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  1. AU="Tian, Wei Dong"
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  1. Article: [Application of Extracellular Vesicles Derived from Vascular Endothelial/Endothelial Progenitor Cells in Tissue Regeneration and Repair].

    Li, Mao-Ye / Yu, Mei / Liu, Lei / Tian, Wei-Dong

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2022  Volume 53, Issue 2, Page(s) 355–360

    Abstract: Extracellular vesicles can be released by almost all types of cells and are important mediators of intercellular signal transmssion. Extracellular vesicles regulate the function and activity of recipient cells by delivering biologically active molecules ... ...

    Abstract Extracellular vesicles can be released by almost all types of cells and are important mediators of intercellular signal transmssion. Extracellular vesicles regulate the function and activity of recipient cells by delivering biologically active molecules such as proteins and nucleic acids, which is of great significance in tissue repair and regeneration. According to numerous studies, extracellular vesicles derived from endothelial/endothelial progenitor cells can induce cell proliferation and differentiation, inhibit cell apoptosis, and promote angiogenesis, playing an increasingly important role in regenerative medicine. We reported in this review the latest findings on applying extracellular vesicles derived from endothelial/endothelial progenitor cells in tissue regeneration and repair, and discussed the challenges and future development directions of their application in the field of regenerative medicine.
    MeSH term(s) Apoptosis ; Cell Differentiation ; Endothelial Progenitor Cells ; Extracellular Vesicles/metabolism ; Regenerative Medicine
    Language Chinese
    Publishing date 2022-04-06
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20220360507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microspheres and their Potential in Endodontic Regeneration Application.

    Yang, Ting / Xie, Li / Zhang, Rui Tao / Tian, Wei Dong

    The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)

    2022  Volume 25, Issue 1, Page(s) 29–36

    Abstract: Microspheres have been widely utilised as versatile carriers in biomedical applications. In recent years, as a new type of injectable scaffold, microspheres have attracted increasing attention in the field of regenerative medicine owing to their various ... ...

    Abstract Microspheres have been widely utilised as versatile carriers in biomedical applications. In recent years, as a new type of injectable scaffold, microspheres have attracted increasing attention in the field of regenerative medicine owing to their various advantages including their small size, large specific surface area and mimicry of the 3D native environment. These characteristics enable them to adopt the narrow and irregular anatomy of the tooth and become an ideal scaffold for endodontic regeneration. Microspheres play an important role in carrying biologics (cells, biomolecules and drugs), which effectively regulate the fate of stem cells and control the release of growth factors and drugs. Cell-laden microspheres, which can be divided into microcarriers and microcapsules, have great application prospects in dental pulp regeneration. This paper summarises the properties and characteristics of microsphere scaffolds used in tissue engineering, placing emphasis on their advantages and applications in endodontic regeneration.
    MeSH term(s) Dental Pulp/physiology ; Microspheres ; Regeneration ; Regenerative Medicine ; Tissue Engineering
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2129164-0
    ISSN 1867-5646 ; 1462-6446
    ISSN (online) 1867-5646
    ISSN 1462-6446
    DOI 10.3290/j.cjdr.b2752709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advances in Research on Stem Cell-Based Pulp Regeneration.

    Lee, Hua-Nien / Liang, Cheng / Liao, Li / Tian, Wei-Dong

    Tissue engineering and regenerative medicine

    2021  Volume 18, Issue 6, Page(s) 931–940

    Abstract: Although root canal therapy is the most common and widely used treatment at clinical presentation, there are still some postoperative complications. As cell biology and tissue engineering techniques advance rapidly, the use of biological therapy to ... ...

    Abstract Although root canal therapy is the most common and widely used treatment at clinical presentation, there are still some postoperative complications. As cell biology and tissue engineering techniques advance rapidly, the use of biological therapy to regenerate dental pulp has become a new trend; Relevant literatures in recent five years were searched using key words such as "root canal therapy", "Dental pulp stem cells", "Dental pulp regeneration", and "Cell homing" in PubMed, Web of Science, etc; Dental pulp stem cells (DPSCs) have multi-differentiation potential, self-renewal capability, and high proliferative ability. Stem cell-based dental pulp regeneration has emerged as a new research hot spot in clinical therapy. Recently, dental pulp-like structures have been generated by the transplantation of exogenous DPSCs or the induction of homing of endogenous DPSCs. Studies on DPSCs are important and significant for dental pulp regeneration and dental restoration; In this review, the existing clinical treatment methods, dental pulp regeneration, and DPSC research status are revealed, and their application prospects are discussed. The stem cell-based pulp regeneration exerts promising potential in clinical therapy for pulp regeneration.
    MeSH term(s) Cell Differentiation ; Dental Pulp ; Regeneration ; Stem Cells ; Tissue Engineering/methods
    Language English
    Publishing date 2021-09-18
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2677535-9
    ISSN 2212-5469 ; 1738-2696
    ISSN (online) 2212-5469
    ISSN 1738-2696
    DOI 10.1007/s13770-021-00389-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications.

    Yuan, Sheng-Meng / Yang, Xue-Ting / Zhang, Si-Yuan / Tian, Wei-Dong / Yang, Bo

    World journal of stem cells

    2022  Volume 14, Issue 7, Page(s) 435–452

    Abstract: For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (MSC)-like ... ...

    Abstract For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (MSC)-like immunophenotypic characteristics, high proliferation rate, potential for multidirectional differentiation and biological features were demonstrated to be superior to those of bone marrow MSCs. In addition, several main application forms of DPSCs and their derivatives have been investigated, including stem cell injections, modified stem cells, stem cell sheets and stem cell spheroids.
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v14.i7.435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biomimetic crystallization for long-pursued -COOH-functionalized gold nanocluster with near-infrared phosphorescence.

    Tian, Wei-Dong / Si, Wei-Dan / Havenridge, Shana / Zhang, Chengkai / Wang, Zhi / Aikens, Christine M / Tung, Chen-Ho / Sun, Di

    Science bulletin

    2023  Volume 69, Issue 1, Page(s) 40–48

    Abstract: As an interdisciplinary product, water-soluble gold nanoclusters (AuNCs) stabilized by ligands containing carboxyl (-COOH) group have garnered significant attention from synthetic chemists and biologists due to their immense potential for biomedical ... ...

    Abstract As an interdisciplinary product, water-soluble gold nanoclusters (AuNCs) stabilized by ligands containing carboxyl (-COOH) group have garnered significant attention from synthetic chemists and biologists due to their immense potential for biomedical applications. However, revealing the crystallographic structures of -COOH-functionalized AuNCs remains a bottleneck. Herein, we successfully applied the salting-out method to obtain a series of high-quality single crystals of -COOH-functionalized Au
    Language English
    Publishing date 2023-11-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Digital design technique in the reconstruction of traumatic craniomaxillofcial deformities].

    Tian, Wei-dong

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

    2012  Volume 47, Issue 8, Page(s) 470–473

    MeSH term(s) Computer-Aided Design ; Humans ; Imaging, Three-Dimensional ; Maxillofacial Injuries/diagnostic imaging ; Maxillofacial Injuries/surgery ; Reconstructive Surgical Procedures/methods ; Surgery, Computer-Assisted/methods ; Tomography, X-Ray Computed
    Language Chinese
    Publishing date 2012-08
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1027950-7
    ISSN 1002-0098
    ISSN 1002-0098
    DOI 10.3760/cma.j.issn.1002-0098.2012.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [A Novel Chemically Defined Medium Enhanced the Osteogenic Potential and Periodontal Bone Regeneration of Dental Papilla Cells].

    Wang, Tao / Wang, Shi-Kai / Chen, Guo-Qing / Tian, Wei-Dong

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2020  Volume 51, Issue 6, Page(s) 735–741

    Abstract: Obejective: To investigate the role of a novel chemically defined medium (CDM) in the regulation of dental papilla cells (DPCs) functional phenotype in vitro and periodontal bone regeneration : Methods: DPCs were isolated and cultured in conventional ...

    Abstract Obejective: To investigate the role of a novel chemically defined medium (CDM) in the regulation of dental papilla cells (DPCs) functional phenotype in vitro and periodontal bone regeneration
    Methods: DPCs were isolated and cultured in conventional medium (CM) or CDM. The surface makers, and the proliferation, migration and osteogenic differentiation abilities of DPCs were evaluated.
    Results: DPCs in the CM group and CDM group showed similar surface markers. Compared to the CM group, the CDM significantly enhanced the proliferation, colony-forming efficiency and migration of DPCs
    Conclusion: CDM is a suitable medium to culture DPCs for periodontal bone regeneration. This research provided a substitute for basic research and set the stage for future clinical application of stem cell transplantation.
    MeSH term(s) Animals ; Bone Regeneration ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Dental Papilla ; Osteogenesis ; Periodontal Ligament ; Rats ; Regeneration ; X-Ray Microtomography
    Language Chinese
    Publishing date 2020-09-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20201160101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neurotrophic effects of dental pulp stem cells in repair of peripheral nerve after crush injury.

    Wang, Dian-Ri / Wang, Yu-Hao / Pan, Jian / Tian, Wei-Dong

    World journal of stem cells

    2020  Volume 12, Issue 10, Page(s) 1196–1213

    Abstract: Background: Nerve diseases and injuries, which are usually accompanied by motor or sensory dysfunction and disorder, impose a heavy burden upon patients and greatly reduce their quality of life. Dental pulp stem cells (DPSCs), derived from the neural ... ...

    Abstract Background: Nerve diseases and injuries, which are usually accompanied by motor or sensory dysfunction and disorder, impose a heavy burden upon patients and greatly reduce their quality of life. Dental pulp stem cells (DPSCs), derived from the neural crest, have many characteristics that are similar to those of neural cells, indicating that they can be an ideal source for neural repair.
    Aim: To explore the potential roles and molecular mechanisms of DPSCs in crushed nerve recovery.
    Methods: DPSCs were isolated, cultured, and identified by multilineage differentiation and flow cytometry. Western blot and immunofluorescent staining were applied to analyze the expression levels of neurotrophic proteins in DPSCs after neural induction. Then, we collected the secretions of DPSCs. We analyzed their effects on RSC96 cell proliferation and migration by CCK8 and transwell assays. Finally, we generated a sciatic nerve crush injury model
    Results: DPSCs highly expressed several specific neural markers, including GFAP, S100, Nestin, P75, and NF200, and were inclined toward neural differentiation. Furthermore, neural-induced DPSCs (N-DPSCs) could express neurotrophic factors, including NGF, BDNF, and GDNF. The secretions of N-DPSCs could enhance the proliferation and migration of Schwann cells.
    Conclusion: In summary, this study demonstrated that DPSCs are inclined to differentiate into neural cells. N-DPSCs express neurotrophic proteins that could enhance the proliferation and migration of SCs. Furthermore, our results suggested that N-DPSCs could help crushed nerves with functional recovery and anatomical repair
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v12.i10.1196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Two triplet emitting states in one emitter: Near-infrared dual-phosphorescent Au

    Si, Wei-Dan / Zhang, Chengkai / Zhou, Meng / Tian, Wei-Dong / Wang, Zhi / Hu, Qingsong / Song, Ke-Peng / Feng, Lei / Huang, Xian-Qiang / Gao, Zhi-Yong / Tung, Chen-Ho / Sun, Di

    Science advances

    2023  Volume 9, Issue 13, Page(s) eadg3587

    Abstract: Intrinsic dual-emission (DE) of gold nanoclusters in the near-infrared (NIR) are fascinating for fundamental importance and practical applications, but their synthesis remains a formidable challenge and sophisticated excited-state processes make ... ...

    Abstract Intrinsic dual-emission (DE) of gold nanoclusters in the near-infrared (NIR) are fascinating for fundamental importance and practical applications, but their synthesis remains a formidable challenge and sophisticated excited-state processes make elucidating DE mechanisms much more arduous. Here, we report an all-alkynyl-protected gold nanocluster,
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg3587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [Clinical and genetic features of Chinese kindreds with Van der Woude syndrome caused by interferon regulatory factor 6 mutation].

    Du, Xin-Ya / Li, Xiao-Yu / Wu, Bin / Xie, Chun / Tian, Wei-Dong

    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

    2018  Volume 36, Issue 6, Page(s) 623–627

    Abstract: Objective: This study aimed to investigate the clinical phenotype and genetic characteristics of Chinese families with Van der Woude syndrome (VWS).: Methods: Clinical manifestations between 14 families and within each family were recorded. Possible ... ...

    Abstract Objective: This study aimed to investigate the clinical phenotype and genetic characteristics of Chinese families with Van der Woude syndrome (VWS).
    Methods: Clinical manifestations between 14 families and within each family were recorded. Possible inheritance modes and pathogenic genes were analyzed. Phenotypic distribution and gene frequencies were calculated.
    Results: Of the pedigrees investigated, an autosomal dominant inheritance pattern was suggested. All patients had typical symptoms. The pathogenic gene was interferon regulatory factor 6 (IRF6). Phenotypic distribution frequencies were as follows: lip pits (91.9%), cleft lip and/or palate (73.0%), and hyperdontia (8.1%). There were significant differences in clinical phenotypes among individuals of different families and individuals of the same family.
    Conclusions: VWS in a Chinese population was dominantly inherited with high penetrance and variable expressivity. The pathogenic gene was IRF6. VWS in a Chinese population was genotyped as VWS1.
    MeSH term(s) Abnormalities, Multiple/genetics ; Cleft Lip/genetics ; Cleft Palate/genetics ; Cysts/genetics ; Humans ; Interferon Regulatory Factors/genetics ; Lip/abnormalities ; Mutation ; Pedigree ; Syndrome
    Chemical Substances IRF6 protein, human ; Interferon Regulatory Factors
    Language Chinese
    Publishing date 2018-12-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 1202342-5
    ISSN 2618-0456 ; 1000-1182
    ISSN (online) 2618-0456
    ISSN 1000-1182
    DOI 10.7518/hxkq.2018.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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