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  1. Article ; Online: Impact of Urbanization and Industrial Structure on Carbon Emissions

    Qinghua Pang / Weimo Zhou / Tianxin Zhao / Lina Zhang

    Land, Vol 10, Iss 1130, p

    Evidence from Huaihe River Eco-Economic Zone

    2021  Volume 1130

    Abstract: Rapid urbanization in China greatly contributes to carbon emissions, while the industrial structure greatly contributes to changes in the variation of carbon emissions. This research addresses the impact of urbanization and industrial structure on carbon ...

    Abstract Rapid urbanization in China greatly contributes to carbon emissions, while the industrial structure greatly contributes to changes in the variation of carbon emissions. This research addresses the impact of urbanization and industrial structure on carbon emissions from 2010 to 2018, by focusing on the Huaihe River Eco-economic Zone, which is an important economic corridor along the north–south division of China. Although many studies have focused on investigating the impact of urbanization or industrial structure on carbon emissions, few studies further addressed an analysis of the impact of both on carbon emissions, using multiple measurement models. This paper reveals the holistic and local impact of industrial structure and urbanization on carbon emissions, by integrating a threshold regression model with geographically weighted regression. The results are as follows: (1) From a holistic point of view, industrial structure and urbanization had both, single threshold, and double threshold effects on carbon emissions in the Huaihe River Eco-economic Zone. (2) From a regional perspective, the coefficients of industrial structure on carbon emissions were all positive, but the rate of increase gradually slowed down. The coefficients of urbanization on carbon emissions were all negative, reaching a maximum value of negative effect in 2013. Understanding the holistic and local impact of urbanization and industrial structure on carbon emissions provides governments with differentiated and forward-looking suggestions for mitigating carbon emissions in the Huaihe River Eco-economic Zone.
    Keywords carbon emissions ; industrial structure ; urbanization ; threshold model ; geographically weighted regression ; Agriculture ; S
    Subject code 550
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Quality Assessment of YouTube Videos as an Information Source for Testicular Torsion

    Gaochen Bai / Xi Pan / Tianxin Zhao / Xiong Chen / Guochang Liu / Wen Fu

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: Background:Testicular torsion is an acute scrotal disease requiring urgent management, and the COVID-19 pandemic has been demonstrated to lead to poor outcomes for this disease. Presently, many people tend to seek health information via YouTube. This ... ...

    Abstract Background:Testicular torsion is an acute scrotal disease requiring urgent management, and the COVID-19 pandemic has been demonstrated to lead to poor outcomes for this disease. Presently, many people tend to seek health information via YouTube. This study aims to quantitatively assess the quality of English YouTube video content as an information source of testicular torsion.MethodsIn this cross-sectional study, a search was performed with the search term “testicular torsion” on YouTube, and the first 100 videos listed by relevance were selected for our analysis. Duplicate, non-English, videos without audio and surgical videos were excluded. Video features (duration, number of days online, views, likes, comments), source of the video, and author's country were collected. Each video included in the study was assessed using DISCERN and Journal of the American Medical Association (JAMA) Benchmark Criteria. A correlation analysis was performed considering video features, video source, DISCERN scores and JAMA scores.ResultsA total of 66 videos were included and analyzed. The most common video content was general information, including etiology, symptoms, and treatment. The majority of videos were from education and training websites (30%), physicians (23%), and independent users (21%). The mean DISCERN and JAMA scores were 36.56 and 2.68, respectively. According to DISCERN, the quality of video uploaded by physicians was relatively high (P < 0.001), and the quality of video uploaded by independent users was relatively low (P < 0.001). The JAMA score had no relevance to the video source (P = 0.813). The correlation between the video features, DISCERN and JAMA scores was controversial by different assessment methods.ConclusionsDespite most of the videos on YouTube being uploaded by medical or education-related authors, the overall quality was poor. The misleading, inaccurate and incomplete information may pose a health risk to the viewers, especially during the COVID-19 pandemic. Much effort needs to be ...
    Keywords testicular torsion ; internet ; quality ; DISCERN ; YouTube ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: LncRNAs activate longevity regulation pathway due to aging of Leydig cells caused by DEHP exposure

    Yuhao Wu / Junke Wang / Tianxin Zhao / Yuexin Wei / Lindong Han / Lianju Shen / Chunlan Long / Shengde Wu / Guanghui Wei

    Ecotoxicology and Environmental Safety, Vol 209, Iss , Pp 111798- (2021)

    A transcriptome-based study

    2021  

    Abstract: Di-(2-ethylhexyl) phthalate (DEHP), one of the most commonly used endocrine-disrupting chemicals, has been shown to cause reproductive dysfunction in humans and animal models. However, very few studies have investigated the impact of DEHP at the post- ... ...

    Abstract Di-(2-ethylhexyl) phthalate (DEHP), one of the most commonly used endocrine-disrupting chemicals, has been shown to cause reproductive dysfunction in humans and animal models. However, very few studies have investigated the impact of DEHP at the post-transcriptional level in mouse testes, and the underlying mechanisms remain unclear. In the present research, TM3 Leydig cells were treated with 200 µM phthalic acid mono-2-ethylhexyl ester (MEHP, bio-metabolite of DEHP), and then the mRNA and lncRNA sequencing of TM3 Leydig cells was performed. Mice were exposed prepubertally to 0 or 500 mg DEHP/kg/day. RNA sequencing of mouse testes was performed to verify the RNA-seq results in vitro. The expression patterns of relevant genes and proteins were verified using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting. DEHP and MEHP exposure led to testicular damage and accelerated cell aging via ROS accumulation. RNA sequencing analyses indicated that FOXO signaling and longevity regulation pathways were activated in resistance to ROS accumulation. FOXO signaling and longevity regulation pathway-related genes and proteins were also activated. By constructing a competing endogenous RNA (ceRNA) network, we observed that the ceRNA network might play a role in regulating FOXO signaling and longevity regulation pathways in response to excessive ROS accumulation and cell aging. In summary, our data here suggests that the ceRNA network may play a role in regulating FOXO signaling and longevity pathways in response to DEHP exposure in mouse testes.
    Keywords Di-(2-Ethylhexyl) phthalate ; Competing endogenous RNA ; Reactive oxygen species ; Mouse ; Testes ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Subject code 572
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: CircCDYL Acts as a Tumor Suppressor in Wilms’ Tumor by Targeting miR-145-5p

    Rui Zhou / Wei Jia / Xiaofeng Gao / Fuming Deng / Kai Fu / Tianxin Zhao / Zhongmin Li / Wen Fu / Guochang Liu

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. However, the possible mechanisms concerning the circRNA in various tumors are still elusive. In this research, we analyzed the expression profile and ... ...

    Abstract Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. However, the possible mechanisms concerning the circRNA in various tumors are still elusive. In this research, we analyzed the expression profile and biological functions of circular RNA CDYL (circCDYL, circBase ID: hsa_circ_0008285) in Wilms’ tumor. Here, miRNA and gene expression were examined by real-time PCR in Wilms’ tumor tissues and cell lines. The functions of circCDYL and its potential targets to influence cell proliferation, migration, and invasion in Wilms’ tumor cells were determined by biological functional experiments in vitro and in vivo. We predicted and analyzed potential miRNA targets through online bioinformatic tools. To validate the interactions between circCDYL and its targets, we performed RNA fluorescence in situ hybridization, biotin-coupled miRNA capture assay, and biotin-coupled probe pull-down assay. Tight junction protein l (TJP1) was proved to be the target gene of the predicted miRNA by dual-luciferase reporter assay. The expression level of TJP1 in Wilms’ tumor cells was identified via Western blot. We showed that circCDYL was downregulated in WT tissue compared with adjacent non-tumor tissue. Upregulation of circCDYL could reduce cell proliferation, migration, and invasion. Mechanically, circCDYL, functioning as a miRNA sponge, decreased the expression level of miR-145-5p and TJP1 3′UTR was validated as the target of miR-145-5p, facilitating the circCDYL/miR-145-5p/TJP1 axis. In conclusion, our study suggested circCDYL as a novel biomarker and therapeutic target for WT treatment.
    Keywords microRNA ; tight junction protein 1 ; Wilms’ tumor ; circular RNA ; mir-145-5p ; biomarker ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Stereological analysis and transcriptome profiling of testicular injury induced by di-(2-ethylhexyl) phthalate in prepubertal rats

    Lindong Han / Junke Wang / Tianxin Zhao / Yuhao Wu / Yuexin Wei / Jiadong Chen / Lian Kang / Lianju Shen / Chunlan Long / Zhengwei Yang / Shengde Wu / Guanghui Wei

    Ecotoxicology and Environmental Safety, Vol 220, Iss , Pp 112326- (2021)

    2021  

    Abstract: Di-(2-ethylhexyl) phthalate (DEHP) is the most common phthalate that can affect the male reproductive system. DEHP exposure at the prepubertal stage could lead to the injury of immature testes, but the mechanism has not been fully clarified. In the ... ...

    Abstract Di-(2-ethylhexyl) phthalate (DEHP) is the most common phthalate that can affect the male reproductive system. DEHP exposure at the prepubertal stage could lead to the injury of immature testes, but the mechanism has not been fully clarified. In the present study, we elucidated the possible underlying mechanism of DEHP-induced prepubertal testicular injury through stereological analysis and transcriptome profiling. Compared with the control group, the DEHP-treated rats had lower body weight gain and decreased testicular weight and organ coefficient. Moreover, lower serum levels of testosterone and LH were observed in the DEHP group, in contrast to the increased FSH level. Additionally, the serum level of estradiol had no significant difference after DEHP exposure. Stereological analysis showed significant reduction in volumes of most testicular structures, especially in the seminiferous tubule and seminiferous epithelium, along with a vast decrease of spermatogenic cells and obvious structural damages with substantial pathological signs (germ cracks, cytoplasmic vacuolization, sloughing, multinucleated giant cell formation, chromatolysis desquamation and dissolution, pyknosis of nuclei) in the seminiferous tubule upon DEHP exposure at the prepubertal stage. Furthermore, transcriptome profiling identified 5548 differentially expressed genes (DEGs) upon DEHP exposure. Pathway enrichment analysis revealed several crucial signaling pathways related to retinol metabolism, oxidative phosphorylation, steroid hormone biosynthesis, and cell adhesion molecules (CAMs). In addition, seven DEGs selected from RNA-seq data were validated by quantitative real-time polymerase chain reaction (qRT-PCR), and the results showed the same trends as the RNA-seq results. In conclusion, the above findings provide basic morphological data and lay a foundation for systematic research on transcriptome profiling in prepubertal testicular injury induced by DEHP.
    Keywords Di-(2-ethylhexyl) phthalate ; Prepubertal testis ; Spermatogenesis ; Steroidogenesis ; Stereology ; RNA-seq ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Subject code 630
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells

    Yanyun Du / Qianwen Peng / Du Cheng / Ting Pan / Wanwei Sun / Heping Wang / Xiaojian Ma / Ruirui He / Huazhi Zhang / Zhihui Cui / Xiong Feng / Zhiqiang Liu / Tianxin Zhao / Wenjun Hu / Lei Shen / Wenyang Jiang / Na Gao / Bradley N. Martin / Cun-Jin Zhang /
    Zhanguo Zhang / Chenhui Wang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: Cancer cells producing ligands for the immune checkpoint molecules PD-1 and CTLA-4 is an important mechanism of tumour immune resistance. Here authors show that BTNL2 expression on cancer cells generates a dysfunctional tumour immune microenvironment via ...

    Abstract Cancer cells producing ligands for the immune checkpoint molecules PD-1 and CTLA-4 is an important mechanism of tumour immune resistance. Here authors show that BTNL2 expression on cancer cells generates a dysfunctional tumour immune microenvironment via promoting IL-17A-producing γδ T cells.
    Keywords Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Directing curli polymerization with DNA origami nucleators

    Xiuhai Mao / Ke Li / Mengmeng Liu / Xinyu Wang / Tianxin Zhao / Bolin An / Mengkui Cui / Yingfeng Li / Jiahua Pu / Jiang Li / Lihua Wang / Timothy K. Lu / Chunhai Fan / Chao Zhong

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and ... ...

    Abstract Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.
    Keywords Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Directing curli polymerization with DNA origami nucleators

    Xiuhai Mao / Ke Li / Mengmeng Liu / Xinyu Wang / Tianxin Zhao / Bolin An / Mengkui Cui / Yingfeng Li / Jiahua Pu / Jiang Li / Lihua Wang / Timothy K. Lu / Chunhai Fan / Chao Zhong

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and ... ...

    Abstract Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.
    Keywords Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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