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Article ; Online: Smartphone-Based Quantitative Detection of Ochratoxin A in Wheat via a Lateral Flow Assay

Tian, Yunxin / Hu, Xiaofeng / Jiang, Jun / Tang, Xiaoqian / Tian, Zhiquan / Zhang, Zhaowei / Li, Peiwu

Foods. 2023 Jan. 17, v. 12, no. 3

2023

Abstract: Ochratoxin A (OTA) poses a severe health risk to livestock along the food chain. Moreover, according to the International Agency for Research on Cancer, it is also categorized as being possibly carcinogenic to humans. The lack of intelligent point-of- ... ...

Abstract	Ochratoxin A (OTA) poses a severe health risk to livestock along the food chain. Moreover, according to the International Agency for Research on Cancer, it is also categorized as being possibly carcinogenic to humans. The lack of intelligent point-of-care test (POCT) methods restricts its early detection and prevention. This work establishes a smartphone-enabled point-of-care test for OTA detection via a fluorescent lateral flow assay within 6 min. By using a smartphone and portable reader, the assay allows for the recording and sharing of the detection results in a cloud database. This intelligent POCT provided (iPOCT) a linearity range of 0.1–3.0 ng/mL and a limit of detection (LOD) of 0.02 ng/mL (0.32 µg/kg in wheat). By spiking OTA in blank wheat samples, the recoveries were 89.1–120.4%, with a relative standard deviation (RSD) between 3.9–9.1%. The repeatability and reproducibility were 94.2–101.7% and 94.6–103.4%, respectively. This work provides a promising intelligent POCT method for food safety.
Keywords	carcinogenicity ; databases ; detection limit ; fluorescence ; food chain ; food safety ; livestock ; mobile telephones ; ochratoxin A ; point-of-care systems ; risk ; standard deviation ; wheat
Language	English
Dates of publication	2023-0117
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12030431
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Discrepancy of Growth Toxicity of Polystyrene Nanoplastics on Soybean (

Su, Dan / Li, Wangwang / Zhang, Zhaowei / Cai, Hui / Zhang, Le / Sun, Yuanlong / Liu, Xiaoning / Tian, Zhiquan

Toxics

2024 Volume 12, Issue 2

Abstract: Nanoplastics, as a hot topic of novel contaminants, lack extensive concern in higher plants; especially the potential impact and mechanism of nanoplastics on legume crops remains elusive. In this study, the toxicity of polystyrene nanoplastics (PS-NPs, ... ...

Abstract	Nanoplastics, as a hot topic of novel contaminants, lack extensive concern in higher plants; especially the potential impact and mechanism of nanoplastics on legume crops remains elusive. In this study, the toxicity of polystyrene nanoplastics (PS-NPs, 200 nm) with diverse doses (control, 10, 50, 100, 200, 500 mg/L) to soybean and mung bean plants grown hydroponically for 7 d was investigated at both the macroscopic and molecular levels. The results demonstrated that the root length of both plants was markedly suppressed to varying degrees. Similarly, mineral elements (Fe, Zn) were notably decreased in soybean roots, consistent with Cu alteration in mung bean. Moreover, PS-NPs considerably elevated malondialdehyde (MDA) levels only in soybean roots. Enzyme activity data indicated mung bean exhibited significant damage only at higher doses of PS-NPs stress than soybean, implying mung bean is more resilient. Transcriptome analysis showed that PS-NPs stimulated the expression of genes associated with the antioxidant system in plant roots. Furthermore, starch and sucrose metabolism might play a key role in coping with PS-NPs to enhance soybean resistance, but the MAPK pathway was enriched in mung bean. Our findings provide valuable perspectives for an in-depth understanding of the performance of plants growing in waters contaminated by nanoplastics.
Language	English
Publishing date	2024-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12020155
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Article: Smartphone-Based Quantitative Detection of Ochratoxin A in Wheat via a Lateral Flow Assay.

Tian, Yunxin / Hu, Xiaofeng / Jiang, Jun / Tang, Xiaoqian / Tian, Zhiquan / Zhang, Zhaowei / Li, Peiwu

Foods (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract	Ochratoxin A (OTA) poses a severe health risk to livestock along the food chain. Moreover, according to the International Agency for Research on Cancer, it is also categorized as being possibly carcinogenic to humans. The lack of intelligent point-of-care test (POCT) methods restricts its early detection and prevention. This work establishes a smartphone-enabled point-of-care test for OTA detection via a fluorescent lateral flow assay within 6 min. By using a smartphone and portable reader, the assay allows for the recording and sharing of the detection results in a cloud database. This intelligent POCT provided (iPOCT) a linearity range of 0.1-3.0 ng/mL and a limit of detection (LOD) of 0.02 ng/mL (0.32 µg/kg in wheat). By spiking OTA in blank wheat samples, the recoveries were 89.1-120.4%, with a relative standard deviation (RSD) between 3.9-9.1%. The repeatability and reproducibility were 94.2-101.7% and 94.6-103.4%, respectively. This work provides a promising intelligent POCT method for food safety.
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12030431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NIR quantum dot construction of a fluorescence anisotropy signal amplification biosensor for sensitive, rapid and separation-free detection of dopamine in serum.

Liu, Jing / Chen, Ming / Zhang, Zhi-Ling / Hong, Xuechuan / Yu, Zi-Li / Tian, Zhi-Quan

The Analyst

2023 Volume 148, Issue 15, Page(s) 3543–3550

Abstract: Dopamine (DA) is an important small-molecule neurotransmitter, which is closely related to the development of many neurological diseases and has received increasing attention in the diagnosis of neurological diseases. Currently, the assays of the ... ...

Abstract	Dopamine (DA) is an important small-molecule neurotransmitter, which is closely related to the development of many neurological diseases and has received increasing attention in the diagnosis of neurological diseases. Currently, the assays of the detection of dopamine such as electrochemical and colorimetric methods have low sensitivity, poor selectivity and susceptibility to interference, which limit the accurate quantification of dopamine. Fluorescence anisotropy immunoassay is a traditional analytical method in which the quantification is based on the change in fluorescence anisotropy values observed when fluorescence molecules are bound to a certain volume and mass of the material. Since dopamine is a small molecule with small volume and mass, we took advantage of the good photostability of the second near-infrared window (NIR-II) quantum dots (QDs) and the low spontaneous interference of the substrate, and designed a biosensor dopamine fluorescence anisotropy probe streptavidin biosensor (DFAP-SAB) based on the NIR-II QDs combined with streptavidin signal amplification to achieve rapid and separation-free detection of dopamine in human serum. The detection signal has a good linearity between 50 nM and 3000 nM with a detection limit of 11.2 nM. The application of NIR-II QDs provides the possibility of biosensor applications for complex samples. The construction of the streptavidin signal amplification device provides a new idea for small molecule detection.
MeSH term(s)	Humans ; Quantum Dots/chemistry ; Dopamine ; Streptavidin ; Biosensing Techniques/methods ; Immunoassay ; Limit of Detection
Chemical Substances	Dopamine (VTD58H1Z2X) ; Streptavidin (9013-20-1)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an00590a
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Article ; Online: NIR-II fluorescent Ag

Deng, Kuhan / Yu, Zi-Li / Hu, Xiaofeng / Liu, Jing / Hong, Xuechuan / Zi, Gong Ga Lan / Zhang, Zhaowei / Tian, Zhi-Quan

Mikrochimica acta

2023 Volume 190, Issue 12, Page(s) 462

Abstract: Fluorescent lateral flow immunoassay (LFA), one tool in point of care testing (POCT) systems for breast cancer, has attracted attention because it is quick, simple, and convenient. However, samples and the constituent material exhibit autofluorescence in ...

Abstract	Fluorescent lateral flow immunoassay (LFA), one tool in point of care testing (POCT) systems for breast cancer, has attracted attention because it is quick, simple, and convenient. However, samples and the constituent material exhibit autofluorescence in the visible region, which is a very large obstacle in the development of fluorescent LFAs. The autofluorescence of biological samples is scarcely found in the second near-infrared (NIR-II) range and samples scatter and absorb less NIR-II light than visible light. Here, we report an NIR-II QD-LFA platform using the NIR-II fluorescent Ag
MeSH term(s)	Polystyrenes ; Biomarkers, Tumor ; Fluorescent Dyes ; Immunoassay ; Light ; Neoplasms
Chemical Substances	Polystyrenes ; Biomarkers, Tumor ; Fluorescent Dyes
Language	English
Publishing date	2023-11-09
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-06039-9
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Article: Target-modulated sensitization of upconversion luminescence by NIR-emissive quantum dots: a new strategy to construct upconversion biosensors

Yu, Tianyu / Wei, Dong-Mei / Li, Zhen / Pan, Liang-Jun / Zhang, Zhi-Ling / Tian, Zhi-Quan / Liu, Zhihong

Chemical communications. 2020 Feb. 13, v. 56, no. 13

2020

Abstract: We herein used Ag₂Se quantum dots (QDs) as a target-modulated sensitizer for upconversion nanoparticles (UCNPs) and the target thrombin as the sensitizing switch to construct a biosensor, circumventing the limited luminescence resonance energy transfer ( ... ...

Abstract	We herein used Ag₂Se quantum dots (QDs) as a target-modulated sensitizer for upconversion nanoparticles (UCNPs) and the target thrombin as the sensitizing switch to construct a biosensor, circumventing the limited luminescence resonance energy transfer (LRET) efficiency of UCNPs, with enhanced signal-to-background ratio (SBR) and assay sensitivity.
Keywords	biosensors ; chemical reactions ; energy transfer ; luminescence ; nanoparticles ; quantum dots ; selenides ; thrombin
Language	English
Dates of publication	2020-0213
Size	p. 1976-1979.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc09220j
Database	NAL-Catalogue (AGRICOLA)

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Article: A near-infrared-II fluorescence anisotropy strategy for separation-free detection of adenosine triphosphate in complex media

Fan, Ya-Ling / Liu, Zhen-Ya / Zeng, Yu-Mei / Huang, Lu-Yao / Li, Zheng / Zhang, Zhi-Ling / Pang, Dai-Wen / Tian, Zhi-Quan

Talanta. 2021 Feb. 01, v. 223

2021

Abstract: Fluorescence anisotropy (FA) has been widely applied for detecting and monitoring special targets in life sciences. However, matrix autofluorescence restricted its further application in complex biological samples. Herein, we report a near-infrared-II ( ... ...

Abstract	Fluorescence anisotropy (FA) has been widely applied for detecting and monitoring special targets in life sciences. However, matrix autofluorescence restricted its further application in complex biological samples. Herein, we report a near-infrared-II (NIR-II) FA strategy for detecting adenosine triphosphate (ATP) in human serum samples and breast cancer cell lysate, which employed NIR-II fluorescent Ag₂Se quantum dots (QDs) as tags to reduce matrix autofluorescence effect and applied graphene oxide (GO) to enhance fluorescence anisotropy signals. In the presence of ATP, the recognition between NIR-II Ag₂Se QDs labeled aptamer (QD-pDNA) and ATP led to the release of QD-pDNA from GO, resulting in the obvious decrease of FA values. ATP could be quantitatively detected in concentrations ranged from 3 nM to 2500 nM, with a detection limit down to 1.01 nM. This study showed that the developed NIR-II FA strategy could be applied for detecting targets in complex biological samples and had great potential for monitoring interactions between biomolecules in biomedical research.
Keywords	adenosine triphosphate ; anisotropy ; biomedical research ; blood serum ; breast neoplasms ; detection limit ; fluorescence ; graphene oxide ; humans ; monitoring ; neoplasm cells ; oligonucleotides ; quantum dots ; sampling
Language	English
Dates of publication	2021-0201
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121721
Database	NAL-Catalogue (AGRICOLA)

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Article: Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy

Li, Yang / Gao, Jianfeng / Wang, Shuping / Li, Shijun / Hou, Xiaowen / Pan, Yanna / Gao, Jialu / Qiao, Xue / Tian, Zhiquan / Chen, Deliang / Deng, Hai / Deng, Zixin / Hong, Xuechuan / Xiao, Yuling

Journal of controlled release. 2022 Feb., v. 342

2022

Abstract: Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper ...

Abstract	Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper clinical applications. Here we report a series of micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II fluorophores HLAnP (n = 1–4) for simultaneous bioimaging and drug delivery. The NIR-II HLA4P nanocarrier displays exceptional non-fouling performance, minimal immunogenicity, ultralong blood half-life, and high tumor accumulation even with different administration routes. When used as a drug carrier, HLA4P with encapsulated doxorubicin (DOX) realized accurate tumor targeting and continuous real-time in vivo NIR-II tracking of drug delivery and therapy, showing a sustained release rate, improved therapeutic effect, and diminished cardiotoxicity as compared to free DOX. This study provides a new perspective on the design of dual-functional NIR-II fluorophores for diagnostic and therapeutic applications.
Keywords	bioimaging ; blood ; blood flow ; cardiotoxicity ; doxorubicin ; encapsulation ; fluorescent dyes ; half life ; immunogenicity ; nanocarriers ; neoplasms ; pharmacokinetics
Language	English
Dates of publication	2022-02
Size	p. 157-169.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.01.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy.

Li, Yang / Gao, Jianfeng / Wang, Shuping / Li, Shijun / Hou, Xiaowen / Pan, Yanna / Gao, Jialu / Qiao, Xue / Tian, Zhiquan / Chen, Deliang / Deng, Hai / Deng, Zixin / Hong, Xuechuan / Xiao, Yuling

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 342, Page(s) 157–169

Abstract	Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper clinical applications. Here we report a series of micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II fluorophores HLAnP (n = 1-4) for simultaneous bioimaging and drug delivery. The NIR-II HLA4P nanocarrier displays exceptional non-fouling performance, minimal immunogenicity, ultralong blood half-life, and high tumor accumulation even with different administration routes. When used as a drug carrier, HLA4P with encapsulated doxorubicin (DOX) realized accurate tumor targeting and continuous real-time in vivo NIR-II tracking of drug delivery and therapy, showing a sustained release rate, improved therapeutic effect, and diminished cardiotoxicity as compared to free DOX. This study provides a new perspective on the design of dual-functional NIR-II fluorophores for diagnostic and therapeutic applications.
MeSH term(s)	Doxorubicin ; Drug Carriers ; Drug Delivery Systems ; Fluorescent Dyes ; Nanoparticles ; Theranostic Nanomedicine/methods
Chemical Substances	Drug Carriers ; Fluorescent Dyes ; Doxorubicin (80168379AG)
Language	English
Publishing date	2022-01-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.01.005
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Article ; Online: Target-modulated sensitization of upconversion luminescence by NIR-emissive quantum dots: a new strategy to construct upconversion biosensors.

Yu, Tianyu / Wei, Dong-Mei / Li, Zhen / Pan, Liang-Jun / Zhang, Zhi-Ling / Tian, Zhi-Quan / Liu, Zhihong

Chemical communications (Cambridge, England)

2020 Volume 56, Issue 13, Page(s) 1976–1979

Abstract: We herein used ... ...

Abstract	We herein used Ag
MeSH term(s)	Biosensing Techniques/methods ; Fluorescence Resonance Energy Transfer ; Humans ; Infrared Rays ; Limit of Detection ; Quantum Dots/chemistry ; Signal-To-Noise Ratio ; Thrombin/analysis
Chemical Substances	Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2020-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc09220j
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