Article: A Study of the Association Between Metabolic Syndrome and Vitamin D Deficiency.
The Journal of the Association of Physicians of India
2022 Volume 70, Issue 4, Page(s) 11–12
Abstract: Metabolic syndrome is a global pandemic. It contributes to early cardiovascular morbidity and mortality. The etiology of Metabolic Syndrome is not completely well understood yet. Insulin resistance remains the most accepted hypothesis. Another such ... ...
| Abstract | Metabolic syndrome is a global pandemic. It contributes to early cardiovascular morbidity and mortality. The etiology of Metabolic Syndrome is not completely well understood yet. Insulin resistance remains the most accepted hypothesis. Another such hypothesis is that of vitamin D deficiency. Exploring a possible association between these two highly prevalent conditions could help in better understanding of the pathophysiology of metabolic syndrome. The clinical impact of this association could help in better control of the health of an individual if lifestyle and pharmacological interventions for Metabolic Syndrome fail. Material: In this cross sectional study, 176 consecutive patients were enrolled. The patients were divided into two groups- cases and controls on the basis of the NCEP ATP III criteria. History, clinical examination and laboratory tests like FBS, fasting lipid profile and vitamin D were done for both the groups and results were compared. Observation: The mean serum vitamin D levels among those with Metabolic Syndrome was lower, 16.50 +/-9.06 ng/ ml compared to those without the syndrome, 20.75 +/- 10.29 ng/ml. This difference was found to statistically significant (p = 0.004) signifying a strong association. FBS and waist circumference showed a significant negative correlation while exposure to sunlight and HDL had a significant positive correlation with vitamin D deficiency. Conclusion: In this study, mean vitamin D levels were lower in those with metabolic syndrome than those without metabolic syndrome and this was found to be statistically significant. Thus in patients of Metabolic Syndrome with poorly controlled metabolic parameters despite adequate lifestyle and pharmacological interventions, correction of the vitamin D, if found to be deficient, can be considered for better control of these parameters. |
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| MeSH term(s) | Cross-Sectional Studies ; Humans ; Metabolic Syndrome ; Prevalence ; Vitamin D ; Vitamin D Deficiency/diagnosis ; Vitamins |
| Chemical Substances | Vitamins ; Vitamin D (1406-16-2) |
| Language | English |
| Publishing date | 2022-04-20 |
| Publishing country | India |
| Document type | Journal Article |
| ZDB-ID | 800766-4 |
| ISSN | 0004-5772 |
| ISSN | 0004-5772 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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