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  1. Article ; Online: Investigating the potential contribution of inter-track interactions within ultra-high dose-rate proton therapy.

    Thompson, Shannon J / Prise, Kevin M / McMahon, Stephen J

    Physics in medicine and biology

    2023  Volume 68, Issue 5

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Proton Therapy/methods ; Protons ; Monte Carlo Method
    Chemical Substances Protons
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acb88a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: High-LET radiation induces large amounts of rapidly-repaired sublethal damage.

    Guerra Liberal, Francisco D C / Thompson, Shannon J / Prise, Kevin M / McMahon, Stephen J

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11198

    Abstract: There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clarify these ... ...

    Abstract There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clarify these effects by quantifying and modelling responses to X-ray and alpha particle combinations. Cells were exposed to X-rays, alpha particles, or combinations, with different doses and temporal separations. DNA damage was assessed by 53BP1 immunofluorescence, and radiosensitivity assessed using the clonogenic assay. Mechanistic models were then applied to understand trends in repair and survival. 53BP1 foci yields were significantly reduced in alpha particle exposures compared to X-rays, but these foci were slow to repair. Although alpha particles alone showed no inter-track interactions, substantial interactions were seen between X-rays and alpha particles. Mechanistic modelling suggested that sublethal damage (SLD) repair was independent of radiation quality, but that alpha particles generated substantially more sublethal damage than a similar dose of X-rays, [Formula: see text]. This high RBE may lead to unexpected synergies for combinations of different radiation qualities which must be taken into account in treatment design, and the rapid repair of this damage may impact on mechanistic modelling of radiation responses to high LETs.
    MeSH term(s) Radiation, Ionizing ; Alpha Particles ; Biological Assay ; DNA Damage ; Radiation Tolerance
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38295-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluating Iodine-125 DNA Damage Benchmarks of Monte Carlo DNA Damage Models.

    Thompson, Shannon J / Rooney, Aoife / Prise, Kevin M / McMahon, Stephen J

    Cancers

    2022  Volume 14, Issue 3

    Abstract: A wide range of Monte Carlo models have been applied to predict yields of DNA damage based on nanoscale track structure calculations. While often similar on the macroscopic scale, these models frequently employ different assumptions which lead to ... ...

    Abstract A wide range of Monte Carlo models have been applied to predict yields of DNA damage based on nanoscale track structure calculations. While often similar on the macroscopic scale, these models frequently employ different assumptions which lead to significant differences in nanoscale dose deposition. However, the impact of these differences on key biological readouts remains unclear. A major challenge in this area is the lack of robust datasets which can be used to benchmark models, due to a lack of resolution at the base pair level required to deeply test nanoscale dose deposition. Studies investigating the distribution of strand breakage in short DNA strands following the decay of incorporated
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14030463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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