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Article ; Online: Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors

Monika Graf / Marta Interlandi / Natalia Moreno / Dörthe Holdhof / Carolin Göbel / Viktoria Melcher / Julius Mertins / Thomas K. Albert / Dennis Kastrati / Amelie Alfert / Till Holsten / Flavia de Faria / Michael Meisterernst / Claudia Rossig / Monika Warmuth-Metz / Johannes Nowak / Gerd Meyer zu Hörste / Chloe Mayère / Serge Nef /
Pascal Johann / Michael C. Frühwald / Martin Dugas / Ulrich Schüller / Kornelius Kerl

Nature Communications, Vol 13, Iss 1, Pp 1-

2022  Volume 19

Abstract: Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the SHH ... ...

Abstract Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the SHH and MYC subtypes.
Keywords Science ; Q
Language English
Publishing date 2022-03-01T00:00:00Z
Publisher Nature Portfolio
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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