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  1. Article ; Online: Improving Accuracy of Medication Reconciliation for Hospitalized Children: A Quality Project.

    Gunkelman, Samantha M / Jamerino-Thrush, Jennifer / Genet, Katherine / Blackford, Martha / Jones, Kerwyn / Bigham, Michael T

    Hospital pediatrics

    2024  Volume 14, Issue 4, Page(s) 300–307

    Abstract: Background and objectives: Medication reconciliation is a complex, but necessary, process to prevent patient harm from medication discrepancies. Locally, the steps of medication reconciliation are completed consistently; however, medication errors still ...

    Abstract Background and objectives: Medication reconciliation is a complex, but necessary, process to prevent patient harm from medication discrepancies. Locally, the steps of medication reconciliation are completed consistently; however, medication errors still occur, which suggest process inaccuracies. We focused on removal of unnecessary medications as a proxy for accuracy. The primary aim was to increase the percentage of patients admitted to the pediatric hospital medicine service with at least 1 medication removed from the home medication list by 10% during the hospital stay by June of 2022.
    Methods: Using the Model for Improvement, a multidisciplinary team was formed at a children's hospital, a survey was completed, and multiple Plan-Do-Study-Act cycles were done focusing on: 1. simplifying electronic health record processes by making it easier to remove medications; 2. continuous resident education about the electronic health record processes to improve efficiency and address knowledge gaps; and 3. auditing charts and real-time feedback. Data were monitored with statistical process control charts.
    Results: The project exceeded the goal, improving from 35% to 48% of patients having at least 1 medication removed from their home medication list. Improvement has sustained for 12 months.
    Conclusions: The combination of interventions including simplifying workflow, improving education, and enhancing accountability resulted in more patients with medications removed from their home medication list.
    MeSH term(s) Child ; Humans ; Medication Reconciliation ; Child, Hospitalized ; Medication Errors/prevention & control ; Patient Admission ; Hospitalization
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2023-007396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Reading for Pleasure: Secondhand but not second-rate.

    Thrush, J

    British medical journal (Clinical research ed.)

    2010  Volume 282, Issue 6268, Page(s) 977–978

    Language English
    Publishing date 2010-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    DOI 10.1136/bmj.282.6268.977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acetaminophen and warfarin: A recipe for supratherapeutic international normalized ratio with postoperative bleeding risk.

    Thrush, Justin / Simonds, Robert / Antony, Ashley / Vidimos, Allison / Lucas, Jennifer

    JAAD case reports

    2023  Volume 43, Page(s) 51–52

    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Angiopoietin-like protein 4 is a chromatin-bound protein that enhances mammosphere formation

    Simeon, Jodi / Thrush, Jessica / Bailey, Tameka A

    Journal of carcinogenesis

    2021  Volume 20, Page(s) 8

    Abstract: Introduction: Metastatic progression in triple-negative breast cancer (TNBC) patients occurs primarily because of nuclear reprogramming that includes chromatin remodeling and epigenetic modifications. The existing and most successful chemotherapies ... ...

    Abstract Introduction: Metastatic progression in triple-negative breast cancer (TNBC) patients occurs primarily because of nuclear reprogramming that includes chromatin remodeling and epigenetic modifications. The existing and most successful chemotherapies available for metastatic TNBC target nuclear proteins or damage DNA. The objectives here are to investigate an undescribed role for the molecular biology of nuclear angiopoietin-like protein 4 (ANGPTL4) and to characterize the effect of ectopic overexpression of ANGPTL4 in the metastatic biology of TNBC.
    Materials and methods: Lentiviral-mediated transduction was used to overexpress ANGPTL4 in the TNBC cell line MD Anderson-metastatic breast cancer 231. The overexpression of ANGPTL4 was confirmed by western blot and ELISA. Subcellular fractionation, western blot, and immunofluorescence microscopy were used to characterize the intracellular localization of ANGPTL4. Mammosphere culture and the anchorage-independent growth assay analyzed the metastatic potential of the cell line. Xenograft assays assessed the effect of ANGPTL4 overexpression on TNBC metastases
    Results: The ANGPTL4 overexpressing cell line formed larger mammospheres and anchorage-independent colonies
    Conclusions: The ANGPTL4 overexpressing cell line showed
    Language English
    Publishing date 2021-06-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2098237-9
    ISSN 1477-3163 ; 1477-3163 ; 0974-6773
    ISSN (online) 1477-3163
    ISSN 1477-3163 ; 0974-6773
    DOI 10.4103/jcar.JCar_20_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Changing comorbidities and complexity among dermatology medicare patients from 2013 to 2019.

    Cwalina, Thomas B / Kumar, Yash / Bullock, Taylor A / Thrush, Justin / Unwala, Rashmi

    Journal of the American Academy of Dermatology

    2023  Volume 89, Issue 1, Page(s) 155–157

    MeSH term(s) Aged ; Humans ; United States/epidemiology ; Medicare ; Dermatology ; Comorbidity
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ulcerating reaction in association with Pfizer-BioNTech COVID-19 vaccine in an 11-year-old boy.

    Thrush, Justin / Polly, Samantha / Anthony, John / Fernandez, James / Taylor, James / Preston, DeVon C / Fernandez, Anthony P

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 1, Page(s) e3–e5

    MeSH term(s) Male ; Humans ; Child ; BNT162 Vaccine ; COVID-19/prevention & control
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bovine coronavirus in the lower respiratory tract of cattle with respiratory disease.

    Rahe, Michael C / Magstadt, Drew R / Groeltz-Thrush, Jennifer / Gauger, Phillip C / Zhang, Jianqiang / Schwartz, Kent J / Siepker, Christopher L

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2022  Volume 34, Issue 3, Page(s) 482–488

    Abstract: Bovine coronavirus (BCoV) is a known cause of enteric disease in cattle; however, its role in bovine respiratory disease (BRD) is poorly understood, with a dearth of evidence of the detection of the virus in respiratory tract lesions. We coupled ... ...

    Abstract Bovine coronavirus (BCoV) is a known cause of enteric disease in cattle; however, its role in bovine respiratory disease (BRD) is poorly understood, with a dearth of evidence of the detection of the virus in respiratory tract lesions. We coupled histologic evaluation of tracheal and lower airway tissues from 104 calves with BRD in which BCoV was detected in the lungs via PCR followed by direct detection of BCoV by immunohistochemistry and an RNA in situ hybridization assay (ISH; RNAscope technology). RNAscope ISH detected BCoV in respiratory epithelium in more cases than did IHC. Using both methods of direct detection, tracheal epithelial attenuation and identification of the virus within lesions were observed commonly. Our results confirm a role of BCoV in respiratory tract infection and pathology, and show that the virus likely plays a role in the development of BRD.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases ; Coronavirus Infections/veterinary ; Coronavirus, Bovine ; Respiratory System/pathology ; Respiratory Tract Infections/veterinary
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387221078583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.

    Yang, Chenghuai / Wang, Leyi / Schwartz, Kent / Burrough, Eric / Groeltz-Thrush, Jennifer / Chen, Qi / Zheng, Ying / Shen, Huigang / Li, Ganwu

    Viruses

    2021  Volume 13, Issue 1

    Abstract: Nodaviruses are small bisegmented RNA viruses belonging to the ... ...

    Abstract Nodaviruses are small bisegmented RNA viruses belonging to the family
    MeSH term(s) Amino Acid Sequence ; Animals ; Base Sequence ; Capsid Proteins/genetics ; Genomics ; Nodaviridae/classification ; Nodaviridae/genetics ; Nodaviridae/isolation & purification ; Phylogeny ; RNA Virus Infections/veterinary ; RNA, Viral/genetics ; Swine/virology ; Swine Diseases/virology ; United States
    Chemical Substances Capsid Proteins ; RNA, Viral
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13010073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Redirecting Nonurgent Patients From the Pediatric Emergency Department to Their Pediatrician Office for a Same-Day Visit-A Quality Improvement Initiative.

    Wolski, Thomas P / Jamerino-Thrush, Jennifer / Bigham, Michael T / Kline-Krammes, Sarah / Patel, Nirali / Lee, Timothy J / Pollauf, Laura A / Joyce, Crystal N / Kunka, Sarah / McNinch, Neil L / Jacobs, Michelle / White, P Cooper

    Pediatric emergency care

    2022  Volume 38, Issue 12, Page(s) 692–696

    Abstract: Objectives: Providing high-quality care in the appropriate setting to optimize value is a worthy goal of an efficient health system. Consequences of managing nonurgent complaints in the emergency department (ED) have been described including ... ...

    Abstract Objectives: Providing high-quality care in the appropriate setting to optimize value is a worthy goal of an efficient health system. Consequences of managing nonurgent complaints in the emergency department (ED) have been described including inefficiency, loss of the primary care-patient relationship, and delayed care for other ED patients. The purpose of this initiative was to redirect nonurgent patients arriving in the ED to their primary care office for a same-day visit, and the SMART AIM was to increase redirected patients from 0% of those eligible to 30% in a 12-month period.
    Methods: The setting was a pediatric ED (PED) and primary care office of a tertiary care pediatric medical system. The initiative utilized the electronic health record to identify and mediate the redirection of patients to the patient's primary care office after ED triage. The primary measurement was the percentage of eligible patients redirected. Additional measures included health benefits during the primary care visit (vaccines, well-visits) and a balancing measure of patients returned to the PED.
    Results: The SMART AIM of >30% redirection was achieved and sustained with a final redirection rate of 46%. In total, 216 of 518 eligible patients were redirected, with zero untoward outcomes. The encounter time for redirected patients was similar for those who remained in the PED, and additional health benefits were appreciated for redirected patients.
    Conclusions: This initiative redirected nonurgent patients efficiently from a PED setting to their primary care office. The process is beneficial to patients and families and supports the patient-centered medical home. The balancing measure of no harm done to patients who accepted redirect reinforced the reliability of PED triage. The benefits achieved through the project highlight the value of the primary care-patient relationship and the continued need to improve access for patients and families.
    MeSH term(s) Humans ; Child ; Quality Improvement ; Reproducibility of Results ; Primary Health Care ; Emergency Service, Hospital ; Pediatricians
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diffuse Telangiectatic Rash Associated With Novel Antibody Drug Conjugate Therapies.

    Sorensen, Eric P / Thrush, Justin / Bartlett, Nancy L / Rosman, Ilana S / Anadkat, Milan J / Jones, Heather A

    JAMA dermatology

    2020  Volume 156, Issue 5, Page(s) 601–603

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Benzodiazepines/administration & dosage ; Benzodiazepines/adverse effects ; Benzodiazepinones/administration & dosage ; Benzodiazepinones/adverse effects ; Humans ; Immunoconjugates/administration & dosage ; Immunoconjugates/adverse effects ; Middle Aged ; Telangiectasis/etiology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Benzodiazepinones ; Immunoconjugates ; rovalpituzumab tesirine ; Benzodiazepines (12794-10-4) ; loncastuximab tesirine (7K5O7P6QIU)
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2020.0208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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