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  1. Article ; Online: Tectonic deformation and rheological structure around the southern Tibetan Plateau based on the GPS observations

    TIAN Zhen

    Acta Geodaetica et Cartographica Sinica, Vol 52, Iss 1, Pp 173-

    2023  Volume 173

    Keywords Mathematical geography. Cartography ; GA1-1776
    Language Chinese
    Publishing date 2023-01-01T00:00:00Z
    Publisher Surveying and Mapping Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Applied Optics Research at Tianjin University: introduction to the feature issue.

    Tian, Zhen

    Applied optics

    2022  Volume 61, Issue 22, Page(s) TU1

    Abstract: The articles in this feature issue provide a small glimpse of Tianjin University's fundamental and applied research in optical engineering. ...

    Abstract The articles in this feature issue provide a small glimpse of Tianjin University's fundamental and applied research in optical engineering.
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.471427
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  3. Article: Editorial: Myelin in white mater function and related diseases.

    Tian, Zhen / Cheng, An

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1284273

    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1284273
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  4. Article: [Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases].

    Yu, Meng-Yuan / Tian, Zhen-Jun

    Sheng li xue bao : [Acta physiologica Sinica

    2023  Volume 75, Issue 5, Page(s) 659–670

    Abstract: Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, ... ...

    Abstract Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, accompanied by abnormal expression of Kal-7, which in turn induces a variety of neurodegenerative diseases. Exercise can upregulate the expression of Kal-7 in related brain regions to alleviate neurodegenerative diseases. By reviewing the literature on Kal-7 and neurodegenerative diseases, as well as the research progress of exercise intervention, this paper summarizes the role and possible mechanism of Kal-7 in the improvement of neurodegenerative diseases by exercise and provides a new rationale for the basic and clinical research on the prevention and treatment of neurodegenerative diseases by exercise.
    MeSH term(s) Humans ; Neurodegenerative Diseases/therapy ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Exercise Therapy
    Chemical Substances Guanine Nucleotide Exchange Factors
    Language Chinese
    Publishing date 2023-11-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604308-2
    ISSN 0371-0874
    ISSN 0371-0874
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  5. Article: Editorial: Second or foreign language learning and cognitive development.

    Shu, Dingfang / Xu, Jinfen / Zhang, Hui / Tian, Zhen

    Frontiers in psychology

    2024  Volume 14, Page(s) 1354329

    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1354329
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  6. Article: Clinical prediction factors of nonchronic total occlusion lesion progression in patients with unstable angina receiving percutaneous coronary intervention for chronic total occlusion lesions.

    Wang, Jian / He, Song-Yuan / Wang, Tian-Zhen

    International journal of cardiology. Heart & vasculature

    2024  Volume 51, Page(s) 101395

    Abstract: Background: In this study, we investigated clinical prediction factors of nonchronic total occlusion lesion (NCTOL) progression in patients who underwent percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) lesions.: Methods: In ...

    Abstract Background: In this study, we investigated clinical prediction factors of nonchronic total occlusion lesion (NCTOL) progression in patients who underwent percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) lesions.
    Methods: In total, 450 patients with unstable angina (mean age = 57.1 ± 9.2 years) who underwent PCI for CTO lesions between January 2016 and December 2018 at Beijing Anzhen Hospital were enrolled in this study. A clinical and angiographic follow-up examination was performed 12 months postoperatively. The patients were divided into NCTOL progression (145 cases) and control (305 cases) groups based on the outcome of the 12-month angiographic follow-up. The clinical and angiographic features of the participants were analyzed.
    Results: The adenosine diphosphate-induced platelet aggregation (ADP-IPA) rate and levels of lipoprotein (a) (
    Conclusions: NCTOL progression is an important cause of recurrent PCI in patients with coronary artery disease after PCI for CTO lesions. The ADP-IPA rate is a useful predictor for NCTOL progression in patients with unstable angina who undergo PCI for CTO lesions.
    Language English
    Publishing date 2024-03-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2024.101395
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  7. Article ; Online: Ultrasonographic evaluation of the gallbladder motor function in the diagnosis and prognosis of intrahepatic cholestasis of pregnancy.

    Tai, Minghui / Chen, Long / He, Yajuan / Wang, Fei / Tian, Zhen

    BMC pregnancy and childbirth

    2024  Volume 24, Issue 1, Page(s) 17

    Abstract: Background: Intrahepatic cholestasis of pregnancy (ICP) is characterized by skin pruritus, elevated liver enzymes, and increased serum total bile acids. Several previous studies have revealed that the fasting and ejection volumes of the gallbladder in ... ...

    Abstract Background: Intrahepatic cholestasis of pregnancy (ICP) is characterized by skin pruritus, elevated liver enzymes, and increased serum total bile acids. Several previous studies have revealed that the fasting and ejection volumes of the gallbladder in cholestasis of pregnancy are greater than those in normal pregnancy. The goal of this study was to explore the gallbladder volume and evaluate the diagnostic and prognostic value of ultrasound in ICP.
    Methods: We prospectively recruited a cohort of 60 ICP patients at the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China from January 2020 to December 2021 and compared their data with those from healthy pregnant women (n = 60). The gallbladder volume was evaluated by real-time ultrasound examination after overnight fasting and at 30, 60, 120, and 180 min after a liquid test meal of 200 mL, and the ejection fraction was calculated. Continuous data between two groups were compared by Student's t test. Differences were considered significant for p < 0.05. The diagnostic and prognostic value of the volume and ejection function of the gallbladder was analyzed by the receiver operating characteristic (ROC) curve.
    Results: The ICP group had significantly higher gallbladder basal volume (43.49 ± 1.34 cm
    Conclusion: Our results indicate abnormal volume and ejection function of the gallbladder in patients with ICP. The ejection fraction at 120 min can assist in the diagnosis if ICP exists, and the gallbladder volume at 60 min may assess the degree of severity of ICP.
    MeSH term(s) Female ; Humans ; Pregnancy ; Cholestasis, Intrahepatic/diagnostic imaging ; Gallbladder/diagnostic imaging ; Pregnancy Complications/diagnostic imaging ; Prognosis
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-06209-w
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  8. Article ; Online: Photocatalytic Aptamer Chemiluminescent System for a Homogeneous, Reliable, Label-Free, Generic Assay of Small Molecules.

    Guo, Zihua / Yang, Bin / Lu, Weiyi / Tian, Zhen / Hao, Huimin

    Analytical chemistry

    2024  Volume 96, Issue 8, Page(s) 3655–3661

    Abstract: Chemiluminescence is a powerful analytical technique with many advantages, while aptamers are well-known as good molecular recognition units. However, many aptamer-based chemiluminescence assays employed interface sensing, which often needed several ... ...

    Abstract Chemiluminescence is a powerful analytical technique with many advantages, while aptamers are well-known as good molecular recognition units. However, many aptamer-based chemiluminescence assays employed interface sensing, which often needed several immobilization, separation, and washing steps. To minimize the risks of contamination and false-positive, we for the first time proposed a photocatalytic aptamer chemiluminescent system for a homogeneous, label-free, generic assay of small molecules. After binding to a DNA aptamer, thioflavin T has a unique photocatalytic oxidase activity to activate the system's luminol chemiluminescence. Then, the specific binding between the aptamer and target molecules will compete with the above process. Therefore, we can realize the efficient assay of different analytes including estradiol and adenosine. Such a homogeneous chemiluminescent system allowed a direct assay of small molecules with limits of detection in a nM level. Several control tests were carried out to avoid possible false-positive results, which were originated from the interactions between analytes and sensing interfaces previously. This homogeneous chemiluminescent system provides a useful strategy to reliably assay various analytes in the pharmacy or biology field.
    MeSH term(s) Biosensing Techniques/methods ; Aptamers, Nucleotide/chemistry ; Luminescent Measurements/methods ; Luminol/chemistry ; Adenosine
    Chemical Substances Aptamers, Nucleotide ; Luminol (5EXP385Q4F) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c00066
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
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  9. Article ; Online: Cation-induced Ti

    Cai, Debin / Wu, Shuai / Tian, Zhen / Guo, Li / Wang, Yanzhong

    Journal of colloid and interface science

    2024  Volume 665, Page(s) 232–239

    Abstract: The self-assembled aerogels are considered as an efficient strategy to address the aggregation and restacking of ... ...

    Abstract The self-assembled aerogels are considered as an efficient strategy to address the aggregation and restacking of Ti
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.03.135
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  10. Article ; Online: MGCNSS: miRNA-disease association prediction with multi-layer graph convolution and distance-based negative sample selection strategy.

    Tian, Zhen / Han, Chenguang / Xu, Lewen / Teng, Zhixia / Song, Wei

    Briefings in bioinformatics

    2024  Volume 25, Issue 3

    Abstract: Identifying disease-associated microRNAs (miRNAs) could help understand the deep mechanism of diseases, which promotes the development of new medicine. Recently, network-based approaches have been widely proposed for inferring the potential associations ... ...

    Abstract Identifying disease-associated microRNAs (miRNAs) could help understand the deep mechanism of diseases, which promotes the development of new medicine. Recently, network-based approaches have been widely proposed for inferring the potential associations between miRNAs and diseases. However, these approaches ignore the importance of different relations in meta-paths when learning the embeddings of miRNAs and diseases. Besides, they pay little attention to screening out reliable negative samples which is crucial for improving the prediction accuracy. In this study, we propose a novel approach named MGCNSS with the multi-layer graph convolution and high-quality negative sample selection strategy. Specifically, MGCNSS first constructs a comprehensive heterogeneous network by integrating miRNA and disease similarity networks coupled with their known association relationships. Then, we employ the multi-layer graph convolution to automatically capture the meta-path relations with different lengths in the heterogeneous network and learn the discriminative representations of miRNAs and diseases. After that, MGCNSS establishes a highly reliable negative sample set from the unlabeled sample set with the negative distance-based sample selection strategy. Finally, we train MGCNSS under an unsupervised learning manner and predict the potential associations between miRNAs and diseases. The experimental results fully demonstrate that MGCNSS outperforms all baseline methods on both balanced and imbalanced datasets. More importantly, we conduct case studies on colon neoplasms and esophageal neoplasms, further confirming the ability of MGCNSS to detect potential candidate miRNAs. The source code is publicly available on GitHub https://github.com/15136943622/MGCNSS/tree/master.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Algorithms ; Computational Biology/methods ; Software ; Colonic Neoplasms/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbae168
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    Zs.A 6262: Show issues Location:
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