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Article ; Online: Low-temperature triple-alpha rate in a full three-body nuclear model.

Nguyen, N B / Nunes, F M / Thompson, I J / Brown, E F

2012 Volume 109, Issue 14, Page(s) 141101

Abstract: A new three-body method is used to compute the rate of the triple-alpha capture reaction, which is the primary source of 12C in stars. In this Letter, we combine the Faddeev hyperspherical harmonics and the R-matrix method to obtain a full solution to ... ...

Abstract	A new three-body method is used to compute the rate of the triple-alpha capture reaction, which is the primary source of 12C in stars. In this Letter, we combine the Faddeev hyperspherical harmonics and the R-matrix method to obtain a full solution to the three-body α+α+α continuum. Particular attention is paid to the long-range effects caused by the pairwise Coulomb interactions. The new rate agrees with the Nuclear Astrophysics Compilation of Reaction rates for temperatures greater than 0.07 GK, but a large enhancement at lower temperature is found (≈10(12) at 0.02 GK). Our results are compared to previous calculations where additional approximations were made. We show that the new rate does not significantly change the evolution of stars around one solar mass. In particular, such stars still undergo a red-giant phase consistent with observations, and no significant differences are found in the final white dwarfs.
Language	English
Publishing date	2012-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.109.141101
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Article ; Online: Neutron-capture cross sections from indirect measurements

Scielzo N.D. / Ressler J.J. / Dietrich F.S. / Burke J.T. / Escher J.E. / Thompson I.J.

EPJ Web of Conferences, Vol 21, p

2012 Volume 01001

Abstract: Cross sections for compound-nuclear reactions reactions play an important role in models of astrophysical environments and simulations of the nuclear fuel cycle. Providing reliable cross section data remains a formidable task, and direct measurements ... ...

Abstract	Cross sections for compound-nuclear reactions reactions play an important role in models of astrophysical environments and simulations of the nuclear fuel cycle. Providing reliable cross section data remains a formidable task, and direct measurements have to be complemented by theoretical predictions and indirect methods. The surrogate nuclear reactions method provides an indirect approach for determining cross sections for reactions on unstable isotopes, which are difficult or impossible to measure otherwise. Current implementations of the method provide useful cross sections for (n,f) reactions, but need to be improved upon for applications to capture reactions.
Keywords	Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
Language	English
Publishing date	2012-02-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity.

Gregory, A E / Williamson, E D / Prior, J L / Butcher, W A / Thompson, I J / Shaw, A M / Titball, R W

Vaccine

2012 Volume 30, Issue 48, Page(s) 6777–6782

Abstract: The efficacy of 15 nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N'- ... ...

Abstract	The efficacy of 15 nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride coupling chemistry. Mice given AuNP-F1 in alhydrogel generated the greatest IgG antibody response to F1-antigen when compared with mice given AuNP-F1 in PBS or given unconjugated F1-antigen in PBS or alhydrogel. Compared with unconjugated F1-antigen, the IgG2a response was enhanced in mice dosed with AuNP-F1 in PBS (p<0.05) but not in mice immunised with AuNP-F1 in alhydrogel. All treatment groups developed a memory response to F1-antigen, the polarity of which was inflenced by formulation in alhydrogel. The sera raised against F1-antigen coupled to AuNPs was able to competitively bind to rF1-antigen, displacing protective macaque sera.
MeSH term(s)	Adjuvants, Immunologic/administration & dosage ; Animals ; Antibodies, Bacterial/blood ; Bacterial Proteins/administration & dosage ; Bacterial Proteins/immunology ; Drug Carriers/administration & dosage ; Female ; Gold/administration & dosage ; Immunoglobulin G/blood ; Immunologic Memory ; Mice ; Mice, Inbred BALB C ; Nanoparticles/administration & dosage ; Plague Vaccine/administration & dosage ; Plague Vaccine/immunology
Chemical Substances	Adjuvants, Immunologic ; Antibodies, Bacterial ; Bacterial Proteins ; Drug Carriers ; Immunoglobulin G ; Plague Vaccine ; caf1 protein, Yersinia pestis ; Gold (7440-57-5)
Language	English
Publishing date	2012-09-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2012.09.021
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Book: Evidence of projectile polarisation effects on the reaction 208 Pb(17 O,16 O)209 Pb

Thompson, I. J

(Preprint / Daresbury Laboratory, Science and Engineering Research Council : DL NUC P ; 267 T)

1988

Author's details	by I. J. Thompson
Series title	Preprint / Daresbury Laboratory, Science and Engineering Research Council : DL NUC P ; 267 T
Language	English
Size	19 Doppels., [4] Bl., graph. Darst.
Publisher	Daresbury Laboratory, Science and Engineering Research Council
Publishing place	Daresbury, Warrington
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Development and operation of the defence COVID-19 lab as a SARS-CoV-2 diagnostic screening capability for UK military personnel.

Weller, Simon A / Armstrong, S R / Bailey, S / Burnell, H T / Burt, E L / Cant, N E / Cawthorne, K R / Chester, M / Choules, J E / Coe, N A / Coward, L / Cox, V L / Emery, E R / Evans, C P / Finn, A / Halford, C M / Hamblin, K A / Harrison, G V / Hartley, M G /

Hudson, C / James, B / Jones, H E / Keyser, E / Lonsdale, C L / Marshall, L E / Maule, C E / Miles, J A / Newstead, S L / Nicholls, M / Osborne, C / Pearcy, A S / Penny, L D / Perrot, R / Rachwal, P / Robinson, V / Rushton, D / Stahl, F M / Staplehurst, S V / Stapleton, H L / Steeds, K / Stephenson, K / Thompson, I J / Thwaite, J E / Ulaeto, D O / Waters, N / Wills, D J / Wills, Z S / Rees, C / Hutley, E J

BMJ military health

2022

Abstract: Background: In the face of the COVID-19 pandemic, the Defence Science and Technology Laboratory (Dstl) and Defence Pathology combined to form the Defence Clinical Lab (DCL), an accredited (ISO/IEC 17025:2017) high-throughput SARS-CoV-2 PCR screening ... ...

Abstract	Background: In the face of the COVID-19 pandemic, the Defence Science and Technology Laboratory (Dstl) and Defence Pathology combined to form the Defence Clinical Lab (DCL), an accredited (ISO/IEC 17025:2017) high-throughput SARS-CoV-2 PCR screening capability for military personnel. Laboratory structure and resource: The DCL was modular in organisation, with laboratory modules and supporting functions combining to provide the accredited SARS-CoV-2 (envelope (E)-gene) PCR assay. The DCL was resourced by Dstl scientists and military clinicians and biomedical scientists. Laboratory results: Over 12 months of operation, the DCL was open on 289 days and tested over 72 000 samples. Six hundred military SARS-CoV-2-positive results were reported with a median E-gene quantitation cycle (Cq) value of 30.44. The lowest Cq value for a positive result observed was 11.20. Only 64 samples (0.09%) were voided due to assay inhibition after processing started. Conclusions: Through a sustained effort and despite various operational issues, the collaboration between Dstl scientific expertise and Defence Pathology clinical expertise provided the UK military with an accredited high-throughput SARS-CoV-2 PCR test capability at the height of the COVID-19 pandemic. The DCL helped facilitate military training and operational deployments contributing to the maintenance of UK military capability. In offering a bespoke capability, including features such as testing samples in unit batches and oversight by military consultant microbiologists, the DCL provided additional benefits to the UK Ministry of Defence that were potentially not available from other SARS-CoV-2 PCR laboratories. The links between Dstl and Defence Pathology have also been strengthened, benefitting future research activities and operational responses.
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3011686-7
ISSN	2633-3775 ; 2633-3767
ISSN (online)	2633-3775
ISSN	2633-3767
DOI	10.1136/military-2022-002134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Contribution of multistep transfers to low-energy elastic and reaction cross sections

Thompson, I. J

(Preprint / Daresbury Laboratory, Science and Engineering Research Council : DL NUC P ; 212 T)

1985

Author's details	by I. J. Thompson
Series title	Preprint / Daresbury Laboratory, Science and Engineering Research Council : DL NUC P ; 212 T
Language	English
Size	8 Doppels., [1] Bl., graph. Darst.
Publisher	Daresbury Laboratory, Science and Engineering Research Council
Publishing place	Daresbury, Warrington
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity

Gregory, A.E / Williamson, E.D / Prior, J.L / Butcher, W.A / Thompson, I.J / Shaw, A.M / Titball, R.W

Vaccine. 2012 Nov. 6, v. 30, no. 48

2012

Abstract: The efficacy of 15nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N′- ... ...

Abstract	The efficacy of 15nm gold nanoparticles (AuNP) coated with Yersinia pestis F1-antigen, as an immunogen in mice, has been assessed. The nanoparticles were decorated with F1-antigen using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride coupling chemistry. Mice given AuNP-F1 in alhydrogel generated the greatest IgG antibody response to F1-antigen when compared with mice given AuNP-F1 in PBS or given unconjugated F1-antigen in PBS or alhydrogel. Compared with unconjugated F1-antigen, the IgG2a response was enhanced in mice dosed with AuNP-F1 in PBS (p<0.05) but not in mice immunised with AuNP-F1 in alhydrogel. All treatment groups developed a memory response to F1-antigen, the polarity of which was inflenced by formulation in alhydrogel. The sera raised against F1-antigen coupled to AuNPs was able to competitively bind to rF1-antigen, displacing protective macaque sera.
Keywords	Yersinia pestis ; antigens ; immune response ; immunoglobulin G ; mice ; nanogold ; nanoparticles ; vaccines
Language	English
Dates of publication	2012-1106
Size	p. 6777-6782.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2012.09.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Coupled-channel calculation of nonelastic cross sections using a density-functional structure model.

Nobre, G P A / Dietrich, F S / Escher, J E / Thompson, I J / Dupuis, M / Terasaki, J / Engel, J

Physical review letters

2010 Volume 105, Issue 20, Page(s) 202502

Abstract: A microscopic calculation of reaction cross sections for nucleon-nucleus scattering was performed by coupling the elastic channel to all particle-hole excitations in the target and one-nucleon pickup channels. The particle-hole states may be regarded as ... ...

Abstract	A microscopic calculation of reaction cross sections for nucleon-nucleus scattering was performed by coupling the elastic channel to all particle-hole excitations in the target and one-nucleon pickup channels. The particle-hole states may be regarded as doorway states through which the flux flows to more complicated configurations, and subsequently to long-lived compound nucleus resonances. Target excitations for (40,48)Ca, 58Ni, 90Zr, and 144Sm were described in a random-phase framework using a Skyrme functional. Reaction cross sections obtained agreed very well with experimental data and predictions of a fitted optical potential. Couplings between inelastic states were found to be negligible, while the pickup channels contribute significantly. For the first time observed absorptions are completely accounted for by explicit channel coupling, for incident energies between 10 and 40 MeV.
MeSH term(s)	Elasticity ; Models, Molecular ; Quantum Theory ; Thermodynamics
Language	English
Publishing date	2010-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.105.202502
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Article: 15C-15F Charge symmetry and the 14C(n,gamma)15C reaction puzzle.

Timofeyuk, N K / Baye, D / Descouvemont, P / Kamouni, R / Thompson, I J

Physical review letters

2006 Volume 96, Issue 16, Page(s) 162501

Abstract: The low-energy reaction 14C(n,gamma)15C provides a rare opportunity to test indirect methods for the determination of neutron capture cross sections by radioactive isotopes versus direct measurements. It is also important for various astrophysical ... ...

Abstract	The low-energy reaction 14C(n,gamma)15C provides a rare opportunity to test indirect methods for the determination of neutron capture cross sections by radioactive isotopes versus direct measurements. It is also important for various astrophysical scenarios. Currently, puzzling disagreements exist between the 14C(n,gamma)15C cross sections measured directly, determined indirectly, and calculated theoretically. To solve this puzzle, we offer a strong test based on a novel idea that the amplitudes for the virtual 15C-->14C + n and the real 15F -->14O + p decays are related. Our study of this relation, performed in a microscopic model, shows that existing direct and some indirect measurements strongly contradict charge symmetry in the 15C and 15F mirror pair. This brings into question the experimental determinations of the astrophysically important (n,gamma) cross sections for short-lived radioactive targets.
Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.96.162501
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Article: Two-proton widths of 12O, 16Ne, and three-body mechanism of Thomas-Ehrman shift.

Grigorenko, L V / Mukha, I G / Thompson, I J / Zhukov, M V

Physical review letters

2002 Volume 88, Issue 4, Page(s) 42502

Abstract: Two-proton decays of 12O and 16Ne ground states are studied in a three-body model. We have found that the two-proton widths for the states should be much less than the existing experimental values (about 10 times for 12O and about 100 times for 16Ne). We ...

Abstract	Two-proton decays of 12O and 16Ne ground states are studied in a three-body model. We have found that the two-proton widths for the states should be much less than the existing experimental values (about 10 times for 12O and about 100 times for 16Ne). We also have found that the structure of these states differs significantly from the mirror isobaric analog states (IAS): breaking of isobaric symmetry is at the level of tens of percents. Together with a corresponding decrease of the Coulomb energy, this effect can be considered as a three-body mechanism of the Thomas-Ehrman shift.
Language	English
Publishing date	2002-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.88.042502
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