Article ; Online: Global burden and epidemiology of Barrett oesophagus and oesophageal cancer.
Nature reviews. Gastroenterology & hepatology
2021 Volume 18, Issue 6, Page(s) 432–443
Abstract: Oesophageal cancer is a global health problem; in 2018 there were more than 572,000 people newly diagnosed with oesophageal cancer worldwide. There are two main histological subtypes of oesophageal cancer, oesophageal adenocarcinoma (EAC) and oesophageal ...
Abstract | Oesophageal cancer is a global health problem; in 2018 there were more than 572,000 people newly diagnosed with oesophageal cancer worldwide. There are two main histological subtypes of oesophageal cancer, oesophageal adenocarcinoma (EAC) and oesophageal squamous cell carcinoma (ESCC), and there has been a dramatic shift in its epidemiology. While the incidence of EAC and its precursor lesion, Barrett oesophagus, has increased in Western populations over the past four decades, the incidence of ESCC has declined in most parts of the world over the same period. ESCC still accounts for the vast majority of all oesophageal cancer cases diagnosed worldwide each year. Prognosis for patients with oesophageal cancer is strongly related to stage at diagnosis. As most patients are diagnosed with late-stage disease, overall 5-year survival for oesophageal cancer remains <20%. Knowledge of epidemiology and risk factors for oesophageal cancer is essential for public health and clinical decisions about risk stratification, screening and prevention. The goal of this Review is to establish the current epidemiology of oesophageal cancer, with a particular focus on the Western world and the increasing incidence of EAC and Barrett oesophagus. |
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MeSH term(s) | Barrett Esophagus/epidemiology ; Esophageal Neoplasms/epidemiology ; Esophagoscopy ; Genetic Predisposition to Disease ; Global Health ; Humans ; Incidence ; Prognosis ; Risk Assessment ; Risk Factors |
Language | English |
Publishing date | 2021-02-18 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 2493722-8 |
ISSN | 1759-5053 ; 1759-5045 |
ISSN (online) | 1759-5053 |
ISSN | 1759-5045 |
DOI | 10.1038/s41575-021-00419-3 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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