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  1. Article ; Online: Intoxication pédiatrique sévère avec une faible dose de clonidine : à propos d'un cas.

    Schmitt, C / Kervégant, M / Ajaltouni, Z / Tauber, M / Tichadou, L / de Haro, L

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2014  Volume 21, Issue 11, Page(s) 1213–1215

    Abstract: Clonidine poisoning's clinical feature is well documented in the medical literature, but the minimal toxic dose has not yet been established. The effectiveness of naloxone is also controversial. The authors describe a clonidine overdose in a 9-year-old ... ...

    Title translation Clonidine poisoning in a child: a case report.
    Abstract Clonidine poisoning's clinical feature is well documented in the medical literature, but the minimal toxic dose has not yet been established. The effectiveness of naloxone is also controversial. The authors describe a clonidine overdose in a 9-year-old boy (25 kg) during a growth hormone test: he received tenfold the prescribed clonidine dose (0.23 mg instead of 0.023 mg) with 6.2 mg betaxolol. About 40 min later, he became drowsy and then complained of low blood pressure, bradycardia, and myosis. By maintaining the Trendelenburg position, administering fluids as well as salbutamol and naloxone (three doses of 0.2 mg were required), he recovered and was discharged from the hospital on day 2. The minimal clonidine toxic dose, the clinical picture, and the effectiveness of naloxone administration are discussed in this paper.
    MeSH term(s) Adrenergic alpha-2 Receptor Agonists/poisoning ; Albuterol/administration & dosage ; Antihypertensive Agents/poisoning ; Betaxolol/administration & dosage ; Betaxolol/poisoning ; Blood Pressure/drug effects ; Child ; Clonidine/administration & dosage ; Clonidine/poisoning ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Drug Overdose/diagnosis ; Drug Overdose/drug therapy ; Drug Therapy, Combination ; Heart Rate/drug effects ; Humans ; Male ; Medication Errors ; Naloxone/administration & dosage
    Chemical Substances Adrenergic alpha-2 Receptor Agonists ; Antihypertensive Agents ; Naloxone (36B82AMQ7N) ; Clonidine (MN3L5RMN02) ; Betaxolol (O0ZR1R6RZ2) ; Albuterol (QF8SVZ843E)
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2014.07.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3942: Show issues Location:
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  2. Article ; Online: Troubles cardiaques sévères après ingestion d'aconit dans le Sud de la France: à propos d'une observation.

    Dominois-Heraud, A-M / Schmitt, C / De Matteis, O / Tichadou, L / de Haro, L

    Annales francaises d'anesthesie et de reanimation

    2012  Volume 31, Issue 3, Page(s) 263–264

    Title translation Severe cardiac disturbances after Monkhood ingestion in southern France.
    MeSH term(s) Aconitum/poisoning ; Aged ; Arrhythmias, Cardiac/chemically induced ; Cardiopulmonary Resuscitation ; Electrocardiography ; Extracorporeal Membrane Oxygenation ; Female ; France ; Heart Diseases/chemically induced ; Hemodynamics/drug effects ; Humans ; Mushroom Poisoning/complications ; Tachycardia, Ventricular/chemically induced ; Tachycardia, Ventricular/therapy ; Ventricular Fibrillation/chemically induced ; Ventricular Fibrillation/therapy
    Language French
    Publishing date 2012-03
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 392411-7
    ISSN 1769-6623 ; 0750-7658
    ISSN (online) 1769-6623
    ISSN 0750-7658
    DOI 10.1016/j.annfar.2011.12.002
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  3. Article: Ingestion volontaire de decoction de henné (Lawsonia inermis) d'un déficit en G6PD.

    Perinet, I / Lioson, E / Tichadou, L / Glaizal, M / de Haro, L

    Medecine tropicale : revue du Corps de sante colonial

    2011  Volume 71, Issue 3, Page(s) 292–294

    Abstract: Henna (Lawsonia inermis) is a shrub bearing leaves that are crushed and used for cosmetic purposes in Asia and Africa. In several countries, henna decoction is ingested as a traditional drug to induce abortion. One component of Henna, known as Lawsone, ... ...

    Title translation Hemolytic anemia after voluntary ingestion of henna (Lawsonia inermis) decoction by a young girl with G6PD deficiency.
    Abstract Henna (Lawsonia inermis) is a shrub bearing leaves that are crushed and used for cosmetic purposes in Asia and Africa. In several countries, henna decoction is ingested as a traditional drug to induce abortion. One component of Henna, known as Lawsone, can induce hemolysis in G6PD-deficient patients after cutaneous exposure or ingestion. The purpose of this report is to describe a case of severe hemolytic anemia after voluntary ingestion of Henna decoction to induce abortion. This complication led to diagnosis of partial moderate G6PD-deficiency in the 17-year-old patient living in Mayotte in the Indian Ocean. This report emphasizes the life-threatening hazards associated with some plant extracts used as traditional medicines.
    MeSH term(s) Abortion, Induced ; Adolescent ; Anemia, Hemolytic/chemically induced ; Comoros ; Female ; Glucosephosphate Dehydrogenase Deficiency/complications ; Humans ; Lawsonia Plant/adverse effects ; Plant Leaves/adverse effects ; Pregnancy
    Language French
    Publishing date 2011-06
    Publishing country France
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 421912-0
    ISSN 0025-682X
    ISSN 0025-682X
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    Zs.A 149: Show issues Location:
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  4. Article ; Online: Ciguatera contracted by French tourists in Mauritius recurs in Senegal.

    Glaizal, M / Tichadou, L / Drouet, G / Hayek-Lanthois, M / De Haro, L

    Clinical toxicology (Philadelphia, Pa.)

    2011  Volume 49, Issue 8, Page(s) 767

    MeSH term(s) Ciguatera Poisoning/diagnosis ; Ciguatera Poisoning/etiology ; Ciguatera Poisoning/therapy ; Female ; France ; Humans ; Male ; Mauritius ; Middle Aged ; Recurrence ; Senegal ; Travel
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.3109/15563650.2011.607461
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    Zs.B 419: Show issues Location:
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  5. Article ; Online: Survenue d'une atteinte cardiaque sévère au cours du syndrome proximien : deux observations originales.

    Besancon, A / Schmitt, C / Glaizal, M / Tichadou, L / Klouche, K / Hayek-Lanthois, M / de Haro, L

    Annales francaises d'anesthesie et de reanimation

    2012  Volume 31, Issue 5, Page(s) 466–468

    Abstract: Amanita proxima is one species of white mushroom which can induce poisonings called in France "proximien" syndrome. The clinical feature of "proximien" syndrome is mainly characterized by early digestive troubles, mild hepatic cytolysis and late renal ... ...

    Title translation Occurrence of severe cardiac alterations in Amanita proxima poisoning: two original observations.
    Abstract Amanita proxima is one species of white mushroom which can induce poisonings called in France "proximien" syndrome. The clinical feature of "proximien" syndrome is mainly characterized by early digestive troubles, mild hepatic cytolysis and late renal impairment. A cardiac insult has never been reported in such a circumstance. The authors describe herein two cases of white mushroom poisoning occurred in the Mediterranean French coast with a typical clinical feature of "proximien" syndrome plus secondary development of severe cardiac alterations. The outcome was good for the two patients thanks to symptomatic treatment. The cases reported here suggest that A. proxima have a potential severe cardiac toxicity leading to include early and precise cardiac examination in the management of patients poisoned by these mushrooms.
    MeSH term(s) Adrenergic beta-Agonists/therapeutic use ; Adult ; Amanita ; Diuretics ; Dobutamine/therapeutic use ; Electrocardiography ; Female ; Furosemide/therapeutic use ; Heart Failure/chemically induced ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Hemodiafiltration ; Hemodynamics/physiology ; Humans ; Long QT Syndrome/chemically induced ; Male ; Middle Aged ; Mushroom Poisoning/diagnostic imaging ; Mushroom Poisoning/physiopathology ; Nausea/chemically induced ; Resuscitation ; Shock, Cardiogenic/chemically induced ; Shock, Cardiogenic/therapy ; Ultrasonography ; Ventricular Dysfunction, Left/chemically induced ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
    Chemical Substances Adrenergic beta-Agonists ; Diuretics ; Dobutamine (3S12J47372) ; Furosemide (7LXU5N7ZO5)
    Language French
    Publishing date 2012-05
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 392411-7
    ISSN 1769-6623 ; 0750-7658
    ISSN (online) 1769-6623
    ISSN 0750-7658
    DOI 10.1016/j.annfar.2012.01.021
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    Zs.B 2591: Show issues Location:
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  6. Article: Méthémoglobinémie après application de crème Emla(®) chez un enfant : circonstances et conséquences d'un surdosage.

    Schmitt, C / Matulic, M / Kervégant, M / Tichadou, L / Boutin, A / Glaizal, M / de Haro, L

    Annales de dermatologie et de venereologie

    2012  Volume 139, Issue 12, Page(s) 824–827

    Abstract: Background: Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.: ... ...

    Title translation Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose.
    Abstract Background: Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.
    Patients and methods: The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two.
    Discussion: This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product.
    MeSH term(s) Anesthetics, Combined/adverse effects ; Child, Preschool ; Dosage Forms ; Drug Overdose ; Female ; Humans ; Lidocaine/adverse effects ; Methemoglobinemia/chemically induced ; Prilocaine/adverse effects
    Chemical Substances Anesthetics, Combined ; Dosage Forms ; EMLA ; Prilocaine (046O35D44R) ; Lidocaine (98PI200987)
    Language French
    Publishing date 2012-12
    Publishing country France
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2012.06.035
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  7. Article ; Online: Paraquat poisonings in France during the European ban: experience of the Poison Control Center in Marseille.

    Kervégant, Morgane / Merigot, Lucie / Glaizal, Mathieu / Schmitt, Corinne / Tichadou, Lucia / de Haro, Luc

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2013  Volume 9, Issue 2, Page(s) 144–147

    Abstract: Paraquat, a widely used herbicide in the world, has caused severe and fatal poisonings. Because of its high toxicity, the European Union withdrew paraquat from its market in July 2007. The purpose of this report is to describe cases of paraquat poisoning ...

    Abstract Paraquat, a widely used herbicide in the world, has caused severe and fatal poisonings. Because of its high toxicity, the European Union withdrew paraquat from its market in July 2007. The purpose of this report is to describe cases of paraquat poisoning recorded at the Poison Control Center in Marseille over the 9-year period starting and ending 4.5 years before and after the paraquat ban. Data analysis showed that the most severe exposures were linked to ingestion. The fatality rate of deliberate consumption was near 50 % (34 suicide attempts and 15 deaths). Our data showed a marginal decline in total number of poisonings observed after the paraquat ban (38 vs 33 after the ban) mostly due to a decrease in the number of unintentional exposure (21 vs 16 after the ban). However, there was no apparent change in the number suicidal attempts using paraquat. Regarding geographical distribution, data showed that most poisonings in mainland France were unintentional, while poisonings in overseas French territories were mostly voluntary. Despite the European ban and the preventive measures, paraquat continues to contribute to severe and life-threatening poisonings in Southeastern and overseas France.
    MeSH term(s) Accidents ; Administration, Oral ; Databases, Factual ; European Union ; France ; Herbicides/administration & dosage ; Herbicides/toxicity ; Humans ; Islands ; Legislation, Drug ; Paraquat/administration & dosage ; Paraquat/toxicity ; Poison Control Centers ; Retrospective Studies ; Spatio-Temporal Analysis ; Suicide, Attempted
    Chemical Substances Herbicides ; Paraquat (PLG39H7695)
    Language English
    Publishing date 2013-02-24
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-012-0283-6
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  8. Article ; Online: Intoxication modérée accidentelle par Nicotiana glauca.

    Lopez, Jean-Guillaume / Kervégant, Morgane / Tichadou, Lucia / Hayek-Lanthois, Maryvonne / de Haro, Luc

    Presse medicale (Paris, France : 1983)

    2013  Volume 42, Issue 11, Page(s) 1538–1539

    Title translation Moderate intoxication by Nicotiana glauca.
    MeSH term(s) Cooking ; Female ; Humans ; Middle Aged ; Plant Poisoning/complications ; Plant Poisoning/diagnosis ; Nicotiana/poisoning
    Language French
    Publishing date 2013-05-22
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2012.12.007
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  9. Article ; Online: Pédérose ou dermatite àPaederus : quatre observations en Provence.

    Drouet, Geneviève / Glaizal, Mathieu / Schmitt, Corinne / Kervégant, Morgane / Tichadou, Lucia / de Haro, Luc

    Presse medicale (Paris, France : 1983)

    2013  Volume 42, Issue 3, Page(s) 355–357

    Title translation Paederus dermatitis: four cases in Provence, Southern France.
    MeSH term(s) Aged ; Aged, 80 and over ; Animals ; Coleoptera ; Dermatitis/parasitology ; Female ; France ; Humans ; Middle Aged
    Language French
    Publishing date 2013-03
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2012.04.012
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  10. Article ; Online: Accidental occupational exposure to phytosanitary products: experience of the Poison Control Center in Marseille from 2008 to 2010.

    Aras, Myriam / Schmitt, Corinne / Glaizal, Mathieu / Kervégant, Morgane / Tichadou, Lucia / de Haro, Luc

    Journal of agromedicine

    2013  Volume 18, Issue 2, Page(s) 117–121

    Abstract: To gain better insight into the problem of accidental occupational exposure to phytosanitary products, a retrospective study of experience at the Poison Control Center in Marseille, France, was conducted for the period between January 1, 2008, and ... ...

    Abstract To gain better insight into the problem of accidental occupational exposure to phytosanitary products, a retrospective study of experience at the Poison Control Center in Marseille, France, was conducted for the period between January 1, 2008, and December 31, 2010. A 129-case series was compiled. The study population was overwhelmingly male (83%), and the most common cause was insecticides (56.6% with a half pyrethrin and 21% organophosphate) and herbicides (26%). Although various exposure routes were observed, the most common were inhalation (43%) and skin contact (34%). The symptoms were mainly neurologic, digestive, and/or cutaneous. The severity of poisoning was generally mild, with no deaths or sequels. Only 5% of cases required hospitalization.
    MeSH term(s) Administration, Inhalation ; Adult ; Female ; France/epidemiology ; Humans ; Insecticides/poisoning ; Male ; Middle Aged ; Occupational Exposure/statistics & numerical data ; Poison Control Centers/statistics & numerical data ; Poisoning/epidemiology ; Poisoning/etiology ; Poisoning/therapy ; Pyrethrins/poisoning ; Retrospective Studies
    Chemical Substances Insecticides ; Pyrethrins
    Language English
    Publishing date 2013
    Publishing country England
    Document type Journal Article
    ZDB-ID 1289325-0
    ISSN 1545-0813 ; 1059-924X
    ISSN (online) 1545-0813
    ISSN 1059-924X
    DOI 10.1080/1059924X.2013.766144
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