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  1. Article ; Online: Comparative chemical characters of

    Sha, Miao / Li, Xiaohuan / Liu, Yu / Tian, Hongyue / Liang, Xu / Li, Xia / Gao, Wenyuan

    Chinese herbal medicines

    2023  Volume 15, Issue 3, Page(s) 439–446

    Abstract: Objective: Pseudostellaria heterophylla: Methods: In this study, the content of polysaccharide in 28 batches of : Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant ... ...

    Abstract Objective: Pseudostellaria heterophylla
    Methods: In this study, the content of polysaccharide in 28 batches of
    Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant from different origins. While the content of heterophyllin B in Anhui and Jiangsu was high. The correlation coefficients of HPLC fingerprints for 28 batches samples ranged from 0.877 to 0.990, and the characteristic map can be used to identify and evaluate the quality of
    Conclusion: HPLC fingerprint was established to evaluate the quality and authenticity of
    Language English
    Publishing date 2023-03-21
    Publishing country Singapore
    Document type Journal Article
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2022.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cationic fructan-based pH and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD.

    Li, Hongyu / Yang, Wenna / Wu, Xiongzhi / Tian, Luyao / Zhang, Weimei / Tian, Hongyue / Liang, Xu / Huang, Luqi / Guo, Lanping / Li, Xia / Gao, Wenyuan

    International journal of biological macromolecules

    2023  Volume 256, Issue Pt 2, Page(s) 127987

    Abstract: Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a ... ...

    Abstract Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-κB/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics.
    MeSH term(s) Mice ; Animals ; Berberine/pharmacology ; Berberine/metabolism ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Colitis/drug therapy ; Colon ; Hydrogen-Ion Concentration ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemical Substances Berberine (0I8Y3P32UF) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2023-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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