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  1. AU="Tien, Chih-Hao"
  2. AU="Twomey, A J"
  3. AU="Caffier, Philipp P"
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  5. AU="Jans, David"
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  13. AU="Goerke, Oliver"
  14. AU="Winter, Jacob M"
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  1. Article: Characterizing the Impact of Compression Duration and Deformation-Related Loss of Closure Force on Clip-Induced Spinal Cord Injury in Rats.

    Lee, Po-Hsuan / Hsu, Heng-Juei / Tien, Chih-Hao / Huang, Chi-Chen / Huang, Chih-Yuan / Chen, Hui-Fang / Yeh, Ming-Long / Lee, Jung-Shun

    Neurology international

    2023  Volume 15, Issue 4, Page(s) 1383–1392

    Abstract: The clip-induced spinal cord injury (SCI) rat model is pivotal in preclinical SCI research. However, the literature exhibits variability in compression duration and limited attention to clip deformation-related loss of closure force. We aimed to ... ...

    Abstract The clip-induced spinal cord injury (SCI) rat model is pivotal in preclinical SCI research. However, the literature exhibits variability in compression duration and limited attention to clip deformation-related loss of closure force. We aimed to investigate the impact of compression duration on SCI severity and the influence of clip deformation on closure force. Rats received T10-level clip-induced SCI with durations of 1, 5, 10, 20, and 30 s, and a separate group underwent T10 transection. Outcomes included functional, histological, electrophysiological assessments, and inflammatory cytokine analysis. A tactile pressure mapping system quantified clip closure force after open-close cycles. Our results showed a positive correlation between compression duration and the severity of functional, histological, and electrophysiological deficits. Remarkably, even a brief 1-s compression caused significant deficits comparable to moderate-to-severe SCI. SSEP waveforms were abolished with durations over 20 s. Decreased clip closure force appeared after five open-close cycles. This study offers critical insights into regulating SCI severity in rat models, aiding researchers. Understanding compression duration and clip fatigue is essential for experiment design and interpretation using the clip-induced SCI model.
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2514727-4
    ISSN 2035-8377 ; 2035-8385
    ISSN (online) 2035-8377
    ISSN 2035-8385
    DOI 10.3390/neurolint15040088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outcomes of surgery and subsequent therapy for central nervous system oligoprogression in EGFR-mutated NSCLC patients.

    Perng, Pang-Shuo / Hsu, Heng-Juei / Lee, Jung-Shun / Wang, Liang-Chao / Huang, Chih-Yuan / Tien, Chih-Hao / Lai, Yu-Hsuan / Su, Po-Lan / Hsu, Hao-Hsiang / Chen, Liang-Yi / Lee, Po-Hsuan

    World journal of surgical oncology

    2023  Volume 21, Issue 1, Page(s) 368

    Abstract: Background: Oligoprogression is an emerging issue in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, the surgical treatment for central nervous system (CNS) oligoprogression is not widely ... ...

    Abstract Background: Oligoprogression is an emerging issue in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, the surgical treatment for central nervous system (CNS) oligoprogression is not widely discussed. We investigated the outcomes of craniotomy with adjuvant whole-brain radiotherapy (WBRT) and subsequent therapies for CNS oligoprogression in patients with EGFR-mutated NSCLC.
    Methods: NSCLC patients with CNS oligoprogression were identified from a tertiary medical center. The outcomes of surgery with adjuvant WBRT or WBRT alone were analyzed, along with other variables. Overall survival and progression-free survival were analyzed using the log-rank test as the primary and secondary endpoints. A COX regression model was used to identify the possible prognostic factors.
    Results: Thirty-seven patients with CNS oligoprogression who underwent surgery or WBRT were included in the study after reviewing 728 patients. Twenty-one patients underwent surgery with adjuvant WBRT, and 16 received WBRT alone. The median overall survival for surgery and WBRT alone groups was 43 (95% CI 17-69) and 22 (95% CI 15-29) months, respectively. Female sex was a positive prognostic factor for overall survival (OR 0.19, 95% CI 0.06-0.57). Patients who continued previous tyrosine kinase inhibitors (OR 3.48, 95% CI 1.06-11.4) and induced oligoprogression (OR 3.35, 95% CI 1.18-9.52) were associated with worse overall survival. Smoking history (OR 4.27, 95% CI 1.54-11.8) and induced oligoprogression (OR 5.53, 95% CI 2.1-14.7) were associated with worse progression-free survival.
    Conclusions: Surgery combined with adjuvant WBRT is a feasible treatment modality for CNS oligoprogression in patients with EGFR-mutated NSCLC. Changing the systemic-targeted therapy after local treatments may be associated with improved overall survival.
    MeSH term(s) Humans ; Female ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Retrospective Studies ; Protein Kinase Inhibitors/therapeutic use ; ErbB Receptors/genetics ; Central Nervous System ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy
    Chemical Substances Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-023-03248-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recurrent inverted papilloma coexisted with skull base lymphoma: A case report.

    Hsu, Heng Juei / Huang, Chi Chen / Chuang, Ming Tsung / Tien, Chih Hao / Lee, Jung Shun / Lee, Po-Hsuan

    World journal of clinical cases

    2021  Volume 9, Issue 2, Page(s) 516–520

    Abstract: Background: Inverted papilloma is an uncommon neoplasm in the nasal cavity. It is a histologically benign tumor, but has a high recurrence and local invasion rate. In addition, nasal or skull base lymphoma is another rare neoplasm. The coexistence of ... ...

    Abstract Background: Inverted papilloma is an uncommon neoplasm in the nasal cavity. It is a histologically benign tumor, but has a high recurrence and local invasion rate. In addition, nasal or skull base lymphoma is another rare neoplasm. The coexistence of these two tumors in one case makes the diagnosis and related treatment difficult.
    Case summary: We report a case of an immunocompetent patient, who had a history of inverted papilloma 20 years ago. The patient presented with an infiltrated mass lesion in the nasal cavity with extension to the frontal base. The repeated biopsies revealed inverted papilloma without any malignant transformation. After the patient underwent a frontobasal craniotomy with total tumor excision, the final pathological examination revealed nasal inverted papilloma coexisting with diffuse large B-cell lymphoma of the skull base.
    Conclusion: Based on this case report, while managing a case of an aggressive recurrent inverted papilloma, not only squamous cell carcinoma transformation, but also other invasive malignancy, such as lymphoma, should be considered.
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i2.516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Teaching NeuroImages: A Ruptured Lumbar Disc Mimicking Spinal Tumor.

    Wong, Chia-En / Lee, Po-Hsuan / Huang, Chi-Chen / Chen, Hui-Wen / Tien, Chih-Hao / Huang, Chih-Yuan / Lee, Jung-Shun

    Neurology

    2021  Volume 96, Issue 24, Page(s) e3003–e3004

    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Author Response: Teaching NeuroImages: A Ruptured Lumbar Disc Mimicking Spinal Tumor.

    Lee, Jung-Shun / Wong, Chia-En / Lee, Po-Hsuan / Huang, Chi-Chen / Chen, Hui-Wen / Tien, Chih-Hao / Huang, Chih-Yuan

    Neurology

    2021  Volume 97, Issue 19, Page(s) 921

    MeSH term(s) Humans ; Intervertebral Disc Displacement/diagnostic imaging ; Lumbar Vertebrae/diagnostic imaging ; Lumbosacral Region ; Spinal Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000012837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intradiploic Epidermoid Cyst in the Skull.

    Chou, Yi-Wei / Tien, Chih-Hao / Lee, Jung-Shun / Chuang, Ming-Tsung

    The Journal of craniofacial surgery

    2015  Volume 26, Issue 7, Page(s) e662–3

    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000002074
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  7. Article ; Online: High-grade glioma in a patient with breast cancer.

    Chang, Che-Chao / Tien, Chih-Hao / Tai, Shih-Huang / Chuang, Ming-Tsung / Sze, Chun-I / Hung, Yu-Chang / Lee, E-Jian

    Asian journal of surgery

    2014  Volume 37, Issue 3, Page(s) 162–166

    Abstract: Breast cancer is one of the most common origins of metastatic lesions in the central nervous system. Many patients with a breast cancer and concurrent brain tumor(s) were diagnosed to have a metastatic lesion or lesions in the brain, based exclusively on ...

    Abstract Breast cancer is one of the most common origins of metastatic lesions in the central nervous system. Many patients with a breast cancer and concurrent brain tumor(s) were diagnosed to have a metastatic lesion or lesions in the brain, based exclusively on their image findings without further pathologic verification, and received radiotherapy alone thereafter. It is, however, possible that a different pathology such as primary brain malignancy, which actually warrants a specific treatment modality, may occur in such patients with an already known malignancy. We, herein, reported a 61-year-old female patient who suffered from an anaplastic oligodendroglioma 1 year after her diagnosis of breast cancer. Demographic data, characteristic imaging findings, treatment, and outcome of the patient were discussed.
    MeSH term(s) Brain Neoplasms/pathology ; Carcinoma, Ductal, Breast/pathology ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasms, Multiple Primary/pathology ; Oligodendroglioma/pathology
    Language English
    Publishing date 2014-07
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2012.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis.

    Chang, Che-Chao / Tien, Chih-Hao / Lee, E-Jian / Juan, Wei-Sheng / Chen, Ying-Hsin / Hung, Yu-Chang / Chen, Tsung-Ying / Chen, Hung-Yi / Wu, Tian-Shung

    Journal of pineal research

    2012  Volume 53, Issue 2, Page(s) 188–197

    Abstract: We explored anti-inflammatory potential of melatonin against the lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. RAW 264.7 and BV2 cells were stimulated by LPS, followed by the treatment with melatonin or vehicle at various time ... ...

    Abstract We explored anti-inflammatory potential of melatonin against the lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. RAW 264.7 and BV2 cells were stimulated by LPS, followed by the treatment with melatonin or vehicle at various time intervals. In a mouse model of meningitis induced by LPS, melatonin (5mg/kg) or vehicle was intravenously injected at 30min postinsult. The activity of matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) was determined by gelatin zymography. Nuclear factor-kappa B (NFκB) translocation and binding activity were determined by immunocytochemistry and electrophoretic mobility shift assay (EMSA). Our results showed that either pretreatment or cotreatment with melatonin at 50-500 μm effectively inhibited the LPS-induced proMMP-9 activation in the RAW 264.7 and BV2 cells, respectively (P<0.05). This melatonin-induced proMMP-9 inhibition remained effective when treatment was delayed up to 2 and 6hr postinsult for RAW 264.7 and BV2 cells, respectively (P<0.05 for both groups). Additionally, melatonin significantly attenuated the rises of circulatory and cerebral MMP-9 activity, respectively (P<0.05) and reduced the loss of body weight (P<0.05) in mice with meningitis. Moreover, melatonin (50μm) effectively inhibited nuclear factor-kappa B (NFκB) translocation and binding activity in the LPS-treated RAW 264.7 and BV2 cells, respectively (P<0.05). These results demonstrate direct inhibitory actions of melatonin against postinflammatory NFκB translocation and MMP-9 activation and highlight its ability to inhibit systemic and cerebral MMP-9 activation following brain inflammation.
    MeSH term(s) Animals ; Cell Line ; Disease Models, Animal ; Electrophoretic Mobility Shift Assay ; Enzyme Activation/drug effects ; Immunohistochemistry ; Lipopolysaccharides/pharmacology ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Meningitis/drug therapy ; Meningitis/metabolism ; Mice ; NF-kappa B/metabolism
    Chemical Substances Lipopolysaccharides ; NF-kappa B ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632697-3
    ISSN 1600-079X ; 0742-3098
    ISSN (online) 1600-079X
    ISSN 0742-3098
    DOI 10.1111/j.1600-079X.2012.00986.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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