuals have ... ...

    Abstract Background: To date, there have been few longitudinal studies of food insecurity among people living with HIV (PLWH). Food insufficiency (FI) is one dimension of the food insecurity construct that refers to periods of time during which individuals have an inadequate amount of food intake because of limited resources. The aim of this analysis was to examine the relationship between FI and HIV treatment outcomes among HIV-infected individuals in New York City (NYC).
    Methods: Associations between FI ("consistent"--food insufficient on both of the last 2 assessments, "inconsistent"--food insufficient on 1 of the last 2 assessments, or neither) and clinical indicators of HIV disease progression (viral load > 200 copies per milliliter, CD4 count < 200 cells per cubic millimeter) were analyzed for NYC Ryan White Part A food and nutrition program clients who were matched to the NYC HIV Surveillance Registry and completed 2 FI assessments between November 2011 and June 2013.
    Results: Among 2,118 PLWH in food and nutrition programs, 61% experienced consistent FI and 25% experienced inconsistent FI. In multivariate analyses controlling for sociodemographic characteristics, consistent FI was independently associated with unsuppressed viral load (adjusted odds ratio = 1.6, confidence interval: 1.1 to 2.5). Consistent FI was only associated with low CD4 counts at the bivariate level.
    Conclusions: Future studies should examine biological, structural, and psychosocial factors that may explain the relationship between FI and HIV treatment outcomes to inform intervention development. Persistent FI among food and nutrition program clients suggests that services are needed to address underlying needs for financial stability (eg, vocational counseling) for PLWH.
    MeSH term(s) CD4 Lymphocyte Count ; Female ; Food Supply ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Longitudinal Studies ; Male ; New York City/epidemiology ; Socioeconomic Factors ; Treatment Outcome ; Viral Load
    Language English
    Publishing date 2014-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000000596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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