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  1. Article ; Online: Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection.

    Damman, Elise / Trecourt, Alexis / de la Fournière, Benoit / Lebreton, Frédérique / Gaillot-Durand, Lucie / Fichez, Axel / Chauvy, Lauriane / Thonnon, Cyrielle / Destras, Gregory / Devouassoux-Shisheboran, Mojgan / Allias, Fabienne

    Placenta

    2023  Volume 136, Page(s) 1–7

    Abstract: Introduction: SARS-Cov-2 infection during pregnancy can lead to severe placental lesions characterized by massive perivillous fibrin deposition, histiocytic intervillositis and trophoblast necrosis. Diffuse placental damage of this kind is rare, but can ...

    Abstract Introduction: SARS-Cov-2 infection during pregnancy can lead to severe placental lesions characterized by massive perivillous fibrin deposition, histiocytic intervillositis and trophoblast necrosis. Diffuse placental damage of this kind is rare, but can sometimes lead to obstetric complications, such as intrauterine fetal death (IUFD). The objectives of this study were to identify possible predictors of severe placental lesions.
    Methods: We retrospectively studied 96 placentas from SARS-Cov-2 positive pregnant women who gave birth between March 2020 and March 2022. Cases with and without severe placental lesions were compared in terms of clinical and laboratory findings.
    Results: Twelve of the 96 patients had severe placental lesions. There was no significant association with diabetes, obesity or severe clinical maternal disease. In contrast, presence of severe placental lesions was significantly associated with neonatal intensive care, cesarean section, prematurity, IUFD, intrauterine growth restriction (IUGR), gestational age, maternal hypofibrinogenemia and thrombocytopenia. No cases of severe placental lesions were observed in vaccinated patients or in those with the Omicron variant.
    Discussion: In these patients, severe placental lesions due to SARS-Cov-2 were significantly associated with the presence of coagulation abnormalities (hypofibrinogenemia and thrombocytopenia), IUGR and gestational age. These results support laboratory and ultrasound monitoring of these parameters in pregnant women with SARS-Cov-2 infection, especially during the second trimester, to predict potential negative fetal outcomes.
    MeSH term(s) Infant, Newborn ; Female ; Pregnancy ; Humans ; Placenta/pathology ; COVID-19/complications ; COVID-19/pathology ; SARS-CoV-2 ; Pregnant Women ; Cesarean Section/adverse effects ; Retrospective Studies ; Afibrinogenemia/complications ; Afibrinogenemia/pathology ; Stillbirth ; Fetal Death/etiology ; Pregnancy Complications, Infectious/pathology ; Fetal Growth Retardation/pathology
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: GGCX-related congenital combined vitamin K-dependent clotting factors deficiency-1: Description of a fetus with chondrodysplasia punctata.

    Mathonnet, Alix / Cunat, Séverine / Allias, Fabienne / Caillot, Sandrine / Thonnon, Cyrielle / Till, Marianne / Attié-Bitach, Tania / Touraine, Renaud / Meunier, Sandrine / Cartellier, Charline / Rossi, Massimiliano / Attia, Jocelyne / Putoux, Audrey

    American journal of medical genetics. Part A

    2021  Volume 188, Issue 1, Page(s) 314–318

    Abstract: Congenital combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare autosomal recessive disease resulting in hemorrhagic symptoms usually associated with developmental disorders and bone abnormalities. Pathogenic variants in two genes ... ...

    Abstract Congenital combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare autosomal recessive disease resulting in hemorrhagic symptoms usually associated with developmental disorders and bone abnormalities. Pathogenic variants in two genes encoding enzymes of the vitamin K cycle, GGCX and VKORC1, can lead to this disorder. We present the case of a male fetus with a brachytelephalangic chondrodysplasia punctata (CDP), absence of nasal bone, growth restriction, and bilateral ventriculomegaly at 18 weeks of gestation. Pathological examination showed a Binder phenotype, hypoplastic distal phalanges, stippled epiphyses, and brain abnormalities suggestive of a brain hemorrhage. Two GGCX pathogenic variants inherited respectively from the mother and the father were identified. To our knowledge, this is the first prenatal description of VKCFD. Even if it remains a rare etiology, which is mostly described in children or adult patients, VKCFD should be considered in fetuses with CDP.
    MeSH term(s) Blood Coagulation Factors ; Carbon-Carbon Ligases/genetics ; Chondrodysplasia Punctata/diagnosis ; Chondrodysplasia Punctata/genetics ; Female ; Fetus ; Humans ; Male ; Pregnancy ; Vitamin K ; Vitamin K 1 ; Vitamin K Epoxide Reductases/genetics
    Chemical Substances Blood Coagulation Factors ; Vitamin K (12001-79-5) ; Vitamin K 1 (84-80-0) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4) ; Carbon-Carbon Ligases (EC 6.4.-)
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2108614-X
    ISSN 1552-4833 ; 0148-7299 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 0148-7299 ; 1552-4825
    DOI 10.1002/ajmg.a.62503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1376/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Intérêt du bilan d'extension dans le cancer du sein avant chimiothérapie adjuvante.

    Thonnon, Cyrielle / Faure, Christelle / Chopin, Nicolas / Beurrier, Frédéric / Ho Quoc, Christophe / Tredan, Olivier / Carrabin, Nicolas

    Bulletin du cancer

    2015  Volume 102, Issue 5, Page(s) 411–416

    Abstract: Introduction: Systematic metastasis staging in early breast cancer is no longer recommended. However, it is still performed before adjuvant chemotherapy.: Materials and methods: We assessed metastasis screening of asymptomatic women with a local ... ...

    Title translation Metastatic screening before adjuvant chemotherapy in breast cancer.
    Abstract Introduction: Systematic metastasis staging in early breast cancer is no longer recommended. However, it is still performed before adjuvant chemotherapy.
    Materials and methods: We assessed metastasis screening of asymptomatic women with a local breast cancer without lymph node involvement when adjuvant chemotherapy was indicated. The screening result was classified in 3 groups: "non-metastatic", "metastatic" and "suspect". For suspect screening, we analyzed the checking period and the consequences on cares.
    Results: Out of 1545 patients with possible indication of chemotherapy, 690 indications of chemotherapy were validated by multidisciplinary meeting. Six hundred and thirty-nine metastasis screening were done. Five hundred and fifty-five screenings (86.9 %) were "non-metastatic", 3 screenings (0.5 %) were "metastatic" and 81 screenings (12.7 %) were "suspect". Out of this 81 suspect screening, only 47 screening have been checked, using 61 further investigations. No breast cancer metastasis was finally identified.
    Conclusion: Low rate of metastasis suggest reassessing metastasis screening before adjuvant chemotherapy for patients without lymph node involvement.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Chemotherapy, Adjuvant ; Female ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Middle Aged ; Retrospective Studies
    Language French
    Publishing date 2015-05
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2015.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.15: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Three-dimensional ultrasound in the management of bladder endometriosis.

    Thonnon, Cyrielle / Philip, Charles-André / Fassi-Fehri, Hakim / Bisch, Christian / Coulon, Agnès / de Saint-Hilaire, Pierre / Dubernard, Gil

    Journal of minimally invasive gynecology

    2015  Volume 22, Issue 3, Page(s) 403–409

    Abstract: Study objective: To assess the performance of three-dimensional (3D) ultrasound with color Doppler in the diagnosis of bladder endometriosis compared with magnetic resonance imaging (MRI) and cystoscopy.: Design: Canadian Task Force classification II- ...

    Abstract Study objective: To assess the performance of three-dimensional (3D) ultrasound with color Doppler in the diagnosis of bladder endometriosis compared with magnetic resonance imaging (MRI) and cystoscopy.
    Design: Canadian Task Force classification II-3.
    Setting: Department of gynecology and obstetrics of a university hospital.
    Patients: Eight women who reported urinary tract symptoms suggestive of bladder endometriosis between May 2012 and November 2013.
    Interventions: For all cases, we assessed the size of the endometriotic nodule, its location on the bladder wall, and the distance between the lesion and the ureteral meatus, with pelvic 3D ultrasound (full bladder), uro-MRI, and cystoscopy. The results were compared with the postoperative histopathologic findings.
    Measurements and main results: The pathology results differed from those produced by imaging by a mean ± SD of -3.5 ± 6.4 mm on transvaginal ultrasound (TVUS) and -5.75 ± 11.9 mm) for MRI. There was no significant difference between imaging and pathology findings (p = .20) or between the 2 imaging findings (TVUS and MRI) (p = .73). Results showed a trend toward better accuracy for 3D ultrasound than MRI with smaller SDs (p = .08). Cystoscopy and ultrasound were compared; however, without any tools to assess the distance in cystoscopy, no statistical result was possible.
    Conclusion: Ultrasound seems to be superior to cystoscopy and is at least as effective as MRI in diagnosing and planning the surgery for bladder endometriosis.
    MeSH term(s) Adult ; Cystoscopy ; Endometriosis/diagnostic imaging ; Endometriosis/pathology ; Endometriosis/surgery ; Female ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Middle Aged ; Ultrasonography, Doppler, Color/methods ; Ureter/diagnostic imaging ; Ureter/pathology ; Urinary Bladder Diseases/diagnostic imaging ; Urinary Bladder Diseases/pathology ; Urinary Bladder Diseases/surgery
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2014.10.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4205: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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