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  1. Article ; Online: Evaluation and management of gastroesophageal reflux disease: A brief look at the updated guidelines.

    Sasankan, Priya / Thota, Prashanthi N

    Cleveland Clinic journal of medicine

    2022  Volume 89, Issue 12, Page(s) 700–703

    Abstract: Gastroesophageal reflux disease (GERD) is the most common gastrointestinal disorder seen in primary care offices and is usually managed with proton pump inhibitors (PPIs). The authors present an overview of the updated guidelines from the American ... ...

    Abstract Gastroesophageal reflux disease (GERD) is the most common gastrointestinal disorder seen in primary care offices and is usually managed with proton pump inhibitors (PPIs). The authors present an overview of the updated guidelines from the American College of Gastroenterology, which address the evaluation and management of GERD, including the consequences of long-term PPI therapy and emerging therapies.
    MeSH term(s) Humans ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/therapy ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Proton Pump Inhibitors
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.89a.22059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Aspirin: the miracle drug?

    Thota, Prashanthi N

    Clinical and translational gastroenterology

    2018  Volume 9, Issue 5, Page(s) 153

    Abstract: Aspirin use is associated with reduction of esophageal adenocarcinoma but it is not known if it does so by preventing the development of Barrett's esophagus or by reducing neoplastic progression in patients with Barrett's esophagus. There is sparse ... ...

    Abstract Aspirin use is associated with reduction of esophageal adenocarcinoma but it is not known if it does so by preventing the development of Barrett's esophagus or by reducing neoplastic progression in patients with Barrett's esophagus. There is sparse literature to support the former assumption especially in women. This study by Jovani et al. based on Nurses' Health Study reports 27% lower risk of Barrett's esophagus among women using aspirin. The protective effect seems to increase with higher frequency and longer duration of aspirin use. This study provides evidence for lower prevalence of Barrett's esophagus in female aspirin users.
    MeSH term(s) Aged ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Aspirin/adverse effects ; Aspirin/therapeutic use ; Barrett Esophagus/prevention & control ; Female ; Humans ; Middle Aged ; Risk Assessment
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2018-05-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.1038/s41424-018-0009-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Barrett's Esophagus in Rubinstein-Taybi Syndrome.

    Kumar, Prabhat / Thota, Prashanthi N

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11709

    Abstract: Rubinstein-Taybi syndrome (RSTS; Online Mendelian Inheritance in ... ...

    Abstract Rubinstein-Taybi syndrome (RSTS; Online Mendelian Inheritance in Man
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11709
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  4. Article: Barrett's esophagus: novel strategies for screening and surveillance.

    Sanghi, Vedha / Thota, Prashanthi N

    Therapeutic advances in chronic disease

    2019  Volume 10, Page(s) 2040622319837851

    Abstract: Barrett's esophagus is the precursor lesion for esophageal adenocarcinoma. Screening and surveillance of Barrett's esophagus are undertaken with the goal of earlier detection and lowering the mortality from esophageal adenocarcinoma. The widely used ... ...

    Abstract Barrett's esophagus is the precursor lesion for esophageal adenocarcinoma. Screening and surveillance of Barrett's esophagus are undertaken with the goal of earlier detection and lowering the mortality from esophageal adenocarcinoma. The widely used technique is standard esophagogastroduodenoscopy with biopsies per the Seattle protocol for screening and surveillance of Barrett's esophagus. Surveillance intervals vary depending on the degree of dysplasia with endoscopic eradication therapy confined to patients with Barrett's esophagus and confirmed dysplasia. In this review, we present various novel techniques for screening of Barrett's esophagus such as unsedated transnasal endoscopy, cytosponge with trefoil factor-3, balloon cytology, esophageal capsule endoscopy, liquid biopsy, electronic nose, and oral microbiome. In addition, advanced imaging techniques such as narrow band imaging, dye-based chromoendoscopy, confocal laser endomicroscopy, volumetric laser endomicroscopy, and wide-area transepithelial sampling with computer-assisted three-dimensional analysis developed for better detection of dysplasia are also reviewed.
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622319837851
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  5. Article: Management of nondysplastic Barrett's esophagus: When to survey? When to ablate?

    Puthenpura, Max M / Sanaka, Krishna O / Qin, Yi / Thota, Prashanthi N

    Therapeutic advances in chronic disease

    2022  Volume 13, Page(s) 20406223221086760

    Abstract: Barrett's esophagus (BE), a precursor for esophageal adenocarcinoma (EAC), is defined as salmon-colored mucosa extending more than 1 cm proximal to the gastroesophageal junction with histological evidence of intestinal metaplasia. The actual risk of EAC ... ...

    Abstract Barrett's esophagus (BE), a precursor for esophageal adenocarcinoma (EAC), is defined as salmon-colored mucosa extending more than 1 cm proximal to the gastroesophageal junction with histological evidence of intestinal metaplasia. The actual risk of EAC in nondysplastic Barrett's esophagus (NDBE) is low with an annual incidence of 0.3%. The mainstay in the management of NDBE is control of gastroesophageal reflux disease (GERD) along with enrollment in surveillance programs. The current recommendation for surveillance is four-quadrant biopsies every 2 cm (or 1 cm in known or suspected dysplasia) followed by biopsy of mucosal irregularity (nodules, ulcers, or other visible lesions) performed at 3- to 5-year intervals. Challenges to surveillance include missed cancers, suboptimal adherence to surveillance guidelines, and lack of strong evidence for efficacy. There is minimal role for endoscopic eradication therapy in NDBE. The role for enhanced imaging techniques, artificial intelligence, and risk prediction models using clinical data and molecular markers is evolving.
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223221086760
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  6. Article ; Online: Post-ablation buried neoplasia in Barrett's esophagus.

    Kumar, Prabhat / Gordon, Ilyssa O / Thota, Prashanthi N

    Scandinavian journal of gastroenterology

    2021  Volume 56, Issue 5, Page(s) 624–628

    Abstract: Endoscopic eradication therapy (EET) with maximal acid suppression is the cornerstone for the management of patients with Barrett's esophagus (BE) associated dysplasia. The occurrence of buried dysplastic glands after re-epithelialization of a neo- ... ...

    Abstract Endoscopic eradication therapy (EET) with maximal acid suppression is the cornerstone for the management of patients with Barrett's esophagus (BE) associated dysplasia. The occurrence of buried dysplastic glands after re-epithelialization of a neo-squamous epithelium is of concern for endoscopists. Here, we present a patient with BE and high-grade dysplasia successfully treated by EET who developed buried dysplastic BE during surveillance. A review of literature on buried dysplasia after successful endoscopic therapy of BE is also discussed.
    MeSH term(s) Barrett Esophagus/surgery ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/surgery ; Esophagoscopy ; Humans ; Hyperplasia ; Precancerous Conditions
    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2021.1896774
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 567: Show issues Location:
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  7. Article ; Online: Metastatic lung adenocarcinoma presenting as diminutive colonic polyp.

    Thota, Prashanthi N / Plesec, Thomas

    AME case reports

    2018  Volume 2, Page(s) 14

    Language English
    Publishing date 2018-04-18
    Publishing country China
    Document type Case Reports
    ISSN 2523-1995
    ISSN (online) 2523-1995
    DOI 10.21037/acr.2018.03.06
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  8. Article ; Online: Is Mass Screening for Barrett's Esophagus a Myth or Reality?

    Thota, Prashanthi N / Chak, Amitabh

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2018  Volume 17, Issue 4, Page(s) 610–612

    MeSH term(s) Barrett Esophagus ; Capsule Endoscopy ; Esophageal Neoplasms ; Humans ; Mass Screening
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2018.09.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Cryotherapy in the management of premalignant and malignant conditions of the esophagus.

    Lal, Pooja / Thota, Prashanthi N

    World journal of gastroenterology

    2018  Volume 24, Issue 43, Page(s) 4862–4869

    Abstract: Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen (liquid nitrogen or carbon ... ...

    Abstract Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen (liquid nitrogen or carbon dioxide) leading to intra and extra-cellular damage. Surgical treatment was once considered the standard therapeutic intervention for neoplastic diseases of the esophagus and is associated with considerable rates of morbidity and mortality. Several trials that evaluated cryotherapy in Barrett's esophagus (BE) associated neoplasia showed reasonable efficacy rates and safety profile. Cryotherapy has also found applications in the treatment of esophageal cancer, both for curative and palliative intent. Cryotherapy has also shown promising results as salvage therapy in cases refractory to radiofrequency ablation treatment. Cryoballoon focal ablation using liquid nitrogen is a novel mode of cryogen delivery which has been used for the treatment of BE with dysplasia and squamous cell carcinoma. Most common side effects of cryotherapy reported in the literature include mild chest discomfort, esophageal strictures and bleeding. In conclusion, cryotherapy is an effective and safe method for the treatment of esophageal neoplastic processes, ranging from early stages of low grade dysplasia to esophageal cancer.
    MeSH term(s) Barrett Esophagus/pathology ; Barrett Esophagus/surgery ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/prevention & control ; Esophageal Neoplasms/surgery ; Esophagoscopy/adverse effects ; Esophagoscopy/methods ; Esophagus/diagnostic imaging ; Esophagus/pathology ; Humans ; Nitrogen/administration & dosage ; Palliative Care/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Precancerous Conditions/pathology ; Precancerous Conditions/surgery ; Salvage Therapy/adverse effects ; Salvage Therapy/methods ; Treatment Outcome
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v24.i43.4862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  10. Article: Recent advances in third space or intramural endoscopy.

    Shanbhag, Akshay B / Thota, Prashanthi N / Sanaka, Madhusudhan R

    World journal of gastrointestinal endoscopy

    2020  Volume 12, Issue 12, Page(s) 521–531

    Abstract: Third space endoscopy or intramural endoscopy is based on the principle that the deeper layers of the gastrointestinal tract can be accessed by tunneling in the submucosal space and maintaining the integrity of the overlying mucosa. The era of third ... ...

    Abstract Third space endoscopy or intramural endoscopy is based on the principle that the deeper layers of the gastrointestinal tract can be accessed by tunneling in the submucosal space and maintaining the integrity of the overlying mucosa. The era of third space endoscopy started with peroral endoscopic myotomy (POEM) for treatment of achalasia and has expanded to treat various other gastrointestinal disorders. The technique is also currently used for treatment of refractory gastroparesis, Zenker's diverticulum (ZD), resection of subepithelial tumors and early cancers of the gastrointestinal tract and Hirschsprung's disease (HD). These procedures are rapidly emerging as minimally invasive alternatives to conventional surgery. They are safe and effective with excellent outcomes. This review focuses on the evolution and current applications of third space endoscopy in various gastrointestinal disorders. Key points: (1) Third space or intramural endoscopy initially started with the POEM procedure for treatment of achalasia; (2) Advancements in procedural techniques have expanded its application to treat other gastrointestinal disorders such as refractory gastroparesis, ZD, HD, resection of subepithelial tumors and early gastrointestinal cancers; (3) These procedures are highly effective with excellent outcomes and low complication rates; and (4) Third space endoscopic procedures are rapidly emerging as minimally invasive alternatives to conventional surgery.
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v12.i12.521
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