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  1. Article ; Online: Co-designing a digital companion with people living with Parkinson's to support self-care in a personalized way

    Sylvie Grosjean / Jean-Luc Ciocca / Amélie Gauthier-Beaupré / Emely Poitras / David Grimes / Tiago Mestre

    Digital Health, Vol

    The eCARE-PD Study

    2022  Volume 8

    Abstract: eHealth technologies play a role in the development of integrated care models for people living with Parkinson disease by improving communication with their health care teams and support self-care practices in a personalized way. This article presents a ... ...

    Abstract eHealth technologies play a role in the development of integrated care models for people living with Parkinson disease by improving communication with their health care teams and support self-care practices in a personalized way. This article presents a co-design approach to designing an eHealth technology, the eCARE-PD platform, that addresses the needs and expectations of people living with Parkinson disease, generates tailored care tips, and recommends actions for managing care priorities at home. We use a co-design approach involving four main iterative phases: (1) preparation, (2) mapping, (3) testing and using, and (4) co-producing solutions and requirements. This approach uses several methods to engage people directly to design this technology. The study allowed us to identify design principles to be integrated in the development of the eCARE-PD platform. These principles incorporate the expectations of future users, which were expressed during the iterative phases of the co-design process: (a) six key design features based on users’ needs and expectations, (b) six main issues users raised during a test at home and key features for improving the design of the eCARE-PD platform, and (c) collective solutions to design an interactive, meaningful, tailored, empathic, and socially acceptable technology. The results of the successive phases of the co-design process allow us to underline the progressive constitution of a technology defined over successive iterations as a digital companion supporting the self-care process at home and having the capacity to generate tailored digital health communication.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases

    Tiago Mestre / Ana Maria Rodrigues / Jorge Cardoso

    Jornal Brasileiro de Pneumologia, Vol 41, Iss 3, Pp 289-

    2015  Volume 291

    Keywords Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language Portuguese
    Publishing date 2015-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Pneumologia e Tisiologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cutaneous focal mucinosis of the scalp and adenocarcinoma of the lung

    Tiago Mestre / Fernando Assis-Pacheco / Jorge Cardoso

    Jornal Brasileiro de Pneumologia, Vol 41, Iss 2, Pp 206-

    association or coincidence?

    2015  Volume 208

    Keywords Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language Portuguese
    Publishing date 2015-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Pneumologia e Tisiologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Co-designing an Integrated Care Network With People Living With Parkinson's Disease: From Patients' Narratives to Trajectory Analysis.

    Sylvie, Grosjean / Farré Coma, Jordi / Ota, Gal / Aoife, Laffan / Anna, Sendra / Johanne, Stuempel / Tiago, Mestre

    Qualitative health research

    2021  Volume 31, Issue 14, Page(s) 2585–2601

    Abstract: An integrated care model for people living with Parkinson's disease (PD) offers the promise of meeting complex care needs in a person-centered way that addresses fragmentation and improves quality of life. The purpose of our research was to co-design a ... ...

    Abstract An integrated care model for people living with Parkinson's disease (PD) offers the promise of meeting complex care needs in a person-centered way that addresses fragmentation and improves quality of life. The purpose of our research was to co-design a care delivery model that supports both social and medical care from the perspective of patients and care partners. In the first step of our co-design approach, participants from five countries were invited to share their experiences of living with PD during a narrative interview. A qualitative analysis of these narrative interviews based on the Corbin and Strauss model was done to map out patients' trajectories. Three typical trajectories were identified: (a) the "unpredictable" trajectory, (b) the "situated" trajectory, and (c) the "demanding" trajectory. Based on the analysis of these trajectories, we were able to integrate various patient experiences into the design of an integrated care network.
    MeSH term(s) Delivery of Health Care, Integrated ; Humans ; Narration ; Parkinson Disease/therapy ; Quality of Life
    Language English
    Publishing date 2021-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1275716-0
    ISSN 1552-7557 ; 1049-7323
    ISSN (online) 1552-7557
    ISSN 1049-7323
    DOI 10.1177/10497323211042605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhancing COVID Rehabilitation with Technology (ECORT)

    Simon Hatcher / Joel Werier / Nicole E. Edgar / James Booth / D. William J. Cameron / Vicente Corrales-Medina / Daniel Corsi / Juthaporn Cowan / Pierre Giguère / Mark Kaluzienski / Shawn Marshall / Tiago Mestre / Bryce Mulligan / Heather Orpana / Amanda Pontefract / Darlene Stafford / Kednapa Thavorn / Guy Trudel

    Trials, Vol 23, Iss 1, Pp 1-

    protocol for an open-label, single-site randomized controlled trial evaluating the effectiveness of electronic case management for individuals with persistent COVID-19 symptoms

    2022  Volume 17

    Abstract: Abstract Background As of May 2022, Ontario has seen more than 1.3 million cases of COVID-19. While the majority of individuals will recover from infection within 4 weeks, a significant subset experience persistent and often debilitating symptoms, known ... ...

    Abstract Abstract Background As of May 2022, Ontario has seen more than 1.3 million cases of COVID-19. While the majority of individuals will recover from infection within 4 weeks, a significant subset experience persistent and often debilitating symptoms, known as “post-COVID syndrome” or “Long COVID.” Those with Long COVID experience a wide array of symptoms, with variable severity, including fatigue, cognitive impairment, and shortness of breath. Further, the prevalence and duration of Long COVID is not clear, nor is there evidence on the best course of rehabilitation for individuals to return to their desired level of function. Previous work with chronic conditions has suggested that the addition of electronic case management (ECM) may help to improve outcomes. These platforms provide enhanced connection with care providers, detailed symptom tracking and goal setting, and access to relevant resources. In this study, our primary aim is to determine if the addition of ECM with health coaching improves Long COVID outcomes at 3 months compared to health coaching alone. Methods The trial is an open-label, single-site, randomized controlled trial of ECM with health coaching (ECM+) compared to health coaching alone (HC). Both groups will continue to receive usual care. Participants will be randomized equally to receive health coaching (± ECM) for a period of 8 weeks and a 12-week follow-up. Our primary outcome is the WHO Disability Assessment Scale (WHODAS), 36-item self-report total score. Participants will also complete measures of cognition, fatigue, breathlessness, and mental health. Participants and care providers will be asked to complete a brief qualitative interview at the end of the study to evaluate acceptability and implementation of the intervention. Discussion There is currently little evidence about the optimal treatment of Long COVID patients or the use of digital health platforms in this population. The results of this trial could result in rapid, scalable, and personalized care for people with Long COVID ...
    Keywords COVID-19 ; SARS-CoV-2 ; Long COVID ; Post-COVID rehabilitation ; Blended care ; Electronic case management ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Correction

    Raquel Pinho / Leonor C Guedes / Lilach Soreq / Patrícia P Lobo / Tiago Mestre / Miguel Coelho / Mário M Rosa / Nilza Gonçalves / Pauline Wales / Tiago Mendes / Ellen Gerhardt / Christiane Fahlbusch / Vincenzo Bonifati / Michael Bonin / Gabriel Miltenberger-Miltényi / Fran Borovecki / Hermona Soreq / Joaquim J Ferreira / Tiago F Outeiro

    PLoS ONE, Vol 12, Iss 12, p e

    Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

    2017  Volume 0190552

    Abstract: This corrects the article DOI:10.1371/journal.pone.0157852.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0157852.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

    Raquel Pinho / Leonor C Guedes / Lilach Soreq / Patrícia P Lobo / Tiago Mestre / Miguel Coelho / Mário M Rosa / Nilza Gonçalves / Pauline Wales / Tiago Mendes / Ellen Gerhardt / Christiane Fahlbusch / Vincenzo Bonifati / Michael Bonin / Gabriel Miltenberger-Miltényi / Fran Borovecki / Hermona Soreq / Joaquim J Ferreira / Tiago F Outeiro

    PLoS ONE, Vol 11, Iss 6, p e

    2016  Volume 0157852

    Abstract: The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether ...

    Abstract The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson's disease (PD) progression, thereby shedding light into potential molecular mechanisms underlying disease development. We compared transcriptional profiles in the blood from 34 PD patients who developed postural instability within ten years with those of 33 patients who did not develop postural instability within this time frame. Our study identified >200 differentially expressed genes between the two groups. The expression of several of the genes identified was previously found deregulated in animal models of PD and in PD patients. Relevant genes were selected for validation by real-time PCR in a subset of patients. The genes validated were linked to nucleic acid metabolism, mitochondria, immune response and intracellular-transport. Interestingly, we also found deregulation of these genes in a dopaminergic cell model of PD, a simple paradigm that can now be used to further dissect the role of these molecular players on dopaminergic cell loss. Altogether, our study provides preliminary evidence that expression changes in specific groups of genes and pathways, detected in peripheral blood samples, may be correlated with differential PD progression. Our exploratory study suggests that peripheral gene expression profiling may prove valuable for assisting in prediction of PD prognosis, and identifies novel culprits possibly involved in dopaminergic cell death. Given the exploratory nature of our study, further investigations using independent, well-characterized cohorts will be essential in order to validate our candidates as predictors of PD prognosis and to definitively confirm the value of gene expression analysis in aiding patient stratification and therapeutic ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.

    Madalena Martins / Alexandra Rosa / Leonor C Guedes / Benedita V Fonseca / Kristina Gotovac / Sara Violante / Tiago Mestre / Miguel Coelho / Mário M Rosa / Eden R Martin / Jeffery M Vance / Tiago F Outeiro / Liyong Wang / Fran Borovecki / Joaquim J Ferreira / Sofia A Oliveira

    PLoS ONE, Vol 6, Iss 10, p e

    2011  Volume 25443

    Abstract: miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in ... ...

    Abstract miRNAs were recently implicated in the pathogenesis of numerous diseases, including neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the nervous system, essential for efficient brain function and play important roles in neuronal patterning and cell specification. To further investigate their involvement in the etiology of PD, we conducted miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of 19 patients and 13 controls using microarrays. We found 18 miRNAs differentially expressed, and pathway analysis of 662 predicted target genes of 11 of these miRNAs revealed an over-representation in pathways previously linked to PD as well as novel pathways. To narrow down the genes for further investigations, we undertook a parallel approach using chromatin immunoprecipitation-sequencing (ChIP-seq) analysis to uncover genome-wide interactions of α-synuclein, a molecule with a central role in both monogenic and idiopathic PD. Convergence of ChIP-seq and miRNomics data highlighted the glycosphingolipid biosynthesis and the ubiquitin proteasome system as key players in PD. We then tested the association of target genes belonging to these pathways with PD risk, and identified nine SNPs in USP37 consistently associated with PD susceptibility in three genome-wide association studies (GWAS) datasets (0.46≤OR≤0.63) and highly significant in the meta-dataset (3.36×10⁻⁴
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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