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Article: New strategy for antimetastatic treatment of lung cancer: a hypothesis based on circulating tumour cells.

Que, Zujun / Tian, Jianhui

2022 Volume 22, Issue 1, Page(s) 356

Abstract: Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung cancer metastasis have been lacking. This hypothesis focuses on circulating tumour cells (CTCs) to develop ...

Abstract	Metastasis is the primary cause of death in lung cancer patients. However, until now, effective drugs and intervention strategies for treating lung cancer metastasis have been lacking. This hypothesis focuses on circulating tumour cells (CTCs) to develop a new antimetastatic therapeutic strategy for lung cancer. Here, we outline the role of CTCs in tumour metastasis and their functional effects during the treatment of lung cancer patients. Additionally, we hypothesized the possibility of CTCs as a novel biomarker and therapeutic target in preventing and treating metastasis in patients with early-stage lung cancer. We hope that the realization of this hypothesis will improve the overall survival of lung cancer.
Language	English
Publishing date	2022-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02782-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response to Lentini and Reinius.

Lyu, Qingji / Yang, Qianying / Tian, Jianhui / An, Lei

Current biology : CB

2023 Volume 33, Issue 10, Page(s) R397

Abstract: Lyu et al. respond to the letter from Lentini and Reinius. ...

Abstract	Lyu et al. respond to the letter from Lentini and Reinius.
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.03.052
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Article ; Online: Computational protocol for the identification of X-linked genes contributing to X chromosome upregulation from RNA-sequencing datasets.

Yang, Qianying / Lyu, Qingji / Tian, Jianhui / An, Lei

STAR protocols

2023 Volume 4, Issue 4, Page(s) 102680

Abstract: The X chromosome/autosome ratio has been widely used to profile XCU at the chromosomal level. However, this approach overlooks features of inside genes. Here, we present a computational protocol for the identification of X-linked genes contributing to X ... ...

Abstract	The X chromosome/autosome ratio has been widely used to profile XCU at the chromosomal level. However, this approach overlooks features of inside genes. Here, we present a computational protocol for the identification of X-linked genes contributing to X chromosome upregulation from RNA-sequencing datasets. We describe steps for selecting data, preparing software, processing data, and data analysis. This protocol quantifies the contribution value and contribution increment of each X-linked gene to XCU. For complete details on the use and execution of this protocol, please refer to Lyu et al. (2022).
MeSH term(s)	Genes, X-Linked ; Up-Regulation/genetics ; X Chromosome ; Base Sequence ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102680
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Article ; Online: NK cell depletion promotes liver metastasis of lung cancer cells.

Yu, Pan / Zhang, Long / Tian, Jianhui / Liu, Jiajun / Que, Zujun / Li, Ge / Zhou, Yiyang

Acta biochimica et biophysica Sinica

2024 Volume 56, Issue 2, Page(s) 323–326

MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Killer Cells, Natural ; Lung/pathology ; Liver Neoplasms/pathology ; Neoplasm Metastasis
Language	English
Publishing date	2024-01-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2023266
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Article: [The TCR repertoire diversity and its application in the prevention and treatment of lung cancer].

Luo, Bin / Chu, Xiaoge / Yu, Pan / Tian, Jianhui

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2022 Volume 38, Issue 10, Page(s) 939–943

Abstract: Immune checkpoint inhibitors have become the standard for advanced lung cancer treatment, but their effect on the prevention of lung cancer metastasis is still unclear. T-cell receptors (TCRs) are key "signal sensors" that recognize neoantigens on the ... ...

Abstract	Immune checkpoint inhibitors have become the standard for advanced lung cancer treatment, but their effect on the prevention of lung cancer metastasis is still unclear. T-cell receptors (TCRs) are key "signal sensors" that recognize neoantigens on the surface of cancer cells. This review summarizes the research progress of TCR-T cell therapy in the prevention and treatment of lung cancer from the perspective of the diversity of TCR repertoire and the mechanism of tumor antigen recognition, in order to improve the efficacy of the prevention and treatment of lung cancer metastasis.
MeSH term(s)	Antigens, Neoplasm ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/prevention & control ; Receptors, Antigen, T-Cell/genetics
Chemical Substances	Antigens, Neoplasm ; Immune Checkpoint Inhibitors ; Receptors, Antigen, T-Cell
Language	Chinese
Publishing date	2022-09-26
Publishing country	China
Document type	Journal Article ; Review
ISSN	1007-8738
ISSN	1007-8738
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Article ; Online: Synthesis and Evaluation of Novel Nitric Oxide-Donating Ligustrazine Derivatives as Potent Antiplatelet Aggregation Agents.

Li, Han-Xu / Tian, Jian-Hui / Li, Hua-Yu / Wan, Xin / Zou, Yu

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: Antiplatelet aggregation agents have demonstrated clinical benefits in the treatment of ischemic stroke. In our study, a series of novel nitric oxide (NO)-donating ligustrazine derivatives were designed and synthesized as antiplatelet aggregation agents. ...

Abstract	Antiplatelet aggregation agents have demonstrated clinical benefits in the treatment of ischemic stroke. In our study, a series of novel nitric oxide (NO)-donating ligustrazine derivatives were designed and synthesized as antiplatelet aggregation agents. They were evaluated for the inhibitory effect on 5'-diphosphate (ADP)-induced and arachidonic acid (AA)-induced platelet aggregation in vitro. The results showed that compound
MeSH term(s)	Platelet Aggregation Inhibitors/pharmacology ; Nitric Oxide/pharmacology ; Platelet Aggregation ; Pyrazines/pharmacology ; Structure-Activity Relationship ; Arachidonic Acid/pharmacology
Chemical Substances	Platelet Aggregation Inhibitors ; tetramethylpyrazine (V80F4IA5XG) ; Nitric Oxide (31C4KY9ESH) ; Pyrazines ; Arachidonic Acid (27YG812J1I)
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083355
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Article ; Online: Optimization of the Countercurrent Continuous Reforming Process Based on Equation-Oriented Modeling and the SQP Algorithm.

Jiang, Hongbo / Li, Zhenming / Sun, Yun / Jiang, Shubao / Tian, Jianhui

ACS omega

2022 Volume 7, Issue 2, Page(s) 1757–1771

Abstract: Catalytic reforming is a key technology in the petroleum refining and petrochemical industry. In recent years, countercurrent continuous reforming has put forward and practiced the new concept of matching the activity of the catalyst with the difficulty ... ...

Abstract	Catalytic reforming is a key technology in the petroleum refining and petrochemical industry. In recent years, countercurrent continuous reforming has put forward and practiced the new concept of matching the activity of the catalyst with the difficulty of the reaction. Based on the equation-oriented method, the steady-state model for the reactor-regenerator section of countercurrent continuous reforming was established, including the reactor module, the regenerator module, the compressor model, the heat exchanger model, the heating furnace model, and the oil property model. The inlet and outlet of each module are connected according to the actual technological process, and the model conforms to the requirement of real-time optimization (RTO). The sequential quadratic programming (SQP) algorithm is used for calculation in this study. The model is calibrated to make the calculated value more consistent with the actual value. The model simulation showed the trend of the reforming reaction and the difference between countercurrent reforming and cocurrent reforming. Finally, the process model was optimized for different goals such as the yield of aromatics, the yield of high-octane gasoline, and the yield of C
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c04651
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Article ; Online: Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis.

Wang, Li / Zhang, Jiting / Zhang, Li / Hu, Lingli / Tian, Jianhui

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 1005392

Abstract: Background: Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing number of ... ...

Abstract	Background: Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing number of studies have investigated the relationship between sepsis and pyroptosis. Appropriate pyroptosis can help to control infection during sepsis, but an immoderate one may cause immune disorders. The present study aimed to identify pyroptosis-related gene biomarkers and their relationship with the immune microenvironment using the genome-wide technique. Methods: The training dataset GSE154918 and the validation dataset GSE185263 were downloaded for bioinformatics analysis. Differentially expressed pyroptosis-related genes (DEPRGs) were identified between sepsis (including septic shock) and healthy samples. Gene Set Enrichment Analysis (GSEA) was performed to explore gene function. CIBERSORT tools were applied to quantify infiltrating immune cells, and the correlation between differentially infiltrating immune cells and DEPRG expression was investigated. Furthermore, based on multivariable Cox regression, the study also utilized a random forest (RF) model to screen biomarkers. Results: In total, 12 DEPRGs were identified. The expression level of PLCG1 was continuously significantly decreased, while the expression level of NLRC4 was elevated from control to sepsis and then to septic shock. GSEA found that one DEPRG (PLCG1) was involved in the T-cell receptor signaling pathway and that many T cell-related immunologic signature gene sets were enriched. The proportions of plasma cells, T cells CD4 memory activated, and some innate cells in the sepsis group were significantly higher than those in the healthy group, while the proportions of T cells CD8, T cells CD4 memory resting, T cells regulatory (Tregs), and NK cells were lower. Additionally, CASP4 was positively correlated with Neutrophils and negatively correlated with T cells CD4 memory resting and Tregs. Lastly, two biomarkers (CASP4 and PLCG1) were identified, and a nomogram model was constructed for diagnosis with area under the curve (AUC) values of 0.998. Conclusion: This study identified two potential pyroptosis-related diagnostic genes, CASP4 and PLCG1, and explored the correlation between DEPRGs and the immune microenvironment. Also, our study indicated that some DEPRGs were satisfactorily correlated with several representative immune cells that can regulate pyroptosis.
MeSH term(s)	Biomarkers ; Cytokines ; Humans ; Pyroptosis/physiology ; Receptors, Antigen, T-Cell ; Sepsis ; Shock, Septic/genetics
Chemical Substances	Biomarkers ; Cytokines ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.1005392
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Article ; Online: A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).

Zhang, Zhanxia / Zhang, Junqian / Tian, Jianhui / Li, Hegen

Journal of nanobiotechnology

2021 Volume 19, Issue 1, Page(s) 323

Abstract: Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are ... ...

Abstract	Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activity with low potential side effects are urgently needed. Herein, a folic acid (FA)-modified polydopamine (PDA) nanomedicine used in photothermal therapy was designed for siRNA delivery. The designed nanovector can undergo photothermal conversion with good biocompatibility. Importantly, this genetic nanomedicine was selectively delivered to liver cancer cells by FA through receptor-mediated endocytosis. Subsequently, the siRNA cargo was released from the PDA nanomedicine into the tumor microenvironment by controlled release triggered by pH. More importantly, the genetic nanomedicine not only inhibited liver cancer cell proliferation but also promoted liver cell apoptosis by slowing ROC1 activity, suppressing the Neddylation pathway, enabling the accumulation of apototic factor ATF4 and DNA damage factor P-H2AX. Combined with photothermal therapy, this genetic nanomedicine showed superior inhibition of the growth of liver cancer in vitro and in vivo. Taken together, the results indicate that this biodegradable nanomedicine exhibits good target recognition, an effective pH response, application potential for genetic therapy, photothermal imaging and treatment of liver cancer. Therefore, this work contributes to the design of a multifunctional nanoplatform that combines genetic therapy and photothermal therapy for the treatment of liver cancer.
MeSH term(s)	Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Gene Knockdown Techniques ; Humans ; Indoles/chemistry ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; NEDD8 Protein/genetics ; NEDD8 Protein/metabolism ; Nanomedicine ; Nanoparticle Drug Delivery System ; Photothermal Therapy ; Polymers/chemistry ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
Chemical Substances	Carrier Proteins ; Indoles ; NEDD8 Protein ; NEDD8 protein, human ; Nanoparticle Drug Delivery System ; Polymers ; RBX1 protein, human ; RNA, Small Interfering ; polydopamine
Language	English
Publishing date	2021-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-021-01063-4
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Article ; Online: Modified Banxiaxiexin decoction benefitted chemotherapy in treating gastric cancer by regulating multiple targets and pathways.

Zhang, Zhipeng / Wu, Chao / Liu, Ningning / Wang, Ziyuan / Pan, Ziyang / Jiang, Yulang / Tian, Jianhui / Sun, Mingyu

Journal of ethnopharmacology

2024 Volume 331, Page(s) 118277

Abstract: Ethnopharmacological relevance: Chemotherapy tolerance weakened efficacy of chemotherapy drugs in the treating gastric cancer (GC). Banxiaxiexin decoction (BXXXD) was widely used in digestive diseases for thousands of years in Traditional Chinese ... ...

Abstract	Ethnopharmacological relevance: Chemotherapy tolerance weakened efficacy of chemotherapy drugs in the treating gastric cancer (GC). Banxiaxiexin decoction (BXXXD) was widely used in digestive diseases for thousands of years in Traditional Chinese medicine (TCM). In order to better treat GC, three other herbs were added to BXXXD to create a new prescription named Modified Banxiaxiexin decoction (MBXXXD). Although MBXXXD potentially treated GC by improving chemotherapy tolerance, the possible mechanisms were still unknown. Aim of the study: To explore the therapeutic effect of MBXXXD on GC patients and explore the possible anti-cancer mechanism. Materials and methods: A randomized controlled trial (n = 146) was conducted to evaluate the clinical efficacy between MBXXXD + chemotherapy (n = 73) and placebo + chemotherapy (n = 73) in GC patients by testing overall survival, progression free survival, clinical symptoms, quality of life score, tumor markers, T cell subpopulation, and adverse reactions. Network pharmacology was conducted to discover the potential mechanism of MBXXXD in treating GC. Metabolic activity assay, cell clone colony formation and mitochondrial apoptosis were detected in human GC cell lines including AGS cell, KNM-45 cell and SGC7901 cell treated by MBXXXD. Multiple pathways including P53, AKT, IκB, P65, P38, ERK, JNK p-AKT, p-P65, p-P38, p-ERK and p-JNK in AGS cell, KNM-45 cell and SGC7901 cell treated by MBXXXD and GC patients treated by MBXXXD + chemotherapy were also detected. Results: MBXXXD + chemotherapy promoted overall survival and progression free survival, improved clinical symptoms and quality of life score, increased T4 lymphocyte ratio and T8 lymphocyte ratio as well as T4/T8 lymphocyte ratio, and alleviated adverse reactions in GC patients. Network pharmacology predicted multiple targets and pathways of MBXXXD in treating GC including apoptosis, P53 pathway, AKT pathway, MAPK pathway. MBXXXD inhibited cell viability, decreased cell clone colony formation, and promoted mitochondrial apoptosis by producing reactive oxygen species (ROS), promoting mitochondrial permeability transition pore (MPTP) and the cleavage of pro-caspase-3 and pro-caspase-9, and decreasing mito-tracker red Chloromethyl-X-rosamine (CMXRos) in AGS cell, KNM-45 cell and SGC7901 cell. MBXXXD up-regulated the expression of P53 and IκB, and down-regulated the expression of p-AKT, p-P65, p-P38, p-ERK, p-JNK, AKT, P65, P38, ERK and JNK AGS cell, KNM-45 cell and SGC7901 cell treated by MBXXXD and GC patients treated by MBXXXD + chemotherapy. Conclusion: MBXXXD benefitted chemotherapy for GC by regulating multiple targets and pathways.
Language	English
Publishing date	2024-04-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118277
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