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Article ; Online: Recent progress on the traditional Chinese medicines that regulate the blood

Hsin-Yi Hung / Tian-Shung Wu

Journal of Food and Drug Analysis, Vol 24, Iss 2, Pp 221-

2016 Volume 238

Abstract: In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, ... ...

Abstract	In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, Chuanxiong Rhizoma, Corydalis Tuber, and Motherwort Herb were selected and reviewed for their recent studies on anti-tumor, anti-inflammatory and cardiovascular effects. Besides, the analytical methods developed to qualify or quantify the active compounds of the herbs are also summarized.
Keywords	analytical methods ; traditional Chinese medicine ; Nutrition. Foods and food supply ; TX341-641 ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2016-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of Lanthanide Shift Reagent to the 1 H-NMR Assignments of Acridone Alkaloids

Sio-Hong Lam / Hsin-Yi Hung / Ping-Chung Kuo / Daih-Huang Kuo / Fu-An Chen / Tian-Shung Wu

Molecules, Vol 25, Iss 5383, p

2020 Volume 5383

Abstract: This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids ( 1 – 3 ) and pyranoacridone alkaloids ( 4 – 6 ). The induced chemical shifts (∆δ) ... ...

Abstract	This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids ( 1 – 3 ) and pyranoacridone alkaloids ( 4 – 6 ). The induced chemical shifts (∆δ) of all protons were observed for the same molecule, and were compared to deduce the positions resulting from the distance nearby the Eu(dpm) 3 . Assignment of the H-2, H-4 and H-8 of polysubstituted acridones could be distinguished based on the least-squares method of lanthanide-induced shifts plotted against the mole ratios of Eu(dpm) 3 to the substrate. The developed method is not only potentially useful for determining the planar structures of polysubstituted compounds, such as acridones, anthraquinones, xanthones, flavonoids, and phenanthrenes, but also applicable for their stereochemistry.
Keywords	acridone alkaloid ; lanthanide shift reagent ; tris(dipivaloylmethanato)-europium(III) ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Recent progress on the traditional Chinese medicines that regulate the blood

Hung, Hsin-Yi / Tian-Shung Wu

Yàowù shípǐn fēnxī. 2016 Apr., v. 24, no. 2

2016

Abstract	In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, Chuanxiong Rhizoma, Corydalis Tuber, and Motherwort Herb were selected and reviewed for their recent studies on anti-tumor, anti-inflammatory and cardiovascular effects. Besides, the analytical methods developed to qualify or quantify the active compounds of the herbs are also summarized.
Keywords	active ingredients ; analytical methods ; Bletilla ; blood ; branches ; Corydalis ; drugs ; herbs ; Leonurus ; Oriental traditional medicine ; Platycladus orientalis ; pollen ; rhizomes ; Rubia ; India
Language	English
Dates of publication	2016-04
Size	p. 221-238.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1292535-4
ISSN	1021-9498
ISSN	1021-9498
DOI	10.1016/j.jfda.2015.10.009
Database	NAL-Catalogue (AGRICOLA)

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Article: Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica

Ito, Chihiro / Makiko Takano / Masataka Itoigawa / Takuya Matsui / Tian-Shung Wu

Natural product research. 2018 Sept. 17, v. 32, no. 18

2018

Abstract: Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated ... ...

Abstract	Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle.
Keywords	adenocarcinoma ; B-lymphocytes ; cell cycle ; cell growth ; cell lines ; cell proliferation ; chemical composition ; growth retardation ; inhibitory concentration 50 ; leukemia ; lungs ; plumbagin ; Plumbago zeylanica ; roots ; Taiwan
Language	English
Dates of publication	2018-0917
Size	p. 2127-2132.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2017.1366476
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Rapid and Feasible 1 H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations

Hsin-Yi Hung / Shih-Min Lin / Chia-Ying Li / Sio-Hong Lam / Yu-Yi Chan / Meei-Jen Liou / Po-Chuen Shieh / Fu-An Chen / Ping-Chung Kuo / Tian-Shung Wu

Molecules, Vol 26, Iss 1599, p

2021 Volume 1599

Abstract: A highly specific and sensitive proton nuclear magnetic resonance ( 1 H-NMR) method has been developed for the quantification of ephedrine alkaloid derivatives in Ephedra herbal commercial prescriptions. At the region of δ 4.0 to 5.0 ppm in the 1 H NMR ... ...

Abstract	A highly specific and sensitive proton nuclear magnetic resonance ( 1 H-NMR) method has been developed for the quantification of ephedrine alkaloid derivatives in Ephedra herbal commercial prescriptions. At the region of δ 4.0 to 5.0 ppm in the 1 H NMR spectrum, the characteristic signals are separated well from each other, and six analogues in total, methylephedrine (ME), ephedrine (EP), norephedrine (NE), norpseudoephedrine (NP), pseudoephedrine (PE), and methylpseudoephedrine (MP) could be identified. The quantities of these compounds are calculated by the relative ratio of the integral values of the target peak for each compound to the known concentrations of the internal standard anthracene. The present method allows for a rapid and simple quantification of ephedrine alkaloid derivatives in Ephedra -related commercial prescriptions without any preliminary purification steps and standard compounds, and accordingly it can be a powerful tool to verify different Ephedra species. In comparison to conventional chromatographic methods, the advantages of this method include the fact that no standard compounds are required, the quantification can be directly performed on the crude extracts, a better selectivity for various ephedrine alkaloid derivatives, and the fact that a very significant time-gain may be achieved.
Keywords	quantitative analysis ; ephedrine ; pseudoephedrine ; Ephedra ; 1 H-NMR ; internal standard ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Constituents from the Fruiting Bodies of Trametes cubensis and Trametes suaveolens in Vietnam and Their Anti-Inflammatory Bioactivity

Yue-Chiun Li / Nguyen Thi Ngan / Kun-Ching Cheng / Tsong-Long Hwang / Tran Dinh Thang / Nguyen Ngoc Tuan / Mei-Lin Yang / Ping-Chung Kuo / Tian-Shung Wu

Molecules, Vol 26, Iss 7311, p

2021 Volume 7311

Abstract: It is reported that various fungi have been used for medicine and edible foods. The tropical Trametes genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi T. cubensis ... ...

Abstract	It is reported that various fungi have been used for medicine and edible foods. The tropical Trametes genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi T. cubensis and T. suaveolens were collected in Vietnam. The preliminary bioactivity screening data indicated that the methanol extracts of the fruiting bodies of T. cubensis and T. suaveolens displayed significant inhibition of superoxide anion generation and elastase release in human neutrophils. Therefore, the isolation and characterization were performed on these two species by a combination of chromatographic methods and spectrometric analysis. In total, twenty-four compounds were identified, and among these ( 1–3 ) were characterized by 1D-, 2D-NMR, and HRMS analytical data. In addition, the anti-inflammatory potentials of some purified compounds were examined by the cellular model for the inhibition of superoxide anion generation and elastase release in human neutrophils. Among the isolated compounds, ( 5 , 14 ), and ( 19 ) displayed significant anti-inflammatory potential. As the results suggest, the extracts and isolated compounds from T. cubensis and T. suaveolens are potential candidates for the further development of new anti-inflammatory lead drugs or natural healthy foods.
Keywords	Trametes cubensis ; Trametes suaveolens ; anti-inflammatory ; superoxide anion generation ; elastase release ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemoreversal Agents from Taiwanofungus Genus and Their More Potent Methyl Derivatives Targeting Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation

Ko-Hua Yu / Chin-Chuan Hung / Tian-Shung Wu / Chin-Fu Chen / I-Ting Wu / Ping-Chung Kuo / Sio-Hong Lam / Hsin-Yi Hung

Pharmaceuticals, Vol 14, Iss 916, p

2021 Volume 916

Abstract: Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR ... ...

Abstract	Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR mechanism pathways. Based on the previous research, zhankuic acid A, B, and C were found to have collateral sensitivity effects on MDR cancer cells, and MDR inhibitory activity of zhankuic acid methyl ester was found to be better than that of its acid. Therefore, we executed a systematic examination of the structure–activity relationship of zhankuic acid methyl ester derivatives to collateral sensitivity in MDR cancer cells. The results showed that compound 12 is the best in terms of chemoreversal activity, where the reversal fold was 692, and the IC 50 value of paclitaxel combined with 10 μM compound 12 treatment was 1.69 nM in MDR KBvin cells. Among all the derivatives, methyl ester compounds were found to be better than their acids, and a detailed discussion of the structure–activity relationships of all of the derivatives is provided in this work. In addition, compounds 8 , 12, and 26 were shown to influence the activation of STAT3 in KBvin cells, accounting for part of their chemoreversal effects. Our results may provide a new combined therapy with paclitaxel to treat multidrug-resistant cancers and provide a new therapy option for patients.
Keywords	multidrug resistance ; signal transducer and activator of transcription 3 (STAT3) ; zhankuic acid ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	571
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells

Tsung-Lin Lee / Shyang-Guang Wang / Wen-Ling Chan / Ching-Hsiao Lee / Tian-Shung Wu / Meng-Liang Lin / Shih-Shun Chen

Cells, Vol 9, Iss 2, p

2020 Volume 371

Abstract: The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to ... ...

Abstract	The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to extra- or intracellular stimuli. Density-based membrane flotation, subcellular fractionation, cell surface biotinylation, and co-immunoprecipitation analyses of bichalcone analog (( E )-1-(4-Hydroxy-3-((4-(4-(( E )-3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one (TSWU-BR4)-treated cancer cells showed dissociation between GRP78 and p85α conferring the recruitment of PTEN to lipid raft membranes associated with p85α. Ectopic expression of GRP78 could overcome induction of lipid raft membrane-associated p85α−unphosphorylated PTEN complex formation and suppression of GRP78−PI3K−Akt−GTP-Rac1-mediated and GRP78-regulated PERK−Nrf2 antioxidant pathway and cancer cell invasion by TSWU-BR4. Using specific inducer, inhibitor, or short hairpin RNA for ASM demonstrated that induction of the lipid raft membrane localization and activation of ASM by TSWU-BR4 is responsible for perturbing homeostasis of cholesterol and ceramide levels in the lipid raft and ER membranes, leading to alteration of GRP78 membrane trafficking and subsequently inducing p85α−unphosphorylated PTEN complex formation, causing disruption of GRP78−PI3K−Akt−GTP-Rac1-mediated signal and ER membrane-associated GRP78-regulated oxidative stress balance, thus inhibiting cancer cell invasion. The involvement of the enrichment of ceramide to lipid raft membranes in inhibition of NF-κB-mediated MMP-2 expression was confirmed through attenuation of NF-κB activation using C2-ceramide, NF-κB specific inhibitors, ectopic expression of NF-κB p65, MMP-2 promoter-driven luciferase, and NF-κB-dependent reporter genes. In conclusion, localization of ASM in the lipid raft membranes by TSWU-BR4 is a key event for initiating formation of ceramide-enriched lipid raft membrane ...
Keywords	p85α ; asm ; bichalcone analog ; ceramide ; grp78 ; lipid raft ; pten ; ros ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation

Shin-Hun Juang / Min-Tsang Hsieh / Pei-Ling Hsu / Ju-Ling Chen / Hui-Kang Liu / Fong-Pin Liang / Sheng-Chu Kuo / Chen-Yuan Chiu / Shing-Hwa Liu / Chen-Hsi Chou / Tian-Shung Wu / Hsin-Yi Hung

Molecules, Vol 26, Iss 164, p

2021 Volume 164

Abstract: Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option. In this study, sixty ... ...

Abstract	Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option. In this study, sixty courmarin derivatives either synthesized or purified from Artemisia capillaris were screened for CAR activation activity. Chemical modifications were on position 5,6,7,8 with mono-, di-, tri-, or tetra-substitutions. Among all the compounds subjected for in vitro CAR activation screening, 6,7-diprenoxycoumarin was the most effective and was selected for further preclinical studies. Chemical modification on the 6 position and unsaturated chains were generally beneficial. Electron-withdrawn groups as well as long unsaturated chains were hazardous to the activity. Mechanism of action studies showed that CAR activation of 6,7-diprenoxycoumarin might be through the inhibition of EGFR signaling and upregulating PP2Ac methylation. To sum up, modification mimicking natural occurring coumarins shed light on CAR studies and the established screening system provides a rapid method for the discovery and development of CAR activators. In addition, one CAR activator, scoparone, did showed anti-diabetes effect in db / db mice without elevation of insulin levels.
Keywords	Yin Chen Hao ; constitutive androstane receptor ; coumarin ; scoparone ; Organic chemistry ; QD241-441
Subject code	380 ; 540
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release

Yu-Yi Chan / Tsong-Long Hwang / Ping-Chung Kuo / Hsin-Yi Hung / Tian-Shung Wu

Molecules, Vol 22, Iss 9, p

2017 Volume 1454

Abstract: Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of ... ...

Abstract	Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.
Keywords	Citrus medica L. var. sarcodactylis Swingle ; Rutaceae ; sesquiterpene ; citrumedin-C ; superoxide anion formation ; elastase release ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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