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Article: Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients.

Tian, Li-Ming / Ke, Dan

Clinical, cosmetic and investigational dermatology

2021 Volume 14, Page(s) 123–128

Abstract: Objective: To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group.: Methods: A total of 104 patients with ... ...

Abstract	Objective: To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group. Methods: A total of 104 patients with acne vulgaris and 126 healthy participants were included in our study. We analyzed the association between acne vulgaris and the polymorphisms in the DEFB1 G-52A, C-44G, and G-20A gene. We then analyzed the relationship between the different genotypes and the susceptibility to acne vulgaris. Results: The frequency of DEFB1 C-44G genetic polymorphisms between the acne vulgaris group and the control group was significantly different (P < 0.05). The frequency of DEFB1 G-20A genetic polymorphisms between the acne vulgaris group and the control group was also significantly different (P < 0.05). Conclusion: The -44G or -20A allele showed a low expression in acne vulgaris, which has already been shown to correlate with the low risk of acne vulgaris among Chinese Han patients. This further supports the contribution of the DEFB1 gene to the pathogenesis of acne.
Language	English
Publishing date	2021-02-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S292797
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Article ; Online: Effects of Qi-Bao-Mei-Ran-Dan on proliferative activity and expressions of apoptosis-related genes Bcl-2, Bax and autophagy-related protein LC3II in fibroblasts of aging skin.

Li, Heng / Yang, Ting / Tian, Li-Ming / Zhang, Peng-Cheng

Asian journal of surgery

2022 Volume 45, Issue 6, Page(s) 1319–1321

MeSH term(s)	Apoptosis ; Autophagy-Related Proteins ; Fibroblasts/metabolism ; Humans ; Skin Aging/genetics ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Autophagy-Related Proteins ; bcl-2-Associated X Protein
Language	English
Publishing date	2022-03-30
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.01.043
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Article: Variation of Ferroptosis-Related Markers in HaCaT Cell Photoaging Models Induced by UVB.

Zhang, Peng-Cheng / Hong, Yi / Zong, Shi-Qin / Chen, Long / Zhang, Chong / Tian, Dai-Zhi / Ke, Dan / Tian, Li-Ming

Clinical, cosmetic and investigational dermatology

2023 Volume 16, Page(s) 3147–3155

Abstract: Objective: To investigate the variation of ferroptosis-related markers in HaCaT cell photoaging models induced by ultraviolet-B (UVB).: Methods: UVB-treated HaCaT cells served as the model (UVB group) for cellular photoaging, whereas untreated HaCaT ... ...

Abstract	Objective: To investigate the variation of ferroptosis-related markers in HaCaT cell photoaging models induced by ultraviolet-B (UVB). Methods: UVB-treated HaCaT cells served as the model (UVB group) for cellular photoaging, whereas untreated HaCaT cells served as the control group. HaCaT cells were exposed to UVB and the ferroptosis inhibitor Ferrostatin-1 (Fer-1) as part of the UVB+Fer-1 group, and co-cultured with the ferroptosis inducer Erastin as part of the UVB+Erastin group. Reactive oxygen species (ROS) detection kit and senescence-related β galactosidase (SA-β-gal) staining were used to evaluate the senescence of HaCaT cells. Lipid reactive oxygen species were detected by C11 BODIPY581/591 probe and mitochondrial morphology was observed by transmission electron microscopy. The mRNA expressions of glutathione peroxidase 4 (GPX4) and ferroptosis-suppressor-protein 1 (FSP1) were detected by real-time reverse transcription-PCR (RT-RCP), and the level of GPX4 protein was measured by immunofluorescence assay. Results: The UVB group had considerably greater levels of ROS, SA-β-gal, and lipid reactive oxygen species than the control group. The UVB group's mitochondrial volume was reduced, the membrane density increased, and the mitochondrial crest decreased or even disappeared. GPX4 and FSP1 expression levels were similarly found to be lower in the UVB group. Furthermore, the positive rate of SA-β-gal and lipid reactive oxygen species in the UVB+Fer-1 group was much lower than in the UVB group, but it was reverse in the UVB+Erastin group. This study showed that induced ferroptosis can aggravate aging, and vice versa. Conclusion: According to the findings, ferroptosis may be linked to UVB-induced skin photoaging, which could be attenuated by inhibition of ferroptosis.
Language	English
Publishing date	2023-11-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S433071
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Article: The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China.

Yang, Ting / Wu, Wen-Juan / Tian, Li-Ming / Zhang, Deng-Feng / Yang, Xiao-Yan / Qi, Jue / Tu, Ying / He, Li

Clinical, cosmetic and investigational dermatology

2021 Volume 14, Page(s) 313–331

Abstract: Objective: Androgens acting through the androgen receptor play a crucial role in the pathogenesis of acne. This study aimed to identify whether two key genes (: Methods: We carried out a standard questionnaire survey about acne and enlisted 600 ... ...

Abstract	Objective: Androgens acting through the androgen receptor play a crucial role in the pathogenesis of acne. This study aimed to identify whether two key genes ( Methods: We carried out a standard questionnaire survey about acne and enlisted 600 Pillsbury III-IV severe acne vulgaris patients and 652 healthy controls of Han Chinese descent from Yunnan, China in the study. Twenty-two single nucleotide polymorphisms (SNPs) were genotyped by SNaPshot assay and analyzed for association with severe acne. Results: There was no significant difference in gender between the two groups ( Conclusion: This study shed a light on a potentially important effect of
Language	English
Publishing date	2021-03-29
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S293171
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Article: Productive Overcompensation of Alpine Meadows in Response to Yak Grazing in the Eastern Qinghai-Tibet Plateau.

Mipam, Tserang-Donko / Zhong, Lin-Ling / Liu, Jian-Quan / Miehe, Georg / Tian, Li-Ming

Frontiers in plant science

2019 Volume 10, Page(s) 925

Abstract: Understanding the interaction between large herbivores and pasture production, especially with respect to the grazing optimization hypothesis, is critical for pasture management and generating theoretical and testable predictions. However, the ... ...

Abstract	Understanding the interaction between large herbivores and pasture production, especially with respect to the grazing optimization hypothesis, is critical for pasture management and generating theoretical and testable predictions. However, the optimization hypothesis remains contradictory in alpine meadows on the Qinghai-Tibet Plateau (QTP). In this study, we tested the grazing optimization hypothesis using four yak-grazing intensities (no grazing, light grazing, moderate grazing and heavy grazing) in alpine meadow habitats from 2015 to 2017. The results indicated that species diversity did not differ significantly among grazing regimes during the experimental period. However, the aboveground net primary production (ANPP) under moderate grazing consistently significantly exceeded that in control enclosures over 3 years, confirming the grazing optimization hypothesis. Levels of overcompensation varied among grazing intensities and years, and grazing-induced plant compensation may only occur in the short term. The enhanced regrowth of
Language	English
Publishing date	2019-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2019.00925
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Article: Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking.

Han, Miao / Li, Heng / Ke, Dan / Tian, Li-Ming / Hong, Yi / Zhang, Chong / Tian, Dai-Zhi / Chen, Long / Zhan, Li-Rui / Zong, Shi-Qin

Clinical, cosmetic and investigational dermatology

2022 Volume 15, Page(s) 763–781

Abstract: Purpose: To study the efficacy of Ba Zhen Tang in delaying skin photoaging and its potential mechanism based on network pharmacology and molecular docking.: Methods: First, we screened the active components and targets of Ba Zhen Tang by Traditional ... ...

Abstract	Purpose: To study the efficacy of Ba Zhen Tang in delaying skin photoaging and its potential mechanism based on network pharmacology and molecular docking. Methods: First, we screened the active components and targets of Ba Zhen Tang by Traditional Chinese Medicine Database and Analysis Platform (TCMSP) and The Universal Protein Resource (UniProt). The target genes of skin photoaging were obtained from GeneCards and GeneMap database. Then, we analyzed the protein-protein interaction (PPI) by STRING database. The network map was constructed by Cytoscape. Finally, we performed Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis by Metascape database. The molecular docking via Autodock Vina and Pymol. Furthermore, skin photoaging cellular models were established, and the effects of Ba Zhen Tang on ameliorating skin photoaging were investigated. Results: A total of 160 active ingredients in Ba Zhen Tang and 60 targets of Ba Zhen Tang for delaying skin photoaging were identified. By GO enrichment analysis, 1153 biological process entries, 45 cellular component entries and 89 molecular functional entries were obtained. A total of 155 signal pathways were obtained by KEGG analysis. Ba Zhen Tang is related to MAPK signaling pathway, TNF signaling pathway and AGE-RAGE signaling pathway in diabetic complications, etc., which directly affect the key nodes of photoaging. The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, β-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53). Ba Zhen Tang-treated mouse serum inhibited the senescence and p16 Conclusion: Our study elucidated the potential pharmacological mechanism of Ba Zhen Tang in the treatment of photoaging through multiple targets and pathways. The therapeutic effects of Ba Zhen Tang on skin photoaging were validated in cellular models.
Language	English
Publishing date	2022-04-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S344138
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Article ; Online: A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging.

Ke, Dan / Zhang, Han / Tian, Li-Ming / Han, Miao / Zhang, Chong / Tian, Dai-Zhi / Chen, Long / Zhan, Li-Rui / Zong, Shi-Qin / Zhang, Ping

Journal of cosmetic dermatology

2022 Volume 21, Issue 10, Page(s) 4956–4964

Abstract: Objective: The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.: Methods: The traditional Chinese medicine systems pharmacology ... ...

Abstract	Objective: The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging. Methods: The traditional Chinese medicine systems pharmacology database and analysis platform, and the traditional Chinese medicine integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan. The human gene database GeneCards and the gene database of the National Center for Biotechnology Information were jointly adopted to obtain skin aging-related target genes. The search tool for the retrieval of interacting genes/proteins (STRING) database was used for core analysis of protein-protein interaction. Results: In total, 72 effective active ingredients, 273 action targets, 234 skin aging target genes, and 64 intersecting core targets were identified. GO enrichment analysis provided 393 biological process entries, and the KEGG analysis was represented by the tumor necrosis factor (TNF) signaling pathway, where the core targets of TNF-α and matrix metalloproteinase-1 (MMP-1) were enriched. The experimental results showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group than in the model group. Conclusion: Qibao Meiran Dan may regulate oxidative stress injury and collagen metabolism by downregulating the expression of TNF-α and MMP-1, thus slowing skin aging.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/pharmacology ; Matrix Metalloproteinase 1/genetics ; Skin Aging ; Tumor Necrosis Factor-alpha ; Network Pharmacology
Chemical Substances	Drugs, Chinese Herbal ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14908
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Article ; Online: Efficacy of integrating short-course chemotherapy with Chinese herbs to treat multi-drug resistant pulmonary tuberculosis in China: a study protocol.

Zhang, Shun-Xian / Qiu, Lei / Li, Cui / Zhou, Wei / Tian, Li-Ming / Zhang, Hui-Yong / Ma, Zi-Feng / Wu, Xian-Wei / Huang, Xing / Jiang, Yu-Wei / Zhang, Shao-Yan / Lu, Zhen-Hui

Infectious diseases of poverty

2021 Volume 10, Issue 1, Page(s) 131

Abstract: Background: Tuberculosis (TB) caused Mycobacterium tuberculosis (M.tb) is one of infectious disease that lead a large number of morbidity and mortality all over the world. Although no reliable evidence has been found, it is considered that combining ... ...

Abstract	Background: Tuberculosis (TB) caused Mycobacterium tuberculosis (M.tb) is one of infectious disease that lead a large number of morbidity and mortality all over the world. Although no reliable evidence has been found, it is considered that combining chemotherapeutic drugs with Chinese herbs can significantly improves the cure rate and the clinical therapeutic effect. Methods: Multi-drug resistant pulmonary tuberculosis (MDR-PTB, n = 258) patients with Qi-yin deficiency syndrome will be randomly assigned into a treatment group (n = 172) or control/placebo group (n = 86). The treatment group will receive the chemotherapeutic drugs combined with Chinese herbs granules (1 + 3 granules), while the control group will receive the chemotherapeutic drugs combined with Chinese herbs placebo (1 + 3 placebo granules). In addition, MDR-PTB (n = 312) patients with Yin deficiency lung heat syndrome will be randomly assigned to a treatment (n = 208) or control/placebo (n = 104) group. The treatment group will receive the chemotherapeutic regimen combined with Chinese herbs granules (2 + 4 granules), while the control group will receive the chemotherapeutic drugs and Chinese herbs placebo (2 + 4 placebo granules). The primary outcome is cure rate, the secondary outcomes included time to sputum culture conversion, lesion absorption rate and cavity closure rate. BACTEC™ MGIT™ automated mycobacterial detection system will be used to evaluate the M.tb infection and drug resistance. Chi-square test and Cox regression will be conducted with SAS 9.4 Statistical software to analyze the data. Discussion: The treatment cycle for MDR-PTB using standardized modern medicine could cause lengthy substantial side effects. Chinese herbs have been used for many years to treat MDR-PTB, but are without high-quality evidence. Hence, it is unknown whether Chinese herbs enhances the clinical therapeutic effect of synthetic drugs for treating MDR-PTB. Therefore, this study will be conducted to evaluate the clinical therapeutic effect of combining Chinese herbs and chemotherapeutic drugs to treat MDR-PTB cases. It will assist in screening new therapeutic drugs and establishing treatment plan that aims to improve the clinical therapeutic effect for MDR-PTB patients. Trial registration: This trial was registered at ClinicalTrials.gov (ChiCTR1900027720) on 24 November 2019 (prospective registered).
MeSH term(s)	China ; Drug Resistance, Multiple ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Tuberculosis, Pulmonary/drug therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-11-06
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2689396-4
ISSN	2049-9957 ; 2049-9957
ISSN (online)	2049-9957
ISSN	2049-9957
DOI	10.1186/s40249-021-00913-5
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Article: [Analysis of the toll-like receptor 2 Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome].

Tian, Li-Ming / Wang, Wei-Zhen / Yang, Tin

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2012 Volume 32, Issue 1, Page(s) 50–53

Abstract: Objective: To study the toll-like receptor 2 (TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome, thus laying the foundation for genetics studies on its occurrence.! ...

Abstract	Objective: To study the toll-like receptor 2 (TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome, thus laying the foundation for genetics studies on its occurrence. Methods: The distribution and the frequency of allelic genes were studied in 75 acne patients of damp-heat in the interior syndrome, and 87 acne patients with Gan-depression induced qi stagnation syndrome, as well as 70 healthy subjects (as the normal control group) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: There was significant difference in the frequency of the genotype Arg/Gln + Gln/Gln in the TLR2 Arg753Gln genetic polymorphisms [26. 44% (23/87) in Gan-depression induced qi stagnation syndrome, 41.33% (31/75) in damp-heat in the interior syndrome, and 12.86% (9/70) in the normal control group] (P < 0.05). Conclusion: The existence of 753Gln allele in the Arg753Gln of TLR2 increased the onset risk of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome.
MeSH term(s)	Acne Vulgaris/diagnosis ; Acne Vulgaris/ethnology ; Acne Vulgaris/genetics ; Adolescent ; Adult ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Medicine, Chinese Traditional ; Phenotype ; Polymorphism, Genetic ; Qi ; Toll-Like Receptor 2/genetics ; Young Adult
Chemical Substances	TLR2 protein, human ; Toll-Like Receptor 2
Language	Chinese
Publishing date	2012-01
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article ; Online: CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.

He, Wei-Peng / Guo, Yun-Yun / Yang, Gui-Ping / Lai, Hui-Ling / Sun, Ting-Ting / Zhang, Zu-Wei / Ouyang, Ling-Long / Zheng, Yu / Tian, Li-Ming / Li, Xiao-Hui / You, Ze-Shan / Xie, Dan / Yang, Guo-Fen

International journal of medical sciences

2020 Volume 17, Issue 15, Page(s) 2387–2395

Abstract: Chromodomain helicase DNA binding protein 1-like (CHD1L) gene has been proposed to play an oncogenic role in human hepatocellular carcinoma. Previously we reported that CHD1L overexpression is significantly associated with the metastasis proceeding of ... ...

Abstract	Chromodomain helicase DNA binding protein 1-like (CHD1L) gene has been proposed to play an oncogenic role in human hepatocellular carcinoma. Previously we reported that CHD1L overexpression is significantly associated with the metastasis proceeding of epithelial ovarian cancer (EOC), and may predict a poor prognosis in EOC patients. However, the potential oncogenic mechanisms by which CHD1L acts in EOC remain unclear. To elucidate the oncogenic function of CHD1L, we carried out a series of
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/mortality ; Carcinoma, Ovarian Epithelial/pathology ; Carcinoma, Ovarian Epithelial/surgery ; Cell Line, Tumor ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Kaplan-Meier Estimate ; Methionyl Aminopeptidases/genetics ; Middle Aged ; Neoplasm Invasiveness/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Ovariectomy ; Ovary/pathology ; Ovary/surgery ; Tissue Array Analysis ; Up-Regulation
Chemical Substances	Biomarkers, Tumor ; DNA-Binding Proteins ; METAP2 protein, human (EC 3.4.11.18) ; Methionyl Aminopeptidases (EC 3.4.11.18) ; DNA Helicases (EC 3.6.4.-) ; CHD1L protein, human (EC 3.6.4.12)
Language	English
Publishing date	2020-08-29
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.48615
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