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Book ; Online: Systemic Risk and Reinsurance

Tian, Weidong

2020

Keywords	Coins, banknotes, medals, seals (numismatics) ; optimal reinsurance ; general risk measure ; risk sharing ; systemic risk ; capital insurance ; welfare ; equilibrium ; conditional value-at-risk ; mean-CVaR portfolio optimization ; risk minimization ; Neyman-Pearson problem ; interconnectedness ; financial conglomerate ; contagion ; capital requirement for premium risk ; collective risk model ; reinsurance strategies ; Solvency II ; community structure ; complex networks ; financial markets ; insurance sector ; deltaCoVaR ; minimum spanning trees-topological indicators ; tail dependence
Size	1 electronic resource (146 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044744
ISBN	9783039362998 ; 3039362992
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Prospect on the application of mesenchymal stem cell-derived extracellular vesicles in the regeneration of dental and maxillofacial tissues.

Liao, Li / Tian, Weidong

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

2024 Volume 40, Issue 1, Page(s) 7–13

Abstract: Extracellular vesicles (EVs) are the essential mediators of communication between different cells or tissues. EVs participate in the development, homeostasis, repair, and regeneration of tissues. Mesenchymal stem cells(MSCs) secrete a range of bioactive ... ...

Abstract	Extracellular vesicles (EVs) are the essential mediators of communication between different cells or tissues. EVs participate in the development, homeostasis, repair, and regeneration of tissues. Mesenchymal stem cells(MSCs) secrete a range of bioactive factors, which are important in MSC-mediated tissue regeneration. Great progress has been made in the research of EVs derived from MSCs (MSC-EVs) in the regeneration of dental and maxillofacial tissues. Emerging evidence confirmed that MSC-EVs can efficiently modulate the proliferation, differentiation, survival, and migration of stem or progenitor cells and stimulate the regeneration of the neurovascular system. MSC-EVs have been used in regenerating dental pulp, periodontium, jawbone, temporomandibular joint, and maxillofacial soft tissues. Having the advantages of low immunogenicity, versatile function, and suitability for large-scale production, EVs have excellent clinical application prospect. Along with investigations on molecular mechanisms of action and development of standard manufactory and testing systems, therapies u-sing MSC-EVs are promising strategies for regenerating dental and maxillofacial tissues.
Language	Chinese
Publishing date	2024-04-10
Publishing country	China
Document type	Journal Article
ZDB-ID	1202342-5
ISSN	2618-0456 ; 1000-1182
ISSN (online)	2618-0456
ISSN	1000-1182
DOI	10.7518/hxkq.2022.01.002
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Article ; Online: Advances Focusing on the Application of Decellularized Extracellular Matrix in Periodontal Regeneration.

Liang, Chao / Liao, Li / Tian, Weidong

Biomolecules

2023 Volume 13, Issue 4

Abstract: The decellularized extracellular matrix (dECM) is capable of promoting stem cell proliferation, migration, adhesion, and differentiation. It is a promising biomaterial for application and clinical translation in the field of periodontal tissue ... ...

Abstract	The decellularized extracellular matrix (dECM) is capable of promoting stem cell proliferation, migration, adhesion, and differentiation. It is a promising biomaterial for application and clinical translation in the field of periodontal tissue engineering as it most effectively preserves the complex array of ECM components as they are in native tissue, providing ideal cues for regeneration and repair of damaged periodontal tissue. dECMs of different origins have different advantages and characteristics in promoting the regeneration of periodontal tissue. dECM can be used directly or dissolved in liquid for better flowability. Multiple ways were developed to improve the mechanical strength of dECM, such as functionalized scaffolds with cells that harvest scaffold-supported dECM through decellularization or crosslinked soluble dECM that can form injectable hydrogels for periodontal tissue repair. dECM has found recent success in many periodontal regeneration and repair therapies. This review focuses on the repairing effect of dECM in periodontal tissue engineering, with variations in cell/tissue sources, and specifically discusses the future trend of periodontal regeneration and the future role of soluble dECM in entire periodontal tissue regeneration.
MeSH term(s)	Decellularized Extracellular Matrix ; Extracellular Matrix/metabolism ; Hydrogels/pharmacology ; Tissue Engineering ; Periodontium/cytology ; Periodontium/physiology ; Regeneration
Chemical Substances	Decellularized Extracellular Matrix ; Hydrogels
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13040673
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Article: How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion.

Dong, Jia / Wu, Bin / Tian, Weidong

Frontiers in endocrinology

2023 Volume 14, Page(s) 1146991

Abstract: Chronic skin wound healing, especially in diabetes mellitus, is still unsolved. Although many efforts have been made to treat diabetic skin wounds, current strategies have achieved limited effectiveness. Nowadays, a great number of studies have shown ... ...

Abstract	Chronic skin wound healing, especially in diabetes mellitus, is still unsolved. Although many efforts have been made to treat diabetic skin wounds, current strategies have achieved limited effectiveness. Nowadays, a great number of studies have shown that exosomes might be a promising approach for treating diabetic wounds. Many studies and reviews have focused on investigating and discussing the effectiveness and mechanism of exosomes. However, maximizing its value in treating skin wounds in diabetes mellitus requires further consideration. In this review, we reviewed and discussed the aspects that could be further improved in this process, including finding a better source of exosomes, engineering exosomes, adjusting dosage and frequency, and combining more efficient delivery methods. This review provided an overview and idea of what we can do to improve the therapeutic effect of exosomes on skin wounds in diabetes mellitus. Only by combining all the factors that affect the effectiveness of exosomes in diabetic wound healing can we further promote their clinical usefulness.
MeSH term(s)	Animals ; Humans ; Diabetes Mellitus, Experimental/therapy ; Exosomes ; Wound Healing
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1146991
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Article ; Online: A Novel Magnetic Manipulation Promotes Directional Growth of Periodontal Ligament Stem Cells.

Li, Weiguang / Tian, Weidong / Wu, Yafei / Guo, Shujuan

Tissue engineering. Part A

2023 Volume 29, Issue 23-24, Page(s) 620–632

Abstract: Periodontium is the rally of soft and hard tissues, which will be devastated continuously by the compromise of periodontitis. Current periodontal therapeutic methods cannot effectively reconstruct periodontal ligament (PDL), which is oriented at an angle ...

Abstract	Periodontium is the rally of soft and hard tissues, which will be devastated continuously by the compromise of periodontitis. Current periodontal therapeutic methods cannot effectively reconstruct periodontal ligament (PDL), which is oriented at an angle with tooth root and combined hard tissues to form cementum-PDL-alveolar bone complex. Hence, it is urgent to find new techniques for PDL reconstruction to achieve functional regeneration of periodontium. Herein, we developed a novel method to manipulate the distribution and growth of periodontal ligament stem cells (PDLSCs) by utilizing highly paralleled static magnetic field (SMF) and magnetic nanoparticles (MNPs). PDLSCs were incubated with MNPs
MeSH term(s)	Periodontal Ligament ; Cell Differentiation/physiology ; Cells, Cultured ; Stem Cells/physiology ; Collagen/pharmacology ; Magnetic Phenomena ; Osteogenesis/physiology
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2420582-5
ISSN	1937-335X ; 1937-3341
ISSN (online)	1937-335X
ISSN	1937-3341
DOI	10.1089/ten.TEA.2023.0112
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Article ; Online: Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages.

Dong, Jia / Wu, Bin / Tian, Weidong

Stem cell research & therapy

2023 Volume 14, Issue 1, Page(s) 67

Abstract: Background: Successful regenerative medicine strategies need the manipulation and control of macrophages' phenotypic switching. Our previous study indicated that rat and porcine adipose tissue-derived small extracellular vesicles could successfully ... ...

Abstract	Background: Successful regenerative medicine strategies need the manipulation and control of macrophages' phenotypic switching. Our previous study indicated that rat and porcine adipose tissue-derived small extracellular vesicles could successfully promote soft tissue repair. However, whether human adipose tissue-derived small extracellular vesicles (h-sEV-AT) showed the same ability to promote soft tissue regeneration and whether adipose tissue-derived small extracellular vesicles (sEV-AT) contribute to modulating the polarization of macrophages were unknown. Methods: In this study, we, for the first time, isolated h-sEV-AT from liposuction adipose tissue and characterized the morphology, size distribution, and marker protein. In vitro, we treated adipose-derived stromal/stem cells (ASCs), endothelial cells (ECs), and M1 macrophages with h-sEV-AT. In vivo, the ability of h-sEV-AT to promote soft tissue regeneration and polarize macrophages was investigated. Results: The results indicated that h-sEV-AT possessed the characteristics of small extracellular vesicles (sEVs). In vitro, an obvious increase in adipogenesis and angiogenesis was induced by h-sEV-AT. In vivo, h-sEV-AT successfully induced the regeneration of adipose tissue and effectively accelerated full-thickness skin wound healing. Besides, we found that h-sEV-AT showed the ability to increase the percentage of M2 macrophages both in vivo and in vitro, which had been reported to contribute to tissue repair and regeneration. Conclusions: Taken together, these results suggested that h-sEV-AT showed the ability to induce soft tissue repair supported by not only the differentiation of ASCs and ECs but also the polarization of macrophages. Considering the abundant sources, high yield, and guaranteed effectiveness, this study provided a cell-free strategy for soft tissue regeneration that directly isolated small extracellular vesicles from human liposuction adipose tissue.
MeSH term(s)	Humans ; Rats ; Animals ; Swine ; Endothelial Cells ; Adipose Tissue ; Adipocytes ; Extracellular Vesicles/metabolism ; Macrophages/metabolism
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03306-7
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Article ; Online: Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration.

Chen, Liangrui / Zhu, Shasha / Guo, Shujuan / Tian, Weidong

Stem cell research & therapy

2023 Volume 14, Issue 1, Page(s) 26

Abstract: Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achieve periodontal tissue regeneration; thus, ... ...

Abstract	Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achieve periodontal tissue regeneration; thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. Accumulating evidence supports the view that the role of MSCs in regenerative medicine is mainly achieved by the paracrine pathway rather than direct proliferation and differentiation at the injured site. Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. As a cell-free therapy, MSCs-derived extracellular vesicles (MSC-EVs) have some preponderance on stability, immune rejection, ethical supervision, and other problems; therefore, they may have a broad clinical application prospect. Herein, we gave a brief introduction to MSC-EVs and focused on their mechanisms and clinical application in periodontal regeneration.
MeSH term(s)	Humans ; Extracellular Vesicles/metabolism ; Periodontium ; Periodontitis/therapy ; Periodontitis/metabolism ; Periodontal Ligament/physiology ; Mesenchymal Stem Cells/metabolism
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03242-6
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Article ; Online: Exosomes derived from hypoxia-preconditioned mesenchymal stem cells (hypoMSCs-Exo): advantages in disease treatment.

Dong, Jia / Wu, Bin / Tian, Weidong

Cell and tissue research

2023 Volume 392, Issue 3, Page(s) 621–629

Abstract: Mesenchymal stem cells (MSCs)-based therapy has been reported to be a potential approach to treat various diseases and the paracrine role might be the underlying mechanism. Exosomes were considered an important part of this paracrine role. It was ... ...

Abstract	Mesenchymal stem cells (MSCs)-based therapy has been reported to be a potential approach to treat various diseases and the paracrine role might be the underlying mechanism. Exosomes were considered an important part of this paracrine role. It was reported that maintenance of MSCs in hypoxia conditions for a short time has shown to be beneficial for the therapeutic effect of MSCs and MSCs-derived exosomes. In this review, we summarized the recent developments on exosomes derived from hypoxia-preconditioned mesenchymal stem cells (hypoMSCs-Exo), including the characteristics of hypoMSCs-Exo in morphology and contents, diseases in which hypoMSCs-Exo showed more effective, and the cellular and molecular mechanisms that hypoMSCs-Exo showed more effective in disease treatment. Besides, we also discussed the limitations of current studies and the issues that needed to be improved in the application of hypoMSCs-Exo. This review aimed to promote a comprehensive and systematic understanding of this type of exosome with great therapeutic potential.
MeSH term(s)	Humans ; Exosomes ; Mesenchymal Stem Cells ; Apoptosis ; Neovascularization, Physiologic ; Hypoxia/therapy
Language	English
Publishing date	2023-02-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-023-03758-6
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Article ; Online: Preparation of Apoptotic Extracellular Vesicles from Adipose Tissue and Their Efficacy in Promoting High-Quality Skin Wound Healing.

Dong, Jia / Wu, Bin / Tian, Weidong

International journal of nanomedicine

2023 Volume 18, Page(s) 2923–2938

Abstract: Purpose: A lot of strategies have been attempted to achieve high-quality skin wound healing, among them, fat transplantation has been used for skin wound repair and scar management and has shown beneficial effects. However, the underlying mechanism is ... ...

Abstract	Purpose: A lot of strategies have been attempted to achieve high-quality skin wound healing, among them, fat transplantation has been used for skin wound repair and scar management and has shown beneficial effects. However, the underlying mechanism is still unclear. Recently, studies found that transplanted cells underwent apoptosis within a short period and apoptotic extracellular vesicles (ApoEVs) might play the therapeutic role. Methods: In this study, we directly isolated apoptotic extracellular vesicles from adipose tissue (ApoEVs-AT) and evaluated their characteristics. In vivo, we investigated the therapeutic role of ApoEVs-AT in full-thickness skin wounds. The rate of wound healing, the quality of granulation tissue, and the area of scars were evaluated here. In vitro, we investigated the cellular behaviors of fibroblasts and endothelial cells induced by ApoEVs-AT, including cellular uptake, proliferation, migration, and differentiation. Results: ApoEVs-AT could be successfully isolated from adipose tissue and possessed the basic characteristics of ApoEVs. In vivo, ApoEVs-AT could accelerate skin wound healing, improve the quality of granulation tissue, and reduce the area of scars. In vitro, ApoEVs-AT could be engulfed by fibroblasts and endothelial cells, significantly enhancing their proliferation and migration. Moreover, ApoEVs-AT could promote adipogenic differentiation and inhibit the fibrogenic differentiation of fibroblasts. Conclusion: These findings indicated that ApoEVs could be successfully prepared from adipose tissue and showed the ability to promote high-quality skin wound healing by modulating fibroblasts and endothelial cells.
MeSH term(s)	Humans ; Wound Healing ; Cicatrix/pathology ; Endothelial Cells ; Skin/pathology ; Adipose Tissue ; Extracellular Vesicles
Language	English
Publishing date	2023-06-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S411819
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Article ; Online: PhenoBERT: A Combined Deep Learning Method for Automated Recognition of Human Phenotype Ontology.

Feng, Yuhao / Qi, Lei / Tian, Weidong

IEEE/ACM transactions on computational biology and bioinformatics

2023 Volume 20, Issue 2, Page(s) 1269–1277

Abstract: Automated recognition of Human Phenotype Ontology (HPO) terms from clinical texts is of significant interest to the field of clinical data mining. In this study, we develop a combined deep learning method named PhenoBERT for this purpose. PhenoBERT uses ... ...

Abstract	Automated recognition of Human Phenotype Ontology (HPO) terms from clinical texts is of significant interest to the field of clinical data mining. In this study, we develop a combined deep learning method named PhenoBERT for this purpose. PhenoBERT uses BERT, currently the state-of-the-art NLP model, as its core model for evaluating whether a clinically relevant text segment (CTS) could be represented by an HPO term. However, to avoid unnecessary comparison of a CTS with each of ∼14,000 HPO terms using BERT, we introduce a two-levels CNN module consisting of a series of CNN models organized at two levels in PhenoBERT. For a given CTS, the CNN module produces only a short list of candidate HPO terms for BERT to evaluate, significantly improving the computational efficiency. In addition, BERT is able to assign an ancestor HPO term to a CTS when recognition of the direct HPO term is not successful, mimicking the process of HPO term assignment by human. In two benchmarks, PhenoBERT outperforms four traditional dictionary-based methods and two recently developed deep learning-based methods in two benchmark tests, and its advantage is more obvious when the recognition task is more challenging. As such, PhenoBERT is of great use for assisting in the mining of clinical text data.
MeSH term(s)	Humans ; Deep Learning ; Benchmarking ; Data Mining ; Family ; Phenotype
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2022.3170301
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