Article ; Online: Integrative Analyses of Mendelian Randomization and Transcriptomic Data Reveal No Association between Leptin and Chronic Obstructive Pulmonary Disease.
2023 Volume 20, Issue 1, Page(s) 321–326
Abstract: As a key adipokine, leptin has been extensively investigated for its potential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, concordant conclusions have not been attained. In this study, we investigated the ... ...
Abstract | As a key adipokine, leptin has been extensively investigated for its potential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, concordant conclusions have not been attained. In this study, we investigated the relationship between leptin and COPD using an integrative analysis that combined a Mendelian randomization (MR) study with transcriptomic data analysis. Here, the MR analysis was performed on the online platform MR-Base, and the bioinformatics analyses were performed with the aid of R Bioconductor packages. No evidence was found by the integrative analysis to support the association of the two attributes. All methods detected a null causal effect of leptin on COPD in the MR analysis. In particular, when the genetically predicted leptin level increased one unit, the risk of developing COPD was estimated as 0.999 ( |
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MeSH term(s) | Humans ; Transcriptome ; Leptin/genetics ; Mendelian Randomization Analysis ; Pulmonary Disease, Chronic Obstructive/genetics ; Gene Expression Profiling ; Genome-Wide Association Study |
Chemical Substances | Leptin |
Language | English |
Publishing date | 2023-10-09 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2171107-0 |
ISSN | 1541-2563 ; 1541-2555 |
ISSN (online) | 1541-2563 |
ISSN | 1541-2555 |
DOI | 10.1080/15412555.2023.2260890 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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