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  1. Article ; Online: Current use of testosterone therapy in LGBTQ populations.

    Tijerina, A N / Srivastava, A V / Patel, V R / Osterberg, E C

    International journal of impotence research

    2021  Volume 34, Issue 7, Page(s) 642–648

    Abstract: Testosterone therapy (TT) is a type of gender-affirming hormone therapy (GAHT) in lesbian, gay, bisexual, transgender, and genderqueer (LGBTQ) populations for gender dysphoria (GD), body uneasiness, and sexual dysfunction. The physical and physiological ... ...

    Abstract Testosterone therapy (TT) is a type of gender-affirming hormone therapy (GAHT) in lesbian, gay, bisexual, transgender, and genderqueer (LGBTQ) populations for gender dysphoria (GD), body uneasiness, and sexual dysfunction. The physical and physiological effects of TT vary widely depending on the dosing regimen and duration of treatment. An individualized approach prioritizing patient-specific desired effects in the context of pre-existing characteristics and health history is strongly recommended. Although TT is an effective treatment for many patients, there has been an increase in the illegitimate acquisition of TT in recent years. Non-judicious prescribing and lack of physician surveillance increases the risk of unintended side effects and potential serious health consequences.
    MeSH term(s) Humans ; Female ; Testosterone/adverse effects ; Sexual and Gender Minorities ; Gender Identity ; Bisexuality ; Sexual Behavior
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-021-00490-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preoperative and intraoperative factors predictive of complications and stricture recurrence following multiple urethroplasty techniques.

    Kay, H E / Srikanth, P / Srivastava, A V / Tijerina, A N / Patel, V R / Hauser, N / Laviana, A A / Wolf, J S / Osterberg, E C

    BJUI compass

    2021  Volume 2, Issue 4, Page(s) 286–291

    Abstract: Objectives: To investigate factors predictive of postoperative recurrence and complications in patients undergoing urethroplasty for stricture repair at a single center.: Patients and methods: We retrospectively reviewed the records of 108 men who ... ...

    Abstract Objectives: To investigate factors predictive of postoperative recurrence and complications in patients undergoing urethroplasty for stricture repair at a single center.
    Patients and methods: We retrospectively reviewed the records of 108 men who underwent urethroplasty for urethral stricture disease (USD) at a single center from 2016 to 2020. Demographic data, comorbidities, stricture history including etiology and prior treatments, patient-reported symptoms, and outcomes data were collected for analysis. Data were analyzed in aggregate, then, stratified by type of urethroplasty performed. Descriptive statistics, univariate analysis, multivariate logistic regression, and intergroup comparisons were completed using STATA, with an alpha value of 0.05 and a confidence interval of 95%.
    Results: The median age of our patients was 58 years (interquartile range: 42-69; range: 29-83), with a median stricture length of 2.0 cm (interquartile range: 1.0-4.5; range: 0.5-10). The most common stricture etiology was iatrogenic (n = 33, 31%) and the most common urethroplasty was anterior anastomotic urethroplasty (n = 38, 35%), followed by buccal mucosal graft (BMG) urethroplasty (n = 35, 32%). Twenty-four patients (22%) had stricture recurrence. Within the aggregate data, recurrence was significantly predicted by obesity (BMI > 30) (Odds Ratio [OR] 3.2, 95% Confidence Interval [CI]: 1.06-10), and the presence of postoperative complications (OR 6.3, CI: 1.9-21). The presence of any postoperative complications within 90 days was significantly predicted by stricture length ≥ 5 cm (OR 3.5, CI 1.09-12) and recurrence (OR 6.0, CI 1.7-21).
    Conclusion: Despite serving as the most definitive treatment for urethral stricture management, stricture recurrence and postoperative complications are not uncommon after urethroplasty. Obesity and stricture length negatively impact outcomes while a penile stricture location is associated with a lower recurrence rate, though this is not statistically significant.
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 2688-4526
    ISSN (online) 2688-4526
    DOI 10.1002/bco2.83
    Database MEDical Literature Analysis and Retrieval System OnLINE

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