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Article: Las ciencias sociales sistémicas y la pandemia del coronavirus

Arnold, Marcelo Pignuoli Sergio Thumala Daniela

Cinta de moebio

Abstract: Abstract: Given the multiplicity of perspectives that accompany the observation of the current pandemic, becomes relevant to identify those that achieve the greatest resonance Thus, it is observed how citizens and decision makers have increased their ... ...

Abstract	Abstract: Given the multiplicity of perspectives that accompany the observation of the current pandemic, becomes relevant to identify those that achieve the greatest resonance Thus, it is observed how citizens and decision makers have increased their demands for valid information by applying rationality, methods, and procedures of science in an exponential manner In this paper we develop a synthetic set of selected guidelines on how the current pandemic is approached from systemic social sciences, and then present some of their proposals regarding the conditions, at the organizational level, which could enable the achievement of the levels of dialogue and cooperation required to address the current pandemic
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #910826
Database	COVID19

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Article ; Online: The "when" matters: Evidence from memory markers in the clinical continuum of Alzheimer's disease.

Forno, Gonzalo / Parra, Mario A / Thumala, Daniela / Villagra, Roque / Cerda, Mauricio / Zitko, Pedro / Ibañez, Agustín / Lillo, Patricia / Slachevsky, Andrea

Neuropsychology

2023 Volume 37, Issue 7, Page(s) 753–768

Abstract: Objective: Cognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) ... ...

Abstract	Objective: Cognitive assessment able to detect impairments in the early neuropathological stages of Alzheimer's disease (AD) is urgently needed. The visual short-term memory binding task (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) have been recommended by the neurodegenerative disease working group as promising tests to aid in the early detection of AD. In this study, we investigated their complementary value across the clinical stages of the AD continuum. Method: One hundred and seventeen older adults with subjective cognitive complaint (SCC), 79 with mild cognitive impairment (MCI), 31 patients with AD dementia (ADD), and 37 cognitively unimpaired (CU) subjects, underwent assessment with the VSTMBT and the picture version of the Spanish FCSRT. Results: After controlling for multiple comparisons, significant differences were found across groups. The VSTMBT was the only test that "marginally" differentiated between CU and SCC ( Conclusions: Our results suggest that the VSTMBT and the FCSRT are sensitive to the clinical continuum of AD. Whereas the former detects changes in the early prodromal stages, the latter is more sensitive to the advanced prodromal stages of AD. These novel tests can aid in the early detection, monitor disease progression and response to treatment, and thus support drug development programs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Neurodegenerative Diseases ; Prodromal Symptoms ; Neuropsychological Tests ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000891
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Article ; Online: Impact of the Pandemic Time on the Mental Health of People with Dementia and Their Family Caregivers in Brazil and Chile: One-Year Follow-Up.

Olavarría, Loreto / Caramelli, Paulo / Lema, José / Andrade, Caíssa Bezerra de / Pinto, Alejandra / Azevedo, Lílian Viana Dos Santos / Thumala, Daniela / Vieira, Maria Carolina Santos / Rossetti, Adriana Peredo / Generoso, Alana Barroso / Carmona, Karoline Carvalho / Sepúlveda-Loyola, Walter / Pinto, Ludmilla Aparecida Cardoso / Barbosa, Maira Tonidandel / Slachevsky, Andrea

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 2, Page(s) 691–698

Abstract: Background: Previous studies reported the negative impact of social isolation on mental health in people with dementia (PwD) and their caregivers, butlongitudinal studies seem scarcer.: Objective: To describe a one-year follow-up impact of the COVID- ... ...

Abstract	Background: Previous studies reported the negative impact of social isolation on mental health in people with dementia (PwD) and their caregivers, butlongitudinal studies seem scarcer. Objective: To describe a one-year follow-up impact of the COVID-19 pandemic on PwD and their caregivers in both Brazil and Chile. Methods: This study analyzed the impact of the pandemic on the psychological and physical health of PwD and their family caregivers after one year of follow-up in three outpatient clinics in Brazil (n = 68) and Chile (n = 61). Results: In both countries, PwD reduced their functional capacity after one year of follow-up (p = 0.017 and p = 0.009; respectively) and caregivers reported worse physical and mental health (p = 0.028 and p = 0.039). Only in Chile, caregivers reported more sadness associated with care (p = 0.001), and reduced time sleeping (p = 0.07). Conclusions: In conclusion, the COVID-19 pandemic appears to have had a long-lasting impact on PwD and their caregivers. However, it is essential to acknowledge that the inherent progression of dementia itself may also influence changes observed over a year.
MeSH term(s)	Humans ; Caregivers/psychology ; Pandemics ; Mental Health ; Dementia/epidemiology ; Dementia/psychology ; Follow-Up Studies ; Chile/epidemiology ; Brazil/epidemiology ; COVID-19/epidemiology
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231310
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Article: Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy.

Custodio, Nilton / Wheelock, Ana / Thumala, Daniela / Slachevsky, Andrea

Frontiers in aging neuroscience

2017 Volume 9, Page(s) 221

Abstract: Population aging is among the most important global transformations. Today, 12% of the world population is of age 60 and over and by the middle of this century this segment will represent 21.5%. The increase in population of those aged 80 and over, also ... ...

Abstract	Population aging is among the most important global transformations. Today, 12% of the world population is of age 60 and over and by the middle of this century this segment will represent 21.5%. The increase in population of those aged 80 and over, also referred to as the "oldest old" or the "very elderly", will be even more pronounced, going from 1.7% of the population to 4.5% within the same period. Compared to European and North American countries, Latin America (LA) is experiencing this unprecedented demographic change at a significantly faster rate. Due to demographic and health transitions, the number of people with dementia will rise from 7.8 million in 2013 to over 27 million by 2050. Nowadays, the global prevalence of dementia in LA has reached 7.1%, with Alzheimer's Disease (AD) being the most frequent type. This level is similar to those found in developed countries; however, the dementia rate is twice as high as that of the 65-69 years age group in developed countries. In addition, the prevalence and incidence of dementia is higher among illiterate people. Mortality rates due to dementia have risen considerably. The burden and costs of the disease are high and must be covered by patients' families. The prevention of dementia and the development of long-term care policies and plans for people with dementia in LA, which take into account regional differences and similarities, should be urgent priorities.
Language	English
Publishing date	2017-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2017.00221
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Article ; Online: Assessing subjective cognitive decline in older adults attending primary health care centers: what question should be asked?

Molina-Donoso, Matías / Parrao, Teresa / Meillon, Céline / Thumala, Daniela / Lillo, Patricia / Villagra, Roque / Ibañez, Agustín / Cerda, Mauricio / Zitko, Pedro / Amieva, Hélène / Slachevsky, Andrea

Journal of clinical and experimental neuropsychology

2023 Volume 45, Issue 3, Page(s) 313–320

Abstract: Introduction: Subjective Cognitive Decline (SCD) refers to a self-perceived experience of decreased cognitive function without objective signs of cognitive impairment in neuropsychological tests or daily living activities. Despite the abundance of ... ...

Abstract	Introduction: Subjective Cognitive Decline (SCD) refers to a self-perceived experience of decreased cognitive function without objective signs of cognitive impairment in neuropsychological tests or daily living activities. Despite the abundance of instruments addressing SCD, there is no consensus on the methods to be used. Our study is founded on 11 questions selected due to their recurrence in most instruments. The objective was to determine which one of these questions could be used as a simple screening tool. Methods: 189 participants aged 65 and over selected from Primary Care centers in Santiago de Chile responded to these 11 questions and were evaluated with the MiniMental State Examination (MMSE), the Free and Cued Selective Reminding Test (FCSRT), the Pfeffer functional scale, and the Geriatric Depression Scale (GDS). An Item ResponseTheory (IRT) method was performed to assess the contribution of each of the 11 questions to the SCD latent trait and its discrimination ability. Results: Based on the results of the exploratory factor analysis showing very high/low saturation of several questions on the factors, and the high residual correlation between some questions, the IRT methods led to select one question ("Do you feel like your memory has become worse?") which revealed to be the most contributive and discriminant. Participants who answered yes had a higher GDS score. There was no association with MMSE, FCSRT, and Pfeffer scores. Conclusion: The question "Do you feel like your memory has become worse?" may be a good proxy of SCD and could be included in routine medical checkups.
MeSH term(s)	Humans ; Aged ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Cognition ; Neuropsychological Tests ; Cues ; Primary Health Care
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605982-x
ISSN	1744-411X ; 0168-8634 ; 1380-3395
ISSN (online)	1744-411X
ISSN	0168-8634 ; 1380-3395
DOI	10.1080/13803395.2023.2221399
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Article ; Online: Coping processes that foster accommodation to loss in old age.

Thumala, Daniela / Gajardo, Bárbara / Gómez, Camila / Arnold-Cathalifaud, Marcelo / Araya, Alfonso / Jofré, Pamela / Ravera, Valeria

Aging & mental health

2018 Volume 24, Issue 2, Page(s) 300–307

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Adaptation, Psychological ; Aged ; Aged, 80 and over ; Aging/psychology ; Female ; Health Status ; Humans ; Internal-External Control ; Interviews as Topic ; Male ; Mental Health/statistics & numerical data ; Middle Aged ; Qualitative Research ; Quality of Life/psychology
Language	English
Publishing date	2018-12-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2018.1531378
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Article ; Online: GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly.

Slachevsky, Andrea / Zitko, Pedro / Martínez-Pernía, David / Forno, Gonzalo / Court, Felipe A / Lillo, Patricia / Villagra, Roque / Duran-Aniotz, Claudia / Parrao, Teresa / Assar, Rodrigo / Orellana, Paulina / Toledo, Carolina / Rivera, Rodrigo / Ibañez, Agustín / Parra, Mario A / González-Billault, Christian / Amieva, Helena / Thumala, Daniela

BMC geriatrics

2020 Volume 20, Issue 1, Page(s) 505

Abstract: Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause ...

Abstract	Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and functional decline, incident mild cognitive impairment, and incident dementia. The GERO cohort is the Chilean core clinical project of the Geroscience Center for Brain Health and Metabolism (GERO). The objective of the GERO cohort is to analyze the rate of functional decline and progression to clinical dementia and their associated risk factors in a community-dwelling elderly with subjective cognitive complaint, through a population-based study. We also aim to undertake clinical research on brain ageing and dementia disorders, to create data and biobanks with the appropriate infrastructure to conduct other studies and facilitate to the national and international scientific community access to the data and samples for research. Methods: The GERO cohort aims the recruitment of 300 elderly subjects (> 70 years) from Santiago (Chile), following them up for at least 3 years. Eligible people are adults not diagnosed with dementia with subjective cognitive complaint, which are reported either by the participant, a proxy or both. Participants are identified through a household census. The protocol for evaluation is based on a multidimensional approach including socio-demographic, biomedical, psychosocial, neuropsychological, neuropsychiatric and motor assessments. Neuroimaging, blood and stool samples are also obtained. This multidimensional evaluation is carried out in a baseline and 2 follow-ups assessments, at 18 and 36 months. In addition, in months 6, 12, 24, and 30, a telephone interview is performed in order to keep contact with the participants and to assess general well-being. Discussion: Our work will allow us to determine multidimensional risks factors associated with functional decline and conversion to dementia in elderly with subjective cognitive complain. The aim of our GERO group is to establish the capacity to foster cutting edge and multidisciplinary research on aging in Chile including basic and clinical research. Trial registration: NCT04265482 in ClinicalTrials.gov. Registration Date: February 11, 2020. Retrospectively Registered.
MeSH term(s)	Activities of Daily Living ; Aged ; Alcoholism ; Chile/epidemiology ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cohort Studies ; Genome-Wide Association Study ; Humans ; Male ; Membrane Glycoproteins ; Neuropsychological Tests ; Pilot Projects ; Quality of Life ; Receptors, Immunologic
Chemical Substances	Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-020-01866-4
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Article ; Online: Impact of Social Isolation on People with Dementia and Their Family Caregivers.

Azevedo, Lílian Viana Dos Santos / Calandri, Ismael Luis / Slachevsky, Andrea / Graviotto, Héctor Gastón / Vieira, Maria Carolina Santos / Andrade, Caíssa Bezerra de / Rossetti, Adriana Peredo / Generoso, Alana Barroso / Carmona, Karoline Carvalho / Pinto, Ludmilla Aparecida Cardoso / Sorbara, Marcos / Pinto, Alejandra / Guajardo, Tania / Olavarria, Loreto / Thumala, Daniela / Crivelli, Lucía / Vivas, Ludmila / Allegri, Ricardo Francisco / Barbosa, Maira Tonidandel /

Serrano, Cecilia M / Miranda-Castillo, Claudia / Caramelli, Paulo

Journal of Alzheimer's disease : JAD

2021 Volume 81, Issue 2, Page(s) 607–617

Abstract: Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms.: Objective: To investigate the impacts of ...

Abstract	Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms. Objective: To investigate the impacts of social isolation due to the COVID-19 pandemic on individuals with dementia and their family caregivers. Methods: Two semi-structured questionnaires were applied via telephone to family caregivers of people diagnosed with dementia in three cities in Argentina, Brazil, and Chile, in order to assess clinical and behavioral changes in people with dementia and in their caregivers. Results: In general, 321 interviews were conducted. A significant decline in memory function has been reported among 53.0%of people with dementia. In addition, 31.2%of individuals with dementia felt sadder and 37.4%had increased anxiety symptoms. These symptoms of anxiety were greater in individuals with mild to moderate dementia, while symptoms of agitation were greater in individuals with severe dementia. Moreover, compulsive-obsessive behavior, hallucinations, increased forgetfulness, altered appetite, and increased difficulty in activities of daily living were reported more frequently among individuals with moderate to severe dementia. Caregivers reported feeling more tired and overwhelmed during this period and these symptoms were also influenced by the severity of dementia. Conclusion: Social isolation during the COVID-19 pandemic triggered a series of negative behavioral repercussions, both for people with dementia and for their family caregivers in these three South American countries.
MeSH term(s)	Activities of Daily Living ; Adult ; Aged ; Aged, 80 and over ; Argentina ; Brazil ; COVID-19/psychology ; Caregivers/psychology ; Chile ; Dementia/psychology ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Physical Distancing ; Social Isolation/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2021-03-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-201580
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Article ; Online: Aging and Health Policies in Chile: New Agendas for Research.

Thumala, Daniela / Kennedy, Brian K / Calvo, Esteban / Gonzalez-Billault, Christian / Zitko, Pedro / Lillo, Patricia / Villagra, Roque / Ibáñez, Agustín / Assar, Rodrigo / Andrade, Maricarmen / Slachevsky, Andrea

Health systems and reform

2018 Volume 3, Issue 4, Page(s) 253–260

Abstract: Abstract-Population aging is among the most important global transformations. Compared to European and North American countries, Chile is among the countries with the fastest growth of life expectancy at birth during recent decades. The aging of Chile's ... ...

Abstract	Abstract-Population aging is among the most important global transformations. Compared to European and North American countries, Chile is among the countries with the fastest growth of life expectancy at birth during recent decades. The aging of Chile's population is related to the improvement of living conditions, but also entails risks that tend to be associated with a rapid economic growth accompanied by large income inequalities and a chronic deficit of basic social benefits. The rapid demographic transition towards an aged population has unfolded in a context of poor development of public policies to tackle the opportunities and needs associated with an aging society. This article provides a brief overview of current Chilean public policy on aging, with a focus on healthy aging as defined by World Health Organization. The discussion addresses core challenges to successfully achieve healthy aging in Chile.
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article
ISSN	2328-8620
ISSN (online)	2328-8620
DOI	10.1080/23288604.2017.1353844
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Article ; Online: The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America.

Babulal, Ganesh M / Torres, Valeria L / Acosta, Daisy / Agüero, Cinthya / Aguilar-Navarro, Sara / Amariglio, Rebecca / Ussui, Juliana Aya / Baena, Ana / Bocanegra, Yamile / Brucki, Sonia Maria Dozzi / Bustin, Julian / Cabrera, Diego M / Custodio, Nilton / Diaz, Monica M / Peñailillo, Lissette Duque / Franco, Idalid / Gatchel, Jennifer R / Garza-Naveda, Ana Paola / González Lara, Mariana /

Gutiérrez-Gutiérrez, Lidia / Guzmán-Vélez, Edmarie / Hanseeuw, Bernard J / Jimenez-Velazquez, Ivonne Z / Rodríguez, Tomás León / Llibre-Guerra, Jorge / Marquine, María J / Martinez, Jairo / Medina, Luis D / Miranda-Castillo, Claudia / Morlett Paredes, Alejandra / Munera, Diana / Nuñez-Herrera, Alberto / de Oliveira, Maira Okada / Palmer-Cancel, Santiago J / Pardilla-Delgado, Enmanuelle / Perales-Puchalt, Jaime / Pluim, Celina / Ramirez-Gomez, Liliana / Rentz, Dorene M / Rivera-Fernández, Claudia / Rosselli, Monica / Serrano, Cecilia M / Suing-Ortega, Maria Jose / Slachevsky, Andrea / Soto-Añari, Marcio / Sperling, Reisa A / Torrente, Fernando / Thumala, Daniela / Vannini, Patrizia / Vila-Castelar, Clara / Yañez-Escalante, Tatiana / Quiroz, Yakeel T

EClinicalMedicine

2021 Volume 35, Page(s) 100848

Abstract: Background: In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic's impact on the well-being and cognition of older adults living in the ... ...

Abstract	Background: In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic's impact on the well-being and cognition of older adults living in the United States (US), Argentina, Chile, Mexico, and Peru. Methods: 1,608 (646 White, 852 Latino, 77 Black, 33 Asian; 72% female) individuals from the US and four Latin American countries aged ≥ 55 years completed an online survey regarding well-being and cognition during the pandemic between May and September 2020. Outcome variables (pandemic impact, discrimination, loneliness, purpose of life, subjective cognitive concerns) were compared across four US ethnoracial groups and older adults living in Argentina, Chile, Mexico, and Peru. Findings: Mean age for all participants was 66.7 ( Interpretation: The COVID-19 pandemic has differentially impacted the well-being of older ethnically diverse individuals in the US and Latin America. Future studies should examine how mediators like income and coping skills modify the pandemic's impact. Funding: Massachusetts General Hospital Department of Psychiatry.
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.100848
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