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  1. Article ; Online: Stillbirth Associated With Anomalous Origin and Course of the Left Coronary Artery: A Report of 2 Cases.

    Price, Erica / Thomas, Kristen M / Ernst, Linda M

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2024  , Page(s) 10935266231223278

    Abstract: Coronary artery anomalies and their potential sequelae are not well studied in association with stillbirth. Herein, we report the autopsy findings in two term stillborn fetuses with coronary artery anomalies. Both fetuses showed identical findings ... ...

    Abstract Coronary artery anomalies and their potential sequelae are not well studied in association with stillbirth. Herein, we report the autopsy findings in two term stillborn fetuses with coronary artery anomalies. Both fetuses showed identical findings consisting of an abnormal origin of the left coronary artery from the right sinus of Valsalva and an interarterial course of the left coronary artery. Histologic vascular and myocardial changes were also present. These coronary artery findings are associated with sudden death in adults and neonates, and therefore, their potential to be a cause and/or contributor to fetal death is suspected.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/10935266231223278
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  2. Article ; Online: Characterizing COVID-19 maternal-fetal transmission and placental infection using comprehensive molecular pathology.

    Schwartz, David A / Thomas, Kristen M

    EBioMedicine

    2020  Volume 60, Page(s) 102983

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Pandemics ; Pathology, Molecular ; Placenta ; Pneumonia, Viral ; Pregnancy ; Pregnancy Complications, Infectious ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterizing COVID-19 maternal-fetal transmission and placental infection using comprehensive molecular pathology

    Schwartz, David A. / Thomas, Kristen M.

    EBioMedicine

    2020  Volume 60, Page(s) 102983

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102983
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Filling in the "GAPPS": an unusual presentation of a child with gastric adenocarcinoma and proximal polyposis of the stomach.

    Grossman, Arielle / Colavito, John / Levine, Jeremiah / Thomas, Kristen M / Greifer, Melanie

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2021  Volume 25, Issue 2, Page(s) 468–472

    Abstract: Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is a very rare gastric polyposis syndrome characterized by numerous polyps of the gastric fundus and body. We present the unusual case of a 10-year-old Polish-American male with history ...

    Abstract Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) is a very rare gastric polyposis syndrome characterized by numerous polyps of the gastric fundus and body. We present the unusual case of a 10-year-old Polish-American male with history of eosinophilic esophagitis, who was found to have multiple fundic gland polyps (FGP) with low grade dysplasia on esophagogastroduodenoscopy. Subsequent evaluation including genetic testing confirmed the diagnosis of GAPPS, and after exhaustive multidisciplinary consultation the decision was made to proceed with prophylactic total gastrectomy given the markedly increased risk of gastric adenocarcinoma in GAPPS patients. To our knowledge, this represents the youngest patient diagnosed with GAPPS and the youngest patient who has undergone prophylactic gastrectomy for this disease at age 8 and 10 years, respectively. The pathophysiology, presentation, and treatment of GAPPS in a pediatric patient are discussed.
    MeSH term(s) Adenocarcinoma/pathology ; Adenomatous Polyps/diagnosis ; Child ; Gastrectomy ; Humans ; Male ; Stomach Neoplasms/pathology
    Language English
    Publishing date 2021-09-28
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-021-01249-7
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    Zs.A 5290: Show issues Location:
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  6. Article ; Online: Association of SARS-CoV-2 placental histopathology findings with maternal-fetal comorbidities and severity of COVID-19 hypoxia.

    Meyer, Jessica A / Roman, Ashley S / Limaye, Meghana / Grossman, Tracy B / Flaifel, Abdallah / Vaz, Michelle J / Thomas, Kristen M / Penfield, Christina A

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2021  Volume 35, Issue 25, Page(s) 8412–8418

    Abstract: Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited ...

    Abstract Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited by small study cohorts with mild disease, review by multiple pathologists, and potential confounding by maternal-fetal comorbidities that can also influence placental findings. This study aims to identify pathologic placental findings associated with COVID-19 disease and severity, as well as to distinguish them from changes related to coexisting maternal-fetal comorbidities.
    Methods: This is an observational study of 61 pregnant women with confirmed SARS-CoV-2 infection who delivered and had a placental histological evaluation at NYU Langone Health between March 19, 2020 and June 30, 2020. Primary outcomes were the prevalence of placental histopathologic features and their association with maternal-fetal comorbidities and severity of COVID-19 related hypoxia. Analysis was performed using Fisher's exact test and
    Results: Sixty-one placentas were included in the study cohort, 71% from pregnancies complicated by at least one maternal-fetal comorbidity. Twenty-five percent of placentas were small for gestational age and 77% exhibited at least one feature of maternal vascular malperfusion. None of the histopathologic features in the examined placentas were associated with the presence of any specific maternal-fetal comorbidity. Thirteen percent of the cohort required maternal respiratory support for COVID-19 related hypoxia. Villous trophoblast necrosis was associated with maternal supplemental oxygen requirement (67
    Conclusion: In pregnancies complicated by COVID-19 disease, there was a high prevalence of placental histopathologic changes identified, particularly features of maternal vascular malperfusion, which could not be attributed solely to the presence of maternal-fetal comorbidities. The significantly increased prevalence of villous trophoblast necrosis in women needing respiratory support suggests a connection to the severity of COVID-19 illness.
    MeSH term(s) Female ; Pregnancy ; Humans ; SARS-CoV-2 ; COVID-19/complications ; Placenta/pathology ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/pathology ; Comorbidity ; Hypoxia/epidemiology ; Necrosis/epidemiology ; Necrosis/pathology
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2021.1977791
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    Zs.A 3510: Show issues Location:
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  7. Article: Persistent organic pollutant exposure and celiac disease: A pilot study

    Gaylord, Abigail / Trasande, Leonardo / Kannan, Kurunthachalam / Thomas, Kristen M / Lee, Sunmi / Liu, Mengling / Levine, Jeremiah

    Environmental research. 2020 July, v. 186

    2020  

    Abstract: Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollutants (POPs) are known endocrine disruptors and, given ...

    Abstract Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollutants (POPs) are known endocrine disruptors and, given the interplay between the endocrine and immune systems, are plausible contributors to celiac disease. The current study aims to elucidate the association between POPs and celiac disease. We conducted a single-site pilot study of 88 patients recruited from NYU Langone's Hassenfeld Children's Hospital outpatient clinic, 30 of which were subsequently diagnosed with celiac disease using standard serology and duodenal biopsy examination. Polybrominated diphenyl ether (PBDEs), perfluoroalkyl substances (PFASs), and p,p’-dichlorodiphenyldichloroethylene (DDE) and HLA-DQ genotype category were measured in blood serum and whole blood, respectively. Multivariable logistic regressions were used to obtain odds ratios for celiac disease associated with serum POP concentrations. Controlling for sex, race, age, BMI, and genetic susceptibility score, patients with higher serum DDE concentrations had 2-fold higher odds of celiac disease (95% CI: 1.08, 3.84). After stratifying by sex, we found higher odds of celiac disease in females with serum concentrations of DDE (OR = 13.0, 95% CI = 1.54, 110), PFOS (OR = 12.8, 95% CI = 1.17, 141), perfluorooctanoic acid (OR = 20.6, 95% CI = 1.13, 375) and in males with serum BDE153, a PBDE congener (OR = 2.28, 95% CI = 1.01, 5.18). This is the first study to report on celiac disease with POP exposure in children. These findings raise further questions of how environmental chemicals may affect autoimmunity in genetically susceptible individuals.
    Keywords autoimmunity ; biopsy ; blood serum ; celiac disease ; genotype ; hospitals ; perfluorocarbons ; perfluorooctanoic acid ; persistent organic pollutants ; polybrominated diphenyl ethers ; research ; risk ; serology
    Language English
    Dates of publication 2020-07
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.109439
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  8. Article ; Online: Testicular Changes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

    Flaifel, Abdallah / Guzzetta, Melissa / Occidental, Michael / Najari, Bobby B / Melamed, Jonathan / Thomas, Kristen M / Deng, Fang-Ming

    Archives of pathology & laboratory medicine

    2020  Volume 145, Issue 1, Page(s) 8–9

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/pathology ; Cadaver ; Epididymis/pathology ; Epididymis/virology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Testis/pathology ; Testis/virology ; Young Adult
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Letter
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2020-0487-LE
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  9. Article ; Online: Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples.

    Penfield, Christina A / Brubaker, Sara G / Limaye, Meghana A / Lighter, Jennifer / Ratner, Adam J / Thomas, Kristen M / Meyer, Jessica A / Roman, Ashley S

    American journal of obstetrics & gynecology MFM

    2020  Volume 2, Issue 3, Page(s) 100133

    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19 Nucleic Acid Testing/methods ; COVID-19 Nucleic Acid Testing/statistics & numerical data ; Extraembryonic Membranes/virology ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Neonatal Screening/methods ; New York/epidemiology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/physiopathology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2020.100133
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  10. Article ; Online: Persistent organic pollutant exposure and celiac disease: A pilot study.

    Gaylord, Abigail / Trasande, Leonardo / Kannan, Kurunthachalam / Thomas, Kristen M / Lee, Sunmi / Liu, Mengling / Levine, Jeremiah

    Environmental research

    2020  Volume 186, Page(s) 109439

    Abstract: Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollutants (POPs) are known endocrine disruptors and, given ...

    Abstract Celiac disease affects approximately 1% of the population worldwide. Little is known about environmental factors that may modulate risk in genetically susceptible populations. Persistent organic pollutants (POPs) are known endocrine disruptors and, given the interplay between the endocrine and immune systems, are plausible contributors to celiac disease. The current study aims to elucidate the association between POPs and celiac disease. We conducted a single-site pilot study of 88 patients recruited from NYU Langone's Hassenfeld Children's Hospital outpatient clinic, 30 of which were subsequently diagnosed with celiac disease using standard serology and duodenal biopsy examination. Polybrominated diphenyl ether (PBDEs), perfluoroalkyl substances (PFASs), and p,p'-dichlorodiphenyldichloroethylene (DDE) and HLA-DQ genotype category were measured in blood serum and whole blood, respectively. Multivariable logistic regressions were used to obtain odds ratios for celiac disease associated with serum POP concentrations. Controlling for sex, race, age, BMI, and genetic susceptibility score, patients with higher serum DDE concentrations had 2-fold higher odds of celiac disease (95% CI: 1.08, 3.84). After stratifying by sex, we found higher odds of celiac disease in females with serum concentrations of DDE (OR = 13.0, 95% CI = 1.54, 110), PFOS (OR = 12.8, 95% CI = 1.17, 141), perfluorooctanoic acid (OR = 20.6, 95% CI = 1.13, 375) and in males with serum BDE153, a PBDE congener (OR = 2.28, 95% CI = 1.01, 5.18). This is the first study to report on celiac disease with POP exposure in children. These findings raise further questions of how environmental chemicals may affect autoimmunity in genetically susceptible individuals.
    MeSH term(s) Celiac Disease/chemically induced ; Celiac Disease/epidemiology ; Celiac Disease/genetics ; Child ; Dichlorodiphenyl Dichloroethylene ; Environmental Pollutants/toxicity ; Female ; Halogenated Diphenyl Ethers/analysis ; Halogenated Diphenyl Ethers/toxicity ; Humans ; Male ; Pilot Projects ; Polychlorinated Biphenyls
    Chemical Substances Environmental Pollutants ; Halogenated Diphenyl Ethers ; Dichlorodiphenyl Dichloroethylene (4M7FS82U08) ; Polychlorinated Biphenyls (DFC2HB4I0K)
    Language English
    Publishing date 2020-05-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.109439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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