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Article ; Online: Effect of smoking on thrombotic antiphospholipid syndrome: a 10-year prospective cohort study.

Jiang, Hui / Huang, Can / Shi, Yu / Wang, Chu-Han / Chen, Si-Yun / Li, Jun / Wang, Qian / Li, Meng-Tao / Tian, Xin-Ping / Zeng, Xiao-Feng / Zhao, Yan / Zhao, Jiu-Liang

Rheumatology (Oxford, England)

2023

Abstract: Objectives: Cigarette smoking is an established risk factor for autoimmune diseases. However, whether smoking plays a clear role in thrombotic antiphospholipid syndrome (TAPS) has not been determined. We aimed to investigate the effects of smoking on ... ...

Abstract	Objectives: Cigarette smoking is an established risk factor for autoimmune diseases. However, whether smoking plays a clear role in thrombotic antiphospholipid syndrome (TAPS) has not been determined. We aimed to investigate the effects of smoking on clinical characteristics and prognosis of TAPS. Methods: This was a prospective cohort study from 2013 to 2022. During the study period, 297 patients were diagnosed with TAPS, including 82 smokers and 215 non-smokers. After propensity score matching, 57 smokers and 57 non-smokers matched by age and sex were analysed. Results: Overall, smokers with TAPS had more cardiovascular risk factors (CVRFs) than non-smokers, including hypertension (36.59% vs. 14.42%, P<0.001), obesity (15.85% vs. 7.44%, P=0.029), dyslipidaemia (64.63% vs. 48.37%, P=0.012), and hyperhomocysteinaemia (62.20% vs. 36.28%, P<0.001). Arterial thrombotic events were more common in smokers at diagnosis (62.20% vs. 46.05%, P=0.013), especially myocardial infarction, visceral thrombosis, and peripheral vascular thrombosis. After matching, smokers showed balanced CVRFs with non-smokers at baseline, but retained a higher prevalence of arterial thrombosis (59.65% vs. 33.33%, P=0.005), mainly distributed in cerebral vascular, cardiovascular, and retinal vascular territories. During follow-up, smokers presented a tendency for more recurrent arterial thrombosis and less recurrent venous thrombosis. Smokers had significantly poorer outcomes for organ damage with higher DIAPS (median, 2.00 vs. 1.00, P=0.008), especially in the cardiovascular (26.32% vs. 3.51%, P=0.001), gastrointestinal (15.79% vs. 1.75%, P=0.016), and ophthalmologic (10.53% vs. 00.00%, P=0.027) systems. Conclusion: Smoking is related to increased arterial events and poor prognosis in TAPS patients. Patients with TAPS should be fully encouraged to avoid smoking.
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead498
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Article ; Online: Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs.

Hu, Chao-Jun / Zhang, Li / Zhou, Shuang / Jiang, Nan / Zhao, Jiu-Liang / Wang, Qian / Tian, Xin-Ping / Zeng, Xiao-Feng

Journal of orthopaedic surgery and research

2021 Volume 16, Issue 1, Page(s) 457

Abstract: Background: This study aims to evaluate the efficacy and safety of the iguratimod (IGU) as monotherapy or combined therapy in patients with rheumatoid arthritis (RA) by using meta-analysis.: Methods: We searched Medline, EMBASE, Cochrane library, ... ...

Abstract	Background: This study aims to evaluate the efficacy and safety of the iguratimod (IGU) as monotherapy or combined therapy in patients with rheumatoid arthritis (RA) by using meta-analysis. Methods: We searched Medline, EMBASE, Cochrane library, CNKI, Wanfang medical network from initial to 30 June, 2020, for randomized clinical trials (RCTs). Two authors independently screened the studies via reading the title, abstract, and full text. The risk of bias in individual studies was assessed using the Cochrane Risk of Bias tool. STATA 12.0 was used for pooled analysis of all included studies. Results: A total of 23 RCTs were included in this analysis. Meta-analysis showed that patients in the IGU monotherapy or combined therapy group had significantly higher ACR20 (OR = 1.97, 95% CI 1.29 to 3.00, P = 0.002), lower DAS28-CRP (SMD = -3.49, 95% CI -5.40 to -1.58, P < 0.001) and DAS28-ESR (SMD = -2.61, 95% CI -3.64 to -1.57, P < 0.001), as well as shorter duration of morning stiffness (SMD = -2.06, 95% CI -2.86 to -1.25, P < 0.001) and lower HAQ score (SMD = -0.91, 95% CI -1.61 to -0.21, P = 0.011), than those received other disease-modifying antirheumatic drugs (DMARDs) monotherapy (primarily comprising methotrexate). For the safety profile, IGU monotherapy had similar risks for gastrointestinal reactions (P = 0.070), leucopenia (P = 0.309), increment in transaminase (P = 0.321), increase of ALT (P = 0.051), and liver damage (P = 0.182) to methotrexate monotherapy, and IGU combined with other DMARDs therapy did not increase the risks of these AEs (P > 0.05). Conclusions: Our evidence suggests that IGU is effective and tolerant as monotherapy or combined therapy especially with methotrexate in patients with active RA. IGU may be regarded as a potential alternative to methotrexate, and a preferable choice when combined with other DMARDs for the treatment of RA.
MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Chromones/therapeutic use ; Drug Therapy, Combination ; Humans ; Randomized Controlled Trials as Topic ; Sulfonamides/therapeutic use
Chemical Substances	Antirheumatic Agents ; Chromones ; Sulfonamides ; iguratimod (4IHY34Y2NV)
Language	English
Publishing date	2021-07-16
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1749-799X
ISSN (online)	1749-799X
DOI	10.1186/s13018-021-02603-2
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Article ; Online: Gastrointestinal complications of systemic sclerosis.

Tian, Xin-Ping / Zhang, Xuan

World journal of gastroenterology

2013 Volume 19, Issue 41, Page(s) 7062–7068

Abstract: Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness. Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality; however, the gastrointestinal tract is the most ... ...

Abstract	Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness. Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality; however, the gastrointestinal tract is the most commonly damaged system. Virtually all parts of the gastrointestinal (GI) tract can be involved, although the esophagus is the most frequently reported. The mechanisms that cause such extensive damage are generally unclear, but vascular changes, immunological abnormalities, excessive accumulation of collagen in the submucosa, smooth muscle atrophy and neuropathy may participate because these are the most common histological findings in biopsies and autopsies. Most patients with GI tract involvement complain about dyspepsia, nausea, vomiting, abdominal bloating/distension, and fecal incontinence. These symptoms are generally mild during the early stage of the disease and are likely ignored by physicians. As the disease becomes more advanced, however, patient quality of life is markedly influenced, whereby malnutrition and shortened survival are the usual consequences. The diagnosis for systemic sclerosis is based on manometry measurements and an endoscopy examination. Supportive and symptomatic treatment is the main therapeutic strategy; however, an early diagnosis is critical for successful management.
MeSH term(s)	Early Diagnosis ; Endoscopy, Gastrointestinal ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Humans ; Manometry ; Predictive Value of Tests ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy ; Treatment Outcome
Language	English
Publishing date	2013-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v19.i41.7062
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Article: Cardiac manifestations in a Chinese cohort of fetuses from mothers with anti-Ro and anti-La antibodies.

Wang, Xin / Liu, Xiao-Wei / Han, Ling / Li, Meng-Tao / Zhao, Jiu-Liang / Sun, Lin / Han, Jian-Cheng / Zeng, Xiao-Feng / Tian, Xin-Ping / Zhao, Ying / He, Yi-Hua

Frontiers in pediatrics

2022 Volume 10, Page(s) 904138

Abstract: Objectives: To analyze the clinical characteristics, echocardiographic features, and prognosis of fetuses based on three groups of cardiac manifestations associated with maternal anti-Ro and anti-La antibodies in China. This study included three groups: ...

Abstract	Objectives: To analyze the clinical characteristics, echocardiographic features, and prognosis of fetuses based on three groups of cardiac manifestations associated with maternal anti-Ro and anti-La antibodies in China. This study included three groups: the isolated-arrhythmia, isolated-endocardial fibroelastosis (EFE), and mixed groups. Methods: We prospectively evaluated 36 fetuses with cardiac manifestations due to maternal anti-Ro and anti-La antibodies from our center between 2016 and 2020 in China. Clinical and echocardiographic data were collected. Results: There were 13 patients (36%) in the isolated-arrhythmia group, eight (22%) in the isolated-EFE group, and 15 (42%) in the mixed group. All patients in the isolated-EFE group presented with mild EFE. Severe EFE was identified in four patients (27%) in the mixed group. Atrioventricular block (AVB) was more common in the isolated-arrhythmia group (13, 100%) than in the mixed group (6, 40%; Conclusion: Fetal cardiac manifestations due to maternal anti-Ro and anti-La antibodies can be divided into three groups, i.e., the isolated-arrhythmia, isolated-EFE, and mixed groups. AVB usually occurs in the isolated-arrhythmia group. Severe EFE, moderate-severe mitral regurgitation, and DCM mainly appear in the mixed group. Location of mild EFE significantly reduces after birth and the outcome of fetuses with mild EFE depends on the presence of arrhythmia and its subtypes.
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.904138
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Article ; Online: Gastrointestinal involvement in systemic lupus erythematosus: insight into pathogenesis, diagnosis and treatment.

Tian, Xin-Ping / Zhang, Xuan

World journal of gastroenterology

2010 Volume 16, Issue 24, Page(s) 2971–2977

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by the presence of a plethora of autoantibodies and immune complex formation. Virtually every system and organ can be affected by SLE. Gastrointestinal symptoms are ... ...

Abstract	Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by the presence of a plethora of autoantibodies and immune complex formation. Virtually every system and organ can be affected by SLE. Gastrointestinal symptoms are common in SLE patients, and more than half of them are caused by adverse reactions to medications and viral or bacterial infections. Though not as common as lupus nephritis, SLE-related gastrointestinal involvement is clinically important because most cases can be life-threatening if not treated promptly. Lupus mesenteric vasculitis is the most common cause, followed by protein-losing enteropathy, intestinal pseudo-obstruction, acute pancreatitis and other rare complications such as celiac disease, inflammatory bowel diseases, etc. No specific autoantibody is identified as being associated with SLE-related gastroenteropathy. Imaging studies, particularly abdominal computed tomography scans, are helpful in diagnosing some SLE-related gastroenteropathies. Most of these complications have good therapeutic responses to corticosteroids and immunosuppressive agents. Supportive measures such as bowel rest, nutritional support, antibiotics and prokinetic medications are helpful in facilitating functional recovery and improving the outcome.
MeSH term(s)	Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; Pancreatitis/therapy ; Prognosis ; Protein-Losing Enteropathies/diagnosis ; Protein-Losing Enteropathies/epidemiology ; Protein-Losing Enteropathies/etiology ; Protein-Losing Enteropathies/therapy
Language	English
Publishing date	2010-06-22
Publishing country	United States
Document type	Editorial ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v16.i24.2971
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Article ; Online: Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study.

Jiang, Hui / Wang, Chu-Han / Jiang, Nan / Li, Jing / Wu, Chan-Yuan / Wang, Qian / Li, Meng-Tao / Tian, Xin-Ping / Zhao, Jiu-Liang / Zhao, Yan / Zeng, Xiao-Feng

Arthritis research & therapy

2021 Volume 23, Issue 1, Page(s) 138

Abstract: Background: Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematically compared their clinical characteristics and prognosis.: Objective: The objective of this study ...

Abstract	Background: Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematically compared their clinical characteristics and prognosis. Objective: The objective of this study is to identify key differences between thrombotic APS (tAPS) and obstetric APS (oAPS). Methods: This single-center, prospective study included consecutive patients with primary antiphospholipid syndrome (APS) receiving treatment at the Peking Union Medical College Hospital during a period from 2013 to 2020. Results: Screening of the database yielded a total of 244 women with positive antiphospholipid antibody (aPL). Among the 105 women with primary APS, 39 (37.14%) had isolated tAPS (ItAPS), 44 (41.90%) had isolated oAPS (IoAPS), and 9 (8.57%) had both tAPS and tAPS+oAPS. In comparison to those with IoAPS, patients with ItAPS had older age (41.92 ± 11.97 vs. 33.16 ± 4.22 years, P < 0.01), higher rate of cardiovascular risk (at least one positive of coronary heart disease, hypertension, obesity, diabetes, and hyperlipidemia) (41.03% vs. 6.82%, P < 0.01), and higher frequency of thrombocytopenia (43.59% vs. 20.45%, P < 0.05). Antibody profiles were generally similar among the groups, but isolated anti-β2GPI positivity was more common in patients with IoAPS (52.27% vs. 17.94% for ItAPS, P = 0.01). Triple aPL positivity was more common in patients with both tAPS and oAPS (66.67% vs. 46.15% for ItAPS vs. 25% for IoAPS, P = 0.022). Blood homocysteine was higher in patients with ItAPS (11.20 vs. 9.90 μmol/L for IoAPS, P < 0.05), but there were no differences in inflammatory markers or complements. Recurrence rate of thrombosis was higher in patients with ItAPS (33.33% vs. 2.27% for IoAPS, P ≤ 0.001) with a mean follow-up of 61 months. Conclusion: Despite generally similar antibody and biochemical profiles, patients with ItAPS had much higher risk of recurrent thrombosis than IoAPS, supporting distinct mechanisms of pathogenesis.
MeSH term(s)	Aged ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/epidemiology ; Female ; Humans ; Pregnancy ; Prognosis ; Prospective Studies ; Thrombosis/epidemiology
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-021-02515-w
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Zs.A 5490: Show issues

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Article: [Pay attention to fibromyalgia].

Tian, Xin-ping / Tang, Fu-lin

Zhonghua yi xue za zhi

2004 Volume 84, Issue 9, Page(s) 712–713

MeSH term(s)	Acetaminophen/therapeutic use ; Analgesics, Non-Narcotic/therapeutic use ; Analgesics, Opioid/therapeutic use ; Biomedical Research/methods ; Biomedical Research/standards ; Fibromyalgia/diagnosis ; Fibromyalgia/drug therapy ; Fibromyalgia/etiology ; Humans ; Immune System/pathology ; Muscles/pathology ; Nervous System/pathology ; Pain Clinics ; Tramadol/therapeutic use
Chemical Substances	Analgesics, Non-Narcotic ; Analgesics, Opioid ; Acetaminophen (362O9ITL9D) ; Tramadol (39J1LGJ30J)
Language	Chinese
Publishing date	2004-05-02
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
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Article ; Online: Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients.

Wang, Ying / Wang, Ya-Hong / Tian, Xin-Ping / Wang, Hong-Yan / Li, Jing / Ge, Zhi-Tong / Yang, Yun-Jiao / Cai, Sheng / Zeng, Xiao-Feng / Li, Jian-Chu

Clinical rheumatology

2019 Volume 39, Issue 4, Page(s) 1229–1235

Abstract: Introduction: Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity ...

Abstract	Introduction: Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with arteritis activity. We aimed to use CEUS to evaluate disease activity in Takayasu arteritis (TAK) patients. Method: We used CEUS to analyze 28 consecutive TAK patients. Disease activity was assessed according to the NIH criteria. We measured CEUS grades and assessed the correlation between contrast features and disease activity. Results: Higher erythrocyte sedimentation rates (ESRs) were found (35 ± 28.7 vs. 13 ± 7.4 mm/h, p < 0.01), and CEUS carotid wall enhancement was more frequently (100% vs. 36.6%, p < 0.01) seen in TAK patients in the active phase than in those in the inactive phase. With increasing CEUS grades, both the artery wall thickness and ESR increased, and patients were more likely to be in the active phase (0 in grade 0, 42.9% in grade 1, and 75% in grade 2). Receiver operating characteristic (ROC) curve analysis showed that CEUS had an area under the ROC curve (AUC) of 0.872 (95% CI 0.785-0.959, p < 0.01), demonstrating good diagnostic accuracy. Conclusions: Higher CEUS grades reliably identify patients with active TAK.Key Points• No CEUS vascularization is obviously relative with the inactive disease of TAK patients.• Obvious CEUS vascularization is obviously relative with the active disease of TAK patients.
MeSH term(s)	Adult ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology ; Contrast Media ; Disease Progression ; Female ; Humans ; Male ; Neovascularization, Pathologic/diagnosis ; Neovascularization, Pathologic/diagnostic imaging ; ROC Curve ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/diagnostic imaging ; Ultrasonography/methods ; Young Adult
Chemical Substances	Contrast Media
Language	English
Publishing date	2019-08-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-019-04698-9
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Article ; Online: Treatment satisfaction with rheumatoid arthritis in patients with different disease severity and financial burden: A subgroup analysis of a nationwide survey in China.

Li, Hong-Bin / Wu, Li-Jun / Jiang, Nan / Yang, Ping-Ting / Liu, Sheng-Yun / Shi, Xiao-Fei / Fang, Yong-Fei / Zhao, Yi / Xu, Jian / Jiang, Zhen-Yu / Wu, Zhen-Biao / Duan, Xin-Wang / Wang, Qian / Li, Meng-Tao / Tian, Xin-Ping / Zeng, Xiao-Feng

Chinese medical journal

2020 Volume 133, Issue 8, Page(s) 892–898

Abstract: Background: Despite the recent advances in treatments for rheumatoid arthritis (RA), there are still unmet needs in disease outcomes. This study aimed to analyze the satisfaction with drug therapies for RA according to the levels of disease severity ( ... ...

Abstract	Background: Despite the recent advances in treatments for rheumatoid arthritis (RA), there are still unmet needs in disease outcomes. This study aimed to analyze the satisfaction with drug therapies for RA according to the levels of disease severity (patient-assessed) and proportions of treatment cost to household income. Methods: This was a subgroup study of a cross-sectional study in patients with RA and their physicians. The patients were subdivided into different subgroups based on their self-assessed severity of RA and on the proportions of treatment cost to household income (<10%, 10-30%, 31-50%, and >50%). The Treatment Satisfaction Questionnaire for Medication version II was used to assess patients' treatment satisfaction. Results: When considering all medications, effectiveness, convenience, and global satisfaction scores were lower in the severe and moderate RA subgroups than those in the mild and extremely mild RA subgroups (all P < 0.001). Effectiveness, side effects, and convenience scores were higher in the <10% subgroup compared to those in the >50% subgroup (all P < 0.05). Global satisfaction score was higher in the <10% subgroup than that in the 31% to 50% subgroup (F = 13.183, P = 0.004). For biological disease-modifying anti-rheumatic drugs, effectiveness and convenience scores were lower in the severe RA subgroup than those in the extremely mild RA subgroup (both P < 0.05). Convenience score was higher in the <10% subgroup compared to that in the 31% to 50% and >50% subgroups (F = 12.646, P = 0.005). Global satisfaction score was higher in the <10% subgroup than that in the 31% to 50% subgroup (F = 8.794, P = 0.032). Conclusion: Higher disease severity and higher financial burden were associated with lower patient satisfaction.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; China ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Patient Satisfaction ; Severity of Illness Index ; Surveys and Questionnaires
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2020-03-10
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000749
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Article: China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN): Rationale, Design, and Baseline Characteristics of the First 11764 Enrollees

Gong, Xun / Liu, Wei-xiang / Li, Da / Peng, Qiu-wei / Xia, Cong-min / Chang, Tian / Guan, Jin-zhi / Song, Meng-ge / Zhang, Fu-yuan / Tang, Xiao-po / Liu, Ying / Liu, Jian / Peng, Jiang-yun / He, Dong-yi / Huang, Qing-chun / Gao, Ming-li / Yu, Jian-ping / Liu, Wei / Zhang, Jian-yong /

Zhu, Yue-lan / Hou, Xiu-juan / Wang, Hai-dong / Fang, Yong-fei / Wang, Yue / Su, Yin / Tian, Xin-ping / Su, Xiao / Meng, Qing-liang / Wen, Shu-yun / Wang, Bei / Li, Ze-guang / Liu, Ju / Jiang, Hong / Hu, Yan / Li, Hui-Ling / Wei, Shu-Feng / Zhu, Wan-Hua / Lyu, Ai-ping / Zhang, Chi / Jiang, Quan

Phytomedicine. 2022 June 01,

2022

Abstract: Chinese medicine (CM) has become a popular interventional treatment for rheumatoid arthritis (RA). However, limited knowledge about general characteristics and long-term clinical outcomes hampers the development of CM for RA. The main objectives of the ... ...

Institution	CERTAIN Group
Abstract	Chinese medicine (CM) has become a popular interventional treatment for rheumatoid arthritis (RA). However, limited knowledge about general characteristics and long-term clinical outcomes hampers the development of CM for RA. The main objectives of the China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN) were to describe the population of RA patients receiving CM treatment in multiple centers in China using different variables and compare these findings with internationally reported data. The CERTAIN is a prospective, multicenter, observational disease registry. Adult RA patients who fulfilled the 2010 American College of Rheumatology/ European League Against Rheumatism classification criteria for RA and received CM treatment were recruited into the CERTAIN by rheumatologists from 145 hospitals across 30 provinces in China. Data on demographics, disease characteristics, comorbidities, treatments, and adverse events, with a 2-year follow-up, were collected and documented using a predefined protocol. In the 2 years since the study began in September 2019, 11764 patients have been enrolled (enrolment is ongoing), and 13.10% of participants have completed the 6-month follow-up. We present the baseline characteristics of the first 11764 enrollees. The CERTAIN is the first nationwide registry to document comprehensive data on CM treatment in patients with RA. The development of the CERTAIN resource is a significant step forward for Chinese RA patients, herbal medicine users, and research communities and will deepen our understanding of CM for RA. The study was registered at ClinicalTrials.gov (NCT05219214)
Keywords	Oriental traditional medicine ; adults ; demographic statistics ; herbal medicines ; rheumatoid arthritis ; China
Language	English
Dates of publication	2022-0601
Publishing place	Elsevier GmbH
Document type	Article
Note	Pre-press version
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154236
Database	NAL-Catalogue (AGRICOLA)

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Full text online

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In stock of ZB MED Cologne/Königswinter

Order via subito