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Article ; Online: Atazanavir / ritonavir versus Lopinavir / ritonavir-based combined antiretroviral therapy (cART) for HIV-1 infection: a systematic review and meta-analysis.

Tigabu, Bereket Molla / Agide, Feleke Doyore / Mohraz, Minoo / Nikfar, Shekoufeh

2020 Volume 20, Issue 1, Page(s) 91–101

Abstract: Background: This systematic review and meta-analysis was conducted to evaluate the safety and effectiveness of Atazanavir/ritonavir over lopinavir/ritonavir in human immunodeficiency virus-1 (HIV-1) infection.: Methods: Clinical trials with a head-to- ...

Abstract	Background: This systematic review and meta-analysis was conducted to evaluate the safety and effectiveness of Atazanavir/ritonavir over lopinavir/ritonavir in human immunodeficiency virus-1 (HIV-1) infection. Methods: Clinical trials with a head-to-head comparison of atazanavir/ritonavir and lopinavir/ritonavir in HIV-1 were included. Electronic databases: PubMed/Medline CENTRAL, Embase, Scopus, and Web of Science were searched. Viral suppression below 50 copies/ml at the longest follow-up period was the primary outcome measure. Grade 2-4 treatment-related adverse drug events, lipid profile changes and grade 3-4 bilirubin elevations were used as secondary outcome measures. Results: A total of nine articles from seven trials with 1938 HIV-1 patients were included in the current study. Atazanavir/ritonavir has 13% lower overall risk of failure to suppress the virus level < 50 copies/ml than lopinavir/ritonavir in fixed effect model (pooled RR: 0.87; CI: 0.78, 0.96; P=0.006). The overall risk of hyperbilirubinemia is very high for atazanavir/ritonavir than lopinavir/ritonavir in the random effects model (pooled RR: 45.03; CI: 16.03, 126.47; P< 0.0001). Conclusion: Atazanavir/ritonavir has a better viral suppression at lower risk of lipid abnormality than lopinavir/ritonavir. The risk and development of hyperbilirubinemia from atazanavir-based regimens should be taken into consideration both at the time of prescribing and patient follow-up.
MeSH term(s)	Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/methods ; Atazanavir Sulfate/pharmacology ; Atazanavir Sulfate/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Protease Inhibitors/pharmacology ; HIV Protease Inhibitors/therapeutic use ; HIV-1/drug effects ; Humans ; Hyperbilirubinemia/chemically induced ; Lopinavir/pharmacology ; Lopinavir/therapeutic use ; Ritonavir/adverse effects ; Treatment Outcome ; Viral Load
Chemical Substances	HIV Protease Inhibitors ; Lopinavir (2494G1JF75) ; Atazanavir Sulfate (4MT4VIE29P) ; Ritonavir (O3J8G9O825)
Language	English
Publishing date	2020-12-15
Publishing country	Uganda
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v20i1.14
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Article ; Online: Factors Influencing Prescribing Decisions of Physicians: A Review.

Davari, Majid / Khorasani, Elahe / Tigabu, Bereket Molla

Ethiopian journal of health sciences

2018 Volume 28, Issue 6, Page(s) 795–804

Abstract: Background: The pharmaceutical bill is increasing at an alarming rate. The physician practice variation has a pronounced effect on healthcare spending. A number of factors can influence the prescribing behavior of physicians. The aim of this review was ... ...

Abstract	Background: The pharmaceutical bill is increasing at an alarming rate. The physician practice variation has a pronounced effect on healthcare spending. A number of factors can influence the prescribing behavior of physicians. The aim of this review was to identify the factors affecting the prescribing decision of physicians. Methods: Electronic databases including Scopus, PubMed/MEDLINE CENTRAL, Cochrane Libraries and Google scholar were searched systematically for literatures on factors influencing prescribing decisions of physicians from 2000 to 2016. There was no restriction on the study designs. Results: Thirty-three studies met the inclusion criteria from 1122 search results. A total of 33 factors were identified. The most frequent factors were patients' clinical condition, pharmaceutical industries, physician attributes, patient preference and cost of medicine. Conclusion: Physicians' personal attributes, cost of the medicine and pharmaceutical industries' marketing and promotion strategies were mostly mentioned to influence prescribing decision. The identified factors showed that prescribing is not only geared for patient benefit, but also towards personal interest. The use of valid and reliable practice guidelines could reduce the negative impact of wide ranges of factors and promote the rational prescribing effectively.
MeSH term(s)	Decision Making ; Drug Costs ; Drug Industry ; Humans ; Marketing ; Physicians ; Practice Patterns, Physicians'
Language	English
Publishing date	2018-11-01
Publishing country	Ethiopia
Document type	Journal Article ; Systematic Review
ZDB-ID	2705970-4
ISSN	2413-7170 ; 2413-7170
ISSN (online)	2413-7170
ISSN	2413-7170
DOI	10.4314/ejhs.v28i6.15
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Article ; Online: Bioactives from Marine Organisms and their Potential Role as Matrix Metalloproteinase Inhibitors.

Thomas, Noel Vinay / Monica Diyya, Apoorva Salomy / Kim, Se-Kwon / Faraj, Kaeuis Aziz / Ghafoor, Dlzar Dlshad / Qian, Zhong Ji / Tigabu, Bereket Molla

Current pharmaceutical design

2022 Volume 28, Issue 41, Page(s) 3351–3362

Abstract: Recent research has revealed the role of metalloproteinases in a number of severe pathological illnesses, including cardiac, cartilage, neurological, and cancer-related diseases that are fatal to humans. Metalloproteinases are a subclass of ... ...

Abstract	Recent research has revealed the role of metalloproteinases in a number of severe pathological illnesses, including cardiac, cartilage, neurological, and cancer-related diseases that are fatal to humans. Metalloproteinases are a subclass of endopeptidases that comprise structurally identical enzymes known as Matrix Metalloproteinases (MMPs) that are solely involved in extracellular matrix degradation and play a significant regulatory function in tissue remodeling. Improper regulation and expression of MMPs have been linked to several life-threatening pathological conditions in humans. Hence there is an ever-growing interest in various research communities to identify and report the Matrix Metalloproteinase Inhibitors (MMPIs). In spite of several chemically synthesized MMPIs being available currently, several unpleasant side effects, un-successful clinical trials have made use of synthetic MMPIs as a risky strategy. Several natural product researchers have strongly recommended and reported many natural resources like plants, microorganisms, and animals as greater resources to screen for bioactives that can function as potential natural MMPIs. Marine environment is one of the vast and promising resources that harbor diverse forms of life known to synthesize biologically active compounds. These bioactive compounds from marine organisms have been reported for their unparalleled biological effects and have profound applications in cosmeceutical, nutraceutical, and pharmaceutical research. Several research groups have reported an umpteen number of medicinally unmatched compounds from marine flora and fauna, thus driving researchers to screen marine organisms for natural MMPIs. In this review, our group has reported the potential MMPIs from marine organisms.
MeSH term(s)	Animals ; Humans ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use ; Aquatic Organisms/metabolism ; Matrix Metalloproteinases/metabolism ; Biological Products
Chemical Substances	Matrix Metalloproteinase Inhibitors ; Matrix Metalloproteinases (EC 3.4.24.-) ; Biological Products
Language	English
Publishing date	2022-10-23
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666221121145614
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Zs.A 4714: Show issues

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Article: Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis.

Arero, Amanuel Godana / Vasheghani-Farahani, Ali / Tigabu, Bereket Molla / Arero, Godana / Ayene, Beniyam Yimam / Soltani, Danesh

Frontiers in medicine

2022 Volume 9, Page(s) 1065476

Abstract: Background: Long-term risk and predictors of cerebrovascular events following sepsis hospitalization have not been clearly elucidated. We aim to determine the association between surviving sepsis hospitalization and cerebrovascular complications in ... ...

Abstract	Background: Long-term risk and predictors of cerebrovascular events following sepsis hospitalization have not been clearly elucidated. We aim to determine the association between surviving sepsis hospitalization and cerebrovascular complications in adult sepsis survivors. Method: We searched MEDLINE, Embase, Scopus, Web of Sciences, Cochrane library, and Google scholar for studies published from the inception of each database until 31 August 2022. Results: Of 8,601 screened citations, 12 observational studies involving 829,506 participants were analyzed. Surviving sepsis hospitalization was associated with a significantly higher ischemic stroke [adjusted hazard ratio (aHR) 1.45 (95% CI, 1.23-1.71), Conclusion: Our findings showed a significant association between sepsis and a subsequent risk of cerebrovascular events. The risk of cerebrovascular events can be predicated by patient and sepsis-related baseline variables. New therapeutic strategies are needed for the high-risk patients.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1065476
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Article ; Online: A systematic review of health promotion interventions to increase breast cancer screening uptake: from the last 12 years.

Agide, Feleke Doyore / Sadeghi, Roya / Garmaroudi, Gholamreza / Tigabu, Bereket Molla

European journal of public health

2018 Volume 28, Issue 6, Page(s) 1149–1155

Abstract: Background: The outcome of breast cancer treatment largely depends on the timing of detection. The health promotion interventions have an immense contribution to early detection and improved survival. Therefore, this review aimed to provide evidence on ... ...

Abstract	Background: The outcome of breast cancer treatment largely depends on the timing of detection. The health promotion interventions have an immense contribution to early detection and improved survival. Therefore, this review aimed to provide evidence on the efficacy of the health promotion interventions to increase the uptake of breast cancer screening and to develop effective interventions targeting women. Methods: Online databases (PubMed/MEDLINE/PubMed Central, Ovid/MEDILINE, EMBASE, Web of Science and Google Scholar) were searched for studies published between January 2005 and January 2017. A quality coding system was assessed using Cochrane checklists for randomized controlled trial (RCT) and Downs and Black checklists for non-RCT. The score was rated for the included articles by each researcher independently and the average score is given accordingly. This study was registered in PROSPERO as [PROSPERO 2017: CRD42017060488]. Results: The review dovetailed 22 studies. Thirteen studies (59.10%) were conducted in the Unite States, 4 in Iran (18.18%), 2 in India (9.09%) and 1 each in Turkey, Saudi Arabia and Israel. The interventions were classified as 'individual-based', 'community-based', 'group-based teachings and training' and 'behavioral model based'. The majority of the studies showed favorable outcomes after health promotion interventions, including improvements in women's view of breast screening, breast self-examination and knowledge of breast screening. Conclusion: The review confirmed that most of the health promotion interventions targeting women boosted the breast screening in one or another way. However, the limited quality of the included studies showed that further research is needed to improve the trials in the next future.
MeSH term(s)	Breast Neoplasms/diagnosis ; Early Detection of Cancer ; Female ; Health Promotion ; Humans ; India ; Iran ; Israel ; Mass Screening/trends ; Patient Acceptance of Health Care ; Turkey
Language	English
Publishing date	2018-05-20
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckx231
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Zs.A 3499: Show issues

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Article ; Online: Response to letter to the editor: Fluid volume, fluid balance and patient outcome in severe sepsis and septic shock: A systematic review.

Tigabu, Bereket Molla / Davari, Majid / Kebriaeezadeh, Abbas / Mojtahedzadeh, Mojtaba

Journal of critical care

2018 Volume 50, Page(s) 314–315

MeSH term(s)	Humans ; Sepsis ; Shock, Septic ; Water-Electrolyte Balance
Language	English
Publishing date	2018-11-15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2018.11.011
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Zs.A 2152: Show issues

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Article ; Online: Fluid volume, fluid balance and patient outcome in severe sepsis and septic shock: A systematic review.

Tigabu, Bereket Molla / Davari, Majid / Kebriaeezadeh, Abbas / Mojtahedzadeh, Mojtaba

Journal of critical care

2018 Volume 48, Page(s) 153–159

Abstract: Purpose: This systematic review and meta-analysis was conducted to evaluate the mortality risk in severe sepsis and septic shock with a low and high fluid volume/balance.: Methods: Cohort studies that compared the mortality of patients with low or ... ...

Abstract	Purpose: This systematic review and meta-analysis was conducted to evaluate the mortality risk in severe sepsis and septic shock with a low and high fluid volume/balance. Methods: Cohort studies that compared the mortality of patients with low or high fluid volume/balance were included. Electronic databases: PubMed/Medline PLUS, Embase, Scopus, and Web of Science were searched. Patient mortality at the longest follow-up was the primary outcome measure. The data were analyzed using STATA 14 statistical software. Results: The current study included fifteen studies with 31,443 severe sepsis and/or septic shock patients. Patients with a high fluid balance have a 70% increased risk of mortality (pooled RR: 1.70; CI: 1.20, 2.41; P = .003). Survivors of severe sepsis and/or septic shock received higher fluid volume in the first three hours. However, fluid volume administered in the first 24 h was higher for non-survivors. Low volume resuscitation in the first 24 h had a significant mortality reduction (P = .02). Conclusion: High fluid balance from the first 24 h to ICU discharge increases the risk of mortality in severe sepsis and/or septic shock. However, randomized clinical trials should be conducted to resolve the dilemma of fluid resuscitation.
MeSH term(s)	Fluid Therapy ; Humans ; Iran ; Sepsis/mortality ; Sepsis/physiopathology ; Shock, Septic/mortality ; Shock, Septic/physiopathology ; Water-Electrolyte Balance
Language	English
Publishing date	2018-08-20
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2018.08.018
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Article ; Online: Efficacy and safety of interleukin-1 antagonists in rheumatoid arthritis: a systematic review and meta-analysis.

Nikfar, Shekoufeh / Saiyarsarai, Parisa / Tigabu, Bereket Molla / Abdollahi, Mohammad

Rheumatology international

2018 Volume 38, Issue 8, Page(s) 1363–1383

Abstract: Rheumatoid arthritis patients have a high level of pro-inflammatory interleukin-1. Augmenting the blockade of interleukin-1 receptors by external interleukin-1 receptor antagonist modifies the progression of the disease. Therefore, the aim of this study ... ...

Abstract	Rheumatoid arthritis patients have a high level of pro-inflammatory interleukin-1. Augmenting the blockade of interleukin-1 receptors by external interleukin-1 receptor antagonist modifies the progression of the disease. Therefore, the aim of this study was to evaluate the clinical efficacy and safety of interleukin-1 receptor antagonist (anakinra) in the treatment of rheumatoid arthritis. Clinical trials and extension studies that compared anakinra with placebo or other medications were included. Electronic bibliographic databases: PubMed, Scopus, and Web of Sciences were searched from inception to November 2017. The American College of Rheumatology 20% (ACR20) improvement was the primary efficacy outcome measure. Total number of adverse drug events, serious adverse drug events, total treatment withdrawals, and treatment-related withdrawals were safety outcome measures. Ten studies were included in this review. One study did not fulfil quantitative criteria and was assessed qualitatively. Six clinical trials and three extension studies were included in meta-analysis. Patients treated with anakinra are 42% more likely to have ACR20 response than patients without IL-1Ra (pooled RR 1.42; 95% CI 1.01, 2.00). Patients on 30-150 mg anakinra have lower Health Assessment Questionnaire (HAQ) score than patients without IL-1Ra (SMD - 0.28; 95% CI - 0.53, - 0.03). The inflammatory marker erythrocyte sedimentation rate (ESR) was significantly lower among patients treated with 30-150 mg anakinra (SMD - 0.44; 95% CI - 0.65, - 0.23). Patients on anakinra have a 34% more risk of treatment-related withdrawal than placebo. The other parameters were not found to be statistically significant. Anakinra has a significant improvement in ACR20, HAQ, and ESR. The ACR20 response is maintained after 48 weeks of treatment. Anakinra shows higher episodes of treatment-related withdrawals than placebo.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Blood Sedimentation ; Double-Blind Method ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Treatment Outcome
Chemical Substances	Antirheumatic Agents ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
Language	English
Publishing date	2018-05-08
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-018-4041-1
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Zs.A 1639: Show issues

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Article: The relationship between lifestyle and anthropometric factors with the sleep characteristics among university students in Iran: the MEPHASOUS study.

Varmaghani, Mehdi / Mansouri, Masoume / Shams-Beyranvand, Mehran / Tigabu, Bereket Molla / Saiyarsarai, Parisa / Emamikhah, Maziar / Yaghubi, Hamid / Tabrizi, Yousef Moghadas / Sharifi, Farshad

Journal of diabetes and metabolic disorders

2020 Volume 19, Issue 2, Page(s) 1019–1026

Abstract: Background: Healthy sleep habits have an important role in normal cognitive function, emotional performance, and well-being. The aims of this study were to describe the characteristics of sleep among university students in Iran. In addition, we assessed ...

Abstract	Background: Healthy sleep habits have an important role in normal cognitive function, emotional performance, and well-being. The aims of this study were to describe the characteristics of sleep among university students in Iran. In addition, we assessed the relationship between lifestyle and anthropometric factors with the sleep characteristics. Methods: This population-based cross-sectional study was conducted using the data of "Mental and Physical Health Assessment of University Students in Iran" survey 2012-2013. This survey was conducted on newly admitted students in 74 public universities in 28 provinces. The participants were younger adults. Univariate and multivariate logistic regression models were utilized to recognize associated factors with sleep pattern and range. Result: Of total 78,848 students who completed the survey, 54.64% ( Conclusion: Our findings indicated that irregular sleep pattern is associated with overweight and obesity. So, these results underscore the need to educate students on importance of healthy sleep pattern and duration on health conditions.
Language	English
Publishing date	2020-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-020-00598-x
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Article: Drug-related problems among medical ward patients in Jimma university specialized hospital, Southwest Ethiopia.

Tigabu, Bereket Molla / Daba, Daniel / Habte, Belete

Journal of research in pharmacy practice

2014 Volume 3, Issue 1, Page(s) 1–5

Abstract: Objective: The increasing number of available drugs and drug users, as well as more complex drug regimens led to more side effects and drug interactions and complicates follow-up. The objective of this study was to assess drug-related problems (DRPs) ... ...

Abstract	Objective: The increasing number of available drugs and drug users, as well as more complex drug regimens led to more side effects and drug interactions and complicates follow-up. The objective of this study was to assess drug-related problems (DRPs) and associated factors in hospitalized patients. Methods: A hospital-based cross-sectional study design was employed. The study was conducted in Jimma University Specialized Hospital, Jimma, located in the south west of Addis Ababa. All patients who were admitted to the medical ward from February 2011 to March 2011 were included in the study. Data on sociodemographic variables, past medical history, drug history, current diagnosis, current medications, vital signs, and relevant laboratory data were collected using semi-structured questionnaire and data collection forms which were filling through patient interview and card review. Data were analyzed using SPSS version 16 for windows. Descriptive statistics, cross-tabs, Chi-square, and logistic regression were utilized. Findings: Out of 257 study participants, 189 (73.5%) had DRPs and a total of 316 DRPs were identified. From the six classes of DRPs studied, 103 (32.6%) cases related to untreated indication or need additional drug therapy, and 49 (15.5%) cases related to high medication dosage. Unnecessary drug therapy in 49 (15.5%) cases, low medication dosage in 44 (13.9%) cases, and ineffective drug therapy in 42 (13.3%) cases were the other classes of problems identified. Noncompliance in 31 (9.8%) cases was the least prevalent DRP. Independent factors which predicted the occurrence of DRPs in the study population were sex, age, polypharmacy, and clinically significant potential drug-drug interactions. The prevalence of DRPs was substantially high (73.5%). Conclusion: Drug-related problems are common among medical ward patients. Indication-related problems, untreated indication and unnecessary drug therapy were the most common types of DRPs among patients of our medical ward.
Language	English
Publishing date	2014-06-02
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/2279-042X.132702
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