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Article ; Online: Eating disorders.

Treasure, Janet / Duarte, Tiago Antunes / Schmidt, Ulrike

2020 Volume 395, Issue 10227, Page(s) 899–911

Abstract: Eating disorders are disabling, deadly, and costly mental disorders that considerably impair physical health and disrupt psychosocial functioning. Disturbed attitudes towards weight, body shape, and eating play a key role in the origin and maintenance of ...

Abstract	Eating disorders are disabling, deadly, and costly mental disorders that considerably impair physical health and disrupt psychosocial functioning. Disturbed attitudes towards weight, body shape, and eating play a key role in the origin and maintenance of eating disorders. Eating disorders have been increasing over the past 50 years and changes in the food environment have been implicated. All health-care providers should routinely enquire about eating habits as a component of overall health assessment. Six main feeding and eating disorders are now recognised in diagnostic systems: anorexia nervosa, bulimia nervosa, binge eating disorder, avoidant-restrictive food intake disorder, pica, and rumination disorder. The presentation form of eating disorders might vary for men versus women, for example. As eating disorders are under-researched, there is a great deal of uncertainty as to their pathophysiology, treatment, and management. Future challenges, emerging treatments, and outstanding research questions are addressed.
MeSH term(s)	Adolescent ; Adult ; Diagnosis, Differential ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/physiopathology ; Feeding and Eating Disorders/psychology ; Feeding and Eating Disorders/therapy ; Humans ; Nutritional Status
Language	English
Publishing date	2020-03-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(20)30059-3
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Article ; Online: Undergraduate nursing students' knowledge and experience in infusion therapy and peripheral vascular acces.

Alvarenga, Jaciara Tiago Antunes / Nicolussi, Adriana Cristina / Ramos, Aline Maria Pereira Cruz / Gomes, Lucas Fernando Antunes / Monteiro, Damiana Aparecida Trindade / Toffano, Silmara Elaine Malaguti

Revista brasileira de enfermagem

2023 Volume 76, Issue 3, Page(s) e20220219

Abstract: Objectives: to analyze the knowledge and experience of undergraduate nursing students regarding infusion therapy and peripheral vascular access.: Methods: descriptive, cross-sectional, analytical study with 123 undergraduate nursing students who ... ...

Abstract	Objectives: to analyze the knowledge and experience of undergraduate nursing students regarding infusion therapy and peripheral vascular access. Methods: descriptive, cross-sectional, analytical study with 123 undergraduate nursing students who answered a semi-structured instrument. Results: the majority were women, with a median age of 51 years old; 87% considered the teaching received insufficient to perform in clinical practice. The mean overall knowledge score was 78.1 (SD± 8.97). The themes catheter flushing and lock (38.1%), catheter selection (34.2%), infusion equipment (30.9%) and insertion site (30.9%) presented a significant number of errors. Conclusions: practical classes and execution of procedures in health services were predictors for a better knowledge about infusion therapy and vascular access by undergraduate nursing students.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Students, Nursing ; Education, Nursing, Baccalaureate/methods ; Cross-Sectional Studies ; Surveys and Questionnaires
Language	Portuguese
Publishing date	2023-08-07
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731983-6
ISSN	1984-0446 ; 0034-7167
ISSN (online)	1984-0446
ISSN	0034-7167
DOI	10.1590/0034-7167-2022-0219
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Article ; Online: Biosynthesis of Cytosporones in Leotiomycetous Filamentous Fungi.

Li, Li / Zhong, Weimao / Liu, Hang / Espinosa-Artiles, Patricia / Xu, Ya-Ming / Wang, Chen / Verdugo Robles, Jose Manuel / Paz, Tiago Antunes / Cascaes Inácio, Marielle / Chen, Fusheng / Xu, Yuquan / Gunatilaka, A A Leslie / Molnár, István

Journal of the American Chemical Society

2024 Volume 146, Issue 9, Page(s) 6189–6198

Abstract: Polyketides with the isochroman-3-one pharmacophore are rare among fungal natural products as their biosynthesis requires an unorthodox S-type aromatic ring cyclization. Genome mining uncovered a conserved gene cluster in select leotiomycetous fungi that ...

Abstract	Polyketides with the isochroman-3-one pharmacophore are rare among fungal natural products as their biosynthesis requires an unorthodox S-type aromatic ring cyclization. Genome mining uncovered a conserved gene cluster in select leotiomycetous fungi that encodes the biosynthesis of cytosporones, including isochroman-3-one congeners. Combinatorial biosynthesis in total biosynthetic and biocatalytic formats in
MeSH term(s)	Fungi/genetics ; Saccharomyces cerevisiae/metabolism ; Polyketide Synthases/metabolism ; Polyketides/chemistry ; Biological Products/metabolism
Chemical Substances	Polyketide Synthases (79956-01-7) ; Polyketides ; Biological Products
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c14066
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Article ; Online: Yield performance and nutritional quality of tomato hybrids in response to protected environments during the Amazonian summer

Vicente Pataraico Junior / Flavio Fernandes Junior / Marcio Roggia Zanuzo / Rene Arnoux da Silva Campos / Franciely da Silva Ponce / Silvia de Carvalho Campos Botelho / Ivone Vieira da Silva / Darley Tiago Antunes / Maria Shirlyane Pereira do Nascimento / Santino Seabra Junior

Advances in Horticultural Science, Vol 37, Iss

2024 Volume 4

Abstract: This study evaluated the yield performance of the tomato hybrids 'DS0060', 'Thaise' and 'Trucker' in the open field and environments protected by agricultural film (F) and polycarbonate panels (P) during the Amazonian summer. In the protected environment, ...

Abstract	This study evaluated the yield performance of the tomato hybrids 'DS0060', 'Thaise' and 'Trucker' in the open field and environments protected by agricultural film (F) and polycarbonate panels (P) during the Amazonian summer. In the protected environment, the crops produced significantly higher yields than in the open field. 'Thaise' has high thermotolerance and is adaptable to a wide temperature range, making it the best-performing hybrid in environment F. Highest yields were found for 'Thaise' in environment F or P (86.2 and 92.5 t ha-1) together with 'DS0060' and 'Trucker' in environment F (75.3 and 88.2 t ha-1), demonstrating the high yield potential in the interim growing season (January to April). In the open field, the fruit color was paler, fruit flesh firmer and ripening index lower. In environment F, the fruits contained highest levels of soluble solids, lycopene and β-carotene. 'Thaise' contained higher concentrations of these two compounds. Under environment P, the yield of the evaluated tomato hybrids increased considerably, indicating it as a promising possibility for tomato cultivation in tropical regions. 'Thaíse' stood out with high yield and good quality traits, when grown in an F or P environment. These results prove the viability of tomato production as interim crop in tropical regions, under high rainfall and heat, as well as the difference protected environments make for tomato cultivation, in particular the choice of the most suitable cover material for the crop, to ensure high yields coupled with desirable quality properties.
Keywords	Carotenoids ; fruit production ; physicochemical properties ; protected cultivation ; Solanum lycopersicum L ; Biology (General) ; QH301-705.5 ; Botany ; QK1-989
Subject code	571
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Firenze University Press
Document type	Article ; Online
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Article ; Online: Project and Implementation of an Educational Large-Scale Water Distillation Unit with a Closed-Circuit Condenser

Luís Carlos Matos / Ana Eulálio / Tiago Antunes / José Miguel Loureiro / Alexandre Ferreira / Adélio Mendes

Sustainability, Vol 12, Iss 3239, p

2020 Volume 3239

Abstract: Water is one of the scarcest resources in the world, and it is becoming rarer fast, year after year. Chemical engineers are particularly suited to addressing the challenges of saving water and producing more fresh water. Proper education is then critical ...

Abstract	Water is one of the scarcest resources in the world, and it is becoming rarer fast, year after year. Chemical engineers are particularly suited to addressing the challenges of saving water and producing more fresh water. Proper education is then critical to prepare them for the upcoming decades. All student laboratories need distilled water, which is typically produced using commercial distillation units, which consume up to 70 L of fresh water per liter of distillated water. This work reports the design, construction, optimization, and operation of a water distillation unit that produces 10 liters per hour at 4 µS∙cm −1 and wastes no fresh water. Developed by a committed team made up of students, lab technicians, and instructors, this unit saves ca. 550 m 3 of fresh water annually while spending less electrical power.
Keywords	distilled water ; heat transfer ; distillation ; automation and control ; chemical engineering education ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333 ; 690
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots.

Inácio, Marielle Cascaes / Paz, Tiago Antunes / Pereira, Ana Maria Soares / Furlan, Maysa

Journal of chemical ecology

2019 Volume 45, Issue 9, Page(s) 789–797

Abstract: Peritassa campestris (Celastraceae) root bark accumulates potent antitumor quinonemethide triterpenes (QMTs). When grown in their natural habitat, plants of the family Celastraceae produce different QMTs such as celastrol (3) and pristimerin (4). However, ...

Abstract	Peritassa campestris (Celastraceae) root bark accumulates potent antitumor quinonemethide triterpenes (QMTs). When grown in their natural habitat, plants of the family Celastraceae produce different QMTs such as celastrol (3) and pristimerin (4). However, when they are inserted in in vitro culture systems, they accumulate maytenin (1) as the main compound. Recently, Bacillus megaterium was detected as an endophytic microorganism (EM) living inside P. campestris roots cultured in vitro. We hypothesized that compound (1) controls EM growth more efficiently, and that the presence of EMs in the root culture causes compound (1) to accumulate. For the first time, this work has explored plant-microorganism interaction in a species of the family Celastraceae by co-culture with an EM. Live endophytic bacteria were used, and QMT accumulation in P. campestris adventitious roots was our main focus. The antimicrobial activity of the main QMTs against endophytic B. megaterium was also evaluated. Our results showed that compound (1) and maytenol (5) were more effective than their precursors QMTs (3) and (4) in controlling the EM. Co-culture of B. megaterium with roots significantly reduced bacterial growth whereas root development remained unaffected. Compound (1) production was 24 times higher after 48 hr in the presence of the highest B. megaterium concentration as compared to the control. Therefore, P. campestris adventitious roots affect the development of the endophyte B. megaterium through production of QMTs, which in turn can modulate production of compound (1).
MeSH term(s)	Anti-Infective Agents/chemistry ; Antineoplastic Agents/chemistry ; Bacillus megaterium/metabolism ; Celastraceae/metabolism ; Endophytes/metabolism ; Plant Extracts/chemistry ; Plant Roots/metabolism ; Time Factors ; Triterpenes/chemistry
Chemical Substances	Anti-Infective Agents ; Antineoplastic Agents ; Plant Extracts ; Triterpenes ; celastrol (L8GG98663L)
Language	English
Publishing date	2019-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	800130-3
ISSN	1573-1561 ; 0098-0331
ISSN (online)	1573-1561
ISSN	0098-0331
DOI	10.1007/s10886-019-01096-y
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Article ; Online: DESEMPENHO DE CULTIVARES DE TOMATE ITALIANO DE CRESCIMENTO DETERMINADO EM CULTIVO PROTEGIDO SOB ALTAS TEMPERATURAS

Daiane Andréia Trento / Darley Tiago Antunes / Flávio Fernandes Júnior / Márcio Roggia Zanuzo / Rivanildo Dallacort / Santino Seabra Júnior

Nativa, Vol 9, Iss

2021 Volume 4

Abstract: O objetivo desse trabalho foi avaliar a produção, a qualidade e tempo de prateleira de cultivares de tomate tipo italiano de crescimento determinado, produzidos sob ambiente protegido em condições de altas temperaturas. O cultivo foi realizado em Nova ... ...

Abstract	O objetivo desse trabalho foi avaliar a produção, a qualidade e tempo de prateleira de cultivares de tomate tipo italiano de crescimento determinado, produzidos sob ambiente protegido em condições de altas temperaturas. O cultivo foi realizado em Nova Mutum – MT, foram avaliados cinco cultivares: Fascínio (Feltrin sementes), Hy Color (Horticeres), Santa Adélia (TopSeed), SM-16 (Seminis) e Supera F1 (TopSeed), dispostos em blocos casualizados, com quatro repetições. As plantas foram conduzidas em “meia estaca” e não foram podadas. Os parâmetros avaliados foram relativos a produção, a qualidade dos frutos, tempo de prateleira e qualidade no pós-colheita. A cultivar Fascínio apresentou produtividade de 186,1 t ha-1, maior massa média de frutos (144,3g), maior calibre de fruto, (60,7mm), e menor perda de massa no pós-colheita (6,23%). Os melhores resultados de sólidos solúveis totais dos frutos que completaram a maturação na planta foram obtidos das cultivares Santa Adélia (4,3), Fascínio (4,27) e Hy Color (4,21), e dos frutos colhidos no estádio verde-maduro obteve destaque a cultivar Santa Adélia (5,85), e os frutos que ficaram em temperatura ambiente obtiveram maior média de sólidos solúveis totais (5,55). Palavras-chave: termotolerância; Lycopersicum esculentum Mill; produtividade; pós colheita; ambiente protegido. The performance of determinate growth italian tomato cultivars in protected cropping under high temperatures ABSTRACT: This study aimed to evaluate the production, quality and shelf time of determinate growth Italian tomato cultivars from a protected environment under high temperature conditions. The cultivation was conducted in Nova Mutum, state of Mato Grosso, Brazil. Five cultivars were evaluated: ‘Fascínio’ (Feltrin Sementes), ‘Hy Color’ (Horticeres), ‘Santa Adélia’ (TopSeed), ‘SM-16’ (Seminis) and ‘Supera F1’ (TopSeed), disposed in randomized blocks with four repetitions. The plants were managed into the “meia estaca” tutoring method and were not pruned. The parameters evaluated were related to ...
Keywords	termotolerância ; Lycopersicum esculentum Mill ; produtividade ; pós colheita ; ambiente protegido ; Agriculture ; S ; Environmental sciences ; GE1-350
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Universidade Federal de Mato Grosso (UFMT)
Document type	Article ; Online
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Article ; Online: MANDATORY DETENTION OF PUBLIC POLICY IN THE STATE OF SÃO PAULO

Tiago Antunes Rezende / Maria Angélica Chichera Santos

Revista de Sociologia, Antropologia e Cultura Jurídica, Vol 2, Iss

COMPARATIVE ANALYSIS OF JEREMY BENTHAM PARADIGMS AND JOHN RAWLS

2016 Volume 1

Abstract: Thisworkistheobjectofstudygovernmentprogramofcompulsoryhospitalizationofdrug addictsdeployedinthestateofSãoPaulo.Thus,theobjectiveofthisresearchistoconducta comparativeanalysisofthethoughtsofJeremyBenthamandJohnRawlsastheconception ... ...

Abstract	Thisworkistheobjectofstudygovernmentprogramofcompulsoryhospitalizationofdrug addictsdeployedinthestateofSãoPaulo.Thus,theobjectiveofthisresearchistoconducta comparativeanalysisofthethoughtsofJeremyBenthamandJohnRawlsastheconception ofjusticeincasesofcompulsoryhospitalization.Forthis,itwillusethehypothetical- deductivemethodbyanalyzingbooks,scientificarticles,nationallegislationandofficialdata toreachascientificallyvalidconclusion.Thus,thestudyoftheinitialhypothesisonthe perception of justice and injustice of public policies applied to chemical addicts.
Keywords	Justiça ; Políticas públicas ; Internação compulsória ; Law ; K ; Social sciences (General) ; H1-99
Language	Portuguese
Publishing date	2016-10-01T00:00:00Z
Publisher	Conselho Nacional de Pesquisa e Pós-graduação em Direito (CONPEDI)
Document type	Article ; Online
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Article ; Online: Copper ion-based chemical elicitation induces production of new benzofurans in Anthostomella brabeji, an endophytic fungus of Paepalanthus planifolius.

Hilario, Felipe / Polinário, Giulia / de Amorim, Marcelo Rodrigues / Botero, Weslei Bruno / Peixoto, Talita / Paz, Tiago Antunes / Furlan, Maysa / de Luca Batista, Andrea Nastri / Junior, João Marcos Batista / Bauab, Taís Maria / Dos Santos, Lourdes Campaner

Fitoterapia

2023 Volume 171, Page(s) 105706

Abstract: The present work reports the effects of chemical elicitors and epigenetic modifiers on the production and diversification of secondary metabolites produced by Anthostomella brabeji - an endophytic fungus isolated from Paepalanthus planifolius ( ... ...

Abstract	The present work reports the effects of chemical elicitors and epigenetic modifiers on the production and diversification of secondary metabolites produced by Anthostomella brabeji - an endophytic fungus isolated from Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated under four different small-scale culture conditions in potato dextrose broth (PDB): PDB (control), PDB + Mg
MeSH term(s)	Eriocaulaceae ; Copper ; Molecular Structure ; Ascomycota ; Plant Extracts/chemistry
Chemical Substances	Copper (789U1901C5) ; Plant Extracts
Language	English
Publishing date	2023-10-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105706
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Article ; Online: Total, Unbound, Renal, and Hepatic Clearances of Raltegravir and the Formation and Elimination Clearances of Raltegravir Glucuronide in Pregnant Women.

Moreira, Fernanda de Lima / Paz, Tiago Antunes / Melli, Patrícia Pereira Dos Santos / Thomaz, Matheus de Lucca / Marques, Maria Paula / Rocha, Adriana / Duarte, Geraldo / Lanchote, Vera Lucia

Journal of clinical pharmacology

2023 Volume 63, Issue 9, Page(s) 1053–1060

Abstract: This work aimed to evaluate the total, unbound, renal, and hepatic clearances of raltegravir (RAL) and the formation and elimination clearances of raltegravir glucuronide (RAL GLU) in pregnant women living with HIV. The participants received RAL 400 mg ... ...

Abstract	This work aimed to evaluate the total, unbound, renal, and hepatic clearances of raltegravir (RAL) and the formation and elimination clearances of raltegravir glucuronide (RAL GLU) in pregnant women living with HIV. The participants received RAL 400 mg twice daily during the third trimester (n = 15) of gestation, delivery (n = 15), and the postpartum period (n = 8). Pharmacokinetic parameter values were calculated on the basis of plasma and urine data using noncompartmental methods. RAL clearances for the third trimester of gestation were as follows: total clearance: geometric mean, 63.63 L/h (95% CI, 47.5-85.25); renal clearance: geometric mean, 2.56 L/h (95% CI, 1.96-3.34); hepatic clearance: geometric mean, 60.52 L/h (95% CI, 44.65-82.04); and unbound clearance: geometric mean, 281.14 L/h (95% CI, 203.68-388.05). RAL GLU formation and elimination clearances for the third trimester of gestation were 7.57 L/h (95% CI, 4.94-11.6) and 8.71 L/h (95% CI, 6.71-11.32), respectively. No differences were observed in RAL GLU pharmacokinetic parameters between the third trimester of gestation and the postpartum period, except for higher formation (7.57 vs 4.03 L/h) and elimination (8.71 vs 4.92 L/h) clearances during the third trimester. The findings based on plasma and urine data are consistent with an increase in the hepatic uridine 5' diphospho-glucuronosyltransferase isoenzymes activities involved in RAL metabolism during pregnancy, and the formation of RAL GLU is a minor route of RAL elimination. Compared to the postpartum period, in the third trimester of gestation, the similar RAL plasma exposure in pregnant women reinforces the maintenance of an RAL regimen including a 400-mg oral dose twice daily during pregnancy.
MeSH term(s)	Female ; Humans ; Pregnancy ; Raltegravir Potassium/pharmacokinetics ; Glucuronides ; Pregnant Women ; HIV Infections/drug therapy ; Postpartum Period
Chemical Substances	Raltegravir Potassium (43Y000U234) ; Glucuronides
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.2287
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