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  1. Article ; Online: IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools

    Christina Kober / Sandro Manni / Svenja Wolff / Thomas Barnes / Shatanik Mukherjee / Thomas Vogel / Lea Hoenig / Peter Vogel / Aaron Hahn / Michaela Gerlach / Martin Vey / Eleonora Widmer / Björn Keiner / Patrick Schuetz / Nathan Roth / Uwe Kalina

    PLoS ONE, Vol 17, Iss

    2022  Volume 1

    Abstract: Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not ...

    Abstract Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247–567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to Spike-1 protein and the receptor-binding domain correlates strongly with viral neutralization in vitro. Furthermore, despite accounting for only approximately 12% of total immunoglobulin mass, collectively IgG3 and IgM account for approximately 80% of the total neutralization. This may have important implications for the development of potent therapies for COVID-19, as it indicates that hyperimmune globulins or convalescent plasma donations with high IgG3 concentrations may be a highly efficacious therapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools.

    Christina Kober / Sandro Manni / Svenja Wolff / Thomas Barnes / Shatanik Mukherjee / Thomas Vogel / Lea Hoenig / Peter Vogel / Aaron Hahn / Michaela Gerlach / Martin Vey / Eleonora Widmer / Björn Keiner / Patrick Schuetz / Nathan Roth / Uwe Kalina

    PLoS ONE, Vol 17, Iss 1, p e

    2022  Volume 0262162

    Abstract: Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not ...

    Abstract Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247-567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to Spike-1 protein and the receptor-binding domain correlates strongly with viral neutralization in vitro. Furthermore, despite accounting for only approximately 12% of total immunoglobulin mass, collectively IgG3 and IgM account for approximately 80% of the total neutralization. This may have important implications for the development of potent therapies for COVID-19, as it indicates that hyperimmune globulins or convalescent plasma donations with high IgG3 concentrations may be a highly efficacious therapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The effects of a four week primary and secondary speed training protocol on 40 yard sprint times in female college soccer players

    Jason Daniel Wagganer / Ronald D. Williams, Jr / Jeremy Thomas Barnes

    Journal of Human Sport and Exercise, Vol 9, Iss 3, Pp 713-

    2015  Volume 726

    Abstract: Improvements in running speed have been attributed to both primary and secondary speed training techniques. Primary techniques involve attention to running mechanics and form, and secondary techniques involve resisted or assisted sprinting. The purpose ... ...

    Abstract Improvements in running speed have been attributed to both primary and secondary speed training techniques. Primary techniques involve attention to running mechanics and form, and secondary techniques involve resisted or assisted sprinting. The purpose of this study was to assess the effect of combining both primary and secondary speed training techniques on 40 yard sprint speed in young soccer players. PURPOSE: To compare the effects of pre- and post- four week speed training protocol on 40-yard sprint times in female collegiate soccer players. METHODS: Twelve (19.5+1.5y) normal weight (BMI: 22.7+3.4 kg∙m-2) and body composition (BF: 27.75+3.8%) active white female collegiate soccer players participated in a four week training protocol which implemented primary and secondary speed training methods. A standard running mechanics program was implemented two times per week and was immediately followed by resisted or assisted sprinting. Sled towing was chosen for resisted sprinting, while elastic towing devices were chosen for assisted sprinting. Forty yard sprint times were assessed pre and post protocol. Statistical analysis was conducted using SPSS. RESULTS: A paired samples t-test showed the four week speed training protocol elicited statistically significant reductions in 40 yard sprint times (p<0.001). The average sprint time decreased by 0.248 seconds (pre=5.463+0.066 vs post=5.215+0.053). CONCLUSION: A four week speed training protocol of primary and secondary techniques may play a significant role in reducing 40 yard sprint times in college female soccer athletes. Values are presented as (mean+SEM)
    Keywords Biomechanics ; Sprinting ; Exercise physiology ; Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2015-03-01T00:00:00Z
    Publisher University of Alicante
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: Diseases and parasites of livestock in the tropics

    Hall, Harold Thomas Barnes

    (Intermediate tropical agriculture series)

    1985  

    Author's details H.T.B. Hall
    Series title Intermediate tropical agriculture series
    Keywords Animal Diseases ; Livestock/Diseases ; Parasitic Diseases, Animal ; Tropical Climate ; Veterinary parasitology ; Veterinary tropical medicine ; Parasit ; Nutztiere ; Tropen ; Infektionskrankheit ; Haustiere
    Subject Nutztier ; Landwirtschaftliche Nutztiere ; Vieh ; Nutzvieh ; Schmarotzer ; Parasiten ; Haustier ; Ansteckende Krankheit ; Kontagiöse Krankheit ; Infektionskrankheiten
    Language English
    Size XX, 328 Seiten, Illustrationen
    Edition Second edition
    Publisher Longman
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT021689355
    ISBN 0-582-77514-0 ; 978-0-582-77514-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    858/1748 +2 order for loan Geschlossenes Magazin (U2)

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  5. Article: Life history of Argyrosomus japonicus, a large sciaenid at the southern part of its global distribution: Implications for fisheries management

    Ferguson, Greg J / Alex Ivey / Thomas Barnes / Tim M. Ward

    Elsevier B.V. Fisheries research. 2014 Mar., v. 151

    2014  

    Abstract: The life-history of the sciaenid Argyrosomus japonicus in South Australia was investigated to inform a review of fisheries management. Validated, otolith-based growth coefficients for females (Linf=1430.52, K=0.137, t0=−0.303, n=209) and males (Linf=1356. ...

    Abstract The life-history of the sciaenid Argyrosomus japonicus in South Australia was investigated to inform a review of fisheries management. Validated, otolith-based growth coefficients for females (Linf=1430.52, K=0.137, t0=−0.303, n=209) and males (Linf=1356.23, K=0.159, t0=0.000, n=185) suggested high asymptotic size and low growth rates, relative to other populations. A growth performance index (ω) was lower for A. japonicus in South Australia than for other populations. Sizes at 50 and 95% maturity (SAM50,95) were 850 and 1028mm TL, respectively for females and 778 and 923mm TL, respectively for males. Age structures from 2011 appeared truncated compared to those from 2001 and 2002 with no individuals greater than 10 years old. The dominant year class observed in age structures from 2001 and 2002 was not present in 2011. This may reflect the combined effects of historically severe drought from 2002 to 2010 and fishing. This population is vulnerable to fishing as juveniles in estuarine habitat and as adults in spawning aggregations in marine habitat. Loss of protected estuarine habitat for juveniles from flow regulation and drought may make this population particularly vulnerable to overfishing. Whilst maintenance of appropriately timed freshwater inflows to estuarine habitat is important for this population their availability is uncertain. Populations of A. japonicus in South Australia would benefit from management measures that: (i) aim to preserve capacity for egg production; (ii) allow recruits to enter the adult population; and that (iii) rebuild and maintain long-tailed age structures. Amendments to the legal minimum size and the protection of juveniles in estuaries and the adult spawning/feeding aggregations are recommended.
    Keywords adults ; Argyrosomus japonicus ; drought ; egg production ; estuaries ; females ; fisheries management ; freshwater ; geographical distribution ; growth performance ; habitats ; juveniles ; life history ; males ; overfishing ; spawning ; South Australia
    Language English
    Dates of publication 2014-03
    Size p. 148-157.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 406532-3
    ISSN 0165-7836
    ISSN 0165-7836
    DOI 10.1016/j.fishres.2013.11.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3666: Show issues

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  6. Book: Diseases and parasites of livestock in the Tropics

    Hall, Harold Thomas Barnes

    (Intermediate tropical agriculture series)

    1977  

    Author's details H.T.B. Hall
    Series title Intermediate tropical agriculture series
    Language English
    Size 288 S. : Ill.
    Publisher Longman
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018305068
    ISBN 0-582-60618-7 ; 978-0-582-60618-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    858/1748 order for loan Geschlossenes Magazin (U2)

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  7. Article ; Online: Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population levelResearch in context

    Anouschka Akerman / Vanessa Milogiannakis / Tyra Jean / Camille Esneau / Mariana Ruiz Silva / Timothy Ison / Christina Fichter / Joseph A. Lopez / Deborah Chandra / Zin Naing / Joanna Caguicla / Daiyang Li / Gregory Walker / Supavadee Amatayakul-Chantler / Nathan Roth / Sandro Manni / Thomas Hauser / Thomas Barnes / Anna Condylios /
    Malinna Yeang / Maureen Wong / Charles S.P. Foster / Kenta Sato / Sharon Lee / Yang Song / Lijun Mao / Allison Sigmund / Amy Phu / Ann Marie Vande More / Stephanie Hunt / Mark Douglas / Ian Caterson / Warwick Britton / Kerrie Sandgren / Rowena Bull / Andrew Lloyd / Jamie Triccas / Stuart Tangye / Nathan W. Bartlett / David Darley / Gail Matthews / Damien J. Stark / Kathy Petoumenos / William D. Rawlinson / Ben Murrell / Fabienne Brilot / Anthony L. Cunningham / Anthony D. Kelleher / Anupriya Aggarwal / Stuart G. Turville

    EBioMedicine, Vol 90, Iss , Pp 104545- (2023)

    2023  

    Abstract: Summary: Background: The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a ... ...

    Abstract Summary: Background: The Omicron era of the COVID-19 pandemic commenced at the beginning of 2022 and whilst it started with primarily BA.1, it was latter dominated by BA.2 and the related sub-lineage BA.5. Following resolution of the global BA.5 wave, a diverse grouping of Omicron sub-lineages emerged derived from BA.2, BA.5 and recombinants thereof. Whilst emerging from distinct lineages, all shared similar changes in the Spike glycoprotein affording them an outgrowth advantage through evasion of neutralising antibodies. Methods: Over the course of 2022, we monitored the potency and breadth of antibody neutralization responses to many emerging variants in the Australian community at three levels: (i) we tracked over 420,000 U.S. plasma donors over time through various vaccine booster roll outs and Omicron waves using sequentially collected IgG pools; (ii) we mapped the antibody response in individuals using blood from stringently curated vaccine and convalescent cohorts. (iii) finally we determine the in vitro efficacy of clinically approved therapies Evusheld and Sotrovimab. Findings: In pooled IgG samples, we observed the maturation of neutralization breadth to Omicron variants over time through continuing vaccine and infection waves. Importantly, in many cases, we observed increased antibody breadth to variants that were yet to be in circulation. Determination of viral neutralization at the cohort level supported equivalent coverage across prior and emerging variants with isolates BQ.1.1, XBB.1, BR.2.1 and XBF the most evasive. Further, these emerging variants were resistant to Evusheld, whilst increasing neutralization resistance to Sotrovimab was restricted to BQ.1.1 and XBF. We conclude at this current point in time that dominant variants can evade antibodies at levels equivalent to their most evasive lineage counterparts but sustain an entry phenotype that continues to promote an additional outgrowth advantage. In Australia, BR.2.1 and XBF share this phenotype and, in contrast to global variants, are ...
    Keywords SARS-CoV-2 ; Variants ; TMPRSS2 ; Covid-19 ; Neutralising antibodies ; Sotrovimab ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Primary care management of cardiovascular risk for people with severe mental illnesses

    David Osborn / Alexandra Burton / Kate Walters / Lou Atkins / Thomas Barnes / Ruth Blackburn / Thomas Craig / Hazel Gilbert / Ben Gray / Sarah Hardoon / Samira Heinkel / Richard Holt / Rachael Hunter / Claire Johnston / Michael King / Judy Leibowitz / Louise Marston / Susan Michie / Richard Morris /
    Steve Morris / Irwin Nazareth / Rumana Omar / Irene Petersen / Robert Peveler / Vanessa Pinfold / Fiona Stevenson / Ella Zomer

    Programme Grants for Applied Research, Vol 7, Iss

    the Primrose research programme including cluster RCT

    2019  Volume 2

    Abstract: Background: Effective interventions are needed to prevent cardiovascular disease (CVD) in people with severe mental illnesses (SMI) because their risk of CVD is higher than that of the general population. Objectives: (1) Develop and validate risk models ... ...

    Abstract Background: Effective interventions are needed to prevent cardiovascular disease (CVD) in people with severe mental illnesses (SMI) because their risk of CVD is higher than that of the general population. Objectives: (1) Develop and validate risk models for predicting CVD events in people with SMI and evaluate their cost-effectiveness, (2) develop an intervention to reduce levels of cholesterol and CVD risk in SMI and (3) test the clinical effectiveness and cost-effectiveness of this new intervention in primary care. Design: Mixed methods with patient and public involvement throughout. The mixed methods were (1) a prospective cohort and risk score validation study and cost-effectiveness modelling, (2) development work (focus groups, updated systematic review of interventions, primary care database studies investigating statin prescribing and effectiveness) and (3) cluster randomised controlled trial (RCT) assessing the clinical effectiveness and cost-effectiveness of a new practitioner-led intervention, and fidelity assessment of audio-recorded appointments. Setting: General practices across England. Participants: All studies included adults with SMI (schizophrenia, bipolar disorder or other non-organic psychosis). The RCT included adults with SMI and two or more CVD risk factors. Interventions: The intervention consisted of 8–12 appointments with a practice nurse/health-care assistant over 6 months, involving collaborative behavioural approaches to CVD risk factors. The intervention was compared with routine practice with a general practitioner (GP). Main outcome measures: The primary outcome for the risk score work was CVD events, in the cost-effectiveness modelling it was quality-adjusted life-years (QALYs) and in the RCT it was level of total cholesterol. Data sources: Databases studies used The Health Improvement Network (THIN). Intervention development work included focus groups and systematic reviews. The RCT collected patient self-reported and routine NHS GP data. Intervention appointments were ...
    Keywords severe mental illness ; schizophrenia ; bipolar ; psychosis ; primary care ; general practice ; statin ; cholesterol ; cardiovascular risk ; randomised controlled trial ; risk score ; qualitative ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher NIHR Journals Library
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book: Diseases and parasites of livestock in the tropics

    Hall, Harold Thomas Barnes

    1988  

    Author's details Harold Thomas Barnes Hall
    Language Undetermined
    Size 328 S
    Edition 2. ed
    Document type Book
    ISBN 0582775140 ; 9780582775145
    Database Special collection on veterinary medicine and general parasitology

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  10. Book: Diseases and parasites of livestock in the tropics

    Hall, Harold Thomas Barnes

    (Intermediate tropical agriculture series)

    1985  

    Author's details H.T.B. Hall. --
    Series title Intermediate tropical agriculture series
    Keywords Veterinary tropical medicine. ; Veterinary parasitology ; Parasitic diseases.
    Language English
    Size xx, 328 p. :, ill. ;, 22 cm. --
    Edition 2nd ed. --
    Publisher Longman
    Publishing place London ; New York
    Document type Book
    ISBN 0582775140 ; 9780582775145
    Database NAL-Catalogue (AGRICOLA)

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