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  1. Article ; Online: The natural history of bleeding disorder of unknown cause.

    Thomas, Will

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 7, Page(s) 1747–1749

    MeSH term(s) Humans ; Blood Coagulation Disorders ; Hemorrhagic Disorders
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.03.025
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  2. Article ; Online: Bleeding disorders of unknown cause; the role of physiological anticoagulants.

    Monard, Amaury / Thomas, Will / Heubel-Moenen, Floor

    Thrombosis research

    2024  Volume 237, Page(s) 216–217

    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Hemorrhage
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.02.025
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  3. Article ; Online: A Systematic Review of Efficacy and Safety of Plasma-Derived von Willebrand Factor/Factor VIII Concentrate (Voncento) in von Willebrand Disease.

    Rugeri, Lucia / Thomas, Will / Schirner, Kathrin / Heyder, Lisa / Auerswald, Günter

    Thrombosis and haemostasis

    2024  

    Abstract: Background:  For the treatment of von Willebrand disease (VWD), von Willebrand factor (VWF) concentrates can be used in on-demand, long-term prophylaxis, and surgical prophylaxis regimens.: Methods:  This systematic literature review was conducted to ...

    Abstract Background:  For the treatment of von Willebrand disease (VWD), von Willebrand factor (VWF) concentrates can be used in on-demand, long-term prophylaxis, and surgical prophylaxis regimens.
    Methods:  This systematic literature review was conducted to evaluate the efficacy, consumption, and safety of plasma-derived human coagulation FVIII/human VWF (pdVWF/FVIII; Voncento/Biostate) for the treatment of patients with any inherited VWD type. An electronic search was conducted in MEDLINE and Cochrane Library databases on VWD therapies. All retrieved publications were assessed against predefined inclusion/exclusion criteria following the Cochrane group recommendations. Associated pharmacovigilance data were collected across the same time period.
    Results:  Eleven publications from eight study cohorts were identified for data retrieval. All were from multicenter studies and included both pediatric and adult patients. Eight publications included evaluations of the efficacy of pdVWF/FVIII for on-demand treatment, eight included long-term prophylactic treatment, and eight included surgical prophylaxis. Treatment protocols and VWF administration methods differed between studies, as did safety evaluations. The clinical response was rated as excellent/good for on-demand treatment in 66 to 100% of nonsurgical bleeds, 89 to 100% in the treatment of breakthrough bleeds during long-term prophylaxis treatment, and hemostatic efficacy in surgical procedures was 75 to 100%. Pharmacovigilance data confirmed a low incidence of adverse events in treated patients.
    Conclusion:  This review provides a comprehensive summary of studies that evaluated the use of pdVWF/FVIII in VWD demonstrating the long-term effectiveness and safety of this pdVWF/FVIII across all ages, types of VWD, and treatment settings.
    Language English
    Publishing date 2024-04-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2253-9701
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  4. Article ; Online: Effect of applied shading during fruit ripening on tannin structure–activity relationships of grape skin extracts

    Campbell, James R. / Thomas, Will / Waterhouse, Andrew L. / Kennedy, Jim

    Journal of the Science of Food and Agriculture. 2024 Jan. 15, v. 104, no. 1, p. 352-361

    2024  , Page(s) 352–361

    Abstract: BACKGROUND: Historically, the effect of wine grape shading on flavonoids has investigated the impact of light incidence on proanthocyanidin (PA), flavonol, or anthocyanin concentration. In addition to concentration, the current experiment was designed to ...

    Abstract BACKGROUND: Historically, the effect of wine grape shading on flavonoids has investigated the impact of light incidence on proanthocyanidin (PA), flavonol, or anthocyanin concentration. In addition to concentration, the current experiment was designed to look at changes in PA composition, size and tannin activity through ripening. Tannin activity is a methodology for assessing the impact of structure and size on the affinity of tannin towards a hydrophobic surface and is considered to be a proxy for predicted astringency descriptive quality. In 2016 a shade cloth study was imposed on Cabernet Sauvignon on Mt Veeder, within the larger Napa Valley viticultural area. A control, which was unshaded, and two treatments consisting of 40% and 80% shade were applied at the onset of veraison. RESULTS: Results showed significant differences in the composition and concentration of anthocyanins throughout ripening. Compositional differences in PA were also observed, where shaded treatments had a significantly higher proportion of galloylated subunits. The molecular mass of the extracted tannin was significantly lower in the unshaded control than in the 80% shade treatment. These factors led to a lower measured tannin activity in extracts from exposed fruit. CONCLUSION: This work suggests that manipulation of canopy architecture, such as artificial shading, leads to changes in berry pigmentation, tannin composition and activity. These results show that the astringency and mouthfeel characteristics of a wine may be altered by vineyard management practices. © 2023 Society of Chemical Industry.
    Keywords agriculture ; anthocyanins ; astringency ; canopy ; flavonols ; fruits ; hydrophobicity ; molecular weight ; mouthfeel ; pigmentation ; proanthocyanidins ; ripening ; vineyards ; viticulture ; wine grapes ; wines
    Language English
    Dates of publication 2024-0115
    Size p. 352-361
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.12926
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  5. Article ; Online: Understanding good leadership in the context of English care home inspection reports.

    Mongan, Ceara / Thomas, Will

    Leadership in health services (Bradford, England)

    2021  Volume ahead-of-print, Issue ahead-of-print

    Abstract: Purpose: As part of their inspection of care homes in England, the statutory inspector (the Care Quality Commission [CQC]) makes a judgement on the quality of the home's leadership. Their view is critical as it is intended to inform consumer choice and ... ...

    Abstract Purpose: As part of their inspection of care homes in England, the statutory inspector (the Care Quality Commission [CQC]) makes a judgement on the quality of the home's leadership. Their view is critical as it is intended to inform consumer choice and because the statutory nature of inspection means these views hold considerable authority. The purpose of this paper is to look at the content of a selection of reports and seek to determine what the CQC understands by the concept of "good leadership".
    Design/methodology/approach: A purposive sample of recent CQC inspection reports was selected and subjected to a qualitative content analysis. Inspections are structured around five main questions. The resulting themes describe areas of focus within the section of reports that feature the question "Are they well-led?".
    Findings: Inspection reports were found to focus on four main themes: safety and quality of care; day-to-day management of staff; governance and training in the home; and integration and partnership working. In the discussion section, the authors reflect on these themes and suggest that the CQC's view of leadership is rather limited. In particular, while an emphasis is placed within the literature and policy on the importance of leadership in delivering change and quality improvement, little attention is paid to this within the leadership section of inspection reports.
    Research limitations/implications: The authors' research is based on a small-scale sample of inspection reports; nevertheless, it suggests a number of avenues for further research into the way in which leadership and management capabilities are developed and monitored in the sector.
    Originality/value: The analysis in this report offers a view of how the inspection regime implements its own guidance and how it assesses leadership. The reports, as public-facing documents, are artefacts of the inspection regime and critical not just as evidence of the practice of inspection but as influence on care home operations and the choices of care home residents and their families.
    MeSH term(s) England ; Humans ; Leadership ; Quality Improvement ; Quality of Health Care
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279996-5
    ISSN 1751-1887 ; 1751-1879 ; 1366-0756
    ISSN (online) 1751-1887
    ISSN 1751-1879 ; 1366-0756
    DOI 10.1108/LHS-11-2020-0098
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  6. Article ; Online: Effect of applied shading during fruit ripening on tannin structure-activity relationships of grape skin extracts.

    Campbell, James R / Thomas, Will / Waterhouse, Andrew L / Kennedy, James A

    Journal of the science of food and agriculture

    2023  Volume 104, Issue 1, Page(s) 352–361

    Abstract: Background: Historically, the effect of wine grape shading on flavonoids has investigated the impact of light incidence on proanthocyanidin (PA), flavonol, or anthocyanin concentration. In addition to concentration, the current experiment was designed ... ...

    Abstract Background: Historically, the effect of wine grape shading on flavonoids has investigated the impact of light incidence on proanthocyanidin (PA), flavonol, or anthocyanin concentration. In addition to concentration, the current experiment was designed to look at changes in PA composition, size and tannin activity through ripening. Tannin activity is a methodology for assessing the impact of structure and size on the affinity of tannin towards a hydrophobic surface and is considered to be a proxy for predicted astringency descriptive quality. In 2016 a shade cloth study was imposed on Cabernet Sauvignon on Mt Veeder, within the larger Napa Valley viticultural area. A control, which was unshaded, and two treatments consisting of 40% and 80% shade were applied at the onset of veraison.
    Results: Results showed significant differences in the composition and concentration of anthocyanins throughout ripening. Compositional differences in PA were also observed, where shaded treatments had a significantly higher proportion of galloylated subunits. The molecular mass of the extracted tannin was significantly lower in the unshaded control than in the 80% shade treatment. These factors led to a lower measured tannin activity in extracts from exposed fruit.
    Conclusion: This work suggests that manipulation of canopy architecture, such as artificial shading, leads to changes in berry pigmentation, tannin composition and activity. These results show that the astringency and mouthfeel characteristics of a wine may be altered by vineyard management practices. © 2023 Society of Chemical Industry.
    MeSH term(s) Tannins/analysis ; Fruit/chemistry ; Vitis/chemistry ; Anthocyanins/analysis ; Wine/analysis ; Structure-Activity Relationship
    Chemical Substances Tannins ; Anthocyanins
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.12926
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  7. Article ; Online: Prevalence of myeloperoxidase deficiency determined using an ADVIA 2120i.

    Gleghorn, Daniel Mark / Thomas, Will

    International journal of laboratory hematology

    2020  Volume 42, Issue 5, Page(s) e220–e223

    MeSH term(s) Female ; Humans ; Male ; Metabolism, Inborn Errors/blood ; Metabolism, Inborn Errors/epidemiology ; Middle Aged ; Neutrophils/metabolism ; Prevalence
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13265
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  8. Article ; Online: Severe refractory warm autoimmune haemolytic anaemia after the SARS-CoV-2 Pfizer-BioNTech vaccine (BNT162b2 mRNA) managed with emergency splenectomy and complement inhibition with eculizumab.

    Jackson, Emma Marguerite / Harper, Simon / Webb, Gwilym J / Thomas, Will

    BMJ case reports

    2022  Volume 15, Issue 8

    Abstract: A male in his teens with a history of liver transplant for biliary atresia (aged 2 years) and autoimmune haemolytic anaemia (AIHA, aged 6 years) presented with jaundice, dark urine, fatigue and chest discomfort that began 48 hours after the first dose of ...

    Abstract A male in his teens with a history of liver transplant for biliary atresia (aged 2 years) and autoimmune haemolytic anaemia (AIHA, aged 6 years) presented with jaundice, dark urine, fatigue and chest discomfort that began 48 hours after the first dose of SARS-CoV-2 Pfizer-BioNTech vaccine (BNT162b2 mRNA). Investigations revealed a warm AIHA picture. Over 4 weeks the patient developed life-threatening anaemia culminating in haemoglobin of 35 g/L (after transfusion), lactate dehydrogenase of 1293 units/L and bilirubin of 228 µmol/L, refractory to standard treatment with corticosteroids and rituximab. An emergency splenectomy was performed that slowed haemolysis but did not completely ameliorate it. Eculizumab, a terminal complement pathway inhibitor, was initiated to arrest intravascular haemolysis and showed a favourable response. AIHA is rare but described after the SARS-CoV-2 Pfizer-BioNTech vaccine. This case highlights the rare complication of AIHA, the use of emergency splenectomy for disease control, and the use of eculizumab.
    MeSH term(s) Adolescent ; Anemia, Hemolytic, Autoimmune/complications ; Antibodies, Monoclonal, Humanized ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/adverse effects ; Bilirubin ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Complement Inactivating Agents/therapeutic use ; Hemoglobins ; Hemolysis ; Humans ; Immunologic Factors/therapeutic use ; Lactate Dehydrogenases ; Male ; RNA, Messenger/therapeutic use ; Rituximab/therapeutic use ; SARS-CoV-2 ; Splenectomy/adverse effects
    Chemical Substances Antibodies, Monoclonal, Humanized ; COVID-19 Vaccines ; Complement Inactivating Agents ; Hemoglobins ; Immunologic Factors ; RNA, Messenger ; Rituximab (4F4X42SYQ6) ; eculizumab (A3ULP0F556) ; Lactate Dehydrogenases (EC 1.1.-) ; BNT162 Vaccine (N38TVC63NU) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250774
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  9. Article ; Online: Thrombin generation measured by two platforms in patients with a bleeding tendency: Comment.

    Thomas, Will / White, Danielle / MacDonald, Stephen

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 19, Issue 11, Page(s) 2896–2899

    MeSH term(s) Blood Coagulation Disorders ; Hemorrhagic Disorders ; Humans ; Thrombin
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15524
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  10. Article ; Online: Daratumumab for refractory immune-mediated thrombotic thrombocytopenic purpura.

    Aggarwal, Asha / White, Danielle / Pavord, Sue / Thomas, Will / Desborough, Michael J R

    British journal of haematology

    2023  Volume 202, Issue 2, Page(s) 429–433

    MeSH term(s) Humans ; Purpura, Thrombotic Thrombocytopenic/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Rituximab ; Plasma Exchange
    Chemical Substances daratumumab (4Z63YK6E0E) ; Antibodies, Monoclonal ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18854
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