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Article ; Online: Photofrin PDT for Barrett's oesophagus with high-grade dysplasia.

Thorpe, J A C / Moghissi, K

2008 Volume 5, Issue 1, Page(s) 36–37

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Barrett Esophagus/drug therapy ; Dihematoporphyrin Ether/therapeutic use ; Dose-Response Relationship, Radiation ; Humans ; Photochemotherapy
Chemical Substances	Antineoplastic Agents ; Dihematoporphyrin Ether (97067-70-4)
Language	English
Publishing date	2008-03
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2008.01.007
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Article ; Online: The Alara Metriscan phalangeal densitometer: evaluation and triage thresholds.

Thorpe, J A / Steel, S A

The British journal of radiology

2008 Volume 81, Issue 970, Page(s) 778–783

Abstract: The Metriscan (Alara Inc, CA) is a compact digital radiographic absorptiometry device capable of determining phalangeal bone mineral density in arbitrary units (BMD(au)) from the second phalanges of the middle three digits. We have examined the utility ... ...

Abstract	The Metriscan (Alara Inc, CA) is a compact digital radiographic absorptiometry device capable of determining phalangeal bone mineral density in arbitrary units (BMD(au)) from the second phalanges of the middle three digits. We have examined the utility and the in vitro and in vivo performances of the Metriscan, and established triage thresholds based on the UK's National Osteoporosis Society guidelines on peripheral densitometry. 170 white female participants (70 osteoporotic and 100 non-osteoporotic at the hip or spine) aged between 55 years and 70 years were recruited from patients attending for routine dual X-ray absorptiometry (DXA) examination. All participants underwent two scans of the non-dominant hand (with repositioning) and one of the dominant hand. An additional 10 participants were excluded owing to finger or hand deformities. Radiation exposure to the patient per scan was <0.1 microSv, and a controlled area of 1 m was established around the device. Phantom-based in vitro short-term precision (%CV) was 0.17% without, and 0.22% with, repositioning. Long-term in vitro precision was 0.31% over a 6-month period. In vivo short-term precision was 1.42% for the group as a whole, and 1.30% and 2.23% for the non-osteoporotic and osteoporotic groups, respectively. Triage thresholds for reassurance/referral or referral/treatment were 54.30 BMD(au) and 46.89 BMD(au), respectively, for the non-dominant hand, and 55.02 BMD(au) and 48.73 BMD(au) for the dominant hand. The dominant side proved superior for triage purposes, with a triage referral rate of 44%, compared with 48% for the non-dominant hand. The Metriscan is suitable for use on post-menopausal women in a community-based setting preferably in a triage role as an adjunct to axial BMD.
MeSH term(s)	Absorptiometry, Photon/instrumentation ; Absorptiometry, Photon/methods ; Aged ; Bone Density ; Female ; Finger Phalanges/diagnostic imaging ; Fractures, Spontaneous/prevention & control ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal/diagnostic imaging ; Osteoporosis, Postmenopausal/physiopathology ; Phantoms, Imaging ; Triage
Language	English
Publishing date	2008-10
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr/69540165
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Article ; Online: Lobectomy vs. segmentectomy. A propensity score matched comparison of outcomes.

Roman, M / Labbouz, S / Valtzoglou, V / Ciesla, A / Hawari, M / Addae-Boateng, E / Thorpe, J A / Duffy, J P / Majewski, A

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2018 Volume 45, Issue 5, Page(s) 845–850

Abstract: Background: Segmentectomy has emerged as a lung parenchymal sparring alternative to the gold standard lobectomy in non-small cell lung cancer (NSCLC) patients. We hypothesized that there is parity between functional, local recurrence and survival ... ...

Abstract	Background: Segmentectomy has emerged as a lung parenchymal sparring alternative to the gold standard lobectomy in non-small cell lung cancer (NSCLC) patients. We hypothesized that there is parity between functional, local recurrence and survival outcomes. Patients and methods: Parenchymal sparring procedures including anatomical segmentectomies were propensity score matched 1:1 with lobectomies (n = 64). The primary outcomes included survival, functional and oncological outcomes. The oncological outcomes were: post-operative histology, clear margins and local recurrence rates. Kaplan Meier survival curves were used to compare the survival. Oncological and functional variables were assessed by Fischer exact test and t-test. Results: The pre-operative performance status, ASA grade, lung function, risk factors, surgical approach and tumour histology were similar between the groups. The tumour size was significantly higher for lobectomies (32.4 ± 17 vs. 24.6 ± 12 mm, p = 0.01). The tumour staging in the segmentectomy group was similar to the lobectomy group (Ia; 50 vs. 34%; Ib: 29 vs. 37%; IIa 11 vs. 9.3%; IIb 5 vs. 14%; IIIa 5 vs. 4.6%, p = 0.83). The loco-regional recurrence was lower in the segmentectomy group (1.5 vs. 3.1%, p = 0.69). The up-staging and down-staging post-surgery was similar in both groups, while neo-adjuvant therapy was used in 5 lobectomy and 3 segmentectomy cases. The survival was similar at 1 year between the groups (88 vs. 92%, p = 0.65). Between 4 and 5 years, the survival reduced in the parenchymal sparing group to 39% vs. 68% in the lobectomy group (p = 0.04). Conclusion: Surgical selection bias could be an important confounder in the selection of patients undergoing segmentectomy. Similar up and down staging were demonstrated in the two groups. This is one of the first studies to investigate the results of segmentectomy versus lobectomy in stage II/IIIa NSCLC tumours. No significant differences were found in functional outcomes, but the survival decreased after 4 years in the segmentectomy group, which could be explained by lower survival in the stage II/IIIa tumours treated with segmentectomy.
MeSH term(s)	Aged ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Female ; Humans ; Length of Stay/statistics & numerical data ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Pneumonectomy/methods ; Propensity Score ; Respiratory Function Tests ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2018-11-01
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2018.10.534
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Semantic and associative factors in probability learning with words.

Schipper, L M / Hanson, B L / Taylor, G / Thorpe, J A

Memory & cognition

2013 Volume 1, Issue 3, Page(s) 291–296

Abstract: Using a probability-learning technique with a single word as the cue and with the probability of a given event following this word fixed at .80, it was found (1) that neither high nor low associates to the original word and (2) that neither synonyms nor ... ...

Abstract	Using a probability-learning technique with a single word as the cue and with the probability of a given event following this word fixed at .80, it was found (1) that neither high nor low associates to the original word and (2) that neither synonyms nor antonyms showed differential learning curves subsequent to original learning when the probability for the following event was shifted to .20. In a second study when feedback, in the form of knowledge of results, was withheld, there was a clear-cut similarity of predictions to the originally trained word and the synonyms of both high and low association value and a dissimilarity of these words to a set of antonyms of both high and low association value. Two additional studies confirmed the importance of the semantic dimension as compared with association value as traditionally measured.
Language	English
Publishing date	2013-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	185691-1
ISSN	1532-5946 ; 0090-502X
ISSN (online)	1532-5946
ISSN	0090-502X
DOI	10.3758/BF03198111
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Zs.A 4560: Show issues

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Article: The DXL Calscan heel densitometer: evaluation and diagnostic thresholds.

Thorpe, J A / Steel, S A

The British journal of radiology

2006 Volume 79, Issue 940, Page(s) 336–341

Abstract: The DXL Calscan (Demetech AB) is a new dual energy X-ray absorptiometry device for determining heel bone mineral density (BMD). The system is based on the standard technique of dual energy X-ray absorptiometry (DXA), using a fan beam configuration, but ... ...

Abstract	The DXL Calscan (Demetech AB) is a new dual energy X-ray absorptiometry device for determining heel bone mineral density (BMD). The system is based on the standard technique of dual energy X-ray absorptiometry (DXA), using a fan beam configuration, but introduces an additional laser measurement of heel thickness intended to improve accuracy. We have examined the utility, in vitro and in vivo performance of the DXL Calscan and established triage thresholds based on the UK's National Osteoporosis Society guidelines on peripheral densitometry. The Calscan proved convenient, easy to use and was stable over time and within a range of operating temperatures. Short-term in vitro precision as %CV, with phantom repositioning, was 0.75% and long term precision 0.73%. Precision in vivo, determined from duplicate right heel scans of 67 subjects, was 1.19%. Effective radiation dose to the patient was <0.1 microSv per scan. 140 white females (70 osteoporotic and 70 non-osteoporotic), aged 55-70 years underwent scans of both heels. Subjects were defined as osteoporotic or non-osteoporotic on the basis of axial DXA (spine L2-L4 and total hip). Triage thresholds for reassurance-referral or referral-treatment were 0.391 g cm(-2) and 0.306 g cm(-2) for non-dominant and 0.395 g cm(-2), 0.294 g cm(-2) for dominant heel, respectively. The non-dominant heel proved slightly superior to the dominant for triage purposes. Of the seven non-osteoporotic subjects misclassified as osteoporotic by Calscan of either heel, six had severe axial osteopenia. If operated by trained personnel and used in appropriate populations exhibiting risk factors, the Calscan is well suited for use in the management of post-menopausal osteoporosis.
MeSH term(s)	Absorptiometry, Photon/instrumentation ; Absorptiometry, Photon/methods ; Aged ; Bone Density ; Bone Diseases/diagnosis ; Calcaneus/physiopathology ; Female ; Humans ; Middle Aged ; Phantoms, Imaging ; Sensitivity and Specificity
Language	English
Publishing date	2006-04
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr/22191429
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Article: Screening for lung cancer.

Moghissi, K / Thorpe, J A

Journal of the Royal Society of Medicine

2001 Volume 94, Issue 4, Page(s) 206

MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Mass Screening/methods
Language	English
Publishing date	2001-04
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	6731-3
ISSN	1758-1095 ; 0141-0768 ; 0035-9157
ISSN (online)	1758-1095
ISSN	0141-0768 ; 0035-9157
DOI	10.1177/014107680109400423
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Article ; Online: Photofrin PDT for early stage oesophageal cancer: long term results in 40 patients and literature review.

Moghissi, K / Dixon, Kate / Stringer, Mark / Thorpe, J A C

Photodiagnosis and photodynamic therapy

2009 Volume 6, Issue 3-4, Page(s) 159–166

Abstract: Background: Yorkshire Laser Centre experience of PDT in early oesophageal cancer (EOCa) to determine long survival at 3 and 5 years (absolute) and factors which might influence outcome.: Material/method: The records of patients who had PDT (1997-2009) ...

Abstract	Background: Yorkshire Laser Centre experience of PDT in early oesophageal cancer (EOCa) to determine long survival at 3 and 5 years (absolute) and factors which might influence outcome. Material/method: The records of patients who had PDT (1997-2009) for oesophageal cancer were reviewed and those with EOCa were studied and analysed. All patients had standard work up and staging. PDT was carried out using Photofrin 2 mg/kw bw, iv followed 24-72 h later by endoscopic illumination with 630 nm laser light. Results were assessed based on pathological response to treatment and survival at 3 and 5 years post-PDT. Results: There were 40 patients with EOCa amongst 144 who had PDT for oesophageal cancer. 30 male and 10 female (mean age 77, range 48-84). 35 had adenocarcinoma and 5 squamous cell carcinoma. 20 of the former had Barrett's mucosa. There was no operative or 30-day mortality and no serious complications. Adverse effects were noted in 10 patients including 2 with skin photosensitivity and 3 with mild stricture requiring one dilatation. The median follow up was 76.1 (range 36-150 months). In this period 24 patients have died between 2 and 150 months (median 41 months). 16 patients are alive in between 36 and 110 months. 3 and >or=5 years or more survival (absolute) were 72.5% and 53.8%, respectively. Conclusion: Endoscopic PDT should be considered as the treatment of choice in patients with EOCa who are ineligible for surgical resection. We suggest that a carefully designed study of a cohort of patients with EOCa comparing surgical resection with endoscopic PDT is warranted.
MeSH term(s)	Aged ; Dihematoporphyrin Ether/therapeutic use ; Early Detection of Cancer ; Endoscopy ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Photosensitizing Agents/therapeutic use
Chemical Substances	Photosensitizing Agents ; Dihematoporphyrin Ether (97067-70-4)
Language	English
Publishing date	2009-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2009.07.026
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Article: Image resolution of the Lunar Expert-XL.

Thorpe, J A / Steel, S A

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

1999 Volume 10, Issue 2, Page(s) 95–101

Abstract: The Lunar Expert-XL is an example of the latest generation of fan beam densitometers, with the X-ray source and detector array mounted on a C-arm to enable supine lateral imaging. Image resolution for anteroposterior (AP) spine, femur, hand, forearm and ... ...

Abstract	The Lunar Expert-XL is an example of the latest generation of fan beam densitometers, with the X-ray source and detector array mounted on a C-arm to enable supine lateral imaging. Image resolution for anteroposterior (AP) spine, femur, hand, forearm and lateral morphometry on the Expert-XL were assessed in vitro with the 07-541 Nuclear Associates line pair test pattern. Each scan type was investigated at all available tube currents and scan speeds, and at the maximum, minimum and default bed heights. The effect of soft tissue thickness on resolution was investigated by using varying amounts of Perspex attenuator. The in vitro median lateral (x-axis) resolutions at the default bed height for the default scan types were 0.9 line pairs (lps)/mm for the 5 mA fast AP spine and femur scans, and l.0 lps/mm for 1 mA fast hand, forearm and 5 mA fast morphometry scans. This equates to a resolution of about 1 mm. The best resolution achieved was 1.2 lps/mm (0.83 mm), obtainable on all scan modes with the bed at maximum elevation, but only consistently with the forearm mode. Lower tube current did not affect resolution but did change the range of soft tissue thickness over which an image could be resolved. Turbo scan modes greatly reduced longitudinal (y-axis) resolution but had little effect on lateral resolution. This study demonstrates the importance of including an assessment of resolution when validating new equipment, especially if morphometric investigations are to be conducted.
MeSH term(s)	Absorptiometry, Photon/instrumentation ; Bone Density ; Humans ; In Vitro Techniques ; Quality Control ; Reproducibility of Results
Language	English
Publishing date	1999
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s001980050201
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Zs.A 3163: Show issues

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Article: Empyema due to spilled stones during laparoscopic cholecystectomy.

Kelty, C J / Thorpe, J A

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

1998 Volume 13, Issue 1, Page(s) 107–108

Abstract: We describe a patient who suffered right pleuritic chest pain and an exudative pleural effusion, leading to empyema formation. Thoracotomy revealed this to be due to a subphrenic abscess around spilled gall stones. ...

Abstract	We describe a patient who suffered right pleuritic chest pain and an exudative pleural effusion, leading to empyema formation. Thoracotomy revealed this to be due to a subphrenic abscess around spilled gall stones.
MeSH term(s)	Aged ; Cholecystectomy, Laparoscopic/adverse effects ; Cholelithiasis/complications ; Cholelithiasis/surgery ; Disease-Free Survival ; Empyema, Pleural/diagnostic imaging ; Empyema, Pleural/etiology ; Empyema, Pleural/surgery ; Female ; Humans ; Radiography ; Thoracotomy
Language	English
Publishing date	1998-01
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1016/s1010-7940(97)00262-5
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Zs.A 2303: Show issues

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Article: Recurrent chest wall haemangioma -- 'A vascular lake'.

Karthik, S / Milton, R / Thorpe, J A C

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2004 Volume 26, Issue 1, Page(s) 209–210

MeSH term(s)	Adult ; Female ; Hemangioma/pathology ; Hemangioma/surgery ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Thoracic Neoplasms/pathology ; Thoracic Neoplasms/surgery ; Thoracic Wall
Language	English
Publishing date	2004-07
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1016/j.ejcts.2004.04.023
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